EKS-DAR-00603

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00603

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	450.0	9.7E-135	164	483	320

Status

Unreviewed

Ensembl Protein

ENSDARP00000090845

UniProt Accession

F1QSN1;

Protein Name

Protein Synonyms/Alias

Gene Name

dyrk1aa

Gene Synonyms/Alias

dyrk1aa;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000063570	ENSDARP00000120004	ENSDART00000144722
ENSDARG00000063570	ENSDARP00000122301	ENSDART00000141723
ENSDARG00000063570	ENSDARP00000090845	ENSDART00000100073

Organism

Danio rerio

Functional Description

Protein Length

734

Protein Sequence
(FASTA)

MCCIVFAGGE TSACKPSSVR LAPSFSFHSA GVQMDAQTPH SHPPFSDAHP QGAADQSAAA 60

LPYNPQAPQP SATQVTADMV MLQRRMPQCF RDPATAPLRK LSIELIKTYK HINEVYYAKK 120

KRRHQQGQGE DSSNKKERKI YNDGYDDDNF DYIVKNGEKW MDRYEIDSLI GKGSFGQVVK 180

AYDRVEQEWV AIKIIKNKKA FLNQAQIEVR LLELMNKHDT EMKYYIVHLK RHFMFRNHLC 240

LVFEMLSYNL YDLLRNTNFR GVSLNLTRKF AQQLCTALLF LATPELSIIH CDLKPENILL 300

CNPKRSAIKI VDFGSSCQLG QRIYQYIQSR FYRSPEVLLG MPYDLAIDMW SLGCILVEMH 360

TGEPLFSGAN EVDQMNKIVE VLGVPPSHIL EQAPKARKFF EKMPDSMWCA KKTKDGKRYK 420

PAGSRKLHSI LGVEAGGPGG RRAGESGHAV ADYLKFKDLI LRMLDYDPKT RIQPYYALQH 480

SFFKKTADEG TNTSSSVSTS PALEQSQSSG VCVCVAGGSS GTSTSGRARS DPTHQHRHSG 540

GGHFSAAVAM DCHNLCPQAR QAFVPALGWV GDGLQQASGE THPVQETTFH VPPHQPKALH 600

PHQHHHHHHH HPPPHGQGPA RPRPRLYSPS HSASTQDSME VTHGHLSMTS LSSSASSSST 660

SSSSTGNHHY AYQSRPLPHG LGFGHSGSMT LGLGAFSNPR QETGVAGVGL RPGLEREESP 720

MAGVCVQQSS VASS 734

Nucleotide Sequence
(FASTA)

