EKS-DAR-00802

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00802

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	453.7	3.6E-136	14	275	262

Status

Unreviewed

Ensembl Protein

ENSDARP00000078749

UniProt Accession

A5WVL9;

Protein Name

Protein Synonyms/Alias

Death-associated protein kinase; Novel protein similar to H.sapiens DAPK1, death-associated protein kinase 1 (DAPK1);

Gene Name

si:ch211-66i11.1

Gene Synonyms/Alias

si:ch211-66i11.1; CH211-66I11.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000060093	ENSDARP00000078749	ENSDART00000084314
ENSDARG00000060093	ENSDARP00000105928	ENSDART00000124059

Organism

Danio rerio

Functional Description

Protein Length

1439

Protein Sequence
(FASTA)

MTVFNQENVE DYYEIGGELG SGQFAVVKKC RHKSTGVEYA AKFIKKRRSK SSRRGVSKDD 60

IEREVSILKE IQHPNVITLH DVFENKHEVI LILELVAGGE LFDFLAEKES LSEEEATEFL 120

KQILDGVSYL HSKRISHFDL KPENIMLLNR NVPHPRIKLI DFGLAHKIDF GNDFKNIFGT 180

PEFVAPEVVN YEPLGLEADM WSIGVITYIL LSGASPFLGE NKQETLANVS AVDYEFDEDY 240

FSHTSALAKD FIARLLIKDP KKRMTILDSL QHPWIKPKDT QQALSRKESA VNMEKFKKFA 300

ARRKWKQSVR LISLCNRLSR SFLSRSNMSV ARSDDTLDEE DSFVMKAIIH AINDDNVPGL 360

KHLLGSLTSY DINQPNKHGT PPLLIAAGCG NVQIIDVLMK KGAEIQAFDK TGASAIYYAA 420

RHGHVGTLRF LHEKKCPLDI QDKSGETALH VAARYGNVDV VQYLCSIHAN PDLLDREQET 480

PLHCAAWHGY SAVARALCEA GCDVNARNRE GESPLLTASA RGFKDIVECL LEHGADMDSA 540

DKDGHIALHL AVRRCQVEVV KCLLSHHCYV DHQDRHGNTP LHIACKDANM PVVTQLCAAK 600

ANLDIPNKFG RTPLHLAASN GGLEVVRHLC LSGANTEAIT NDGKTAEDLA TAEQQEHVAV 660

LLAKLKKDNH KSIYIQQLRP TQTLQHRLKL KLFGHSGAGK STLVESLKCG ILRSFFRRRR 720

TRLTNPVRHP ASPVTSKPAV SVSISNLYPG CENVSVRSRS MMFEPSLTKG VLEVFSPVHN 780

ALSTADDTAT KAIDIQNANV NGVGDFSIWE FSGNPVYYCS YDYFAANDAT AIHLVLFSLE 840

EPYETQLNQV TFWLNCLKAL TLPEDNIAFG GKIRNPLRVV LVATHADIVN LPRSFGGEFS 900

YDKERSLLKE VRNRFGNDLL ITEKLFVMDA GASNSKDIKL LRNLLFELRS TIISTCRPMT 960

QLAEKLLSTL PSWRKLNGPN QLISWQQFVV DVQEQINPLA SEEDLRGLAS QLHSMGEINI 1020

MQSETVQDVV LLDPRWLCSN VLGKLLSIET PKAIHHYRGR YRVEELQHLV SEGDIDELLQ 1080

VLDAMDVCAR DLANPGMVDI PALIRTGGLQ HTWTDEEDVE GEDALLYGGV RMVPVEHLAP 1140

FPCGLFHKLQ VNLCRWSRQQ KPEVEADDVR LWSGGARIGL GGVEALVLLV NHGQGMEVQL 1200

RGPDTDPGRC YALLDTLCGM AEGLLAATLP GLLTARHYLS PQQLREHHGP VMLYQPRDFF 1260

RAQARGENAL SNTMGGYRES FVSIVALGCI HVYKQGNLGG EVAVAEVSLL ARRKLCRLLD 1320

PPDALGKDWC LLAMNLGLSE LAAKYSSGIN GTPPADPLSL PSPTATLLQE WSQRPDSTIG 1380

VLVAKLRELG RRDAADFLLR AAPVFRVNLE ILGTPSEPYS PVCNGGGTSY NSISSVISR 1439

Nucleotide Sequence
(FASTA)

