EKS-DAR-00435
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00435
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR532.92.5E-160578854277
StatusUnreviewed
Ensembl ProteinENSDARP00000091059
UniProt AccessionB7ZVT9;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene Namefgfr4
Gene Synonyms/Alias fgfr4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000069105ENSDARP00000091059ENSDART00000100286
OrganismDanio rerio
Functional Description
Protein Length922
Protein Sequence
(FASTA)
MLSILKVFIA ICFMELVCSR SITSGEPRAK DIRVSRHILT PGYPENATVL VGGHVKLVCK 60
LHQPASTRLQ WFKKDSNRLG PDGSPVLTAL TPLLENLSKV NIFPLVNISL EDAGEYVCKA 120
ENSAGQATRS AWVEVLTEVS EEPTEEPSEH LLLELGDVLK LRCDTNRPGA VQWFKSGVRV 180
QHNARIQIRA AVMEIADVTY EDSGVYVCML RGTKEALRNF TITVADAVGS GDDDDEDNGL 240
DDIGPETEND QVYISRAPYW THTQRMEKKL YAVPAGNTVK FRCPATGSPL PTIRWLKNGR 300
EFRGEHRIGG IKLRHQHWSL VMESVVPSDR GNYSCVVENK YGSIAHTYLL DVLERSPHRP 360
ILQAGLPKNT TAIVGGDAQF LCKVYSDAQP HIQWLKHIEM NGSRYGPDGI PYVKIVKTGS 420
LNMSEVEVLY LTNISMEDAG EYTCLAGNSI GFSHQSAWLT VLSEEDVAKE VDLMEAKYTD 480
IIIYASGFLA LVMAIVIVVL CRMQVHPSRE PFDTLPVQKL SKFPLRRQYS VESNSSGKSS 540
ASLMRVARLS SSCSPMLAGV MEFELPYDPD WEFPRENLTL GKPLGEGCFG QVVRAEAYGI 600
NKENQDHMAT VAVKMLKDDA TDKDLADLIS EMELMKVMDK HKNIINLLGV CTQDGPLYVL 660
VEYASKGSLR EYLRARRPPG MDYTFDVTKV PEEQLTFKDL VSCAYQVARG MEYLASKRCI 720
HRDLAARNVL VTEDNVMKIA DFGLARGVHQ IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ 780
SDVWSFGVLM WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPSNCTHELY MKMRECWHAV 840
PTQRPTFKQL VEELDRVLVS ISDEYLDLST PFEQYSPSCE DTSSSCSSDN DSVFTHDALS 900
TEPCLLGYHD VHSRMDLKTT MR 922
Nucleotide Sequence
(FASTA)
ATGTTGAGCA TCTTAAAGGT TTTCATTGCC ATCTGTTTCA TGGAACTGGT GTGCTCAAGA 60
AGCATAACAT CCGGGGAACC CAGGGCAAAA GATATCAGAG TTTCACGACA CATACTTACT 120
CCTGGATATC CTGAGAATGC TACTGTGTTG GTCGGAGGAC ATGTGAAGCT GGTGTGTAAG 180
CTCCACCAGC CAGCCTCAAC ACGTCTCCAG TGGTTCAAGA AGGACAGTAA TCGCCTGGGG 240
CCTGATGGAT CACCAGTACT TACAGCTCTT ACGCCTCTTC TTGAGAACCT CTCCAAAGTC 300
AACATATTTC CTTTGGTTAA TATCTCTTTG GAAGATGCTG GAGAGTATGT ATGCAAGGCG 360
GAAAACTCAG CTGGTCAGGC TACTCGCTCT GCCTGGGTGG AAGTCTTAAC GGAAGTTTCA 420
GAGGAGCCAA CTGAGGAACC ATCAGAGCAC CTGCTGTTGG AGCTCGGGGA TGTACTTAAA 480
CTCCGTTGTG ACACAAACCG TCCTGGAGCT GTCCAGTGGT TCAAGAGTGG TGTTCGGGTG 540
CAACACAATG CCCGTATCCA GATAAGAGCG GCAGTCATGG AAATTGCAGA TGTTACCTAT 600
GAAGATTCAG GAGTATATGT GTGTATGCTA CGTGGCACCA AAGAGGCTCT ACGCAACTTC 660
ACTATCACAG TGGCAGATGC TGTAGGGTCG GGAGATGATG ATGATGAAGA TAATGGTCTT 720
GATGACATTG GTCCTGAGAC CGAAAATGAC CAGGTCTACA TATCCAGAGC ACCATACTGG 780
ACTCACACTC AAAGGATGGA AAAGAAGCTG TATGCAGTCC CGGCTGGAAA TACTGTCAAG 840
TTCCGCTGCC CTGCCACTGG GAGCCCCCTT CCCACCATTC GCTGGCTAAA AAATGGCAGA 900
GAATTCCGAG GAGAGCACAG GATTGGTGGC ATCAAGCTAC GACATCAGCA CTGGAGCCTG 960
GTCATGGAGA GTGTGGTTCC CTCAGACCGT GGGAATTACA GTTGTGTGGT GGAGAACAAA 1020
TATGGATCCA TCGCTCACAC CTACCTCTTG GACGTGTTGG AACGCTCTCC ACACAGGCCA 1080
ATTCTTCAAG CTGGTCTCCC CAAAAACACT ACAGCTATAG TGGGTGGAGA TGCCCAGTTC 1140
CTGTGTAAAG TGTACAGTGA TGCTCAGCCT CACATCCAGT GGCTCAAGCA TATAGAAATG 1200
AATGGCAGCC GTTATGGGCC TGATGGCATT CCTTATGTGA AGATTGTGAA GACAGGAAGC 1260
TTGAACATGT CTGAAGTTGA AGTCTTGTAT CTTACCAATA TCTCAATGGA GGATGCTGGA 1320
GAATACACCT GCTTGGCTGG AAACTCTATT GGTTTCTCTC ATCAATCTGC CTGGCTCACA 1380
GTCTTATCAG AGGAGGATGT AGCCAAGGAG GTGGACCTAA TGGAGGCCAA ATACACTGAC 1440
