EKS-DAR-00430

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00430

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	448.1	1.3E-134	195	440	246

Status

Unreviewed

Ensembl Protein

ENSDARP00000095046

UniProt Accession

A0JMN4;

Protein Name

Protein Synonyms/Alias

C-src tyrosine kinase;

Gene Name

csk

Gene Synonyms/Alias

csk;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000070805	ENSDARP00000095046	ENSDART00000104271
ENSDARG00000070805	ENSDARP00000124767	ENSDART00000148408

Organism

Danio rerio

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSTFEATWPA GTECVARYNF PGTADQDLPM CKGDVLTIVG VTKDPNWYRA KNSAGREGTI 60

PANYVQKREG VKSASKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IIYHNGKLSI DEEEYFENLM QLMEHYTKDA DGLCTRLIKP KIMEGTVAAQ 180

DEFSRSGWAL NRKELKLIQT IGKGEFGDVM VGDYRGKKVA VKCIKHDATA QAFVAEASVM 240

TQLRHNNLVQ LLGVIVEEKG SLYIVTEYMA KGSLVDYLRS RGRTVIGGDR LINFSMDVCK 300

AMEYLEANNF VHRDLAARNV LVSEDNIAKV SDFGLTKEAS STQDTAKLPV KWTSPEALRE 360

KKFSTKSDVW SYGILLWEIY SFGRVPYPRI PLKEVVPRVE KGYKMDSPDG CPPVVYDIMK 420

QCWTLDAVVR PSFRDLREKL QDIITNELYR 450

Nucleotide Sequence
(FASTA)

ATGTCTACCT TTGAGGCGAC CTGGCCTGCG GGCACCGAGT GTGTGGCCAG GTACAACTTC 60

CCTGGAACGG CAGACCAGGA CTTGCCCATG TGCAAAGGAG ATGTGCTTAC TATAGTTGGA 120

GTAACTAAGG ACCCTAATTG GTACAGAGCG AAAAACTCTG CTGGACGAGA GGGCACCATC 180

CCAGCAAACT ACGTTCAGAA GAGAGAAGGA GTAAAGTCCG CCAGCAAACT GAGCCTTATG 240

CCATGGTTCC ATGGAAAGAT CACACGCGAG CAGGCTGAGA GACTGCTCTA CCCCCCAGAA 300

ACAGGCCTCT TCCTGGTGCG TGAGAGCACC AACTACCCTG GAGACTACAC CCTTTGTGTC 360

AGCTGCGACG GCAAGGTGGA GCATTACCGC ATCATCTACC ACAACGGCAA ACTGTCCATC 420

GATGAGGAGG AGTACTTCGA AAACCTCATG CAGCTCATGG AGCACTACAC TAAAGATGCA 480

GATGGACTCT GTACGCGACT CATCAAACCT AAAATCATGG AGGGGACTGT GGCAGCCCAG 540

GATGAGTTCT CCAGAAGTGG CTGGGCTTTG AATAGAAAAG AACTGAAGCT TATCCAGACT 600

ATTGGAAAGG GAGAGTTTGG AGATGTGATG GTTGGAGACT ACAGAGGAAA GAAAGTAGCG 660

GTGAAGTGTA TCAAACATGA TGCCACAGCA CAGGCCTTCG TTGCAGAGGC TTCAGTCATG 720

ACTCAATTAC GGCATAATAA CCTGGTGCAG CTGCTGGGGG TGATCGTGGA AGAAAAGGGC 780

AGCCTTTACA TCGTCACTGA GTACATGGCC AAGGGTAGTC TTGTGGACTA TCTGCGCTCC 840

AGAGGTCGTA CTGTTATCGG TGGAGATCGT TTGATCAATT TCTCAATGGA TGTGTGCAAG 900

GCAATGGAAT ATCTTGAGGC CAATAACTTT GTGCACCGGG ACCTTGCCGC TCGTAATGTT 960

CTTGTGTCAG AGGACAACAT AGCTAAAGTC AGTGATTTCG GCCTCACCAA GGAAGCCTCG 1020

TCTACTCAAG ATACAGCCAA ACTCCCTGTT AAGTGGACTT CACCTGAGGC CTTACGAGAG 1080

AAGAAATTTT CCACTAAGTC GGATGTATGG AGTTATGGGA TCTTACTGTG GGAGATCTAT 1140

TCTTTTGGTC GGGTACCATA TCCAAGAATT CCTCTAAAGG AAGTGGTCCC GCGTGTAGAG 1200

AAGGGTTATA AGATGGACTC CCCCGACGGC TGTCCTCCAG TGGTGTACGA CATCATGAAG 1260

CAGTGCTGGA CTCTGGATGC TGTGGTGCGG CCAAGCTTCA GAGACCTCCG AGAGAAACTG 1320

CAAGATATCA TAACCAATGA GCTCTACCGA TAA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+ g+yrg+kvavk+ik+dataqaf++easvmt+l+h+nlv+llgv

Q: 195   LKLIQTIGKGEFGDVMVGDYRGKKVAVKCIKHDATAQAFVAEASVMTQLRHNNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         i+eek +ly+vtey+akgslvdylrsrgr++++ ++l++f++dv+++meyle++++vhrd

Q: 255   IVEEKgSLYIVTEYMAKGSLVDYLRSRGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRD  314

         *****88*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed++akvsdfgl+ke+s+++d++klpvkwt+peal+ekkfstksdvws+gi

Q: 315   LAARNVLVSEDNIAKVSDFGLTKEASSTQDTAKLPVKWTSPEALREKKFSTKSDVWSYGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplk+vv++vekgykm++p+gcpp vy++mk++w l+a  rpsf+

Q: 375   LLWEIYSFGRVPYPRIPLKEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFR  434

         ************************************************************

S: 240   klkekl  245

         +l+ekl

Q: 435   DLREKL  440

         ****97

Domain Sequence
(FASTA)

LKLIQTIGKG EFGDVMVGDY RGKKVAVKCI KHDATAQAFV AEASVMTQLR HNNLVQLLGV 60

IVEEKGSLYI VTEYMAKGSL VDYLRSRGRT VIGGDRLINF SMDVCKAMEY LEANNFVHRD 120

LAARNVLVSE DNIAKVSDFG LTKEASSTQD TAKLPVKWTS PEALREKKFS TKSDVWSYGI 180

LLWEIYSFGR VPYPRIPLKE VVPRVEKGYK MDSPDGCPPV VYDIMKQCWT LDAVVRPSFR 240

DLREKL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0060027	; P:convergent extension involved in gastrulation

KEGG

dre:556454

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013