EKS-DAR-00380

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00380

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	429.5	9.4E-129	1048	1306	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000079102

UniProt Accession

E7EYX4;

Protein Name

Protein Synonyms/Alias

Gene Name

mst1ra

Gene Synonyms/Alias

mst1ra; CR847900.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000060235	ENSDARP00000079102	ENSDART00000084667
ENSDARG00000060235	ENSDARP00000123874	ENSDART00000150226

Organism

Danio rerio

Functional Description

Protein Length

1350

Protein Sequence
(FASTA)

MFISPKTLLT CFWLQIHLTC AQKTCPTIQQ MNVNFSVTYP VYFFQTTNAI QNIVFNEYFD 60

EVYVASQNVV EALDKNLTKL WELKTGPVGS PDCQTCNCDI ENEPGTSLDT DNQVLVLEPQ 120

QHLDFLYICG STQYGVCNML ELDKGNIASS PECLFNKKAN SPSDCPDCVA SPLGTKVTVV 180

DEGYSTYFFT AATVNSTIAG SFGKHSLSIR RLLNTENGFH DVKNLTVLPK FQDVFTIDYI 240

YTFSTTEYVY FLSVQWESLM KPNAKLQTHL GRLPIKDSEL WMYREIILEC RFEPKRRRRS 300

FRDVVYNSVQ AAHFSTAGKE LADDLGVRID SPILYGVFAV TDQKGNPMRQ SALCAFPLDY 360

VNSAIEKGVD ACCSSLTEQI SRGLCHFQPC EMCPVENSDS LTCKTTPTMV SKPYYRVDFF 420

NGQMSNVLFT SILVTTIETK TVAHIGTDHG RLLQIILSRS IPVVFANYSL VEDAQKVSRI 480

AAIHSSLESL LFVVGNKLIN VSPRGPGCSH FLNCSACLAA PRFMGCGWCG EVCSQQHQCE 540

DQWSGDSCPP VITQFFPRTV PSNGTSELIL CGWNFQSASR PAITQESHQV RVGNSDCTVV 600

PEKTSSSLLV CRIVGEESGL HQSVNITIQV NEKKAGSGYF ISGKAGIQGF SFVTPEITDI 660

SPSFGPKIGG TLITLSGKHL DAGGSRTISL GDRNCPVESV SSDGTSIVCR SEGVKDTLEV 720

DVKVVIDGST ISSTKTFSYR VNPEVTGVNP NCGFRRGSKI IITGQNLDSV SQAVIKYKGG 780

YKDPVETVCS GQGNPTQMEC MSPVCEESTG ILSVDLDGAK DLQSQTFTCH ANGEPIPFET 840

EDRVLELSPG QDEVSLHHKK LALVSGCMEI IMTVNGVDCN AKVLDNEITC RIPKNLTIPR 900

QGAPVKVLVN REEHDIGMVV MKNSNLIVGV VLGILAAVGV GAAIVYVAMA QERKKKKAAL 960

VEVRLSMHSN RTTAENYDRS PDGDYRRGLS VSPFHGSGTT FTSLPYAGSM DSAAAPLMRR 1020

QVSMSALRPD LLEEVKNVLI SPDKIKIQHE QIIGKGHFGT VYHGYLTDSD NKETHCAVKS 1080

LNRITDLEEV EQFLREGLFM KAFHHSHVLS LLGIVLPSDG LPLVILPYMK HGDLRHFIRS 1140

PERSPTVKDL IGFGLQVAKG MEYLANKKFV HRDLAARNCM LDESFTVKVA DFGMARDVYD 1200

KEYYSIQDSK KAKLPVKWMA LESLQTQKFT TKSDVWSYGV LMWELLTRGA SPYPDVDPYD 1260

ITPYLMQGRR LPQPQYCFDS LWSVLMQCWH PEPEKRPGFT TLVQAVQDIH SSLDGEHYIN 1320

LQITYVNLDQ PRPYPSLCPA TPAHSDQSST 1350

Nucleotide Sequence
(FASTA)

