EKS-DAR-00559

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00559

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	359.4	1.9E-107	22	273	252

Status

Unreviewed

Ensembl Protein

ENSDARP00000084386

UniProt Accession

E7F378;

Protein Name

Protein Synonyms/Alias

Gene Name

sik2b

Gene Synonyms/Alias

sik2b; BX572077.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000062315	ENSDARP00000084386	ENSDART00000089953

Organism

Danio rerio

Functional Description

Protein Length

896

Protein Sequence
(FASTA)

MVMADCHQKP AALRGPVRVG FYDIERTLGK GNFAVVKLAR HRITKTEVAI KIIDKTQLDA 60

VNLEKIYREV QIMKMLDHPH IIKLYQVMET KNMLYLVTEY AKNGEIFDYL AKHGRLSEPE 120

ARRKFWQILS AVEYCHNRNI VHRDLKAENL LLDGHMNIKI ADFGFGNFFQ SGKPLATWCG 180

SPPYAAPEVF EGQQYEGPQL DIWSMGVVLY VLVCGALPFD GPSLPVLRQR VLEGRFRIPY 240

FMTEDCEHLI RRMLVLDPSK RLSIGQIKEH KWMVMEVPVQ RPMLYQQTTE GEAGVGEYNE 300

QVLRLMHSLG IDQHKTVESL QNKSYNHFAA IYYLLVERLK AHRCSFPVEP RLDARQRRPS 360

TIAEQTLVKA SSAAPQVSLL PQNVRLLRPP AVPQTSADSF TFPQSSCAAE HSLMEEEEVG 420

TPKINGCMLD PLPPVAVRKS SASSPSNMME TSIDEGIETE EPDTEDDHTH VFNAYQTARF 480

GQRRHTLSEV TNQPGIITSG GKLFSMGHNP SLGSVDSEYD MGSMHSDLSL LEDGPSLNEV 540

VLANTPVTRL TPPFISARPA NPTMQALSTQ RRETHNRSPI SFREGRRASD TSLTQGLVAF 600

RQHLQNLART KGILELNKVY AQMGSGETPS LGLLSPQAHP HGLLDPALQE ERGHQPDIAL 660

CSGGTHPALL SRRQSLEPQY LPHRIQKATL MANSPSSCQM FCKETPRSLE QQLQEHRLQQ 720

KRLYLQKQTQ MQAYFNQMHI VEDPFAPCAT MGHQDSGAPP QPQGSLAPAH QQPQSSPPFA 780

HAQPLGPLME PNPEALAYET YLGLYPQLQP LPQSYPAQLQ QPEPLNYTYP PCDPSHSPSG 840

EALYPEQYDY PLDPGQLPPP AEVSTAGYEG LALGDPFLDS EMMETVDSQH GFVLVN 896

Nucleotide Sequence
(FASTA)

