EKS-DAR-00829

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00829

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	299.7	4.2E-89	4	254	251

Status

Unreviewed

Ensembl Protein

ENSDARP00000081199

UniProt Accession

A8WFS2;

Protein Name

Protein Synonyms/Alias

Zgc:152944 protein;

Gene Name

stk36

Gene Synonyms/Alias

stk36; zgc:152944;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000061095	ENSDARP00000081199	ENSDART00000086765

Organism

Danio rerio

Functional Description

Protein Length

1231

Protein Sequence
(FASTA)

MDQYHILEVI GEGSFGRVYK GRRKFSGQVV ALKFIPKVGR SEKDLRSLKR EIDIMRGLKH 60

PNIVLLLDSF ETEREVVVVT EYAEGELFQI LEDDGSLPEK QVREIACQLV SALYYLHSHR 120

ILHRDMKPQN ILLGKGGVVK LCDFGFARAM SVSTLVLTSI KGTPLYMSPE LVEEKPYDHS 180

TDLWSLGCIL YELHTGAPPF YTNSIFQLVQ LIVRDPVKWP DNMSQDCLSF LKGLLMKEPE 240

KRLSWPDLLH HPFVADGVLM VSDEGSSNPL TVPPSPDVQA LKHQQVAEKT TVRSGEGKLL 300

GKARELREKE KTNRREVASG SAARCKTASA GGASNTGHSL GSTFSVYQNS SQPATNRHQA 360

NDNSVTRARS APHKGQISRD YAREFPSVEV GPRQFLKRPG HEQDMDSDYE WQRLVELSDQ 420

GPVNASILQG LKIKLLQAKT QLLVRKGEET SSILLPLKVL RNIVQGCRIG DVETVGKELE 480

LPHLLFSLIE DVLNIPDLMQ ESQGETVLAD LMSVLIMYLE KSPGWEIKGR RAEDLCQLFI 540

SVFLSGDPKR SALLAAAVLT LFTQRGVSVN VGIEKLTAVL GDVLTYTEAH NPLPAGWGLC 600

DGLLSLILHR LAECESSSLL DFQQSDLWPC LWAKVNIMLQ NTPSQSCHFS PNGLYMFLSL 660

ALLLFSSDPY TCVTLLSDNT TNCSSTLGHL LTTSCSASLL ERGLFWGDSE INSLSVMSCH 720

LLCIPFSLDL PLEKHLSVLQ SYQSSNIVAG LVQMIQTIPI ALVELPLCLL NRLLLSDPQH 780

TTPCLITAAQ ASAFLPHGTE SSDNGADHTQ TQLKHSGNGV ERSKSNGIVK KTKIDHIKGD 840

IKSKKSLDRP TGDVDASRDK NSSQNAPSRN IRQTKVKSQA KTYPTKAMEH LRDASKIGHI 900

EELMDSLEIH GSSAGLSPQQ GCGISMLIDS LEEFRRSGDR PKTSIRSSPE EARTAGSLLA 960

LLLQSEALSG CAVELLILLS LLTRHPTYQS SFFLPVEFTQ LRLALLHRDD GIRAACCSLL 1020

GHLGLCVIRV INEPKFDLFQ DLLGCLCDPA PSVRRAACKA VGNWLNEIRK TSDNIPSKGL 1080

KSTTDMQTWS VQDKPRRTEG VRYMEADVWM QLAIGAARPL VSLLSDADNV IRQHCCGALA 1140

NLAAFSGGDG ALLNADAPGL ILQTACNDSH HAVRRAAVAT LRVFSQQNTL LQALRSLDAG 1200

RKLCRSSQSS LFQRDYQWLV SKLDGSVEGK T 1231

Nucleotide Sequence
(FASTA)

