EKS-DAR-00082

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00082

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	350.2	1.6E-104	10	297	288

Status

Unreviewed

Ensembl Protein

ENSDARP00000093662

UniProt Accession

E9QFH2;

Protein Name

Protein Synonyms/Alias

Gene Name

cdk6

Gene Synonyms/Alias

cdk6; si:ch211-234f14.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000070228	ENSDARP00000126132	ENSDART00000151269
ENSDARG00000070228	ENSDARP00000122935	ENSDART00000146893
ENSDARG00000070228	ENSDARP00000093662	ENSDART00000102888

Organism

Danio rerio

Functional Description

Protein Length

324

Protein Sequence
(FASTA)

MDKESSTQQY EPVAEIGEGA YGKVYKARDL KNGGRFVALK RVRVQTEEEG MPLSTIREVA 60

VLRQLESFEH PNVVRLFDVC TVSRTDRETK LTLVFEHVDQ DLTTYLEKAP DPGVPPETIK 120

DMMYQLLQGL DFLHSHRVVH RDLKPQNILV TSGGQIKLAD FGLARIYSFQ MALTSVVVTL 180

WYRAPEVLLQ SSYATPVDLW SVGCIFAEMF RRRPLFRGNS DVDQLGKIFD VVGVPSPEDW 240

PQEVGLPQSA FSPRPAQPIE NLVPDMDELG KSLLLRFLSF NPSRRISAYD ALSHLYFQSL 300

DSTSKSLYAQ PFPSKKPSLE ERAA 324

Nucleotide Sequence
(FASTA)

ATGGACAAAG AGAGCTCGAC CCAGCAATAT GAGCCGGTGG CTGAGATCGG CGAAGGTGCA 60

TATGGGAAGG TGTACAAGGC TCGGGATTTG AAGAACGGGG GCCGGTTTGT GGCCCTGAAA 120

AGAGTCCGGG TGCAGACTGA GGAAGAGGGA ATGCCGCTGT CCACCATCCG CGAGGTGGCG 180

GTGCTGAGGC AGCTCGAGTC CTTTGAGCAT CCAAATGTTG TCAGGTTGTT TGACGTATGC 240

ACAGTTTCCA GGACTGACCG GGAAACCAAA CTAACTTTGG TCTTCGAACA TGTGGACCAG 300

GATCTAACTA CATATTTGGA GAAAGCACCT GATCCGGGAG TGCCACCTGA AACCATAAAG 360

GATATGATGT ACCAGCTGCT GCAGGGTCTT GATTTCCTCC ACTCTCACCG TGTGGTTCAT 420

CGGGATCTTA AGCCTCAAAA CATTCTAGTA ACCAGTGGAG GACAGATCAA GCTGGCTGAT 480

TTTGGCCTGG CGCGGATCTA CAGCTTTCAG ATGGCTCTTA CTTCCGTGGT TGTGACATTA 540

TGGTATCGAG CCCCAGAGGT GCTGCTTCAG TCCAGCTATG CTACTCCTGT GGATCTGTGG 600

AGCGTCGGCT GCATCTTTGC TGAGATGTTC AGACGGCGCC CTCTTTTCCG TGGGAACTCT 660

GATGTTGACC AGCTAGGCAA GATTTTTGAT GTGGTGGGAG TCCCGTCTCC AGAGGACTGG 720

CCACAGGAGG TGGGTTTGCC CCAGAGTGCC TTCTCTCCTC GCCCTGCACA GCCCATAGAG 780

AACCTGGTGC CGGACATGGA TGAGCTCGGC AAATCACTCC TACTTCGTTT CCTGTCCTTC 840

AACCCCTCCA GAAGGATATC AGCTTACGAT GCACTGTCTC ACCTGTACTT CCAGAGTCTG 900

GACAGCACCA GCAAGAGCCT GTACGCTCAG CCCTTCCCCA GCAAAAAGCC CTCCCTGGAG 960

GAGAGAGCCG CCTAA 975

Domain Profile

S: 1     yeklekigeGtygkvykakd.ketgevvAlKkirlekekegvpitalrEisllkel...k  56

         ye +++igeG+ygkvyka+d k+ g++vAlK++r+++e+eg+p +++rE+++l++l   +

Q: 10    YEPVAEIGEGAYGKVYKARDlKNGGRFVALKRVRVQTEEEGMPLSTIREVAVLRQLesfE  69

         88899***************888999*****************************99889

S: 57    hknivkLlevva....kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleg  112

         h+n+v+L +v++     +++kl+Lvfe+++qdL+++l+k +  ++++e++k +++qll+g

Q: 70    HPNVVRLFDVCTvsrtDRETKLTLVFEHVDQDLTTYLEKAPDPGVPPETIKDMMYQLLQG  129

         ************99855569****************************************

S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelL  172

         l++lHs++++HRDlKpqN+L+++ g++klaDfGlar +s ++  +t++vvTlwYraPe+L

Q: 130   LDFLHSHRVVHRDLKPQNILVTSGGQIKLADFGLARIYSFQMA-LTSVVVTLWYRAPEVL  188

         *****************************************99.****************

S: 173   lgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklp  232

         l++ +Y t vD+Wsvgci+ae+++r+plf+g+s++dql +if+++g ps ++wp+   lp

Q: 189   LQS-SYATPVDLWSVGCIFAEMFRRRPLFRGNSDVDQLGKIFDVVGVPSPEDWPQEVGLP  247

         *88.5*******************************************************

S: 233   eykksfpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +    f++++++ +++ v++++e + +ll ++l+++p++Risa +al+h yf

Q: 248   QSA--FSPRPAQPIENLVPDMDELGKSLLLRFLSFNPSRRISAYDALSHLYF  297

         965..999999****************************************8

Domain Sequence
(FASTA)

YEPVAEIGEG AYGKVYKARD LKNGGRFVAL KRVRVQTEEE GMPLSTIREV AVLRQLESFE 60

HPNVVRLFDV CTVSRTDRET KLTLVFEHVD QDLTTYLEKA PDPGVPPETI KDMMYQLLQG 120

LDFLHSHRVV HRDLKPQNIL VTSGGQIKLA DFGLARIYSF QMALTSVVVT LWYRAPEVLL 180

QSSYATPVDL WSVGCIFAEM FRRRPLFRGN SDVDQLGKIF DVVGVPSPED WPQEVGLPQS 240

AFSPRPAQPI ENLVPDMDEL GKSLLLRFLS FNPSRRISAY DALSHLYF 288

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013