EPS-DAR-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-DAR-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/aDSP144.93.1E-4231175145
StatusUnreviewed
Ensembl ProteinENSDARP00000078867
UniProt AccessionB3DHB2;
Protein Name
Protein Synonyms/Alias Dual specificity phosphatase 3 (Vaccinia virus phosphatase VH1-related); Novel protein similar to human dual specificity phosphatase 3 (Vaccinia virus phosphatase VH1-related) (DUSP3);
Gene Namedusp3b
Gene Synonyms/Alias dusp3b; dusp3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000060130ENSDARP00000078867ENSDART00000084432
OrganismDanio rerio
Functional Description
Protein Length177
Protein Sequence
(FASTA)
MTSYEVSVQQ LNDLLTDENG DFCMPSKPFH EVYPGILLGN ESAATNVTRL LELGVTHILN 60
AAEGQSDMHV NTDAEYYADT GIIYHGIPAF DTDHFDLSIY FEEASDFIQR ALEMKGKVYV 120
HCQKGYSRSA ALVIAHLMLQ HNMDVRAAVA TVREKREIGP NDGFLRQLCQ LNDRLYD 177
Nucleotide Sequence
(FASTA)
ATGACGAGTT ATGAAGTGTC TGTTCAACAG CTCAATGATC TGCTGACCGA TGAAAATGGA 60
GACTTCTGCA TGCCTTCTAA ACCTTTTCAT GAAGTCTATC CTGGGATACT GCTAGGAAAT 120
GAGTCTGCAG CCACAAATGT GACCCGTTTG CTGGAACTAG GAGTGACACA CATCCTCAAC 180
GCTGCTGAAG GCCAATCAGA CATGCATGTG AACACAGATG CAGAGTACTA TGCAGATACA 240
GGGATCATCT ATCATGGGAT ACCAGCCTTC GACACTGACC ATTTTGACCT CAGCATATAT 300
TTTGAAGAAG CTTCTGATTT TATTCAAAGA GCTTTGGAAA TGAAAGGGAA AGTGTATGTC 360
CACTGTCAAA AAGGCTACAG TCGTTCAGCT GCTCTGGTCA TCGCTCATCT GATGTTGCAG 420
CACAACATGG ACGTGCGAGC TGCAGTGGCC ACAGTCAGAG AGAAACGAGA AATCGGGCCC 480
AATGATGGAT TCCTGCGCCA GCTCTGCCAG CTCAACGACA GGCTGTATGA TTAA 534
Domain Profile
S: 4     eilpglylgdqataldrreLsklgitvvinaslsv..ikvqviPeylikkgityknipvd  61
         e++pg+ lg++  a + + L +lg+t+++na+ +   ++v++  ey+ ++gi y++ip+ 
Q: 31    EVYPGILLGNESAATNVTRLLELGVTHILNAAEGQsdMHVNTDAEYYADTGIIYHGIPAF  90
         89*****************************97651167778899***************
S: 62    DsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAie  121
         D+d++dl+ yf+ea +fi++a e +gkv+vHC+ G+sRSa+lv+a Lm  +++ ++ A+ 
Q: 91    DTDHFDLSIYFEEASDFIQRALEMKGKVYVHCQKGYSRSAALVIAHLMLQHNMDVRAAVA  150
         ************************************************************
S: 122   avkrkrpsiepnegfleQLlelekkl  147
         +v++kr +i pn+gfl+QL++l+ +l
Q: 151   TVREKR-EIGPNDGFLRQLCQLNDRL  175
         ******.**************99876
Domain Sequence
(FASTA)
EVYPGILLGN ESAATNVTRL LELGVTHILN AAEGQSDMHV NTDAEYYADT GIIYHGIPAF 60
DTDHFDLSIY FEEASDFIQR ALEMKGKVYV HCQKGYSRSA ALVIAHLMLQ HNMDVRAAVA 120
TVREKREIGP NDGFLRQLCQ LNDRL 145
KeywordComplete proteome; Hydrolase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005829; C:cytosol
GO:0005654; C:nucleoplasm
GO:0033549; F:MAP kinase phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0046329; P:negative regulation of JNK cascade
GO:0050868; P:negative regulation of T cell activation
GO:0050860; P:negative regulation of T cell receptor signaling pathway
GO:0035335; P:peptidyl-tyrosine dephosphorylation
GO:0045931; P:positive regulation of mitotic cell cycle
KEGG
dre:568344;
InterPros
IPR020417; Atypical_DUSP.
IPR020405; Atypical_DUSP_famA.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR020422; Dual-sp_phosphatase_subgr_cat.
IPR024950; DUSP.
IPR000387; Tyr/Dual-specificity_Pase.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
SMARTs
SM00195; DSPc; 1.
Prosites
PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
Prints
PR01908; ADSPHPHTASE.
PR01909; ADSPHPHTASEA.
Created Date20-Feb-2013