EKS-DAR-00421

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00421

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/Akt	504.9	1.0E-151	148	405	258

Status

Unreviewed

Ensembl Protein

ENSDARP00000087028

UniProt Accession

D9IL79;

Protein Name

Protein Synonyms/Alias

V-akt murine thymoma viral oncogene-like 3 transcript variant 1;

Gene Name

akt3a

Gene Synonyms/Alias

akt3a; akt3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000063400	ENSDARP00000087028	ENSDART00000092596

Organism

Danio rerio

Functional Description

Protein Length

479

Protein Sequence
(FASTA)

MSDVTVVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDADLPYP LNNFSVAKCQ 60

LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEERDEWAE AIQMVADKLQ RQEEERIQCS 120

PTSQIDNMGE EEMDTSISHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 180

KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 240

RVFSEDRTRF YGAEIVSALD YLHSAKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 300

ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 360

EDIKFPRTLS ADAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFTGIDW QDVYDKKLIP 420

PFKPQVSSET DTRYFDEEFT AQTITITPPE KFDEDGMDCM DNERRPHFPQ FSYSASGRE 479

Nucleotide Sequence
(FASTA)

ATGAGCGATG TCACCGTCGT CAAGGAAGGC TGGGTCCAGA AGAGAGGTGA ATATATTAAG 60

AATTGGAGAC CTCGGTACTT CCTGCTCAAA ACAGACGGAT CCTTTATCGG ATACAAGGAG 120

AAGCCACAGG ATGCAGATCT TCCCTATCCT CTCAATAACT TCTCTGTTGC AAAATGCCAG 180

CTGATGAAAA CTGAACGACC AAAGCCGAAC ACTTTTATTA TTAGATGCCT ACAGTGGACT 240

ACAGTCATAG AGAGGACCTT CCATGTGGAC ACACCAGAGG AGAGGGATGA GTGGGCAGAG 300

GCGATCCAGA TGGTGGCAGA TAAACTCCAA AGACAGGAAG AGGAGCGAAT CCAGTGTAGT 360

CCCACCTCAC AGATAGACAA CATGGGAGAG GAGGAGATGG ACACGTCTAT CAGCCACCAC 420

AAACGCAAGA CAATGAATGA CTTTGACTAC TTAAAATTAC TGGGAAAAGG CACTTTTGGA 480

AAAGTCATTC TCGTAAGGGA GAAGGCCAGC GGGAAATATT ATGCAATGAA AATTTTAAAG 540

AAAGAAGTTA TTATAGCAAA GGACGAAGTG GCCCACACGC TCACAGAAAG CAGAGTACTG 600

AAAAACACCA GACATCCTTT TTTAACCTCT TTGAAGTACT CGTTCCAAAC AAAAGACCGC 660

CTATGCTTCG TGATGGAGTA TGTCAATGGA GGAGAGCTGT TTTTCCATTT GTCGAGAGAA 720

CGGGTGTTCT CGGAGGACCG CACGCGCTTC TACGGCGCCG AGATCGTTTC CGCCCTCGAC 780

TACCTGCACT CTGCCAAGAT TGTGTACCGG GATCTCAAGC TGGAGAATTT GATGCTTGAT 840

AAAGATGGTC ACATCAAAAT TACAGACTTT GGCCTCTGCA AAGAAGGAAT CACTGATGCT 900

GCTACCATGA AGACCTTCTG TGGGACGCCA GAGTATTTGG CACCGGAGGT GCTGGAGGAC 960

AATGATTACG GCCGTGCGGT GGACTGGTGG GGTCTCGGGG TGGTCATGTA TGAGATGATG 1020

TGTGGTCGAC TGCCTTTCTA CAATCAGGAC CACGAGAAGC TGTTTGAGCT CATCCTGATG 1080

GAGGACATCA AGTTCCCCAG GACGCTCTCC GCTGATGCCA AGTCCCTGCT GTCCGGCCTG 1140

CTCATCAAAG ATCCCAACAA GAGACTTGGT GGAGGTCCGG ATGATGCTAA GGAAATTATG 1200

CGACATAGTT TCTTTACTGG AATTGACTGG CAGGATGTCT ATGATAAAAA GCTGATACCT 1260

CCCTTCAAGC CTCAGGTGTC GTCAGAGACA GATACCAGAT ATTTTGACGA AGAGTTCACA 1320

GCTCAAACCA TTACAATAAC CCCTCCTGAA AAATTTGATG AAGATGGGAT GGACTGCATG 1380

GACAACGAGC GACGGCCACA CTTCCCCCAG TTCTCCTACT CGGCCAGCGG GAGAGAATGA 1440

Domain Profile

S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60

         fd+lkllGkGtfGkvilvreka++k+ya+kilkkevi+akdevahtlte+rvlk+t+hpf

Q: 148   FDYLKLLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPF  207

         9***********************************************************

S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120

         l++lkysfqtk++lc+v+eyvnGGelffhls+ervfsedr+rfygaeivsaldylhs ++

Q: 208   LTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSAKI  267

         ************************************************************

S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180

         vyrdlklenl+ldkdGhikitdfGlcke+i+d++++ktfcGtpeylapevled+dyg+av

Q: 268   VYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAV  327

         ************************************************************

S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240

         dwwglGvv+yem+cGrlpfyn+dheklfelil+e++kfpr+ls +aksllsGll kdp+k

Q: 328   DWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSADAKSLLSGLLIKDPNK  387

         ************************************************************

S: 241   rlGggkddakeireheff  258

         rlGgg+ddakei++h+ff

Q: 388   RLGGGPDDAKEIMRHSFF  405

         *****************9

Domain Sequence
(FASTA)

FDYLKLLGKG TFGKVILVRE KASGKYYAMK ILKKEVIIAK DEVAHTLTES RVLKNTRHPF 60

LTSLKYSFQT KDRLCFVMEY VNGGELFFHL SRERVFSEDR TRFYGAEIVS ALDYLHSAKI 120

VYRDLKLENL MLDKDGHIKI TDFGLCKEGI TDAATMKTFC GTPEYLAPEV LEDNDYGRAV 180

DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEDIKFPR TLSADAKSLL SGLLIKDPNK 240

RLGGGPDDAK EIMRHSFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:560549

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00169	; PH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013