EKS-DAR-00522

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00522

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKN	543.2	1.8E-163	603	862	260

Status

Unreviewed

Ensembl Protein

ENSDARP00000123235

UniProt Accession

F6NV75;

Protein Name

Protein Synonyms/Alias

Gene Name

pkn1

Gene Synonyms/Alias

pkn1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000060184	ENSDARP00000078947	ENSDART00000084512
ENSDARG00000060184	ENSDARP00000123235	ENSDART00000132555

Organism

Danio rerio

Functional Description

Protein Length

930

Protein Sequence
(FASTA)

MASEEGRNTS LTEQHDDDTI TQTETPSDPG GLSGLERLGL DHSSDYSDSS VQQRLDKERE 60

RIRREIRKEL KIKEGAENLR RATTDKRNAQ QVDSQLRCSN RRLDSLHAEL QELDAHIVVK 120

GTDDTHDDAP QSPGAESRSS AHKERIAALE RQLNIELKVK QGAENMIPIY TNGSTKQMLQ 180

DSKTKIDIIR MQIRKAVQAY EHNDDTQGKP DPCGMELRIE ELRHHYRVEH AVAEGAKNVL 240

RLLGASKAQC RLSESSQRLD LLRDSLDRRL AELPEDHPKA SVIKEELVLA SSPAFSSQHS 300

APYLHNQYST LSKPSPLTGR LQVTLLGCMG LLEVVPGRSR GSQVVLPCYS PGEGRSFMRS 360

GKGLYSRSGS VSGKTPLKTD ELSSDVSAVL KLDNTVVCQT AWKMVGEQGW DQTFIIELER 420

SREMEIAVYW RDYRSLCALK FLKLEDFLDN QKHKVQLELE PQGLLLAEVT FFNPVIERVP 480

RLKRQKNVFS KQQGKAFLRA RQMNVDIGTF VRLLRNAIPT VNNTGTYSPN AHTLQTGEIS 540

VEKLSLDFDS PMKVDIRREV TDISTPERQP STEPLSAPDV TTPIRTHSLS SKQKKTSLSL 600

QDFRLIAVLG RGHFGKVLLA EYKKSGSMYA IKALKKGDIV ARDEVESLMC EKRIFEAVNG 660

AQHPFLVNLF ACFQTPEHVC FVMEYTAGGD LMMHIHADVF TEPRAVFYSA CVVLGLQFLH 720

DNKIVYRDLK LDNLLLDTEG YVKIADFGLC KEGMGFGDRT STFCGTPEFL APEVLTDTSY 780

TRAVDWWGLG VLIYEMLVGE SPFPGDDEEE VFDSIVNDEV RYPRFLSAEA IGIMRRLLRR 840

NPERRLGSSE KDAEDVKKQP FFRNMDWEAL LLRKLPPPFI PSIGGKEDVS NFDEEFTTEA 900

PTLTPPREPR VLSRKDQDSF RDFDYVSDLC 930

Nucleotide Sequence
(FASTA)

