EKS-DAR-00702

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00702

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	362.0	4.6E-108	612	1066	455

Status

Unreviewed

Ensembl Protein

ENSDARP00000120826

UniProt Accession

B8JI14;

Protein Name

Protein Synonyms/Alias

Novel protein (Zgc:152949);

Gene Name

eif2ak3

Gene Synonyms/Alias

eif2ak3; DKEY-12J14.2; DKEY-12J14.2-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000062139	ENSDARP00000083934	ENSDART00000089501
ENSDARG00000062139	ENSDARP00000120826	ENSDART00000142997

Organism

Danio rerio

Functional Description

Protein Length

1099

Protein Sequence
(FASTA)

MERGFQFGNV CISLLLLLVL RTLTATLQTQ SLSEREVEVA PTPNTEAAEH AAVMERPLDN 60

VGGALGIGEV TVEDDDYGST GDSDEPSGDT DANFHKHRRA LVIISTLDGR IAALDPLNQG 120

RKQWDLDVGS GCLVSSSLSK PEIFGNKMFI PSLDGALFQW NRDRESMEAV SFSVESLLDS 180

SYRIGEDTVL VGGKSLTTYG LGAYSGKLKY ICSAVGCSRW GDEEGEPEDV LLLQRTQKTV 240

RAVRPRNGFE KWNFSVGNFE LKFVPEIQSK LNFLEGEAPS GETWREVRRE AQRVIQEETD 300

AQTKNHAKMH PNSAHTQVEG LDLVIKVSVP DWKVMAFSTK PEGQLIWEHQ FCTPIASAWL 360

VGGGKVTPIS LFDDTSYNSQ TETETQEDDD IMEEARGATE SSVYLGMFQG QLYLQSSVRI 420

SEKFPSKSKA LNGWGGDTDM MPPPTVKWKP LIHSPSRTPV LVGSEEFDKC LNNDKFSHEE 480

YSNGALSILQ YPYDNGYYFP YSPRYRNRRD ETAVSVLLKK DGEGSQVRRK DPVLLLPWWK 540

EILGTIFFCI AATTYIVRKF FHPPTTYSRQ RKESETQCQT DTKFEADVTE PKEVVVTDMR 600

PCEYVSRYLT DFEPVQCLGR GGFGVVFEAR NKVDDCNYAI KRIRLPNREL AREKVMREVK 660

ALAKLEHPGI IRYFNAWQES PPQGWQEDMD KRWLKDASTA DWLLSSPEHM EAFSVKVPVA 720

TPSPVDSSCM CAAGGDTSVC VGDQVCVEGL GPDSMMSERD SQADPDAIME VSDSPHSFEL 780

CPPRTVAHGD CTSSSFDIVF EDSGCEHQDN DSDLSGSTPV PPVCLSQSGS KPQRSTSTGP 840

PISLPSRPTT LSLAPSTPCP VVRPLLTPKV YLYIQMQLCR KENLKDWMAQ RCLPELREHT 900

QCLDIFLQIA EAVDFLHSKG LMHRDLKPSN IFFTMDDVVK VGDFGLVTAM DQEEDDEELS 960

TLTPMPIYAR HTGQVGTKLY MSPEQLSGNS YSHKVDIYSL GLILFELLCP FRTQMERVRT 1020

LTEVRALQFP AAFCKANILE AQMVRCMLSR VPAERPEASE ITEAPLFQEL EVPCRIRQRT 1080

RTYSASSAGR PSRQISSSN 1099

Nucleotide Sequence
(FASTA)