ATGTGCTGCA TTGTGTTTGC TGGAGGAGAG ACCTCAGCAT GCAAACCCTC CTCTGTCCGG 60

CTGGCCCCCT CGTTTTCTTT CCACTCGGCT GGTGTGCAGA TGGATGCGCA GACGCCCCAT 120

TCTCACCCGC CGTTCAGTGA TGCTCACCCA CAGGGCGCCG CTGACCAATC CGCTGCTGCG 180

CTGCCCTACA ACCCGCAGGC CCCGCAGCCC AGCGCCACCC AGGTAACTGC TGATATGGTG 240

ATGCTGCAGA GGCGGATGCC TCAGTGTTTC CGGGATCCAG CGACGGCACC CTTAAGAAAA 300

CTCTCCATCG AGCTGATCAA AACATACAAA CACATCAATG AGGTTTACTA TGCAAAAAAG 360

AAGCGTCGTC ACCAACAGGG TCAGGGCGAG GACTCCAGCA ACAAGAAGGA GAGGAAGATT 420

TACAACGACG GCTATGACGA CGACAACTTC GACTACATCG TTAAAAATGG CGAGAAGTGG 480

ATGGACCGAT ATGAGATCGA CTCTTTAATA GGGAAAGGCT CGTTCGGGCA GGTGGTGAAG 540

GCGTACGACC GTGTGGAGCA GGAGTGGGTC GCCATCAAGA TCATAAAGAA TAAAAAGGCC 600

TTCCTGAATC AGGCTCAGAT CGAAGTGCGA CTGCTGGAGC TGATGAACAA GCACGACACC 660

GAGATGAAGT ACTACATCGT TCACCTGAAA CGCCACTTCA TGTTCCGAAA CCACCTGTGT 720

CTGGTGTTCG AGATGCTGTC CTATAACCTG TACGATCTGC TGAGGAACAC CAACTTCCGC 780

GGCGTGTCCC TGAACCTGAC GCGTAAGTTC GCCCAGCAGC TGTGCACCGC GCTGCTGTTC 840

CTGGCCACGC CGGAGCTCAG CATCATCCAC TGTGACCTCA AGCCTGAAAA CATCCTGCTC 900

TGCAACCCCA AGAGGTCCGC CATCAAGATC GTGGACTTCG GGAGCTCCTG CCAGCTGGGC 960

CAGCGGATAT ACCAGTACAT CCAGAGTCGC TTCTACCGCT CGCCCGAGGT CCTGCTGGGG 1020

ATGCCGTACG ATCTGGCCAT CGACATGTGG TCTCTAGGCT GCATCCTGGT GGAGATGCAC 1080

ACCGGAGAAC CGCTCTTCAG CGGCGCTAAT GAGGTTGATC AGATGAATAA GATCGTGGAG 1140

GTGTTGGGCG TTCCTCCCAG TCATATCCTG GAGCAGGCAC CTAAAGCCAG GAAGTTCTTT 1200

GAGAAGATGC CGGACAGTAT GTGGTGCGCC AAGAAGACCA AAGACGGCAA AAGGTATAAG 1260

CCTGCTGGCT CCCGGAAGCT GCACAGTATT CTGGGTGTGG AGGCAGGCGG CCCCGGCGGG 1320

CGCAGAGCCG GAGAGTCGGG TCACGCCGTC GCAGACTACC TGAAGTTCAA GGACCTGATC 1380

CTGCGGATGC TAGACTATGA CCCCAAGACG CGCATCCAGC CGTACTACGC TCTGCAGCAC 1440

AGCTTCTTCA AGAAGACAGC AGACGAGGGC ACCAACACCA GCAGCAGTGT GTCCACCAGC 1500

CCCGCGCTGG AGCAGTCGCA GTCCTCCGGG GTGTGTGTGT GTGTGGCAGG AGGCTCGTCT 1560

GGAACCAGCA CCAGTGGCCG CGCCCGCTCA GACCCCACAC ATCAGCACCG GCACAGCGGA 1620

GGAGGACACT TCAGTGCTGC GGTGGCCATG GACTGCCACA ACCTCTGCCC ACAGGCAAGA 1680

CAGGCGTTTG TGCCGGCGCT GGGCTGGGTT GGAGACGGAC TCCAGCAGGC GTCAGGAGAG 1740

ACTCACCCCG TACAGGAGAC CACTTTCCAC GTGCCCCCAC ACCAGCCCAA AGCCCTGCAC 1800

CCCCACCAAC ACCACCACCA TCATCACCAC CACCCGCCGC CGCATGGACA GGGCCCTGCC 1860

CGACCTCGAC CCCGGCTCTA CTCTCCGTCC CACAGCGCCT CCACGCAGGA CTCAATGGAG 1920

GTGACGCACG GACACCTGTC CATGACCTCG CTGTCTTCCT CCGCCTCGTC CTCCTCCACC 1980

TCCTCCTCCT CCACCGGCAA CCATCACTAC GCCTACCAGA GCCGCCCGCT GCCCCACGGC 2040

CTGGGCTTCG GCCACAGCGG CAGCATGACT CTGGGCCTGG GTGCCTTCTC CAACCCGCGA 2100

CAGGAGACGG GCGTGGCAGG CGTAGGTCTG CGGCCGGGTC TGGAGCGCGA GGAGTCCCCG 2160

ATGGCGGGTG TATGTGTGCA GCAGAGCTCC GTGGCCAGCT CCTGA 2205

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 164   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  223

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 224   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLAt  283

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 284   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  342

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++le+a ka+kff+k

Q: 343   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGVPPSHILEQAPKARKFFEK  402

         ************************************************************

S: 239   keapkyilktk........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.fk  289

         + +++++ k++         ++rk + +l+v+  +     p+ +++ge+ + ++d+l fk

Q: 403   MPDSMWCAKKTkdgkrykpAGSRKLHSILGVEAGG-----PGGRRAGESGHAVADYLkFK  457

         ********999666666555556666666665555.....99******************

S: 290   dllkrmleldpakRitpkealkhpfv  315

         dl+ rml++dp++Ri+p++al+h+f+

Q: 458   DLILRMLDYDPKTRIQPYYALQHSFF  483

         *************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG VPPSHILEQA PKARKFFEKM 240

PDSMWCAKKT KDGKRYKPAG SRKLHSILGV EAGGPGGRRA GESGHAVADY LKFKDLILRM 300

LDYDPKTRIQ PYYALQHSFF 320

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Equus caballus"; ?>Homo sapiens"; ?>Macaca mulatta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013