EKS-DAR-00570

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00570

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	318.3	6.4E-95	29	279	251

Status

Unreviewed

Ensembl Protein

ENSDARP00000087652

UniProt Accession

Q1MTK5;

Protein Name

Protein Synonyms/Alias

Novel protein containing a protein kinase domain;

Gene Name

nuak2

Gene Synonyms/Alias

nuak2; si:rp71-11b17.3; RP71-11B17.3-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000063661	ENSDARP00000116197	ENSDART00000135403
ENSDARG00000063661	ENSDARP00000087652	ENSDART00000093220

Organism

Danio rerio

Functional Description

Protein Length

576

Protein Sequence
(FASTA)

MESVGAPEAP VKRQAVKRHH HKHNLKHRYE FLETLGKGTY GRVKKAMDRS GTAVAIKSIR 60

KEKIRDEQEL THIRREIEIM SSLSHPHIIS IYEVFENKDK IVIVMELASR GDLFDYICDS 120

QPLAETQARH FFRQIVSAVH YCHRNGIVHR DLKLENILLD CNGNIKIADF GLSNLYRGDK 180

LLQTYCGSPL YASPEIVNGR PYRGPEVDSW SLGVLLYTLM HGAMPFDGHD HRILVQQISS 240

GSYRKPSKPS DACGLIRWML MVNPERRATL EDIAGHWWVN WGFELPLLAQ SDPATAHPAS 300

EPAAVVSQTN GSTRIADWLR RSSRPLLESS SKMRCLLRTG EPVQRQRSIR RSRKENNISQ 360

SMQETPRPAK GILKKRGSLK LKAPPEPQLT PLEEKSSNAL VAAVLPPPPK GILKKPSESE 420

SSCCSLSPQN SGQTLGNPSP VPHRKGILKR HSKFSGGLQE FGSLDQLALC SPAVVNRPRP 480

SGAVSEDSIL SSESFDRLDL PEREIPVASM GRLSGKQRMR GCVSADNLLD LQEDRTQGHW 540

EMEIAYRAGV SDSIFSITDC ENVTQTYKQA LGAIAT 576

Nucleotide Sequence
(FASTA)