ATGGCCAGCG AGGAGGGAAG AAATACATCC CTCACAGAGC AGCACGACGA CGACACCATC 60

ACACAGACTG AGACTCCGAG TGATCCCGGT GGGTTGTCTG GATTAGAGCG GCTTGGCTTG 120

GACCACAGCT CTGATTACTC TGACTCGAGC GTACAACAGC GACTGGATAA AGAGCGCGAG 180

CGAATCCGTC GGGAAATCCG CAAGGAGCTG AAGATTAAAG AGGGGGCAGA GAATCTCCGC 240

AGAGCCACTA CAGATAAACG AAATGCTCAG CAGGTGGACA GCCAGTTGCG CTGCTCAAAT 300

CGGCGTCTGG ACTCACTCCA TGCTGAATTA CAAGAACTGG ACGCTCATAT TGTGGTCAAA 360

GGGACCGATG ATACACACGA TGACGCTCCT CAGTCTCCGG GAGCGGAGAG CAGGTCATCG 420

GCACACAAGG AGAGAATTGC TGCTTTGGAA AGGCAGTTAA ACATCGAGCT CAAAGTCAAA 480

CAGGGGGCAG AAAACATGAT CCCCATTTAT ACCAACGGTT CCACCAAGCA GATGCTACAG 540

GACAGCAAGA CAAAGATTGA CATCATCCGC ATGCAGATCC GGAAAGCAGT GCAGGCCTAC 600

GAACACAACG ATGATACACA GGGAAAGCCT GATCCATGTG GTATGGAGCT ACGCATTGAA 660

GAGCTCAGAC ACCATTACCG AGTAGAGCAC GCCGTCGCTG AGGGAGCCAA AAACGTCCTT 720

AGACTTCTTG GAGCCAGTAA AGCTCAGTGT CGTCTGAGTG AATCGTCGCA AAGGTTGGAC 780

CTGCTGCGAG ATTCTTTAGA TCGACGGTTA GCAGAGCTTC CTGAGGATCA TCCCAAAGCT 840

TCTGTTATCA AAGAGGAGCT GGTTTTAGCA TCCTCACCAG CCTTCAGCTC TCAACACAGC 900

GCCCCCTACC TGCACAACCA GTACAGCACT CTCTCCAAAC CCTCACCCCT CACTGGTCGG 960

CTCCAGGTGA CATTATTGGG CTGTATGGGT CTTCTGGAGG TGGTTCCCGG ACGCTCTCGT 1020

GGTAGCCAGG TGGTTTTACC GTGTTACAGT CCAGGAGAGG GACGATCATT CATGCGCAGT 1080

GGAAAAGGCC TGTATAGTCG CAGTGGCAGC GTTAGTGGAA AAACACCCCT CAAAACCGAC 1140

GAACTCTCCT CGGATGTGAG CGCAGTATTG AAGCTGGACA ACACTGTGGT GTGTCAGACG 1200

GCATGGAAGA TGGTTGGAGA ACAGGGCTGG GATCAGACCT TCATCATCGA GCTGGAGAGA 1260

TCCAGAGAGA TGGAGATTGC CGTGTACTGG AGAGACTACC GCTCTCTGTG TGCGCTGAAA 1320

TTTCTCAAGC TGGAGGATTT CTTGGACAAC CAGAAACACA AAGTACAACT AGAGCTAGAA 1380

CCACAGGGAC TGCTGCTGGC AGAGGTTACT TTCTTTAACC CTGTGATTGA GAGGGTTCCA 1440

CGGCTAAAAC GGCAGAAGAA TGTTTTCTCC AAGCAGCAGG GTAAAGCATT TTTGCGAGCT 1500

CGACAGATGA ACGTTGATAT TGGCACATTC GTGAGGTTAC TGAGGAACGC CATACCAACC 1560

GTCAACAACA CAGGAACCTA CAGCCCTAAC GCGCACACTC TACAGACTGG GGAGATATCA 1620

GTGGAGAAGT TGAGTTTAGA TTTTGATTCA CCAATGAAGG TGGACATCCG GCGGGAGGTG 1680

ACAGATATAA GCACTCCGGA GAGGCAGCCG TCCACCGAGC CTCTCTCTGC TCCAGACGTC 1740

ACCACGCCTA TCAGAACACA CTCATTGAGC AGTAAACAGA AGAAGACTTC TCTGAGCCTG 1800

CAGGATTTCC GACTAATTGC AGTTCTTGGC AGAGGCCATT TTGGAAAGGT GCTGCTGGCG 1860

GAATATAAGA AGTCAGGGAG TATGTATGCC ATTAAAGCTC TAAAGAAAGG AGACATTGTA 1920

GCCAGAGATG AAGTAGAAAG TTTGATGTGT GAGAAGCGTA TTTTCGAGGC AGTGAACGGT 1980

GCACAACACC CCTTCCTTGT CAACCTGTTT GCGTGTTTCC AGACTCCAGA ACATGTGTGT 2040

TTTGTGATGG AGTACACAGC AGGCGGTGAC CTCATGATGC ACATACATGC AGACGTCTTC 2100

ACCGAGCCAC GGGCTGTGTT TTATTCTGCT TGTGTAGTTT TAGGGCTTCA GTTTTTACAT 2160

GACAACAAGA TTGTGTACCG AGATCTTAAA TTAGACAACT TGCTGCTTGA CACAGAGGGT 2220