ATGTTCATCA GCCCAAAGAC CTTGTTAACA TGTTTCTGGT TGCAGATACA TCTGACCTGT 60

GCCCAAAAAA CATGCCCTAC CATCCAACAA ATGAATGTAA ACTTTTCTGT GACCTACCCA 120

GTCTACTTTT TCCAAACCAC CAATGCCATA CAGAACATAG TTTTTAATGA ATATTTTGAT 180

GAAGTTTATG TGGCCTCTCA AAATGTAGTT GAAGCCTTGG ACAAAAATCT TACCAAACTA 240

TGGGAATTAA AAACGGGACC AGTTGGCAGT CCAGATTGTC AGACGTGTAA CTGTGATATT 300

GAGAACGAAC CGGGAACATC ATTGGACACT GATAACCAAG TTCTTGTTTT GGAGCCTCAG 360

CAGCATCTGG ACTTCCTGTA CATCTGTGGG AGCACCCAGT ATGGAGTCTG TAACATGCTT 420

GAACTTGATA AAGGCAACAT AGCCTCTAGC CCCGAATGTT TATTTAATAA AAAAGCCAAC 480

TCACCCTCTG ATTGTCCAGA CTGCGTTGCC AGTCCTCTGG GAACGAAGGT CACTGTGGTA 540

GACGAGGGTT ATTCAACATA CTTCTTCACA GCAGCCACCG TCAACAGCAC CATTGCTGGG 600

TCTTTCGGCA AACACTCACT TTCTATCCGT CGCTTGCTTA ACACAGAAAA TGGTTTCCAT 660

GATGTGAAGA ATCTGACCGT TCTTCCCAAA TTCCAGGATG TATTTACAAT TGACTACATC 720

TATACATTTT CCACAACGGA ATATGTTTAT TTCTTATCTG TGCAATGGGA GAGTCTAATG 780

AAACCAAATG CGAAGTTGCA GACTCATCTT GGGCGTCTGC CGATTAAGGA CAGCGAGCTT 840

TGGATGTACA GGGAAATTAT TCTTGAGTGC CGCTTCGAGC CCAAACGCAG GAGAAGGAGC 900

TTCAGGGATG TTGTTTATAA TTCGGTTCAA GCTGCTCACT TCAGTACAGC TGGCAAAGAG 960

CTTGCTGATG ATCTGGGAGT GAGGATAGAC AGCCCGATAC TGTATGGAGT GTTCGCTGTG 1020

ACGGATCAAA AGGGCAATCC AATGAGACAG TCTGCCTTGT GCGCTTTTCC ATTGGACTAT 1080

GTGAACAGTG CCATTGAAAA GGGGGTAGAC GCCTGCTGTT CAAGTTTGAC AGAGCAGATC 1140

TCAAGGGGAT TGTGCCATTT CCAGCCCTGT GAAATGTGTC CAGTTGAGAA TTCAGACAGT 1200

TTGACTTGCA AAACTACTCC CACCATGGTA TCAAAGCCTT ACTACAGAGT GGACTTCTTC 1260

AATGGGCAGA TGAGCAATGT GCTCTTCACC TCTATTCTGG TCACCACCAT TGAGACCAAA 1320

ACTGTGGCCC ACATCGGCAC AGATCACGGA AGACTTCTGC AGATCATTCT GAGCAGATCA 1380

ATCCCTGTAG TGTTTGCCAA CTACTCTCTT GTTGAAGATG CACAGAAAGT GTCACGGATA 1440

GCCGCCATTC ATTCATCATT AGAATCACTG CTCTTTGTTG TCGGAAACAA GCTAATAAAC 1500

GTGTCTCCCA GAGGCCCAGG CTGTAGCCAT TTCCTAAACT GCTCAGCGTG TTTAGCAGCC 1560

CCGAGGTTTA TGGGATGTGG CTGGTGTGGT GAAGTCTGTT CCCAACAGCA TCAGTGTGAA 1620

GATCAGTGGA GCGGCGACTC CTGCCCTCCT GTTATCACCC AGTTTTTCCC CAGGACGGTG 1680

CCTTCAAATG GGACGAGTGA ACTTATTCTT TGCGGCTGGA ATTTCCAGTC AGCTTCCCGT 1740

CCTGCTATCA CTCAAGAGTC TCATCAGGTC AGAGTGGGAA ACAGCGACTG TACAGTTGTA 1800

CCAGAGAAAA CAAGTAGCTC TCTGCTGGTT TGTAGGATTG TTGGAGAGGA ATCAGGCCTG 1860

