EKS-DAR-00772

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00772

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	356.2	2.7E-106	635	890	256

Status

Unreviewed

Ensembl Protein

ENSDARP00000092959

UniProt Accession

E7FEW8;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K6

Gene Synonyms/Alias

wu:fa92h04;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000069933	ENSDARP00000092959	ENSDART00000102183

Organism

Danio rerio

Functional Description

Protein Length

1324

Protein Sequence
(FASTA)

MYTTERRRMS LHETKRKDPV RVSAGSLWQD PLALEVGGAG KNVISPRSRT RALSVVYIAV 60

EDGSLPQTEE TLSLKCLTEA CADAHAVLKS ISYERIALGT TEILDTFYNA DVVVVEMNNS 120

ICQPSLFYHL GVRESFSMTN NVILYCNKQE DDMQVVKEQC GSYTFIPYMV SPQGKVFACD 180

AALMRAVKDF LHSSFKFESL MTSLVDRLVK LLESVHINSS EYLHEAIRRE IRLAREHFTG 240

PALSQELGRI QKRLDSVELL SPDIVMSLLL SYRDIPDYDS IINLVETLNN LPMCMVPAHQ 300

NIKFQYIFAL NRRNHPGDRV RALKLILPIV ESGETVASDV YCLCGRIYKD MFLSSGFKDT 360

NSRDQASKWY GKAFTIEPSL HSGINNVVLL MAAGHEFDTS IELRKIGVTL SSLLGRKGSL 420

EKMQDYWDVG FYLGAGILAN EHKKVIDASE RLYRLKAPMW YVASIMETYI LYKQFAKPRE 480

VNHPKQETAD FWMELMVQAC KPTVSTARCP VLILEPTKVF QPSIISVSEE DDSRTVQLRH 540

VTPLEKGLHE WTFPASAIRG VSISKFDERS CFLYVLYNSD DFQLYFPSDL HCKGFCDLVN 600

SLLHQTESPV EDSSSMRGEE GDLEYIYERN ENGDKVVLGK GTYGVVYAGR DLSNQVRIAI 660

KEIPEKDSTY SQPLHEEIAL HKRLKHRNIV QYLGSVSEDG FIKIFMEEVP GGSLSSLLRS 720

KWGPLKDNEA TIVFYTKQIL DGLKYLHDNQ IVHRDIKGDN VLVNTYSGVL KISDFGTSKR 780

LAGINPCTET FTGTLQYMAP EIIDQGPRGY GKPADIWSLG CTIIEMATGK PPFHELGSPQ 840

AAMFKVGMFK IHPAVPECMS EQAKDFIMCC FEPNPDKRTT ASELLKNGFL KASAKKRLKP 900

LADNSLKEPA GEFHRSMSVP VALRVENTDV EHNELSCSFD LRRATSAFKG NNMAESPPST 960

SGFLTVPDEP QIDMTTSPSG SGENLGLFML RKDSERRDTL HRILTEDISH VVQNIQETMP 1020

QAEEPCITSD HISELIGCLR ENIRSPDKRL LTNSLLTLRS SLLNSSVPLS SLQAVLFSFQ 1080

DAVKKVLRKQ QIKPHWMFAL DNLLRQAVQD AITVLLPELK LQLQSSFENE EGSPETEHPT 1140

EADSESIVTP LAKDKETLVI TKDPEEGHST CNSLPTALIS SYSSLAKELS ELRLESRRLL 1200

MQLNEKEKEF QQLLKTSLQS KQRHINALEH KAASAATDNK QTSHNAQNSA MVRWLRGVPV 1260

DEKTIELLVF HEFTLDSLLH FACKDDLQYC GIKGGMMCRL WAAISKQRKS HLSPVKEDSE 1320

DTFF 1324

Nucleotide Sequence
(FASTA)