ATGGATCAGT ACCATATTTT GGAGGTTATC GGAGAAGGGT CATTCGGACG AGTGTACAAA 60

GGTCGCAGGA AGTTCAGCGG CCAGGTTGTG GCTTTGAAGT TCATTCCCAA AGTTGGCCGC 120

TCAGAGAAGG ACCTGCGCAG TTTGAAAAGA GAGATTGACA TCATGAGGGG GCTTAAGCAT 180

CCCAACATAG TGCTGCTTTT AGACAGTTTT GAGACAGAGA GGGAGGTGGT GGTGGTGACA 240

GAGTATGCAG AGGGGGAACT GTTTCAGATC CTGGAGGATG ACGGGAGTTT ACCTGAGAAG 300

CAGGTGCGTG AAATAGCCTG CCAGCTTGTC TCTGCCTTGT ATTATCTCCA CTCACATCGC 360

ATTTTACACC GTGACATGAA ACCACAAAAC ATCCTGCTGG GAAAAGGAGG AGTCGTGAAG 420

CTGTGTGACT TTGGATTTGC TCGTGCCATG AGTGTGTCTA CTTTGGTGTT GACTTCTATT 480

AAGGGAACGC CTCTCTACAT GTCTCCGGAA TTAGTAGAAG AAAAGCCTTA TGACCACTCG 540

ACTGACCTTT GGTCTCTGGG CTGCATCCTC TATGAGCTCC ACACGGGGGC GCCTCCGTTC 600

TACACCAACT CCATCTTTCA GCTGGTGCAG CTCATAGTGA GAGATCCAGT CAAATGGCCA 660

GACAACATGA GCCAAGACTG CTTGAGTTTT CTGAAGGGAT TGTTGATGAA AGAGCCAGAG 720

AAGAGACTGT CATGGCCTGA CCTGCTCCAT CACCCTTTTG TTGCAGATGG AGTTCTGATG 780

GTGTCAGATG AAGGTTCGAG TAACCCGCTC ACTGTTCCAC CCAGTCCAGA CGTCCAGGCC 840

CTCAAACACC AGCAGGTCGC AGAAAAAACA ACAGTGCGCA GCGGAGAAGG CAAACTACTC 900

GGCAAAGCCA GAGAGCTTCG AGAGAAAGAG AAGACTAACA GACGGGAGGT TGCGAGTGGA 960

AGTGCTGCTC GCTGTAAGAC AGCTTCAGCT GGAGGAGCAT CCAACACCGG CCATTCATTG 1020

GGCAGCACCT TTTCAGTGTA TCAAAATTCA TCTCAGCCAG CAACCAATCG GCATCAAGCA 1080

AATGACAACA GTGTTACCAG GGCACGCTCA GCTCCACATA AAGGTCAGAT CAGTAGAGAC 1140

TATGCGAGGG AGTTTCCTTC AGTAGAGGTG GGACCCCGAC AGTTTCTAAA GCGCCCTGGA 1200

CATGAGCAGG ATATGGACAG TGATTATGAG TGGCAGCGGT TGGTTGAATT GAGCGATCAG 1260

GGACCCGTGA ATGCTTCTAT CCTTCAGGGG TTAAAGATCA AGCTTCTGCA AGCCAAAACC 1320

CAGCTGCTGG TCAGGAAGGG TGAGGAGACC TCTTCAATTC TACTGCCACT GAAGGTCTTG 1380

AGAAACATTG TTCAGGGCTG CCGGATTGGA GATGTTGAAA CTGTGGGAAA AGAGCTGGAA 1440

CTGCCTCATC TTCTGTTCAG CCTTATTGAG GACGTCCTGA ACATTCCAGA TCTGATGCAG 1500

GAGTCGCAGG GTGAGACAGT ATTGGCAGAT CTGATGAGTG TCCTCATAAT GTACCTGGAA 1560

AAGAGCCCGG GCTGGGAGAT AAAGGGCAGA AGAGCTGAGG ATCTCTGTCA GCTATTTATT 1620

TCAGTGTTTC TCAGCGGAGA CCCAAAGCGC TCAGCGCTTT TGGCAGCAGC AGTCTTAACC 1680

TTGTTCACAC AGCGCGGTGT GTCTGTGAAT GTCGGTATAG AAAAGCTCAC GGCCGTTTTG 1740

GGGGATGTTT TGACATACAC AGAGGCTCAT AACCCCTTAC CTGCAGGTTG GGGCCTGTGT 1800

GATGGCCTTC TGTCACTGAT TCTCCACAGG CTAGCTGAGT GTGAGAGCAG CTCACTGCTC 1860

GACTTTCAGC AGTCAGATCT GTGGCCCTGC CTGTGGGCTA AAGTGAACAT CATGCTGCAA 1920

AACACACCAT CCCAAAGCTG CCATTTCTCT CCTAATGGTC TGTATATGTT CCTCTCTCTG 1980

GCTTTATTGC TTTTCTCCAG CGATCCATAC ACCTGTGTGA CTCTCCTATC AGATAACACC 2040

ACAAACTGCT CCTCCACCCT CGGGCACCTT CTCACCACCA GTTGCAGCGC CTCATTGCTT 2100

GAACGTGGTC TTTTCTGGGG CGACTCAGAA ATAAACAGCC TATCAGTGAT GAGCTGTCAT 2160

CTCCTCTGCA TCCCCTTCTC TCTGGACTTG CCCCTGGAAA AACATCTGTC TGTTCTCCAG 2220

TCATATCAAA GCTCAAATAT TGTTGCAGGT CTAGTACAGA TGATTCAGAC TATTCCTATT 2280

GCCTTGGTGG AGCTTCCGTT GTGTCTTCTG AATCGTCTCC TGCTATCTGA CCCACAACAC 2340

ACCACTCCGT GCCTTATCAC TGCCGCCCAG GCCTCCGCTT TCCTCCCGCA CGGCACAGAA 2400

AGCTCAGACA ATGGAGCAGA CCACACTCAG ACTCAACTAA AGCACTCTGG GAATGGTGTT 2460

GAGCGAAGTA AGAGCAACGG AATTGTAAAG AAAACCAAGA TTGATCATAT CAAAGGAGAC 2520

ATCAAATCAA AAAAGAGCTT AGACCGACCC ACAGGCGACG TAGATGCATC CAGGGACAAA 2580

AACAGTTCTC AAAACGCACC ATCCAGAAAT ATTCGCCAAA CCAAAGTCAA GAGTCAAGCC 2640

