EKS-DAR-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	369.0	3.0E-110	675	968	294

Status

Unreviewed

Ensembl Protein

ENSDARP00000087834

UniProt Accession

F1R6Y1;

Protein Name

Protein Synonyms/Alias

Gene Name

cdk12

Gene Synonyms/Alias

cdk12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000063726	ENSDARP00000126079	ENSDART00000150969
ENSDARG00000063726	ENSDARP00000126170	ENSDART00000151540
ENSDARG00000063726	ENSDARP00000087834	ENSDART00000093402

Organism

Danio rerio

Functional Description

Protein Length

1293

Protein Sequence
(FASTA)

MPGSDRLHGT KRKAESLYHQ QLQAAAGDGQ PLQHAGSGRH LTKTTSSSST SSKHKRNKSK 60

HEAETGALCV VSARPAAGAI KPLVEYDDIS SDSDTFLDSP ATGNPVDTRD AEQLDLSDYG 120

EVVAGVAKEN RTHKRKRSRK KSKDRHRVRE SAERPVGAKK SIKDRERVSK ESRKKVKERA 180

SPVACLAASS SRRSGETGAK KLGGGESVSS SAVQSAVSLG SSASSASSSI SKESVRSSKS 240

RKEKRRNEEY EEDRSHRKAA KSRKSSPKGK SQSRRTVVDS PSVAELENSY SSKRKAASPS 300

PYREPPRRSR QRSESPYGRR RSSSPEKDGS PYVSRKHSPG SPYASRRSPS SSPVSRTSLR 360

ARSRSPHYSS SRRSTSHSRS KKHSLYSGGA SGASSHSSRP GSRSPSSSRL PITSSLGAEL 420

TRRKQERQAA AAKNSPALQP NTSNVTNTPV KNTDPPPLET AAAAAAPPEP QRPPSPPAIT 480

VAVEEPAALP PPPLPLSSPP PLPLTSPPPL PASSPPPPPL SSPPPLPLNS PPPAPPPLAP 540

APALSSRPKS PAQKPAKSPA HQMKTSTLPP LPLPPALLGD CRDSPKKSGL SQRLSRKERE 600

KEKEKEKEVR TRLLSELPLP PVLSGGDPSP PQSPARVSPP LLQPSFKKRP KICSPRYGER 660

KQTQTDWGKR CVDKFDIIGI IGEGTYGQVY KAKDKDTGEL VALKKVRLDN EKEGFPITAI 720

REIKILRQLN HRSVVNMKEI VTDKQDALDF KKDKGAFYLV FEYMDHDLMG LLESGLVSFS 780

HEHVQSFMRQ LMEGLDYCHK KNFLHRDIKC SNILLNNSGQ IKLADFGLAR LYNSEESRPY 840

TNKVITLWYR PPELLLGEER YSPAIDVWSC GCILGELFTK KPIFQANQEL LQLELISRLC 900

GSPCPAAWPD VIRLPYFNTM RPKKQYRRRL REEFSFLPTP ALDLLDHMLT LDPSRRCTAE 960

QALASQFLCD VEPNKMPPPD LPHWQDCHEL WSKKRRRQRQ SGVSEDLPVA KVPRKEPAGA 1020

SGGENSRPPP SPPPPPSSAH PAAANTIASE LEGLGAAAEQ LNQTELAVLL NLLQGQSDNL 1080

SIPQMAEILR SSSSEASTSV LSRTPAAPST PEPDTAQQLE LLSQLSTLIQ SSNVPQPADA 1140

PQEDQAGILA LLLEQLIKAP AAEAERADES NGVPPEEGAA HAGSASVTSA DSEDSALVKS 1200

DATDSKSTKH TDDSTPDVAT LLHLISQQAS GSKSPPADLH PNKGPSSPPS PSPPSASSDA 1260

PSPTSSLANT ASETPFTQDQ DLRYTLGGAA GPS 1293

Nucleotide Sequence
(FASTA)