ATGTATACGA CTGAACGTAG GCGCATGAGC CTGCACGAAA CCAAGCGAAA AGATCCCGTC 60

CGAGTTTCAG CTGGAAGTTT GTGGCAGGAT CCTTTGGCTC TTGAAGTAGG TGGCGCGGGT 120

AAAAACGTGA TATCGCCGAG AAGCCGGACC AGGGCTTTGT CTGTGGTGTA CATCGCGGTC 180

GAGGACGGGT CTTTGCCCCA AACTGAGGAG ACACTTTCAC TGAAATGTCT GACTGAAGCT 240

TGCGCGGACG CTCACGCGGT GCTGAAGAGC ATTTCCTACG AGCGCATTGC ACTGGGCACC 300

ACCGAAATCC TGGACACTTT CTACAACGCA GATGTGGTTG TTGTGGAGAT GAATAACTCC 360

ATCTGCCAGC CATCTCTGTT TTATCACCTG GGTGTCAGAG AGAGTTTCAG TATGACCAAC 420

AATGTCATCC TGTACTGTAA CAAACAAGAA GACGATATGC AAGTTGTGAA GGAACAATGT 480

GGGAGCTACA CGTTCATCCC CTACATGGTG TCACCACAGG GTAAAGTGTT TGCCTGTGAT 540

GCAGCACTGA TGAGGGCAGT CAAAGATTTC CTGCATTCCA GCTTTAAATT TGAATCCCTG 600

ATGACATCTC TGGTGGATCG ACTGGTCAAA TTACTGGAAA GCGTTCACAT TAATTCTAGC 660

GAATATCTCC ATGAGGCAAT CCGTAGGGAG ATCCGTCTGG CTCGAGAACA CTTCACTGGC 720

CCAGCTTTGA GTCAGGAGCT GGGACGGATC CAGAAGCGTC TGGACTCTGT GGAGCTTCTG 780

AGTCCAGATA TTGTTATGAG CCTCCTGCTG TCCTACAGAG ACATTCCAGA CTACGACTCC 840

ATAATAAATC TGGTGGAGAC CTTGAATAAT TTGCCCATGT GCATGGTGCC AGCACATCAG 900

AACATCAAAT TTCAGTATAT ATTTGCTTTG AACAGGAGGA ATCACCCTGG TGATCGTGTC 960

AGGGCTTTAA AGCTCATTTT ACCCATTGTG GAGTCAGGGG AGACGGTAGC CTCAGATGTG 1020

TACTGCCTGT GTGGACGCAT CTACAAGGAC ATGTTCCTCA GTTCAGGCTT CAAAGACACA 1080

AACAGCAGAG ATCAGGCATC TAAATGGTAT GGCAAGGCCT TTACGATTGA GCCCAGTTTA 1140

CATTCTGGAA TCAATAACGT TGTGCTCCTG ATGGCCGCTG GGCATGAATT CGACACTTCT 1200

ATTGAACTGC GAAAAATCGG TGTTACCCTC AGTAGTCTGC TGGGCAGGAA GGGCTCCCTC 1260

GAGAAGATGC AGGACTACTG GGATGTGGGA TTTTATCTGG GAGCTGGAAT CCTGGCCAAT 1320

GAACACAAGA AAGTCATAGA TGCTTCAGAG AGACTCTACA GGCTCAAAGC TCCAATGTGG 1380

TATGTTGCAT CCATTATGGA GACGTATATA CTCTACAAGC AGTTTGCCAA ACCCAGAGAA 1440

GTGAATCATC CTAAACAAGA AACTGCAGAC TTTTGGATGG AGTTGATGGT ACAAGCATGC 1500

AAACCTACCG TTTCCACAGC ACGATGCCCA GTTCTGATTC TGGAGCCCAC TAAAGTCTTC 1560

CAGCCCAGTA TAATAAGCGT AAGTGAGGAA GACGACAGCC GTACGGTGCA GCTTAGACAC 1620

GTCACTCCAC TCGAGAAAGG TCTTCACGAG TGGACTTTCC CAGCATCTGC GATTCGTGGA 1680

GTGAGCATTT CCAAGTTTGA CGAACGGAGC TGCTTCCTGT ATGTCCTGTA CAATTCAGAT 1740

GACTTCCAGT TGTACTTTCC CAGTGATCTG CATTGCAAAG GGTTCTGTGA TTTAGTGAAC 1800

TCGCTGTTGC ATCAAACCGA AAGTCCTGTG GAGGATTCCA GTTCAATGAG GGGAGAGGAA 1860