ATGGAGAGTG TCGGTGCCCC GGAGGCGCCC GTAAAACGGC AGGCGGTGAA GAGACACCAC 60

CACAAACACA ACCTCAAACA CCGCTACGAG TTCCTGGAGA CCCTCGGAAA GGGCACTTAT 120

GGCCGGGTCA AGAAGGCCAT GGACCGGTCC GGCACAGCGG TGGCCATTAA ATCCATCCGT 180

AAGGAGAAGA TCAGAGACGA GCAGGAGCTC ACACACATCC GGCGGGAGAT CGAGATCATG 240

TCGTCTCTCA GCCACCCGCA CATCATCAGC ATTTATGAAG TGTTCGAGAA CAAGGATAAG 300

ATCGTGATCG TGATGGAGTT GGCCAGCAGA GGAGATTTAT TCGACTACAT CTGTGACTCT 360

CAGCCGCTGG CAGAGACGCA GGCCAGACAC TTCTTCAGAC AGATCGTCTC TGCTGTACAC 420

TACTGCCACA GGAACGGGAT TGTCCATCGT GACCTGAAGC TGGAGAACAT CTTGCTGGAC 480

TGCAACGGCA ATATAAAAAT CGCAGACTTC GGCCTGTCCA ACTTGTACCG CGGTGATAAA 540

CTGCTGCAGA CGTACTGCGG GAGTCCCCTG TACGCGTCTC CGGAGATCGT GAACGGCCGT 600

CCGTACAGAG GGCCTGAGGT GGACAGCTGG TCTCTGGGGG TCCTGCTCTA CACACTGATG 660

CACGGAGCCA TGCCATTCGA CGGACACGAC CACCGCATAC TGGTGCAGCA GATCAGCAGC 720

GGGAGCTACA GGAAACCCTC CAAACCATCA GATGCGTGTG GTTTGATTCG CTGGATGTTA 780

ATGGTAAACC CGGAGCGCAG AGCGACACTG GAGGACATTG CCGGCCACTG GTGGGTCAAC 840

TGGGGCTTTG AGCTCCCCCT ACTGGCTCAG AGTGACCCTG CAACTGCACA TCCAGCTTCA 900

GAACCAGCAG CTGTAGTGAG CCAAACCAAT GGATCGACCC GCATCGCGGA CTGGCTGCGG 960

CGCAGCTCTC GCCCCCTGCT GGAGAGCAGC TCTAAGATGC GCTGCCTGCT GCGGACAGGA 1020

GAGCCGGTGC AGAGGCAGCG CTCCATACGC AGGTCCCGCA AGGAAAACAA CATCTCGCAG 1080

AGCATGCAGG AGACTCCGCG GCCCGCTAAA GGCATCCTGA AGAAGAGGGG TAGCCTAAAA 1140

CTAAAGGCGC CCCCAGAACC CCAGCTTACT CCCTTAGAGG AGAAGAGCTC TAATGCACTA 1200

GTGGCCGCTG TCCTTCCTCC ACCTCCGAAA GGCATCCTAA AGAAACCTTC GGAAAGCGAG 1260

TCCAGCTGTT GTTCCCTCTC TCCACAGAAC TCTGGCCAAA CCCTTGGGAA CCCATCACCT 1320

GTTCCGCACC GCAAAGGAAT CCTCAAACGC CACAGCAAGT TTTCCGGCGG ACTGCAGGAA 1380

TTCGGCTCAC TGGATCAGCT CGCACTGTGT TCGCCTGCAG TGGTGAACCG ACCTCGACCT 1440

AGCGGAGCGG TTAGCGAAGA CAGCATCCTC TCCTCGGAGT CCTTTGATAG ACTGGACTTA 1500

CCCGAGCGGG AGATCCCTGT TGCATCAATG GGGCGACTGT CGGGAAAACA GAGGATGCGA 1560

GGATGTGTTT CGGCGGACAA TCTCCTGGAC CTGCAGGAAG ACAGGACTCA GGGACACTGG 1620

GAGATGGAGA TCGCCTACCG AGCAGGAGTG TCCGATAGCA TTTTTTCAAT CACCGACTGT 1680

GAAAACGTCA CGCAGACTTA CAAACAAGCC TTGGGAGCAA TCGCAACCTG A 1731

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl.seeslekikrEieilkklkhpn  59

         y++l+tlG+g++g+Vk+a+++  +++va+K i+k+k+ +e++l++i+rEiei+++l+hp+

Q: 29    YEFLETLGKGTYGRVKKAMDR-SGTAVAIKSIRKEKIrDEQELTHIRREIEIMSSLSHPH  87

         99****************997.799***********97888999****************

S: 60    iikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgi  119

         ii+++ev+e+k+k+++v+e+as+g+Lfdyi +++ l e++ar++f+q+vsav+Y+h++gi

Q: 88    IISIYEVFENKDKIVIVMELASRGDLFDYICDSQPLAETQARHFFRQIVSAVHYCHRNGI  147

         ************************************************************

S: 120   vHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkv  179

         vHrDlK+eN+lld ++nikiaDFGl+nl++ +kll+t cGsp Ya+Pe+++g++Y+gp+v

Q: 148   VHRDLKLENILLDCNGNIKIADFGLSNLYRGDKLLQTYCGSPLYASPEIVNGRPYRGPEV  207

         ************************************************************

S: 180   DvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpek  239

         D WslGv+Ly+l+ g++Pfd+++ + l+++i++g+++ p+k s ++  L+r +L+v+pe+

Q: 208   DSWSLGVLLYTLMHGAMPFDGHDHRILVQQISSGSYRKPSKPS-DACGLIRWMLMVNPER  266

         *****************************************66.5668************

S: 240   Ratieeilkhewl  252

         Rat+e+i  h w+

Q: 267   RATLEDIAGHWWV  279

         ************6

Domain Sequence
(FASTA)

YEFLETLGKG TYGRVKKAMD RSGTAVAIKS IRKEKIRDEQ ELTHIRREIE IMSSLSHPHI 60

ISIYEVFENK DKIVIVMELA SRGDLFDYIC DSQPLAETQA RHFFRQIVSA VHYCHRNGIV 120

HRDLKLENIL LDCNGNIKIA DFGLSNLYRG DKLLQTYCGS PLYASPEIVN GRPYRGPEVD 180

SWSLGVLLYT LMHGAMPFDG HDHRILVQQI SSGSYRKPSK PSDACGLIRW MLMVNPERRA 240

TLEDIAGHWW V 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013