EKS-DAR-00379
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00379
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Met461.51.6E-13810801339260
StatusUnreviewed
Ensembl ProteinENSDARP00000095234
UniProt AccessionF1QLR7;
Protein Name
Protein Synonyms/Alias
Gene Namemet
Gene Synonyms/Alias met;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000070903ENSDARP00000123904ENSDART00000148741
ENSDARG00000070903ENSDARP00000095234ENSDART00000104461
OrganismDanio rerio
Functional Description
Protein Length1382
Protein Sequence
(FASTA)
MTIHYSEAAS ILIILQSLWW GLNCQCEEPI ESSKLDLSVT YDLPYFVSDT PIQKLLEING 60
TVYVGAVNRL YALSKDLKKK HEYKTGPVHE GPDCKTPTDQ CSGCENKPRN INNTNMALLM 120
ETFYDLELFS CGSVGNGVCS RHVLEDGPLG AEVTCMYTKK NEGSSHGCPD CLAGPAGTQI 180
LNIMSGRVVR FFVANSEPLE SNGPRLHHTI SIRKMRETQD GFEFFSDQSY MDLAPSLRGN 240
YPLHYVYSFQ SGPYVYFLTV QREGGNSKAF HTRIVRMCSS DSEILRYVEM PFECIYSERR 300
RKKRSAQVVF NVLQAAHVAK VGYDFQQEMG LKEGEDVLFA AFARSKPDSP EPTASSAVCL 360
ISITDINEFF KVFIQKGYTR KLHHFPGSEE KTFNQTFVGD SFSCGKHERG YRLEVTSTNP 420
RRDYFHGRFR NVLLTSIAVV PIQNHTVVSL GTAEGRVIQV VVSRFGKTEP HVDFRLDTLP 480
VSSEMALLSP QHHNGSLLLI TGNKVSKLPV IGPGCEQLWT CSSCLLAPGF MGCGWCRTSN 540
LCTRAPRCPQ SQWIQDSCPL LITSISPSSA PLRGQTNITI CGKNFGFNKK DRFDTKLIDV 600
VVAGTKCKLE RKDSNNNRLV CGLDHVNWSS VDSVVTVRSG KEQAQKDGFS FVNPVIIEIF 660
PEFGPQSGGT MLTISGSFLD SGNVQTVTVG NATCVLQSVS ATMLTCRTPP QPSPSQHKVQ 720
LHIDGVIFEA PVSYTYNKNP HISSVQPKHS FISGGSTVTV NGFYLHSALQ PQMVLTAATE 780
GKLFQVTCSH DEDKRNILCI TPSLKGLSVQ PPVATKMTFV LDGFSTDQYD LLYVEDPKFE 840
EFQKPTVTPR GKKNILEIKV PPVNQEAVKN GEVLRVSNRT CESVTLVGNT LECTVPMELQ 900
TAAKELEVEW KQATSSVILG RVILAQDQDY RILITGGVCV SILLLLLIAV FVWIKRKKHI 960
NDLAKTMVWY DGRAHIPHLD MLANARSVSP TNEMVSHESV DYRTTLLEDQ NLPLSQTESC 1020
RPHLYAHSHV DLSPMLGPME GDLASPLLPS TAPIDLGSLH PELLKEVQHV VIAREDLLLH 1080
VNEIIGRGHF GCVFHGTLLE PDGQKQHCAI KSLNRITDIE EVSQFLKEGI IMKDFSHPNV 1140
LSLLGICLPS EGSPLVVLPY MKHGDLRNFI RDESHNPTVK DLMGFGLQVA KGMEYLASKK 1200
FVHRDLAARN CMLDESYTVK VADFGLARDV YDKEYYSVHN KHGVKLPVKW MALESLQTHK 1260
FTTKSDVWSF GVLLWELMTR GAPPYSDVNS FDITVFLLQG RRLLQPEFCP DALYNVMIEC 1320
WHPKPERRPT FSELVSRISA IFSSFSGEHY ILLNTTYVNI DKMTPYPSLI SSQSNLDRDC 1380
CT 1382
Nucleotide Sequence
(FASTA)
ATGACAATTC ACTATTCTGA AGCTGCTTCC ATCCTAATCA TCCTTCAGTC GCTGTGGTGG 60
GGCTTGAATT GTCAATGTGA GGAACCAATA GAAAGCTCCA AACTCGACCT CTCAGTGACC 120