ATGACCGTGT TCAACCAGGA GAATGTGGAG GATTATTATG AGATTGGAGG AGAACTCGGG 60

AGTGGTCAGT TTGCCGTGGT AAAGAAATGC CGTCATAAGA GCACTGGTGT GGAGTATGCA 120

GCCAAATTTA TCAAGAAGAG GCGGAGCAAA TCAAGCCGAC GAGGGGTCTC AAAAGACGAC 180

ATTGAGAGGG AGGTCAGCAT CCTGAAGGAA ATCCAGCACC CCAATGTCAT CACCCTGCAC 240

GATGTGTTCG AAAACAAGCA TGAAGTCATC CTCATCCTAG AGCTTGTGGC TGGCGGAGAA 300

CTCTTTGACT TTCTAGCAGA GAAAGAGTCA CTGAGTGAAG AGGAGGCCAC CGAGTTCCTC 360

AAGCAGATCT TGGATGGAGT CAGTTACCTG CACTCGAAAC GGATTTCCCA CTTTGACCTG 420

AAGCCGGAGA ACATCATGCT GTTAAACCGG AACGTGCCTC ACCCGCGCAT TAAGCTCATT 480

GACTTTGGCC TGGCCCACAA GATCGATTTT GGCAACGATT TCAAAAACAT CTTTGGTACC 540

CCGGAGTTTG TAGCTCCAGA AGTGGTGAAC TATGAGCCTC TTGGCCTGGA GGCAGACATG 600

TGGAGCATTG GAGTAATCAC TTATATTCTG CTTAGCGGTG CTTCACCTTT CCTGGGTGAA 660

AACAAGCAGG AGACGCTTGC CAATGTGTCA GCCGTGGACT ATGAGTTTGA TGAGGACTAT 720

TTCAGCCACA CCAGCGCTTT GGCCAAAGAC TTCATTGCAC GGTTACTGAT CAAAGATCCA 780

AAAAAAAGAA TGACAATCCT GGACAGTCTT CAACATCCCT GGATCAAGCC AAAGGATACA 840

CAGCAGGCAC TGAGTCGCAA AGAATCAGCT GTCAATATGG AGAAATTCAA GAAGTTTGCT 900

GCCCGAAGAA AATGGAAGCA ATCAGTGCGT CTCATCTCTC TGTGTAACCG GCTCTCCCGC 960

TCCTTTCTGT CCAGGAGCAA CATGAGTGTG GCACGCAGTG ACGACACATT GGATGAAGAG 1020

GACTCGTTTG TCATGAAGGC TATCATCCAC GCAATAAACG ACGACAATGT TCCCGGTCTG 1080

AAACACCTAC TTGGATCTCT GACCAGCTAT GATATCAATC AACCTAACAA GCATGGAACT 1140

CCTCCGCTCC TGATCGCTGC AGGCTGTGGA AACGTCCAGA TCATTGATGT GCTCATGAAA 1200

AAAGGGGCTG AAATTCAAGC CTTTGATAAG ACTGGAGCCA GTGCTATCTA CTACGCCGCC 1260

CGACATGGTC ATGTGGGGAC CTTGAGATTC TTGCATGAAA AGAAGTGCCC TCTGGACATC 1320

CAAGATAAGT CCGGAGAAAC TGCTCTGCAT GTTGCGGCTC GCTATGGTAA TGTGGATGTG 1380

GTCCAATACC TTTGCAGCAT CCATGCCAAC CCTGACCTGT TGGACCGGGA GCAAGAGACG 1440

CCTCTCCATT GCGCGGCCTG GCACGGTTAT TCGGCAGTGG CCAGAGCCCT GTGTGAGGCT 1500

GGCTGTGATG TTAATGCCCG TAACCGTGAG GGTGAGAGTC CACTGCTAAC CGCTTCAGCC 1560

CGTGGCTTCA AGGACATTGT GGAGTGCTTG CTGGAGCATG GGGCTGACAT GGACTCTGCT 1620

GATAAGGATG GTCACATCGC TCTGCATCTA GCCGTGAGGA GGTGCCAGGT TGAGGTGGTC 1680

AAGTGTTTGC TCAGCCATCA CTGCTATGTG GACCACCAGG ATCGTCACGG CAACACACCC 1740

CTTCACATCG CCTGTAAAGA CGCCAACATG CCTGTGGTCA CGCAGCTCTG TGCTGCCAAA 1800

GCCAACCTGG ATATTCCCAA CAAATTTGGG AGAACACCTC TTCACCTGGC AGCGAGTAAC 1860

GGGGGTCTGG AGGTGGTGCG GCATCTCTGT CTTTCAGGAG CAAACACTGA GGCCATCACT 1920

AATGATGGAA AGACGGCGGA GGATCTGGCC ACTGCAGAGC AGCAGGAGCA TGTAGCAGTG 1980