ATGCCTGGAT CAGACCGCCT GCATGGGACC AAGAGGAAGG CTGAATCGCT GTACCACCAA 60

CAGCTGCAGG CGGCCGCCGG GGATGGTCAG CCGCTGCAGC ACGCGGGCTC CGGTAGGCAT 120

CTTACCAAGA CGACGAGCTC CTCGTCCACT TCTTCTAAGC ACAAACGAAA CAAGTCCAAA 180

CACGAGGCCG AAACTGGCGC GTTGTGCGTT GTCTCCGCGC GTCCAGCAGC GGGCGCTATC 240

AAGCCTCTGG TGGAGTACGA CGACATCAGC TCGGATTCGG ACACGTTCCT TGACTCCCCC 300

GCCACCGGGA ACCCGGTGGA CACCAGAGAC GCCGAACAGC TAGATCTGTC GGACTACGGT 360

GAGGTGGTGG CGGGGGTCGC CAAAGAGAAC CGGACTCATA AACGCAAGCG CTCCCGGAAG 420

AAATCCAAAG ACCGGCATCG GGTCAGGGAG TCTGCGGAAA GACCAGTAGG GGCCAAAAAG 480

AGCATCAAGG ACCGGGAGAG GGTGAGCAAA GAGAGCCGAA AGAAGGTTAA GGAGAGGGCT 540

AGTCCAGTCG CGTGCCTTGC TGCTTCATCA TCCAGACGCT CCGGTGAGAC CGGTGCCAAA 600

AAGCTCGGCG GCGGCGAATC GGTGTCCTCC AGCGCGGTGC AGTCAGCTGT CAGCCTGGGC 660

AGCAGCGCCT CCTCCGCATC TTCCTCCATC AGTAAGGAAA GCGTGCGTTC ATCCAAATCT 720

CGCAAAGAAA AGAGAAGGAA CGAGGAGTAT GAGGAGGACC GGAGCCATCG AAAGGCCGCA 780

AAGAGTCGCA AGTCTAGCCC TAAAGGGAAA AGCCAGTCCC GGAGGACCGT GGTGGACAGT 840

CCTTCCGTTG CGGAGCTCGA GAACAGTTAC TCCTCCAAAC GCAAGGCCGC GAGCCCGAGC 900

CCGTACAGAG AGCCGCCCAG GCGGAGCAGA CAGAGGTCCG AGAGCCCCTA CGGGAGAAGG 960

AGGTCTTCCA GCCCTGAGAA GGATGGGAGT CCGTATGTGA GCAGAAAACA CTCACCTGGA 1020

AGTCCTTACG CGAGCAGACG CTCACCCAGC AGCAGTCCAG TGTCCAGGAC ATCTCTGCGT 1080

GCCCGGAGCC GTTCTCCTCA CTACTCCTCG TCCCGCCGTT CCACGTCCCA TTCTCGCTCA 1140

AAGAAACATT CGTTATATTC CGGCGGGGCC AGCGGAGCCT CCTCTCACAG TAGTCGACCT 1200

GGCAGCCGGT CGCCTTCATC TTCACGTTTG CCCATCACCT CCAGCCTCGG AGCCGAACTC 1260

ACAAGAAGAA AGCAGGAACG TCAGGCAGCT GCTGCCAAGA ACTCTCCTGC TCTCCAACCA 1320

AACACGTCCA ATGTGACAAA CACACCAGTG AAAAACACTG ATCCACCGCC ACTGGAGACA 1380

GCAGCAGCAG CAGCGGCGCC CCCTGAGCCT CAAAGACCGC CCTCTCCACC TGCAATCACT 1440

GTGGCTGTGG AGGAGCCTGC TGCGCTTCCT CCTCCACCTC TCCCATTATC CAGTCCTCCT 1500

CCGCTGCCTC TAACGTCTCC TCCGCCTCTT CCAGCCAGCT CTCCTCCTCC TCCTCCTCTG 1560

TCTTCTCCTC CTCCTCTTCC TCTGAACAGT CCTCCGCCGG CTCCTCCACC TTTAGCGCCT 1620

GCACCGGCTC TTTCTTCACG GCCGAAAAGC CCCGCACAGA AGCCCGCGAA AAGTCCTGCG 1680

CACCAGATGA AGACCTCCAC GCTTCCTCCT CTTCCCCTGC CGCCGGCTCT TCTGGGAGAC 1740

TGCAGGGACA GTCCAAAGAA GAGTGGTCTT TCCCAGAGGT TGTCACGAAA GGAAAGGGAG 1800

AAGGAGAAGG AAAAGGAGAA AGAAGTGAGG ACACGCCTCC TCAGTGAGTT GCCCCTCCCT 1860

CCGGTACTTT CTGGTGGAGA CCCTTCACCT CCGCAGTCTC CTGCTCGGGT ATCACCTCCG 1920

CTACTGCAGC CCAGCTTCAA GAAGAGACCA AAGATTTGCT CTCCGAGATA TGGAGAGAGA 1980

AAGCAGACTC AAACCGACTG GGGAAAGCGA TGTGTGGACA AGTTTGACAT CATTGGCATC 2040

ATCGGAGAAG GGACATACGG TCAGGTGTAC AAGGCTAAAG ACAAAGACAC AGGAGAGCTG 2100

GTGGCATTGA AAAAAGTGCG ACTGGATAAC GAAAAAGAGG GTTTCCCCAT CACCGCCATC 2160

AGGGAAATCA AGATCCTGAG GCAACTCAAC CATCGCAGCG TGGTCAACAT GAAAGAGATC 2220

GTCACTGACA AACAAGACGC ACTGGACTTC AAAAAGGACA AAGGTGCTTT TTACCTGGTG 2280

TTTGAGTACA TGGACCATGA CCTAATGGGA CTGCTGGAGT CCGGACTGGT GTCTTTCTCC 2340

CATGAGCATG TGCAGAGCTT CATGCGTCAG CTGATGGAGG GGTTAGACTA TTGCCACAAG 2400

AAGAACTTTC TACACCGAGA TATCAAGTGC TCTAATATCC TGCTAAACAA CAGTGGTCAG 2460

