EKS-DAR-00863

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00863

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	481.9	1.1E-144	27	305	279

Status

Unreviewed

Ensembl Protein

ENSDARP00000115670

UniProt Accession

E7FAU9;

Protein Name

Protein Synonyms/Alias

Gene Name

pik3r4

Gene Synonyms/Alias

pik3r4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000060469	ENSDARP00000115670	ENSDART00000133310
ENSDARG00000060469	ENSDARP00000079663	ENSDART00000085228

Organism

Danio rerio

Functional Description

Protein Length

1340

Protein Sequence
(FASTA)

MGNQLAGIAP SQILSVDSYF SDIHDYEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60

SLPLTSYKQE VEELKIRLHS CQNCLPFQKA TLTEKAAILF RQYVRDNLYD RISTRPFLNN 120

VEKKWIAFQL LNAVDQAHKS GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TYLPEDNPAD 180

FNYFFDTSRR RTCYIAPERF VDGSMFATES DQTTPLVDLS SNSQRTRGEL KQPMDIFSAG 240

CVIAELFTEG VPLFDLSQLL AYRKGHFQTE QVLMKIEDHS IRELVAQMVQ REPEKRLTAE 300

EYLKQQRGKA FPEIFYTFLQ PYMAQFAKET FQSADERVLV IRKNLENILN NLCSGGQTAK 360

AEKQEKASQE FSSSKEQGLV VLVSVITSCL QTLRFCDSKL AALELILHLA GRLNVEILLD 420

RITPYLLHFC NDSMPRVRAE AVRTLTKVLA LVKEVPRNDV NIYPEYILPG IAHLAQDEAT 480

IVRLAYAENI AHLAETALRF LELVQENNLS SEHDLNGEDT EETLHPNENY DSELQALHEM 540

VQQKVVTLLS DPENIVKQTL MENGITRLCV FFGRQKANDV LLSHMITFLN DKNDWHLRGA 600

FFDSIVGVAA YVGWQSSSIL KPLLQQGLSD VEEFVIYKAL NALTCMCQLG LLQKPHIYEF 660

VSDIAPFLCH PNLWIRYGAV GFITVVAQHL NIADVYCKLM PHLNPFITQP IIQIDKEIVL 720

LSVLKEPVSR SIFDYALRSK DIGSLFRHLL LRQKKRNGSI PECPIPEDPA IAQLLKKLLS 780

QGMTEAEEDK LLALKDFMLK SNKAKANIID QSHLSEGAHS GVIDLGTLGI TGRQVDLVKP 840

KQEIEDKRAR KHTKQDSNLN EEWKSMFGSL DPPSSASTPS TIPDSGAAQP RKTTALPTIQ 900

VVQSITGAST YQRRITTCKA ELQQLVQQKR EQCNAERMAK QMMESAEWES RPPLPGWHPK 960

GLLVAHLHEH KSAVNRIRVS DEHSIFATCS NDGTVKIWDS QKMEGKTTTT RSVLTYSRIG 1020

GHVKTLTFCQ GSHYLAVASD NGSIQLLAVE ANKPPKSPKV QPCQTRFLDP KEEGCVVDVH 1080

HFNSGAQTVL AYATVNGFLV GWDLRSNSNA WTLRHDLRLG LITSFAVDMH QCWLCVGTSN 1140

GTMACWDMRF QLPISSHSHP ARARIRRLLM HPLYQSSVIA AVQGNNEVSM WDMETGDRKF 1200

TLWASSAPPL SEMQPSPHSV HGIYCSPADG NPLLLTAGSD MRIRFWDLAY PERSYIVAGG 1260

ANDSLHCPSV FYNRKIIEGT EVVQEIHSKQ KSGSTEDTPR RGPESLPVGH HDIITDIATF 1320

QTTQGFIVTS SRDGIVKVWK 1340

Nucleotide Sequence
(FASTA)