ATGGTCATGG CTGACTGTCA CCAAAAGCCA GCAGCGCTCA GGGGTCCCGT CCGGGTGGGC 60

TTTTACGACA TCGAGCGGAC TCTCGGAAAG GGCAATTTCG CGGTTGTGAA ACTGGCTAGG 120

CATCGCATAA CTAAGACCGA GGTGGCTATA AAGATCATCG ACAAGACCCA GCTGGATGCT 180

GTAAACCTGG AGAAGATCTA TCGTGAAGTG CAGATCATGA AAATGCTGGA CCATCCGCAC 240

ATCATTAAAC TGTACCAGGT CATGGAGACC AAGAATATGC TGTACCTTGT GACGGAATAC 300

GCCAAAAATG GGGAAATCTT TGACTACCTA GCCAAGCATG GACGGCTGAG TGAACCAGAG 360

GCTCGTCGCA AGTTCTGGCA AATTCTGTCT GCTGTCGAGT ACTGTCACAA TCGTAACATC 420

GTTCACCGGG ACTTAAAGGC TGAGAACTTG CTGCTAGACG GACACATGAA CATCAAGATT 480

GCTGATTTTG GCTTTGGAAA TTTCTTCCAG TCAGGCAAGC CTCTGGCCAC ATGGTGTGGG 540

AGTCCTCCAT ATGCGGCCCC AGAGGTGTTT GAGGGACAGC AGTATGAGGG ACCGCAGCTG 600

GACATCTGGA GTATGGGGGT GGTTCTGTAC GTGCTGGTGT GTGGCGCCTT GCCCTTTGAC 660

GGCCCCTCTC TCCCTGTCCT GCGGCAGCGT GTTCTGGAGG GCCGTTTCCG TATCCCTTAC 720

TTCATGACAG AAGACTGTGA GCATCTGATC AGGCGGATGT TGGTGTTAGA CCCCTCCAAG 780

CGTCTATCTA TAGGACAAAT AAAAGAACAC AAGTGGATGG TGATGGAGGT GCCTGTGCAG 840

CGACCGATGT TGTACCAGCA GACCACAGAG GGAGAGGCTG GAGTGGGCGA ATACAACGAA 900

CAGGTGCTCA GGTTGATGCA CAGCCTGGGC ATTGACCAGC ACAAGACTGT GGAGTCTCTT 960

CAGAATAAGA GTTACAATCA CTTTGCTGCT ATCTACTACT TGCTGGTTGA GAGGCTGAAG 1020

GCCCACCGCT GCAGCTTCCC AGTGGAGCCC AGACTCGACG CTCGCCAGAG ACGCCCCAGT 1080

ACGATCGCAG AGCAGACCCT CGTCAAGGCG AGCAGCGCTG CCCCTCAGGT GAGCCTCCTG 1140

CCTCAGAACG TGCGTCTCCT GCGGCCTCCT GCTGTGCCTC AAACCTCTGC AGACTCCTTC 1200

ACTTTCCCAC AATCCTCCTG CGCTGCGGAG CACAGCCTCA TGGAGGAGGA GGAAGTCGGG 1260

ACTCCCAAAA TCAACGGCTG CATGCTGGAC CCCTTGCCCC CCGTGGCCGT TCGCAAATCC 1320

AGCGCTTCGT CCCCCAGCAA CATGATGGAG ACGTCTATAG ATGAGGGTAT CGAAACGGAG 1380

GAGCCAGACA CAGAGGATGA TCATACCCAC GTTTTTAACG CCTACCAGAC GGCCCGCTTT 1440

GGTCAGCGCA GACACACACT ATCTGAGGTC ACCAACCAGC CAGGGATCAT TACAAGTGGA 1500

GGTAAACTGT TCAGCATGGG TCATAACCCC TCTCTGGGTA GCGTGGACTC AGAGTATGAT 1560

ATGGGCTCCA TGCACAGTGA CCTCAGTCTG CTTGAAGACG GGCCCTCTCT TAATGAGGTG 1620

GTCCTGGCCA ACACACCAGT GACCCGCTTG ACTCCACCGT TCATCAGTGC TCGGCCCGCG 1680

AACCCCACCA TGCAGGCACT GAGCACCCAG AGGAGAGAAA CGCACAACCG CTCTCCCATC 1740

AGCTTCAGAG AGGGCCGCAG GGCTTCAGAC ACATCACTCA CACAAGGCTT GGTGGCCTTT 1800

AGACAGCACC TACAGAATCT GGCACGTACC AAAGGTATCC TGGAGCTAAA TAAGGTGTAC 1860

GCGCAGATGG GCTCTGGAGA AACCCCATCC CTGGGGCTGC TGAGCCCTCA GGCCCATCCA 1920

CATGGCTTAC TGGACCCTGC ACTACAGGAG GAAAGAGGTC ACCAGCCTGA CATTGCTCTA 1980

TGCTCAGGTG GAACACACCC TGCTCTATTA TCAAGGAGAC AGAGTCTGGA GCCGCAGTAC 2040

CTCCCCCACA GAATACAGAA AGCGACTCTG ATGGCCAACA GCCCCAGCAG TTGCCAGATG 2100

TTCTGCAAAG AAACTCCTCG CAGTCTGGAG CAGCAGCTGC AGGAGCACAG GCTGCAACAA 2160

AAACGTCTGT ATCTGCAGAA ACAAACCCAA ATGCAGGCGT ACTTCAACCA GATGCACATT 2220

GTGGAGGACC CTTTCGCTCC CTGTGCAACC ATGGGCCACC AGGACTCCGG AGCCCCACCT 2280

CAGCCACAGG GTTCACTAGC ACCAGCACAT CAGCAGCCGC AGAGCTCACC TCCATTTGCA 2340

CACGCACAGC CACTTGGCCC CCTAATGGAG CCAAACCCAG AAGCCCTAGC GTATGAAACC 2400

TACCTGGGCC TTTACCCTCA GCTGCAGCCT CTACCACAAA GCTACCCCGC TCAACTGCAA 2460

CAGCCTGAAC CCCTCAACTA CACCTATCCA CCCTGTGACC CAAGCCACTC GCCATCAGGA 2520

GAAGCACTGT ACCCGGAGCA ATACGACTAC CCTCTTGATC CAGGGCAGCT GCCTCCACCT 2580

GCAGAGGTCA GCACTGCTGG CTATGAAGGC CTGGCATTGG GCGACCCATT TCTGGACAGC 2640

GAAATGATGG AGACGGTGGA CTCTCAGCAC GGTTTTGTGC TGGTGAACTA A 2691

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 22    YDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHI  81

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya++ge+fdy+ ++grl+e ear+ f q++sav+Y+h+++iv

Q: 82    IKLYQVMETKNMLYLVTEYAKNGEIFDYLAKHGRLSEPEARRKFWQILSAVEYCHNRNIV  141

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld ++nikiaDFG++n+f++gk l t+cGsppYaaPe+++g++Yegp++D

Q: 142   HRDLKAENLLLDGHMNIKIADFGFGNFFQSGKPLATWCGSPPYAAPEVFEGQQYEGPQLD  201

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +++++e+L+r++Lv dp+kR

Q: 202   IWSMGVVLYVLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKR  261

         ************************************************************

S: 241   atieeilkhewl  252

         ++i +i++h+w+

Q: 262   LSIGQIKEHKWM  273

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKTQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KNGEIFDYLA KHGRLSEPEA RRKFWQILSA VEYCHNRNIV 120

HRDLKAENLL LDGHMNIKIA DFGFGNFFQS GKPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PSLPVLRQRV LEGRFRIPYF MTEDCEHLIR RMLVLDPSKR 240

LSIGQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:567919

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013