ATCAAGCTTG CTGATTTTGG TTTGGCTCGT CTCTATAACT CAGAGGAAAG TCGACCGTAC 2520

ACTAATAAGG TGATCACACT GTGGTATCGC CCGCCTGAGC TGCTACTGGG GGAGGAAAGA 2580

TACTCACCTG CTATTGATGT CTGGAGCTGC GGGTGTATTT TAGGCGAGCT CTTCACTAAG 2640

AAACCAATTT TCCAAGCCAA CCAAGAGCTT CTCCAGCTTG AGCTGATTAG TCGTTTGTGT 2700

GGTAGTCCAT GTCCTGCTGC TTGGCCAGAT GTAATCCGGC TGCCGTACTT CAATACCATG 2760

AGACCCAAGA AACAGTACAG GCGACGCTTA CGAGAGGAGT TCTCTTTTCT GCCCACCCCT 2820

GCTCTTGACC TGCTGGACCA CATGTTGACG CTGGACCCCT CGAGACGCTG CACAGCCGAA 2880

CAGGCTCTCG CCAGCCAGTT TCTTTGTGAT GTGGAGCCCA ACAAGATGCC TCCGCCAGAT 2940

TTGCCTCATT GGCAAGACTG TCACGAGCTC TGGAGCAAGA AGCGACGGCG GCAGAGGCAA 3000

AGCGGAGTTT CTGAGGATCT TCCTGTCGCC AAAGTCCCCC GAAAGGAACC CGCAGGAGCT 3060

TCAGGAGGGG AAAACAGTCG CCCGCCACCG AGTCCACCTC CGCCACCGTC ATCGGCCCAT 3120

CCTGCAGCCG CTAACACAAT AGCCAGTGAG CTGGAAGGTC TGGGAGCCGC AGCGGAGCAG 3180

TTGAACCAGA CGGAGCTGGC GGTGCTGCTG AACCTGCTCC AGGGCCAGTC AGACAATCTG 3240

AGCATCCCGC AGATGGCAGA GATTCTGCGC AGCTCCTCGT CTGAAGCCTC CACCTCAGTC 3300

CTGTCCCGGA CCCCAGCCGC CCCCTCCACC CCTGAGCCTG ACACTGCGCA GCAGCTCGAA 3360

CTGCTCAGCC AGCTCTCCAC CCTAATCCAG TCCTCTAACG TCCCACAGCC GGCAGATGCC 3420

CCGCAGGAAG ACCAGGCCGG CATCCTGGCG CTCCTATTGG AGCAGCTGAT CAAGGCGCCG 3480

GCGGCAGAGG CGGAGCGGGC CGATGAGAGC AACGGGGTTC CACCAGAGGA GGGCGCTGCA 3540

CATGCCGGCT CCGCTTCTGT CACGAGTGCC GATAGCGAGG ATTCTGCATT GGTTAAGTCC 3600

GATGCGACAG ACTCAAAGTC AACGAAACAC ACTGACGACT CCACACCAGA CGTAGCAACA 3660

CTGCTTCATC TGATTTCCCA GCAGGCCTCA GGAAGCAAAA GTCCTCCTGC AGACCTGCAC 3720

CCCAATAAGG GACCCTCGTC TCCCCCGAGC CCCAGCCCTC CATCAGCCTC ATCTGACGCC 3780

CCATCGCCCA CCTCCAGCCT GGCAAACACT GCTTCAGAAA CTCCGTTCAC CCAGGACCAA 3840

GACTTGCGGT ACACCCTAGG AGGAGCCGCC GGCCCTTCCT GA 3882

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ +

Q: 675   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSV  734

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s+e+v+s+++ql+e

Q: 735   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-SFSHEHVQSFMRQLME  793

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 794   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  853

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Ys a+D+Ws+gcil el+t+kp+fq+++e  qle i++l+g+p  + wp+v +

Q: 854   LLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAAWPDVIR  913

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ l + aldll+++l+ldp++R++a++al+++++

Q: 914   LPYFNTMRPKKQYRrRLREEFSFLPTPALDLLDHMLTLDPSRRCTAEQALASQFL  968

         *****7777777777******999999***********************99985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLNHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVSFSHEHV QSFMRQLMEG 120

LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYSPA IDVWSCGCIL GELFTKKPIF QANQELLQLE LISRLCGSPC PAAWPDVIRL 240

PYFNTMRPKK QYRRRLREEF SFLPTPALDL LDHMLTLDPS RRCTAEQALA SQFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013