CATCAAAGTG TTAACATAAC AATCCAAGTT AATGAAAAAA AAGCGGGAAG TGGATACTTC 1920

ATCTCTGGGA AGGCTGGCAT TCAAGGCTTC AGCTTTGTGA CTCCAGAAAT CACAGATATC 1980

AGTCCAAGCT TTGGACCCAA GATTGGAGGA ACCCTGATCA CCCTGTCTGG AAAGCATCTG 2040

GATGCAGGTG GATCCAGAAC GATCAGCCTT GGAGACAGAA ATTGCCCTGT TGAAAGCGTC 2100

TCCAGTGATG GGACTTCTAT TGTTTGCCGG TCTGAAGGTG TGAAGGATAC TTTAGAAGTG 2160

GATGTGAAGG TTGTAATTGA TGGATCGACT ATTTCCTCCA CAAAAACATT CAGCTACAGG 2220

GTGAATCCCG AGGTGACGGG TGTAAACCCC AACTGTGGTT TTAGAAGAGG ATCAAAAATT 2280

ATCATCACCG GGCAGAATTT GGACTCTGTT TCCCAAGCCG TCATTAAATA CAAAGGCGGC 2340

TACAAAGACC CTGTGGAAAC CGTGTGTTCT GGTCAAGGAA ACCCCACGCA GATGGAGTGT 2400

ATGAGCCCTG TATGTGAGGA GTCAACAGGA ATCCTCTCTG TAGATCTGGA TGGAGCCAAA 2460

GATCTCCAGT CTCAGACTTT TACATGCCAT GCTAATGGAG AACCCATCCC ATTTGAAACA 2520

GAGGACCGAG TGCTGGAGCT CAGCCCAGGC CAGGATGAAG TCTCTCTGCA CCACAAGAAA 2580

CTGGCTCTGG TGTCGGGCTG CATGGAAATC ATCATGACAG TTAATGGCGT GGATTGCAAT 2640

GCTAAAGTTC TGGACAATGA GATCACTTGC AGGATCCCCA AAAATCTGAC TATCCCCCGC 2700

CAAGGGGCAC CAGTCAAGGT GTTAGTGAAT AGAGAAGAGC ATGACATCGG TATGGTTGTA 2760

ATGAAGAACA GCAACTTAAT TGTGGGCGTG GTGCTGGGCA TCTTAGCTGC AGTTGGTGTA 2820

GGAGCAGCTA TTGTCTATGT TGCGATGGCT CAAGAGCGAA AGAAAAAGAA AGCTGCACTT 2880

GTTGAGGTTC GACTGTCCAT GCATTCAAAT CGCACCACAG CAGAGAATTA CGACAGATCA 2940

CCTGATGGCG ACTACAGAAG GGGTCTGTCA GTTTCTCCAT TTCATGGCTC GGGCACCACA 3000

TTCACCAGTC TGCCGTATGC CGGCTCTATG GACTCTGCAG CAGCTCCTCT GATGCGCCGT 3060

CAGGTCTCCA TGTCTGCTCT CCGGCCAGAT CTGCTGGAGG AGGTCAAGAA TGTTTTAATC 3120

TCACCCGATA AGATCAAAAT CCAGCATGAA CAAATCATTG GCAAAGGTCA TTTTGGGACA 3180

GTGTATCATG GATATCTTAC TGATAGTGAT AACAAAGAGA CCCACTGTGC AGTCAAATCA 3240

CTGAATAGGA TCACCGATCT GGAGGAGGTG GAGCAGTTTT TAAGAGAGGG ACTCTTTATG 3300

AAGGCCTTCC ACCATTCTCA CGTCCTGTCA CTTTTGGGCA TTGTGCTTCC CAGCGATGGA 3360

CTTCCTCTGG TTATCCTGCC GTATATGAAA CACGGTGATC TCCGGCATTT CATCCGCTCT 3420

CCAGAAAGGA GTCCCACAGT GAAGGATCTG ATTGGCTTCG GGCTTCAAGT AGCCAAAGGA 3480

ATGGAGTATC TTGCAAACAA GAAGTTTGTG CACAGAGATC TTGCTGCACG CAACTGCATG 3540

CTGGACGAGT CATTTACAGT GAAGGTGGCT GACTTTGGCA TGGCACGTGA TGTCTATGAT 3600

AAGGAATACT ACAGCATCCA GGACAGCAAG AAAGCGAAGC TGCCAGTCAA ATGGATGGCT 3660

TTAGAAAGCC TGCAGACACA GAAATTCACC ACCAAATCAG ATGTGTGGTC TTATGGAGTG 3720