ATGGGGAACC AACTGGCTGG AATTGCTCCA TCGCAGATCC TGTCAGTGGA CAGTTACTTC 60

TCTGACATCC ATGACTACGA ATATGACAAA AGTCTGGGCA GTACACGATT TTTCAAAGTG 120

GCCCGGGCGA AACACAGGGA AGGATTGGTC GTTGTTAAGG TCTTTGCTAT CCAAGACCCT 180

TCTCTACCCC TGACCAGCTA CAAACAAGAG GTGGAGGAGC TGAAAATCCG ACTGCACTCC 240

TGTCAGAACT GCCTGCCTTT CCAAAAAGCC ACGCTTACTG AAAAAGCAGC CATTCTGTTT 300

CGCCAGTATG TTCGGGATAA CTTGTATGAC CGTATTAGTA CGCGGCCTTT CCTCAACAAC 360

GTGGAAAAGA AGTGGATCGC CTTCCAGCTC CTCAATGCTG TGGACCAGGC CCATAAATCG 420

GGAGTGCGTC ACGGAGACAT TAAAACAGAG AACGTCATGG TGACAAGCTG GAACTGGGTG 480

CTTCTAACAG ACTTTGCTAG CTTTAAGCCA ACATACTTGC CTGAAGACAA TCCCGCAGAT 540

TTTAATTACT TCTTCGACAC GTCCAGGAGG AGAACATGTT ACATTGCACC TGAGAGATTT 600

GTGGATGGCA GCATGTTTGC TACAGAAAGT GACCAGACCA CTCCTCTCGT AGATCTTTCT 660

AGTAATAGTC AGAGGACCAG AGGGGAGCTC AAGCAGCCCA TGGACATCTT CTCAGCTGGT 720

TGTGTGATTG CGGAATTGTT CACAGAGGGC GTCCCGCTCT TTGACCTCTC ACAACTGCTG 780

GCTTATCGTA AAGGGCATTT CCAAACCGAA CAAGTGCTGA TGAAAATTGA AGATCACAGT 840

ATTCGAGAAC TGGTGGCTCA AATGGTGCAG AGAGAGCCAG AAAAGCGACT GACAGCTGAA 900

GAATACCTTA AGCAGCAGCG AGGAAAAGCT TTCCCAGAAA TCTTCTACAC CTTCCTTCAA 960

CCGTACATGG CCCAGTTTGC CAAGGAGACC TTCCAGTCTG CTGACGAAAG AGTCTTGGTG 1020

ATCCGTAAAA ACCTGGAGAA CATCCTCAAC AACCTGTGTA GCGGCGGGCA GACGGCGAAG 1080

GCTGAAAAAC AGGAGAAAGC ATCCCAAGAG TTTAGCTCAT CTAAAGAACA AGGCCTGGTG 1140

GTGCTGGTGT CAGTGATCAC TTCATGTCTA CAGACGCTTC GATTTTGTGA CTCCAAGCTG 1200

GCGGCGCTGG AGCTGATCCT TCATCTGGCA GGCCGGCTCA ATGTGGAGAT TCTGCTGGAC 1260

AGGATTACGC CGTATTTGCT GCACTTCTGC AATGACTCTA TGCCGCGTGT CAGAGCTGAG 1320

GCCGTTCGCA CGCTGACTAA GGTGCTGGCG CTGGTCAAGG AGGTTCCCCG CAATGATGTC 1380

AACATCTACC CGGAGTACAT TTTGCCTGGC ATTGCCCACT TGGCCCAAGA TGAAGCCACG 1440

ATTGTCAGAC TTGCTTATGC AGAAAACATA GCCCATCTAG CCGAGACAGC ACTGCGTTTT 1500

CTGGAGCTGG TGCAGGAGAA TAATTTGAGC TCTGAACACG ATCTGAATGG AGAGGACACA 1560

GAAGAAACTC TTCATCCCAA TGAAAACTAT GATTCAGAGT TGCAGGCCTT GCATGAGATG 1620

GTTCAGCAGA AGGTGGTGAC TTTGCTGAGC GATCCTGAAA ACATCGTCAA ACAGACGCTG 1680

ATGGAGAATG GCATTACGCG CCTCTGCGTG TTCTTCGGCA GGCAGAAAGC CAATGACGTC 1740

CTTCTATCCC ACATGATCAC CTTCCTGAAT GACAAGAACG ACTGGCATCT CCGCGGAGCT 1800

TTCTTTGACA GCATTGTAGG TGTAGCAGCA TATGTGGGCT GGCAGAGCTC CTCCATCCTG 1860

AAGCCTCTTC TCCAGCAAGG CCTGAGTGAC GTTGAAGAGT TTGTCATTTA TAAAGCTCTC 1920

