EKS-DAR-00452

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00452

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	420.2	5.9E-126	416	674	259

Status

Unreviewed

Ensembl Protein

ENSDARP00000079873

UniProt Accession

E7FE05;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

LOC565173

Gene Synonyms/Alias

LOC565173;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000060551	ENSDARP00000079873	ENSDART00000085438

Organism

Danio rerio

Functional Description

Protein Length

802

Protein Sequence
(FASTA)

MPSTMEGSSG EGDLFTVKHE LRNANLTGHV ERVGIENFEL LKVLGTGAYG KVFLVRKVSG 60

HDSGKLYAMK VLKKATIVQK AKTAEHTRTE RQVLEHIRQS PFLVTLHYAF QTDTKLHLIL 120

DYVNGGELFT HLVQRVRFKE QEVTLYSGEI VLALEHLHKL GIVYRDLKLE NILLDSNGHI 180

VLTDFGLSKE FHEVERAYSI CGTIEYMAPE IVAGGEGGHD KAVDWWSMGV LMYELLTGGS 240

PFTVDGDENS HSDIAERIMK KDPPFPKDMG PLAKDIIQRL LIKDPKKRLG SGPSGAQNVK 300

KHPFYQKLNW EDLAAKKVRA PFKPVIRDEL DVSNFAEEFT EMDPTYSPAA LPNNCDRIFQ 360

GYSFMAPSIL FKRNAVMDDP AQLCGGSERP GSAAVARSAM MKDSPFYMNY EMDLRHNALG 420

EGSFSICRQC THKKTGQKYA VKIVSKRMEA QTQKEIAALK LCDGHPNIVK LHEIYHDQLH 480

TYLVLELLRG GELLERIRRK QLFSETEASR IMRRLVSAVS HMHDVGVVHR DLKPENLLFT 540

DDTENSEIKI IDFGFARLKP PDNQLLKTPC FTLQYAAPEI LKYSGYDESC DLWSLGVILY 600

TMLSGQVPFQ CQGKSLMHTS AEEIMRKIKQ GDFSFEGEAW RNVSSQAKDL IQELLTVDPD 660

KRIKMCGLRY NTWLQDDSQL SSNPLMTPDI LGSSTISVHS CVKATFNAFN KCKREGFRLQ 720

TVDKAPLAKR RKMKKTSTST DTRSSSSEST HSSSSSSQSQ DKTPTDGEMA NLPQAPVSTP 780

LTLGPDDEPS QGEPQPAFTF TQ 802

Nucleotide Sequence
(FASTA)