ATGGAAAGGG GGTTTCAGTT TGGAAACGTG TGCATATCTC TTCTGCTGTT GCTTGTTTTG 60

AGAACGTTAA CGGCCACCTT GCAAACTCAG TCTCTCTCTG AGAGAGAAGT CGAAGTGGCC 120

CCGACGCCGA ACACCGAGGC GGCGGAACAT GCTGCCGTTA TGGAGCGGCC CCTGGACAAC 180

GTCGGAGGAG CCCTTGGCAT CGGAGAAGTG ACAGTAGAGG ACGACGATTA TGGCTCGACC 240

GGAGACAGCG ACGAACCGTC TGGAGACACC GATGCAAACT TCCACAAGCA CCGCAGGGCT 300

TTGGTGATCA TCAGCACACT GGATGGGAGA ATCGCAGCTC TGGATCCTCT AAACCAGGGG 360

CGCAAGCAGT GGGACCTGGA CGTGGGCTCA GGCTGTTTGG TATCCTCAAG CCTCAGCAAA 420

CCAGAGATTT TTGGCAACAA AATGTTCATT CCCTCTCTGG ACGGAGCTCT GTTCCAGTGG 480

AACAGGGATA GAGAGAGTAT GGAGGCTGTT TCCTTCAGTG TGGAGTCCTT GCTGGACTCC 540

TCGTACCGCA TCGGAGAGGA CACTGTGCTT GTAGGGGGCA AATCCCTCAC CACGTACGGC 600

CTTGGTGCAT ACAGCGGCAA GTTGAAGTAT ATTTGTTCAG CGGTGGGCTG CAGTCGGTGG 660

GGGGACGAGG AAGGAGAGCC AGAGGACGTA TTGTTACTCC AGAGAACACA GAAAACTGTC 720

AGAGCTGTGA GGCCTCGCAA CGGGTTTGAG AAATGGAACT TCAGCGTGGG AAACTTTGAG 780

CTCAAATTTG TTCCGGAGAT TCAGTCCAAA CTCAACTTTT TGGAGGGGGA GGCACCAAGT 840

GGAGAAACGT GGCGAGAGGT CAGACGTGAA GCACAGCGTG TTATCCAGGA GGAGACGGAC 900

GCACAAACCA AAAATCATGC TAAGATGCAC CCAAACTCAG CGCATACTCA GGTAGAGGGC 960

TTAGACCTGG TCATTAAGGT TTCTGTGCCG GACTGGAAAG TCATGGCCTT CAGCACCAAA 1020

CCAGAAGGAC AGCTGATCTG GGAGCATCAG TTTTGCACAC CCATTGCCTC GGCATGGTTG 1080

GTTGGAGGGG GGAAGGTGAC ACCCATTAGC CTGTTTGATG ACACCTCGTA TAACTCCCAA 1140

ACTGAGACTG AGACTCAGGA GGATGATGAC ATCATGGAGG AGGCCCGCGG GGCAACAGAG 1200

TCCAGCGTTT ACCTGGGCAT GTTTCAGGGT CAGCTTTACC TTCAGTCCTC TGTGAGGATC 1260

TCTGAGAAGT TTCCATCTAA ATCCAAAGCT CTGAACGGCT GGGGAGGTGA CACTGACATG 1320

ATGCCACCAC CTACAGTCAA ATGGAAACCC CTCATCCACT CCCCGTCTCG TACTCCAGTC 1380

TTGGTGGGCT CTGAAGAGTT CGATAAATGT CTGAATAATG ATAAATTCTC TCATGAAGAG 1440

TACAGCAATG GAGCTCTTTC AATACTGCAA TACCCGTATG ATAATGGATA CTACTTTCCA 1500

TACAGTCCTC GTTACCGAAA CCGGCGTGAC GAGACTGCAG TGAGTGTTCT GTTGAAAAAA 1560

GACGGAGAAG GCTCACAGGT GAGAAGGAAA GACCCTGTGC TGCTGCTGCC GTGGTGGAAA 1620

GAAATTCTGG GTACCATCTT CTTCTGTATC GCTGCCACCA CGTACATCGT CCGCAAGTTC 1680

TTCCATCCAC CTACAACATA CTCACGGCAA AGAAAGGAGT CTGAGACACA GTGCCAAACT 1740

GACACCAAGT TTGAAGCAGA TGTTACAGAG CCCAAAGAAG TTGTGGTCAC AGATATGCGT 1800

CCCTGCGAAT ATGTCTCCAG ATATTTGACA GACTTTGAGC CAGTGCAGTG TTTGGGACGG 1860

GGTGGATTTG GTGTCGTGTT TGAGGCTCGC AACAAGGTGG ACGACTGCAA CTATGCCATC 1920

AAGAGGATCC GTCTACCAAA CAGGGAGCTG GCCCGTGAGA AGGTCATGCG AGAGGTGAAG 1980

GCTCTGGCTA AGCTGGAACA CCCAGGAATC ATCCGTTACT TCAACGCCTG GCAGGAGAGT 2040

CCGCCTCAGG GCTGGCAGGA GGACATGGAC AAACGCTGGC TCAAAGACGC AAGCACTGCT 2100

GATTGGCTGC TGAGCTCTCC GGAACACATG GAGGCTTTCT CTGTTAAGGT TCCAGTGGCC 2160

ACTCCGTCTC CTGTGGACTC ATCATGCATG TGTGCGGCCG GCGGGGACAC CAGCGTGTGC 2220

GTCGGGGACC AAGTCTGCGT GGAGGGCCTG GGGCCGGACA GTATGATGTC AGAGCGAGAC 2280

AGTCAGGCCG ACCCAGATGC TATTATGGAG GTCTCCGATT CCCCCCACTC CTTTGAGCTC 2340

TGCCCACCTC GCACGGTTGC CCACGGCGAC TGCACCTCTT CCTCTTTCGA CATCGTCTTC 2400

GAGGACTCCG GCTGTGAACA CCAGGACAAT GACAGTGACC TCAGCGGAAG TACACCTGTG 2460

CCACCCGTGT GCCTTTCACA GTCTGGCTCC AAACCCCAGC GCAGTACGTC AACAGGACCA 2520

CCCATTTCCT TACCTTCAAG GCCCACGACT CTGAGTCTTG CTCCCAGTAC CCCCTGTCCC 2580

GTCGTGCGGC CCCTGCTCAC ACCGAAGGTC TACCTGTACA TTCAGATGCA GCTCTGTAGG 2640

AAGGAGAACC TGAAGGACTG GATGGCTCAG AGGTGTTTGC CCGAACTCAG GGAACACACT 2700

CAGTGTCTGG ACATCTTCCT GCAGATCGCT GAAGCTGTGG ACTTCCTGCA TAGCAAAGGA 2760

CTCATGCACA GAGATCTTAA GCCATCTAAT ATTTTCTTCA CAATGGATGA TGTGGTGAAG 2820

GTGGGAGACT TTGGCCTGGT CACTGCCATG GATCAGGAGG AAGATGATGA AGAGCTGAGT 2880