AATGCTCTGA CCTGCATGTG TCAGCTGGGG CTGTTGCAGA AGCCTCACAT CTATGAGTTT 1980

GTCAGCGATA TTGCTCCATT CTTGTGCCAC CCCAATCTGT GGATCCGCTA TGGAGCTGTG 2040

GGTTTCATCA CTGTCGTCGC TCAGCACCTA AACATCGCTG ATGTTTACTG CAAACTTATG 2100

CCACATCTTA ACCCTTTCAT CACACAACCC ATTATACAGA TTGATAAGGA GATTGTGTTG 2160

CTCAGTGTGC TGAAAGAGCC TGTAAGTCGC TCCATCTTTG ACTATGCACT GCGTTCCAAA 2220

GACATCGGAA GCCTTTTCAG ACACCTGTTA CTCCGGCAAA AGAAGCGCAA CGGCTCCATC 2280

CCAGAATGCC CCATTCCTGA GGATCCTGCA ATTGCCCAGC TTCTTAAAAA ACTTCTCTCA 2340

CAGGGCATGA CAGAGGCTGA AGAGGATAAG CTCTTGGCTC TGAAAGATTT CATGCTCAAG 2400

TCTAACAAGG CCAAAGCCAA CATCATAGAC CAGAGCCACC TGAGTGAAGG AGCCCACAGT 2460

GGAGTCATTG ATCTCGGGAC ACTGGGCATC ACTGGCCGAC AGGTGGACCT GGTCAAGCCC 2520

AAGCAGGAGA TTGAAGATAA GAGAGCTCGC AAACATACGA AACAGGACTC CAACTTGAAC 2580

GAAGAGTGGA AGAGCATGTT TGGTTCTCTG GATCCTCCCA GCTCGGCATC CACGCCCTCG 2640

ACGATTCCAG ACAGTGGAGC CGCGCAGCCC CGGAAAACCA CAGCGCTTCC TACTATTCAA 2700

GTGGTTCAGT CGATAACTGG AGCGTCCACA TATCAGCGGC GCATCACCAC ATGTAAAGCA 2760

GAGCTGCAGC AGCTGGTGCA GCAGAAGAGA GAGCAGTGCA ATGCAGAGCG CATGGCCAAA 2820

CAGATGATGG AGAGCGCAGA GTGGGAAAGC AGACCTCCAC TGCCAGGGTG GCATCCAAAA 2880

GGTCTTCTAG TGGCCCATCT ACATGAGCAC AAATCTGCTG TCAACCGAAT CCGAGTCTCA 2940

GATGAGCACT CCATCTTTGC TACCTGCTCC AATGATGGAA CTGTCAAAAT CTGGGACAGC 3000

CAAAAAATGG AGGGCAAGAC GACTACCACG AGGTCTGTGC TGACATATTC TCGGATTGGA 3060

GGTCATGTGA AAACATTGAC ATTTTGCCAG GGATCGCATT ACCTTGCAGT TGCATCAGAT 3120

AATGGTTCCA TCCAACTCCT TGCAGTCGAG GCAAACAAGC CTCCCAAATC ACCCAAAGTC 3180

CAGCCCTGTC AGACAAGGTT TTTGGATCCA AAGGAGGAGG GCTGTGTGGT GGACGTACAT 3240

CATTTTAACT CTGGGGCGCA GACGGTTTTG GCCTACGCTA CTGTAAATGG CTTTTTGGTC 3300

GGTTGGGACC TGCGAAGCAA CAGCAACGCA TGGACTCTTC GCCATGATCT GCGTCTGGGC 3360

CTCATCACTT CCTTTGCTGT TGATATGCAC CAGTGTTGGC TGTGTGTAGG CACAAGTAAT 3420

GGCACAATGG CATGCTGGGA TATGCGGTTT CAGCTACCAA TTTCCAGTCA CTCCCATCCA 3480

GCCCGAGCTC GGATCAGACG CCTTCTGATG CATCCACTCT ATCAGTCATC TGTCATTGCA 3540

GCCGTTCAGG GTAACAATGA GGTCTCCATG TGGGATATGG AGACCGGAGA CAGGAAGTTC 3600

ACCCTGTGGG CGAGCTCTGC GCCTCCGCTT TCGGAGATGC AGCCCTCTCC ACACAGTGTA 3660

CATGGCATAT ACTGCAGCCC TGCGGATGGA AACCCTCTCC TCCTCACAGC CGGATCTGAC 3720

ATGAGAATCA GGTTTTGGGA TTTGGCTTAC CCTGAGAGAT CATACATCGT CGCAGGCGGT 3780

GCTAACGACT CCCTCCACTG CCCTTCTGTT TTCTACAACC GCAAGATCAT CGAAGGAACA 3840

GAAGTGGTTC AGGAGATTCA CAGTAAACAG AAGAGCGGCT CCACCGAGGA TACTCCTCGC 3900