TTGATGTGGG AGTTGTTGAC GAGAGGAGCC AGTCCATATC CTGATGTGGA CCCTTATGAC 3780

ATCACGCCTT ATTTGATGCA AGGCCGTCGA CTACCACAAC CGCAGTATTG CTTTGATTCC 3840

CTCTGGTCAG TTCTGATGCA GTGCTGGCAT CCTGAGCCCG AGAAGAGGCC GGGTTTCACT 3900

ACACTCGTGC AGGCCGTTCA GGACATCCAT TCCAGCCTGG ACGGGGAGCA TTACATCAAC 3960

CTCCAGATCA CCTATGTGAA TCTAGACCAG CCTCGACCGT ACCCGTCACT GTGTCCTGCT 4020

ACACCCGCAC ACTCAGACCA GTCCTCCACC TGA 4053

Domain Profile

S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61

         ++e++iGkGhfG+vy+g l+ds++k++++avksl+ritd+e+ve+flregl mk ++h +

Q: 1048  QHEQIIGKGHFGTVYHGYLTDSDNKETHCAVKSLNRITDLEEVEQFLREGLFMKAFHHSH  1107

         6799********************************************************

S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121

         vlsllGi+l+++glplv+lpymk+Gdl++fir++er++tvkdl++f+lqvakgmeyla+k

Q: 1108  VLSLLGIVLPSDGLPLVILPYMKHGDLRHFIRSPERSPTVKDLIGFGLQVAKGMEYLANK  1167

         ************************************************************

S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181

         kfvhrdlaarnc+lde++tvkvadfG+ardv+dke+y+ ++ ++a+lpvkw+aleslqt+

Q: 1168  KFVHRDLAARNCMLDESFTVKVADFGMARDVYDKEYYSIQDSKKAKLPVKWMALESLQTQ  1227

         ************************************************************

S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241

         k fttksdvws+Gvl+welltrga+py++v+++d+t yl +grrl++p+yc d+l+ v++

Q: 1228  K-FTTKSDVWSYGVLMWELLTRGASPYPDVDPYDITPYLMQGRRLPQPQYCFDSLWSVLM  1286

         *.**********************************************************

S: 242   kcwkakpaerpqfsdlvsii  261

         +cw+++p++rp f+ lv  +

Q: 1287  QCWHPEPEKRPGFTTLVQAV  1306

         ***************99876

Domain Sequence
(FASTA)

QHEQIIGKGH FGTVYHGYLT DSDNKETHCA VKSLNRITDL EEVEQFLREG LFMKAFHHSH 60

VLSLLGIVLP SDGLPLVILP YMKHGDLRHF IRSPERSPTV KDLIGFGLQV AKGMEYLANK 120

KFVHRDLAAR NCMLDESFTV KVADFGMARD VYDKEYYSIQ DSKKAKLPVK WMALESLQTQ 180

KFTTKSDVWS YGVLMWELLT RGASPYPDVD PYDITPYLMQ GRRLPQPQYC FDSLWSVLMQ 240

CWHPEPEKRP GFTTLVQAV 259

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004872	; F:receptor activity
GO:0007275	; P:multicellular organismal development

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 3.

SMARTs

SM00429	; IPT; 3.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013