ATGCCGTCTA CGATGGAGGG CTCATCGGGG GAAGGTGACC TGTTTACCGT CAAACACGAG 60

CTCAGAAACG CCAATCTAAC GGGTCATGTG GAGCGTGTGG GCATCGAGAA CTTTGAGCTG 120

CTGAAAGTGC TGGGAACAGG AGCCTACGGC AAGGTGTTCT TGGTTCGCAA AGTGAGCGGC 180

CACGATTCGG GCAAACTCTA TGCCATGAAG GTGCTGAAAA AGGCAACTAT TGTGCAGAAG 240

GCCAAGACGG CAGAACACAC ACGCACAGAG AGACAGGTCC TCGAGCATAT CAGACAGTCT 300

CCTTTTCTGG TCACACTCCA TTATGCCTTC CAGACAGACA CCAAACTGCA TCTCATTCTA 360

GACTATGTGA ACGGAGGTGA GCTCTTCACA CACTTGGTCC AAAGGGTTCG CTTTAAAGAG 420

CAAGAGGTTA CCTTGTACAG CGGGGAGATT GTACTAGCGC TGGAGCACTT GCATAAGCTG 480

GGAATCGTCT ACAGAGATCT GAAACTTGAG AATATACTTC TTGATTCAAA TGGTCACATT 540

GTGTTGACGG ATTTTGGTCT AAGTAAGGAA TTTCATGAGG TAGAGAGGGC TTATTCCATC 600

TGCGGCACTA TTGAGTACAT GGCCCCTGAG ATCGTAGCAG GAGGAGAAGG AGGACATGAC 660

AAGGCGGTGG ACTGGTGGAG CATGGGAGTT CTGATGTATG AGCTGCTGAC CGGAGGCTCT 720

CCATTCACTG TTGATGGCGA TGAGAACTCA CATTCTGATA TTGCAGAGAG AATTATGAAA 780

AAAGATCCTC CATTCCCCAA AGACATGGGG CCTCTGGCCA AAGACATCAT CCAGCGACTG 840

CTTATTAAAG ACCCAAAGAA GAGACTGGGC TCTGGCCCTT CAGGAGCCCA GAATGTAAAA 900

AAACATCCAT TCTATCAGAA ATTAAACTGG GAGGATTTGG CTGCTAAGAA AGTTCGGGCT 960

CCGTTTAAGC CTGTGATTCG GGATGAGCTG GATGTGAGCA ACTTTGCGGA GGAGTTTACT 1020

GAGATGGACC CGACATACTC GCCAGCAGCA CTTCCAAACA ACTGTGACCG CATCTTCCAG 1080

GGCTATTCCT TCATGGCTCC CTCTATCCTG TTCAAGAGGA ACGCGGTGAT GGATGACCCG 1140

GCTCAGCTGT GTGGTGGGTC AGAAAGGCCG GGCTCTGCTG CTGTTGCCCG TAGCGCTATG 1200

ATGAAGGACT CTCCATTCTA CATGAACTAT GAGATGGACC TGAGGCATAA TGCTCTGGGA 1260

GAGGGAAGCT TCTCCATCTG CAGGCAGTGC ACTCACAAGA AAACCGGACA GAAATATGCT 1320

GTAAAGATCG TCAGTAAAAG AATGGAGGCC CAGACGCAGA AAGAGATCGC AGCTCTGAAA 1380

CTGTGTGATG GACACCCCAA CATAGTAAAG CTACATGAGA TCTACCATGA TCAGCTGCAC 1440

ACATATCTTG TCCTGGAACT CTTGCGAGGT GGTGAGCTTC TGGAGCGGAT CAGAAGGAAG 1500

CAACTCTTCA GCGAGACCGA GGCCAGTCGC ATCATGCGCA GACTGGTGTC TGCCGTCAGC 1560

CACATGCATG ACGTCGGCGT GGTGCACAGG GACCTCAAAC CAGAGAATTT GCTCTTCACT 1620

GATGACACTG AGAATTCGGA GATCAAAATT ATTGACTTTG GTTTTGCACG GCTCAAACCT 1680

CCTGACAATC AGCTCCTGAA GACCCCCTGC TTCACTCTTC AGTATGCCGC ACCAGAAATC 1740

CTCAAATACA GTGGTTACGA CGAGTCCTGC GACCTCTGGA GTTTAGGAGT CATTTTGTAC 1800

ACCATGCTAT CTGGACAGGT CCCGTTTCAG TGTCAGGGGA AGAGCTTAAT GCACACCAGT 1860

GCAGAGGAGA TCATGAGGAA GATCAAACAA GGAGACTTCT CTTTCGAAGG TGAAGCTTGG 1920

AGAAATGTGT CCAGTCAGGC CAAAGATCTA ATACAAGAGC TGCTGACGGT GGACCCTGAC 1980

AAGCGGATAA AGATGTGTGG CTTACGCTAT AATACCTGGC TACAAGATGA CAGTCAGCTG 2040

TCCTCCAACC CACTTATGAC TCCTGACATT CTGGGATCTT CTACCATATC AGTGCACTCC 2100

TGTGTCAAAG CCACCTTCAA TGCCTTTAAT AAGTGCAAGC GGGAGGGTTT CCGACTCCAG 2160

ACGGTTGACA AGGCTCCTCT GGCCAAGCGC AGGAAGATGA AGAAGACCAG CACCAGCACA 2220

GACACTCGCA GCAGCTCCAG TGAAAGCACA CACTCCTCAT CCTCTTCCTC CCAGTCTCAG 2280

GATAAGACGC CAACAGACGG AGAGATGGCC AACCTTCCCC AGGCTCCTGT AAGCACACCA 2340

CTCACTTTGG GCCCTGACGA CGAGCCCTCA CAGGGCGAAC CCCAACCTGC CTTCACTTTT 2400

ACACAGTGA 2409

Domain Profile

S: 4     kedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvy  62

         ++ lG+Gs+s+c++c hk+t+q++avki++k+ +++t++ei++l+++++hpniv+l+++y

Q: 416   HNALGEGSFSICRQCTHKKTGQKYAVKIVSKRmEAQTQKEIAALKLCDGHPNIVKLHEIY  475

         6789****************************9***************************

S: 63    ddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlkpe  122

         +d++++ylvlell+GGell+ri++k+ fse+eas i+r lv+av+++h++Gvvhrdlkpe

Q: 476   HDQLHTYLVLELLRGGELLERIRRKQLFSETEASRIMRRLVSAVSHMHDVGVVHRDLKPE  535

         ************************************************************

S: 123   nilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdlws  182

         n+l++d+++n+e ikiidfGfa+lk+++n+llktpc+tl+++ape+lk  Gyde+cdlws

Q: 536   NLLFTDDTENSE-IKIIDFGFARLKPPDNQLLKTPCFTLQYAAPEILKYSGYDESCDLWS  594

         ************.***********************************************

S: 183   lGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvskl  238

         lGv+lytml+G+vpf    +++ +++aeei+ kik+G+fs++Geaw++vs +akdl+++l

Q: 595   LGVILYTMLSGQVPFqcqgKSLMHTSAEEIMRKIKQGDFSFEGEAWRNVSSQAKDLIQEL  654

         ***************8877778899***********************************

S: 239   ltvdpakrlkleqllkhswl  258

         ltvdp+kr+k+ +l++++wl

Q: 655   LTVDPDKRIKMCGLRYNTWL  674

         *******************7

Domain Sequence
(FASTA)

HNALGEGSFS ICRQCTHKKT GQKYAVKIVS KRMEAQTQKE IAALKLCDGH PNIVKLHEIY 60

HDQLHTYLVL ELLRGGELLE RIRRKQLFSE TEASRIMRRL VSAVSHMHDV GVVHRDLKPE 120

NLLFTDDTEN SEIKIIDFGF ARLKPPDNQL LKTPCFTLQY AAPEILKYSG YDESCDLWSL 180

GVILYTMLSG QVPFQCQGKS LMHTSAEEIM RKIKQGDFSF EGEAWRNVSS QAKDLIQELL 240

TVDPDKRIKM CGLRYNTWL 259

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

dre:565173

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013