AAAACATATC CAACGAAGGC CATGGAGCAT CTTAGAGATG CATCAAAGAT AGGTCATATA 2700

GAGGAGCTCA TGGACAGTCT GGAGATTCAT GGGAGTTCTG CAGGACTCTC CCCTCAGCAA 2760

GGCTGCGGGA TCAGCATGCT CATAGACAGT CTGGAGGAGT TCAGAAGAAG TGGCGATCGC 2820

CCTAAGACCT CGATTCGATC CTCGCCTGAG GAGGCCAGAA CAGCAGGTTC TCTGTTGGCT 2880

CTGCTTCTAC AAAGTGAAGC TCTCAGTGGG TGCGCAGTAG AACTTCTCAT CCTTCTCTCT 2940

CTACTAACAC GTCATCCCAC CTATCAGTCG TCCTTCTTTC TTCCAGTCGA ATTCACCCAA 3000

CTGAGACTCG CATTGCTCCA CCGAGATGAT GGAATCCGAG CCGCCTGCTG TAGCTTGCTG 3060

GGCCACCTGG GTTTATGTGT GATACGGGTT ATCAACGAAC CAAAATTTGA CCTGTTCCAG 3120

GACCTGTTAG GTTGCCTATG CGATCCTGCC CCGTCTGTTC GTAGAGCGGC CTGCAAGGCT 3180

GTGGGAAACT GGTTGAATGA AATCAGAAAA ACCAGTGACA ATATCCCTAG CAAAGGTCTC 3240

AAGAGTACAA CTGACATGCA GACATGGTCA GTACAAGATA AACCGAGGAG GACGGAGGGC 3300

GTCAGGTATA TGGAGGCGGA CGTATGGATG CAGCTCGCCA TAGGAGCCGC TCGTCCTCTG 3360

GTGTCTCTGC TGTCAGATGC TGATAATGTC ATTCGACAGC ACTGCTGTGG GGCCTTGGCT 3420

AATCTGGCTG CCTTCAGTGG AGGAGATGGA GCTCTTCTCA ATGCAGACGC TCCAGGCTTG 3480

ATTCTCCAGA CTGCCTGTAA TGATTCCCAT CATGCAGTGC GACGGGCAGC TGTGGCCACT 3540

CTGCGTGTGT TTAGCCAGCA AAACACATTA CTGCAGGCTC TGAGGTCTCT AGACGCGGGA 3600

AGAAAACTCT GTCGCTCATC CCAAAGCTCT TTATTTCAGA GGGATTATCA ATGGCTTGTC 3660

AGCAAGTTGG ACGGGTCAGT CGAAGGAAAA ACATAA 3696

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++ e iG+Gsf+ vykgr rk + qvvA+k++ k ++ +k l+ l++ei+i++ lkh+n

Q: 4     YHILEVIGEGSFGRVYKGR-RKFSGQVVALKFIPKVGRsEKDLRSLKREIDIMRGLKHPN  62

         7899***************.9*****************99********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         iv lld++et++ev++v+ey++ g+L ++l+++++L+e++vre++ ql+sal++Lhs++i

Q: 63    IVLLLDSFETEREVVVVTEYAE-GELFQILEDDGSLPEKQVREIACQLVSALYYLHSHRI  121

         **********************.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrD+kPqniLl         k + +kl+dFg+ar+++ +++  +++kG+plYm+PE+v+

Q: 122   LHRDMKPQNILLG--------KGGVVKLCDFGFARAMSVSTLVlTSIKGTPLYMSPELVE  173

         *************........899*****************999****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         e+ yd+++DlWS+G+ilyel +G pPf+++si++Lv+ i +++v   ++p+++s+++ ++

Q: 174   EKPYDHSTDLWSLGCILYELHTGAPPFYTNSIFQLVQLIVRDPV---KWPDNMSQDCLSF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         l++LL ++p+kR+s+ +l++hpf+

Q: 231   LKGLLMKEPEKRLSWPDLLHHPFV  254

         **********************96

Domain Sequence
(FASTA)

YHILEVIGEG SFGRVYKGRR KFSGQVVALK FIPKVGRSEK DLRSLKREID IMRGLKHPNI 60

VLLLDSFETE REVVVVTEYA EGELFQILED DGSLPEKQVR EIACQLVSAL YYLHSHRILH 120

RDMKPQNILL GKGGVVKLCD FGFARAMSVS TLVLTSIKGT PLYMSPELVE EKPYDHSTDL 180

WSLGCILYEL HTGAPPFYTN SIFQLVQLIV RDPVKWPDNM SQDCLSFLKG LLMKEPEKRL 240

SWPDLLHHPF V 251

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035083	; P:cilium axoneme assembly
GO:0007368	; P:determination of left/right symmetry
GO:0009953	; P:dorsal/ventral pattern formation
GO:0007224	; P:smoothened signaling pathway

KEGG

dre:566154

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR000225	; Armadillo.
IPR000357	; HEAT.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00514	; Arm; 1.
PF02985	; HEAT; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013