GGAGATTTAG AGTACATTTA TGAGAGGAAT GAGAATGGAG ACAAAGTGGT GCTGGGTAAA 1920

GGAACCTATG GAGTGGTGTA CGCTGGACGG GACCTCAGCA ATCAAGTGCG CATCGCAATC 1980

AAAGAGATTC CAGAGAAGGA CAGCACCTAC TCTCAGCCGC TTCATGAGGA GATTGCTCTG 2040

CACAAGAGGT TAAAACACAG GAACATTGTT CAGTATTTGG GCTCAGTCAG CGAGGATGGC 2100

TTCATCAAGA TCTTCATGGA GGAGGTTCCT GGAGGAAGCT TGTCGTCTCT ATTGCGATCA 2160

AAATGGGGTC CTCTTAAAGA TAATGAAGCA ACCATTGTCT TTTACACCAA GCAGATACTG 2220

GATGGATTGA AATATCTCCA CGATAATCAG ATCGTCCATC GAGATATTAA GGGTGATAAT 2280

GTTTTGGTAA ACACATACAG CGGTGTGCTT AAGATATCCG ATTTCGGCAC CTCTAAGAGA 2340

CTAGCAGGAA TCAATCCCTG TACAGAGACG TTCACAGGGA CTTTGCAGTA CATGGCTCCA 2400

GAGATCATCG ACCAGGGGCC TCGTGGGTAT GGAAAACCGG CTGATATCTG GTCTCTGGGC 2460

TGTACTATCA TTGAAATGGC CACCGGAAAG CCACCCTTTC ATGAGCTGGG AAGTCCTCAG 2520

GCAGCCATGT TTAAGGTGGG CATGTTTAAG ATTCACCCTG CAGTGCCGGA GTGCATGTCA 2580

GAGCAAGCCA AAGACTTCAT CATGTGCTGC TTTGAGCCAA ACCCAGACAA GAGAACCACG 2640

GCATCAGAGC TCCTGAAGAA CGGCTTTCTG AAGGCCAGTG CCAAGAAGAG ACTAAAACCT 2700

CTGGCGGACA ACAGTCTGAA AGAACCTGCC GGAGAATTTC ACAGGAGCAT GTCGGTTCCT 2760

GTTGCGTTGC GTGTGGAGAA CACAGATGTG GAGCACAATG AACTGTCCTG CTCTTTTGAT 2820

CTGAGAAGAG CCACTTCTGC CTTCAAAGGA AACAATATGG CTGAAAGTCC TCCGAGCACC 2880

AGTGGCTTCC TGACAGTGCC AGATGAGCCT CAAATAGACA TGACCACAAG TCCATCAGGT 2940

TCTGGAGAGA ATCTAGGCCT GTTCATGCTC AGAAAAGACA GTGAGCGGAG GGATACGCTA 3000

CACAGGATCC TTACAGAGGA CATCAGCCAT GTAGTTCAAA ACATTCAGGA AACAATGCCG 3060

CAGGCGGAGG AGCCGTGCAT CACCTCAGAT CACATCAGCG AGCTGATCGG CTGCCTGCGA 3120

GAAAACATCC GCTCTCCAGA CAAAAGACTC CTGACCAACA GCCTGCTGAC TTTACGCTCC 3180

AGCCTTTTAA ACTCCTCTGT GCCTCTCAGC AGCCTGCAGG CGGTGCTCTT CAGCTTCCAG 3240

GATGCCGTCA AGAAGGTTCT GAGGAAACAG CAGATTAAAC CTCACTGGAT GTTTGCTTTG 3300

GACAACTTGC TGAGGCAGGC TGTACAAGAT GCAATCACAG TTCTGCTCCC AGAGCTCAAG 3360

CTTCAGCTGC AGTCTTCATT TGAAAACGAG GAGGGTTCAC CAGAAACCGA GCATCCCACA 3420

GAGGCTGATT CTGAATCAAT CGTCACGCCC CTCGCCAAGG ACAAAGAAAC ATTGGTTATC 3480

ACTAAAGATC CTGAAGAAGG TCATTCCACA TGCAACAGTT TACCCACTGC CCTCATCTCC 3540

AGTTACAGTT CACTCGCAAA GGAGCTGTCA GAACTTCGCT TGGAGTCCAG GAGATTGCTG 3600

ATGCAGCTTA ATGAAAAGGA GAAAGAATTC CAACAACTCC TGAAGACCTC ACTTCAGTCC 3660

AAACAAAGAC ACATCAATGC CCTGGAGCAC AAGGCTGCAT CTGCTGCTAC AGATAACAAA 3720