TATGTGAAGA TTGCCGACTT TGGATTGTGT AAAGAAGGTA TGGGTTTTGG GGACCGGACC 2280

AGTACGTTCT GCGGGACTCC AGAGTTTCTG GCTCCAGAGG TTTTGACAGA CACATCGTAC 2340

ACCCGTGCTG TGGACTGGTG GGGTCTCGGA GTGCTTATAT ATGAAATGTT GGTGGGAGAG 2400

TCCCCATTCC CAGGTGATGA CGAAGAGGAA GTTTTTGACA GCATAGTGAA TGATGAAGTT 2460

CGATACCCCA GGTTCCTGTC CGCAGAGGCC ATTGGCATCA TGAGGAGGTT ACTAAGGAGA 2520

AATCCAGAAA GACGACTGGG CTCCAGTGAG AAAGATGCAG AAGATGTAAA GAAACAGCCT 2580

TTCTTCAGGA ATATGGACTG GGAGGCTCTT CTCCTCCGCA AACTCCCTCC TCCTTTTATT 2640

CCATCCATCG GAGGAAAAGA AGACGTCAGC AACTTTGATG AGGAGTTCAC GACAGAAGCG 2700

CCGACTCTCA CTCCTCCCCG CGAGCCTCGA GTGCTTTCGC GCAAAGATCA GGACAGTTTC 2760

CGGGACTTCG ACTATGTGTC TGACCTCTGC TGA 2793

Domain Profile

S: 1     frllavlgrghfgkvllseykstgelyaikalkkgdilardevesllcekrileavssvr  60

         frl+avlgrghfgkvll+eyk++g +yaikalkkgdi+ardevesl+cekri+eav+ ++

Q: 603   FRLIAVLGRGHFGKVLLAEYKKSGSMYAIKALKKGDIVARDEVESLMCEKRIFEAVNGAQ  662

         9***********************************************************

S: 61    hpflvnllacfqtkehvcfvmeyaaggdlmlhihedvfsepravfyaacvvlglqflhek  120

         hpflvnl+acfqt ehvcfvmey+aggdlm+hih dvf+epravfy+acvvlglqflh++

Q: 663   HPFLVNLFACFQTPEHVCFVMEYTAGGDLMMHIHADVFTEPRAVFYSACVVLGLQFLHDN  722

         ************************************************************

S: 121   kivyrdlkldnllldtegyvkiadfglckeglgygdrtstfcgtpeflapevltetsytr  180

         kivyrdlkldnllldtegyvkiadfglckeg+g+gdrtstfcgtpeflapevlt+tsytr

Q: 723   KIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTSTFCGTPEFLAPEVLTDTSYTR  782

         ************************************************************

S: 181   avdwwglgvllyemlvgespfpgddeeevfdsivndevryprflsveaieilrrllrknp  240

         avdwwglgvl+yemlvgespfpgddeeevfdsivndevryprfls+eai+i+rrllr+np

Q: 783   AVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGIMRRLLRRNP  842

         ************************************************************

S: 241   ekrlgaserdaedvkkqpff  260

         e+rlg+se+daedvkkqpff

Q: 843   ERRLGSSEKDAEDVKKQPFF  862

         *******************9

Domain Sequence
(FASTA)

FRLIAVLGRG HFGKVLLAEY KKSGSMYAIK ALKKGDIVAR DEVESLMCEK RIFEAVNGAQ 60

HPFLVNLFAC FQTPEHVCFV MEYTAGGDLM MHIHADVFTE PRAVFYSACV VLGLQFLHDN 120

KIVYRDLKLD NLLLDTEGYV KIADFGLCKE GMGFGDRTST FCGTPEFLAP EVLTDTSYTR 180

AVDWWGLGVL IYEMLVGESP FPGDDEEEVF DSIVNDEVRY PRFLSAEAIG IMRRLLRRNP 240

ERRLGSSEKD AEDVKKQPFF 260

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Drosophila melanogaster"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02185	; HR1; 3.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00742	; Hr1; 3.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013