CTGCTGGCCA AGCTGAAAAA GGACAACCAT AAGAGCATTT ACATCCAGCA GCTGCGGCCT 2040

ACACAGACCC TCCAACATCG CCTCAAACTC AAGCTGTTCG GCCATTCTGG AGCAGGGAAG 2100

AGCACTCTGG TGGAGTCCTT GAAGTGTGGC ATCTTGAGGA GCTTCTTCAG AAGGAGGAGG 2160

ACCAGGCTGA CCAACCCTGT CCGACACCCA GCCTCGCCGG TCACTTCCAA ACCTGCAGTG 2220

TCTGTGAGCA TCTCTAACCT GTATCCGGGG TGTGAGAATG TGAGTGTTCG GAGCCGCAGT 2280

ATGATGTTCG AGCCCAGTTT GACTAAAGGA GTGCTGGAGG TCTTCAGTCC TGTTCATAAT 2340

GCTCTCTCCA CGGCTGACGA CACTGCCACT AAAGCCATCG ACATCCAGAA CGCCAACGTC 2400

AATGGTGTTG GAGACTTCAG TATATGGGAG TTTTCTGGCA ATCCCGTCTA TTATTGCTCG 2460

TATGACTACT TCGCTGCCAA TGATGCCACA GCGATTCATC TGGTCTTATT CAGCCTGGAG 2520

GAGCCCTACG AAACTCAGCT CAACCAGGTC ACATTCTGGC TGAACTGTCT AAAGGCTCTC 2580

ACGCTGCCAG AGGACAACAT CGCCTTTGGA GGGAAGATCA GGAATCCTCT GCGTGTGGTT 2640

CTGGTGGCCA CACATGCTGA CATTGTGAAT CTGCCCCGAT CGTTTGGAGG AGAGTTCAGC 2700

TATGACAAGG AGAGATCTCT ACTGAAGGAA GTCAGAAACA GGTTTGGAAA TGATCTGCTG 2760

ATCACTGAGA AGCTCTTTGT CATGGATGCA GGAGCGTCCA ACTCTAAAGA CATAAAGCTT 2820

CTGAGAAACC TTCTGTTTGA GCTCCGCAGC ACCATCATTT CTACCTGCAG GCCGATGACT 2880

CAGCTGGCAG AGAAGCTGTT GTCCACTCTG CCTTCCTGGA GGAAACTGAA CGGGCCGAAC 2940

CAGCTCATAT CATGGCAACA GTTTGTTGTG GATGTGCAAG AACAAATCAA CCCTCTAGCC 3000

AGCGAAGAGG ATCTGCGGGG ACTGGCTTCA CAACTTCACA GCATGGGAGA GATTAACATC 3060

ATGCAGAGTG AGACAGTCCA AGATGTTGTC CTCTTAGATC CTCGCTGGCT CTGTAGTAAC 3120

GTACTTGGCA AGCTTCTCTC AATTGAAACC CCCAAAGCAA TCCACCATTA TCGCGGCCGA 3180

TACCGTGTAG AAGAGCTCCA ACACCTGGTC TCCGAAGGCG ACATCGATGA ACTTCTCCAA 3240

GTCCTCGACG CCATGGACGT CTGCGCCCGC GACCTGGCCA ACCCAGGAAT GGTGGACATC 3300

CCTGCCCTCA TTCGCACAGG TGGCCTGCAG CATACCTGGA CAGACGAGGA GGACGTGGAG 3360

GGAGAGGACG CTCTGCTTTA CGGTGGAGTC CGTATGGTTC CTGTGGAGCA CCTGGCACCC 3420

TTTCCTTGCG GACTTTTCCA TAAGTTACAG GTGAACTTGT GCAGGTGGAG CCGCCAGCAG 3480

AAGCCTGAGG TGGAGGCTGA TGATGTGAGG TTGTGGAGCG GTGGCGCTCG CATCGGACTT 3540

GGTGGTGTGG AGGCTCTGGT TCTGCTTGTG AACCACGGGC AAGGCATGGA GGTACAGTTA 3600

CGAGGACCTG ACACAGATCC GGGACGCTGC TATGCTTTGT TGGACACTCT GTGCGGCATG 3660

GCTGAGGGTC TGTTAGCTGC TACTTTGCCC GGTTTGCTTA CCGCCCGACA CTATCTCAGC 3720

CCTCAGCAAC TGCGTGAACA CCACGGCCCA GTCATGCTTT ACCAGCCGAG GGACTTTTTT 3780

AGAGCTCAAG CGCGAGGTGA GAACGCTCTG TCGAACACCA TGGGTGGCTA TCGCGAAAGC 3840

TTTGTCAGTA TCGTAGCATT AGGATGCATT CATGTCTACA AACAGGGCAA CCTCGGTGGC 3900

GAAGTGGCTG TAGCAGAGGT CAGTCTTTTG GCTCGACGTA AGCTCTGCCG CCTGCTAGAC 3960

CCGCCTGATG CCCTGGGCAA GGACTGGTGC CTGTTGGCCA TGAACTTGGG CCTTAGCGAA 4020