CGAGGCCCAG AATCCCTTCC AGTGGGCCAC CATGACATCA TAACAGACAT CGCCACTTTC 3960

CAGACCACAC AGGGCTTTAT AGTCACTTCC TCTAGAGATG GCATTGTCAA AGTCTGGAAG 4020

TGA 4023

Domain Profile

S: 2     eyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelklklakaqnclp  61

         ey+k+lgstrf+kva+ak++eG++vvkvf++qdp+l+l+s+kq++eelk++l++ qnclp

Q: 27    EYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPSLPLTSYKQEVEELKIRLHSCQNCLP  86

         79**********************************************************

S: 62    fqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvvhGd  121

         fqk++++ekaa+l+rqyv+dnlydr+strPfln++ekkwiafqll+a+dq+hksgv+hGd

Q: 87    FQKATLTEKAAILFRQYVRDNLYDRISTRPFLNNVEKKWIAFQLLNAVDQAHKSGVRHGD  146

         ************************************************************

S: 122   iktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsalas  181

         iktenv+vtswnWvlltdfasfkPtylpednPadf+yffdtsrrrtcyiaPerfv++ ++

Q: 147   IKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGSMF  206

         ************************************************************

S: 182   deklrdgstelvdldsi.qrlrgelkkamdifsaGcvilelftegrplfelsqllayrsg  240

         ++++ + +t+lvdl s+ qr+rgelk+ mdifsaGcvi+elfteg+plf+lsqllayr+g

Q: 207   ATESDQ-TTPLVDLSSNsQRTRGELKQPMDIFSAGCVIAELFTEGVPLFDLSQLLAYRKG  265

         **9977.99*****997589****************************************

S: 241   eflvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         +f +e+vl kied+++r+lv+q++q+epekr+ ae++lk+

Q: 266   HFQTEQVLMKIEDHSIRELVAQMVQREPEKRLTAEEYLKQ  305

         **************************************97

Domain Sequence
(FASTA)

EYDKSLGSTR FFKVARAKHR EGLVVVKVFA IQDPSLPLTS YKQEVEELKI RLHSCQNCLP 60

FQKATLTEKA AILFRQYVRD NLYDRISTRP FLNNVEKKWI AFQLLNAVDQ AHKSGVRHGD 120

IKTENVMVTS WNWVLLTDFA SFKPTYLPED NPADFNYFFD TSRRRTCYIA PERFVDGSMF 180

ATESDQTTPL VDLSSNSQRT RGELKQPMDI FSAGCVIAEL FTEGVPLFDL SQLLAYRKGH 240

FQTEQVLMKI EDHSIRELVA QMVQREPEKR LTAEEYLKQ 279

Keyword

Complete proteome; Reference proteome; Repeat; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 3.

SMARTs

SM00320

; WD40; 5.

Prosites

PS50077	; HEAT_REPEAT; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 2.
PS50082	; WD_REPEATS_2; 2.
PS50294	; WD_REPEATS_REGION; 2.

Prints

Created Date

20-Feb-2013