CAAACATCCC ATAATGCTCA AAACTCAGCT ATGGTGCGCT GGTTAAGAGG TGTTCCCGTG 3780

GATGAGAAAA CTATAGAACT ACTTGTTTTT CATGAGTTCA CTCTGGATAG TCTCCTCCAT 3840

TTCGCCTGCA AAGATGATTT GCAGTACTGT GGCATCAAAG GCGGGATGAT GTGTCGTCTG 3900

TGGGCCGCCA TCTCCAAACA GAGGAAGTCT CATCTCAGTC CAGTCAAAGA GGACAGTGAA 3960

GATACCTTTT TCTAA 3975

Domain Profile

S: 4     revigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHeni  63

         + v+gkG++g vya++d++++ ++a+Ke+   pek+s+  ++++l+eEi+l+k+lkH+ni

Q: 635   KVVLGKGTYGVVYAGRDLSNQVRIAIKEI---PEKDST--YSQPLHEEIALHKRLKHRNI  689

         789**************************...787775..99******************

S: 64    vkyyGveveeeelkiflEyvegGslsslle.kygkle..esvikkytkqileglayLHek  120

         v+y+G+ +e++ +kif+E v+gGslssll+ k+g+l+  e +i +ytkqil gl+yLH++

Q: 690   VQYLGSVSEDGFIKIFMEEVPGGSLSSLLRsKWGPLKdnEATIVFYTKQILDGLKYLHDN  749

         ******************************9*****99899*******************

S: 121   kivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkk  179

         +ivHRDiKg+N+l+++ sgv+k+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++

Q: 750   QIVHRDIKGDNVLVNTySGVLKISDFGTSKRLAGINPC---TETFTGTLQYMAPEIIDQG  806

         **************************************...8******************

S: 180   ekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdf  239

          +gyg+ aDiWslgc++iem+tgk+Pf+el++++a+mfkvg+ k++P +pe +se++kdf

Q: 807   PRGYGKPADIWSLGCTIIEMATGKPPFHELGSPQAAMFKVGMFKIHPAVPECMSEQAKDF  866

         ************************************************************

S: 240   lekcleldpkkrpsaeeLLkhefl  263

         +  c+e +p+kr++a+eLLk+ fl

Q: 867   IMCCFEPNPDKRTTASELLKNGFL  890

         ********************9885

Domain Sequence
(FASTA)

KVVLGKGTYG VVYAGRDLSN QVRIAIKEIP EKDSTYSQPL HEEIALHKRL KHRNIVQYLG 60

SVSEDGFIKI FMEEVPGGSL SSLLRSKWGP LKDNEATIVF YTKQILDGLK YLHDNQIVHR 120

DIKGDNVLVN TYSGVLKISD FGTSKRLAGI NPCTETFTGT LQYMAPEIID QGPRGYGKPA 180

DIWSLGCTII EMATGKPPFH ELGSPQAAMF KVGMFKIHPA VPECMSEQAK DFIMCCFEPN 240

PDKRTTASEL LKNGFL 256

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Callithrix jacchus"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Microcebus murinus"; ?>Oreochromis niloticus"; ?>Pan troglodytes"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013