CTAGCTGCTA AATACAGTTC TGGCATCAAC GGGACTCCAC CAGCAGACCC GCTTTCTCTC 4080

CCTAGCCCTA CAGCCACACT CCTGCAGGAG TGGAGCCAGA GGCCTGACTC AACCATTGGT 4140

GTTTTGGTTG CAAAGTTGCG AGAACTTGGC CGTCGAGACG CGGCAGATTT CCTGCTTAGA 4200

GCTGCACCAG TGTTTCGGGT GAACTTGGAG ATTTTGGGCA CCCCGTCTGA GCCCTACAGC 4260

CCCGTGTGTA ATGGAGGAGG CACATCCTAC AACTCCATCA GCTCCGTCAT ATCTCGTTAG 4320

Domain Profile

S: 2     etgkelgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirs  61

         e+g elgsG+favv+kcr+kstG eyaakf+kkrr+kssrrgvs+++ierev++lkei+

Q: 14    EIGGELGSGQFAVVKKCRHKSTGVEYAAKFIKKRRSKSSRRGVSKDDIEREVSILKEIQ-  72

         56789******************************************************.

S: 62    epnvinlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhs  121

         +pnvi+lh+v+enk +vililelvaGGelfd+laekeslseeeate+lkqil+gv ylhs

Q: 73    HPNVITLHDVFENKHEVILILELVAGGELFDFLAEKESLSEEEATEFLKQILDGVSYLHS  132

         ************************************************************

S: 122   kkivhldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnye  181

         k+i h+dlkPeni+ll+++vp+++iklidfGl++ki+ g+++k+i+GtPefvaPe+vnye

Q: 133   KRISHFDLKPENIMLLNRNVPHPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYE  192

         ************************************************************

S: 182   plsletdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfi  241

         pl+le+dmwsiGvityillsgasPflG++kqetl+n+sav+++f+e++fs++s lakdfi

Q: 193   PLGLEADMWSIGVITYILLSGASPFLGENKQETLANVSAVDYEFDEDYFSHTSALAKDFI  252

         ************************************************************

S: 242   rrllvkdpekrltieeclehswl  264

          rll+kdp+kr+ti ++l+h+w+

Q: 253   ARLLIKDPKKRMTILDSLQHPWI  275

         **********************8

Domain Sequence
(FASTA)

EIGGELGSGQ FAVVKKCRHK STGVEYAAKF IKKRRSKSSR RGVSKDDIER EVSILKEIQH 60

PNVITLHDVF ENKHEVILIL ELVAGGELFD FLAEKESLSE EEATEFLKQI LDGVSYLHSK 120

RISHFDLKPE NIMLLNRNVP HPRIKLIDFG LAHKIDFGND FKNIFGTPEF VAPEVVNYEP 180

LGLEADMWSI GVITYILLSG ASPFLGENKQ ETLANVSAVD YEFDEDYFSH TSALAKDFIA 240

RLLIKDPKKR MTILDSLQHP WI 262

Keyword

ANK repeat; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

dre:558314

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 2.
PF12796	; Ank_2; 2.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 8.
PS50017	; DEATH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013