EKS-DAR-00537

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00537

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	391.7	3.4E-117	107	372	266

Status

Unreviewed

Ensembl Protein

ENSDARP00000087469

UniProt Accession

B1NA68;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase 4A;

Gene Name

map2k4a

Gene Synonyms/Alias

map2k4a; map2k4, map2k4A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000063583	ENSDARP00000058833	ENSDART00000058834
ENSDARG00000063583	ENSDARP00000106153	ENSDART00000130761
ENSDARG00000063583	ENSDARP00000087469	ENSDART00000093037

Organism

Danio rerio

Functional Description

Protein Length

404

Protein Sequence
(FASTA)

MATSSPSSNP ASASNNPTQL HPAQSQHITT MSSMQGFQIN LSGLPPSKRK ALKLNFANPP 60

IKTTSRITSG LPFQNPHIER LRTHSIESSG KLKISAEQHC DFTAEDLKDL GEIGRGAYGS 120

VNKMAHKPSG QIMAVKRIRS TVDEREQKQL LMDLDVVMRS SDCPYIVQFY GALFREGDCW 180

ICMELMSTSF DKFYKYVYSS LDEVIPEEIL GKITLATVKA LNHLKENLKI IHRDIKPSNI 240

LLDRKGNIKL CDFGISGQLV DSIAKTRDAG CRPYMAPERI DPSASRQGYD VRSDVWSLGI 300

TLYELATGRF PYPKWNSVFD QLTQVVKGDP PQLSSSEERQ FSPKFINFVN LCLTKDESKR 360

PKYKELLKHA FIQMYEERSV DVATYVCRIL DQMPPSPSSP MYVS 404

Nucleotide Sequence
(FASTA)

ATGGCGACGT CCAGCCCAAG CAGTAACCCA GCGTCAGCCT CCAACAACCC AACGCAGCTC 60

CACCCGGCCC AGAGCCAGCA CATCACCACC ATGAGCAGCA TGCAAGGGTT TCAGATAAAC 120

CTGTCTGGAC TTCCTCCAAG TAAACGTAAA GCCCTGAAGT TAAATTTTGC CAATCCTCCA 180

ATCAAAACCA CTTCCAGAAT CACTTCCGGA CTTCCTTTCC AGAACCCACA CATAGAGCGG 240

CTGCGAACAC ACAGTATCGA GTCGTCTGGG AAGCTGAAGA TCTCAGCGGA GCAGCACTGC 300

GATTTCACAG CAGAAGACCT GAAGGATCTC GGCGAGATCG GCAGAGGAGC GTATGGCTCG 360

GTCAACAAGA TGGCGCACAA ACCCAGTGGA CAAATCATGG CCGTCAAGAG GATTCGTTCA 420

ACAGTAGACG AGCGAGAACA GAAGCAGCTG CTGATGGATC TGGATGTGGT CATGAGGAGC 480

AGCGACTGTC CGTACATCGT CCAGTTTTAC GGGGCTCTTT TCAGAGAGGG GGATTGCTGG 540

ATATGCATGG AGCTCATGTC TACCTCCTTC GACAAATTCT ACAAATATGT TTATTCCTCT 600

TTAGACGAAG TGATTCCAGA GGAGATTTTA GGGAAAATAA CATTAGCTAC TGTGAAAGCA 660

CTTAACCACT TAAAAGAAAA CTTGAAAATT ATTCACAGAG ACATAAAGCC ATCAAATATC 720

CTCCTGGACA GGAAAGGCAA CATTAAACTG TGTGATTTTG GCATCAGTGG GCAGCTGGTT 780

GACTCCATCG CCAAAACCAG AGACGCAGGC TGCAGACCGT ATATGGCACC GGAGAGGATA 840

GACCCCAGCG CCTCCAGACA GGGTTATGAC GTGCGCTCGG ATGTGTGGAG TTTGGGCATC 900

ACACTGTATG AGCTGGCCAC GGGACGCTTC CCCTACCCCA AGTGGAACAG TGTGTTTGAC 960

CAGCTGACGC AGGTGGTGAA GGGCGACCCA CCACAGCTCA GCAGCTCCGA GGAGAGACAG 1020

TTCTCCCCCA AGTTCATCAA CTTCGTCAAC CTGTGCCTTA CAAAGGACGA GTCAAAAAGG 1080

CCAAAGTACA AAGAGCTTCT GAAACATGCG TTCATCCAGA TGTACGAGGA GCGCTCGGTG 1140

GACGTGGCCA CTTACGTCTG CAGGATCCTG GATCAGATGC CACCGTCTCC CAGCTCCCCG 1200

ATGTACGTGT CT 1212

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k+ hk+sg+i+avK+ir++++++eqkq+l++l+v+++ss++pyi

Q: 107   LKDLGEIGRGAYGSVNKMAHKPSGQIMAVKRIRSTVDEREQKQLLMDLDVVMRSSDCPYI  166

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm+ ts+dk++k v+++ ++ ipe++lgki++a+vkal++lk

Q: 167   VQFYGALFREGDCWICMELMS-TSFDKFYKYVYSSlDEVIPEEILGKITLATVKALNHLK  225

         *********************.*************9************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL+++kG++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 226   ENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  285

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   +fs++f

Q: 286   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSSSeerQFSPKF  345

         9***********************************************988788******

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+kde++Rpk+kellkhafi

Q: 346   INFVNLCLTKDESKRPKYKELLKHAFI  372

         *************************97

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMAH KPSGQIMAVK RIRSTVDERE QKQLLMDLDV VMRSSDCPYI 60

VQFYGALFRE GDCWICMELM STSFDKFYKY VYSSLDEVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRKG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV KGDPPQLSSS EERQFSPKFI 240

NFVNLCLTKD ESKRPKYKEL LKHAFI 266

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:403052

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013