ATCATCATCT ATGCTTCTGG CTTTTTGGCA CTGGTGATGG CCATTGTGAT TGTGGTCCTC 1500
TGCCGCATGC AGGTTCACCC CAGTCGGGAG CCTTTTGATA CGCTCCCAGT ACAGAAACTC 1560
TCCAAATTTC CTTTGCGCAG ACAGTATTCA GTGGAGTCCA ATTCTTCTGG AAAATCAAGT 1620
GCGTCACTGA TGAGGGTGGC TCGTCTTTCC TCCAGTTGTT CCCCAATGCT GGCTGGAGTT 1680
ATGGAGTTTG AACTGCCTTA TGATCCTGAT TGGGAGTTTC CAAGAGAGAA TTTGACTTTA 1740
GGGAAACCGC TTGGAGAGGG TTGCTTTGGT CAAGTGGTTA GAGCAGAGGC GTATGGGATA 1800
AACAAAGAGA ATCAAGATCA TATGGCAACT GTAGCTGTTA AGATGCTAAA AGATGATGCA 1860
ACCGATAAAG ACCTTGCAGA CCTGATCTCT GAGATGGAGC TCATGAAGGT TATGGACAAG 1920
CACAAGAACA TCATAAATCT TCTTGGTGTT TGTACACAGG ACGGTCCGCT GTACGTGCTG 1980
GTTGAATATG CATCAAAAGG TAGCCTACGG GAATATCTCC GAGCTCGTCG ACCTCCTGGC 2040
ATGGACTACA CCTTTGATGT GACCAAGGTT CCTGAGGAAC AGCTCACCTT CAAAGACCTG 2100
GTTTCTTGTG CTTACCAAGT GGCAAGAGGC ATGGAGTACC TGGCTTCCAA AAGATGCATT 2160
CACAGAGATT TAGCCGCAAG AAATGTTCTT GTGACAGAAG ACAATGTGAT GAAGATCGCA 2220
GACTTTGGCT TGGCAAGAGG AGTGCATCAA ATTGATTACT ACAAGAAGAC AACTAATGGA 2280
CGTCTGCCAG TGAAATGGAT GGCACCAGAA GCCTTGTTTG ACAGAGTCTA CACACACCAG 2340
AGCGACGTAT GGTCTTTCGG GGTTTTGATG TGGGAGATAT TCACATTGGG AGGATCGCCG 2400
TACCCTGGGA TACCAGTAGA GGAGCTTTTT AAGCTGCTGA AGGAAGGCCA TCGGATGGAT 2460
AAACCCTCCA ACTGCACCCA TGAACTCTAC ATGAAGATGA GAGAGTGCTG GCATGCAGTA 2520
CCAACTCAAA GACCAACGTT CAAACAACTT GTGGAAGAGC TCGATAGGGT GCTGGTGTCA 2580
ATTTCAGATG AGTACCTGGA CCTATCCACC CCTTTCGAAC AGTACTCTCC ATCTTGTGAG 2640
GACACCTCCA GCTCATGCTC TTCAGACAAT GATTCTGTGT TTACCCATGA TGCTTTGTCA 2700
ACCGAACCAT GCCTCCTTGG CTACCACGAT GTGCATTCTC GGATGGACCT AAAGACGACA 2760
ATGCGATAG 2769
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea g++k+++++ +tvavkmlk+datdkdladl+seme++k+
Q: 578   LTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKV  637
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         + khkniinllG+ctq+Gplyv+veya+kG lre+lrarrp+g++++ d +k++eeqlt+
Q: 638   MDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTF  697
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylask+cihrdlaarnvlvtednv+kiadfGlar+vh+idyykkt
Q: 698   KDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKT  757
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 758   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  817
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely+ mrecwha++++rptfkqlve+l
Q: 818   RMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEEL  854
         ***********************************86
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVRAEA YGINKENQDH MATVAVKMLK DDATDKDLAD LISEMELMKV 60
MDKHKNIINL LGVCTQDGPL YVLVEYASKG SLREYLRARR PPGMDYTFDV TKVPEEQLTF 120
KDLVSCAYQV ARGMEYLASK RCIHRDLAAR NVLVTEDNVM KIADFGLARG VHQIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPSNCTH ELYMKMRECW HAVPTQRPTF KQLVEEL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00141
EKS-CAE-00120
EKS-CAF-00155
EKS-CAP-00149
EKS-EQC-00146
EKS-FEC-00139
EKS-GAM-00077
EKS-GAG-00124
EKS-GAA-00174
EKS-ICT-00141
EKS-LAC-00159
EKS-LOA-00148
EKS-MEG-00114
EKS-MOD-00149
EKS-MUM-00152
EKS-MUP-00153
EKS-MYL-00158
EKS-ORN-00184
EKS-ORL-00172
EKS-OTG-00154
EKS-PAT-00138
EKS-PES-00131
EKS-RAN-00146
EKS-SAH-00141
EKS-SUS-00130
EKS-TAG-00178
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 3.
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 4.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013