ACTCTCACAC CAATGCCAAT CTATGCCCGG CACACTGGCC AAGTGGGCAC CAAACTCTAC 2940

ATGAGCCCCG AACAGTTGTC CGGCAATTCA TATTCTCACA AGGTGGACAT TTATTCACTT 3000

GGCCTGATTC TTTTTGAGCT CCTCTGTCCA TTCCGCACAC AGATGGAGAG AGTCAGGACT 3060

CTCACAGAGG TCAGAGCCTT GCAGTTTCCT GCTGCTTTCT GCAAGGCCAA CATCCTGGAA 3120

GCTCAGATGG TGCGCTGTAT GCTGTCCCGC GTGCCTGCGG AGCGACCGGA GGCTTCCGAA 3180

ATCACAGAAG CCCCTTTATT CCAGGAGCTG GAGGTGCCCT GCAGAATCAG ACAGCGCACT 3240

CGAACGTACA GCGCCTCTTC TGCGGGACGA CCCTCGCGAC AGATATCCTC TTCAAACTAG 3300

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fe +++lG+GgfgvV++a+nk+d+++yaikri+l++++ ++ekv+revkaLaklehp+i+

Q: 612   FEPVQCLGRGGFGVVFEARNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGII  671

         799*********************************************************

S: 61    rYfaawleekeesl..............................................  74

         rYf+aw+e++++++

Q: 672   RYFNAWQESPPQGWqedmdkrwlkdastadwllsspehmeafsvkvpvatpspvdsscmc  731

         **************8888888888888888877777777777777777777777777777

S: 75    .............................................tdsseveaeaelees  89

Q: 732   aaggdtsvcvgdqvcveglgpdsmmserdsqadpdaimevsdsphS--------------  777

         7777777777777777777776555555555555555555555550..............

S: 90    esseesdtk...................................................  98

Q: 778   --------Felcpprtvahgdctsssfdivfedsgcehqdndsdlsgstpvppvclsqsg  829

         ........0555555555555555555555555556666666666667999999999999

S: 99    .........................................llyiqmelceketLkdwid  117

                                                  +lyiqm+lc+ke+Lkdw+

Q: 830   skpqrststgppislpsrpttlslapstpcpvvrplltpkvYLYIQMQLCRKENLKDWMA  889

         999999******************************************************

S: 118   erkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvKigDFgLata  176

         +r+l e r++  + ++f q++e++++lHskgl+HrdLkpsniF+++dd vK+gDFgL+ta

Q: 890   QRCLPELREHTQClDIFLQIAEAVDFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTA  949

         ************************************************************

S: 177   laealk..edvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLly  234

         +++++   e ++ ++++ +a+htgqvgtklymsPeql++++Y++kvDi+sLGlilfeLl

Q: 950   MDQEEDdeELSTLTPMPIYARHTGQVGTKLYMSPEQLSGNSYSHKVDIYSLGLILFELLC  1009

         9976551044667788888*****************************************

S: 235   pfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksel  291

         pf t+merv+tlte+r +++p++f +    e+++++ +lsr p+eRp+ase+ + +l

Q: 1010  PFRTQMERVRTLTEVRALQFPAAFCKANILEAQMVRCMLSRVPAERPEASEITEAPL  1066

         ************************9989999*********************99876

Domain Sequence
(FASTA)

FEPVQCLGRG GFGVVFEARN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGII 60

RYFNAWQESP PQGWQEDMDK RWLKDASTAD WLLSSPEHME AFSVKVPVAT PSPVDSSCMC 120

AAGGDTSVCV GDQVCVEGLG PDSMMSERDS QADPDAIMEV SDSPHSFELC PPRTVAHGDC 180

TSSSFDIVFE DSGCEHQDND SDLSGSTPVP PVCLSQSGSK PQRSTSTGPP ISLPSRPTTL 240

SLAPSTPCPV VRPLLTPKVY LYIQMQLCRK ENLKDWMAQR CLPELREHTQ CLDIFLQIAE 300

AVDFLHSKGL MHRDLKPSNI FFTMDDVVKV GDFGLVTAMD QEEDDEELST LTPMPIYARH 360

TGQVGTKLYM SPEQLSGNSY SHKVDIYSLG LILFELLCPF RTQMERVRTL TEVRALQFPA 420

AFCKANILEA QMVRCMLSRV PAERPEASEI TEAPL 455

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:559564

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013