TATGACCTCC CTTACTTTGT GTCTGACACC CCCATTCAGA AGCTGTTGGA AATCAATGGA 180
ACAGTGTATG TCGGTGCCGT CAATAGACTT TACGCTCTGT CGAAAGACCT GAAGAAGAAA 240
CATGAGTATA AGACTGGACC GGTCCATGAG GGTCCAGACT GCAAGACCCC AACAGATCAA 300
TGCAGTGGTT GTGAAAACAA GCCCCGTAAC ATAAACAACA CCAATATGGC CCTGTTAATG 360
GAGACGTTCT ATGACCTGGA ACTTTTCAGC TGTGGCTCAG TCGGGAATGG CGTCTGCAGT 420
CGTCATGTGT TAGAGGATGG GCCTCTGGGT GCGGAAGTAA CTTGCATGTA CACCAAAAAG 480
AATGAAGGCA GCAGCCATGG ATGCCCAGAC TGCCTGGCTG GACCTGCGGG CACTCAGATC 540
CTCAACATAA TGAGCGGTCG TGTTGTGAGG TTCTTCGTTG CGAACTCTGA ACCTCTTGAG 600
TCAAACGGTC CACGTCTCCA CCACACTATT TCCATTAGGA AGATGCGTGA AACTCAAGAT 660
GGCTTTGAGT TCTTTTCCGA TCAGTCCTAC ATGGATTTGG CCCCTTCACT GCGGGGGAAC 720
TATCCACTAC ATTATGTCTA CTCTTTCCAG AGTGGTCCTT ATGTATATTT TCTCACCGTC 780
CAACGCGAAG GTGGCAACTC GAAAGCTTTC CACACGAGAA TCGTACGCAT GTGTTCTTCA 840
GATTCTGAGA TCCTGCGTTA TGTAGAAATG CCCTTTGAGT GCATTTACTC TGAGCGAAGG 900
AGAAAAAAGC GTTCGGCTCA AGTGGTTTTC AACGTTCTCC AGGCTGCTCA TGTGGCCAAA 960
GTTGGCTATG ACTTTCAGCA GGAGATGGGC TTGAAAGAAG GAGAGGACGT GCTGTTTGCT 1020
GCCTTTGCCC GGAGCAAACC GGACTCACCA GAGCCCACCG CCAGCTCCGC CGTTTGCCTT 1080
ATCTCCATCA CGGACATCAA TGAATTCTTC AAGGTTTTCA TTCAGAAGGG TTACACAAGG 1140
AAACTCCATC ACTTTCCAGG ATCTGAAGAG AAAACCTTCA ACCAGACGTT TGTAGGAGAT 1200
TCCTTCAGCT GTGGGAAACA TGAAAGAGGC TATCGGCTAG AAGTTACAAG CACCAACCCG 1260
CGCCGGGACT ATTTTCATGG CCGCTTCCGG AATGTTCTTC TCACTTCCAT AGCTGTGGTG 1320
CCGATCCAAA ACCACACTGT GGTCAGCCTT GGCACAGCTG AAGGCCGCGT CATCCAGGTG 1380
GTGGTTTCCC GCTTTGGCAA GACAGAGCCA CATGTGGACT TCCGCTTGGA CACGCTCCCT 1440
GTGTCTTCAG AAATGGCCCT GCTGTCTCCA CAGCATCACA ACGGCTCCTT ATTGTTGATA 1500
ACAGGAAACA AGGTCTCAAA GCTTCCTGTG ATCGGGCCTG GATGTGAGCA GTTGTGGACT 1560
TGTAGCTCGT GTCTTCTTGC TCCGGGCTTC ATGGGCTGTG GATGGTGCAG GACCAGCAAC 1620
CTGTGCACCA GGGCCCCTCG ATGCCCCCAG TCCCAATGGA TCCAGGACTC CTGCCCCCTC 1680
CTCATCACCT CGATCTCTCC TTCCTCCGCT CCACTCAGAG GTCAAACCAA CATCACAATC 1740
TGTGGCAAAA ACTTTGGCTT TAACAAAAAA GACAGATTTG ATACCAAACT GATAGACGTG 1800
GTGGTTGCTG GAACGAAGTG TAAATTGGAA AGGAAGGACA GTAACAATAA TCGGTTGGTC 1860
TGTGGACTGG ATCATGTGAA CTGGTCCAGC GTGGACTCTG TGGTCACAGT GCGCAGTGGC 1920
AAGGAACAGG CCCAGAAAGA TGGCTTCTCA TTTGTGAATC CAGTTATCAT AGAGATCTTC 1980
CCAGAGTTTG GACCTCAGTC TGGTGGGACA ATGCTCACTA TCAGCGGTTC ATTCTTGGAC 2040
AGTGGAAATG TGCAAACAGT CACAGTGGGG AACGCTACCT GTGTGCTGCA GAGTGTTTCA 2100
GCCACAATGT TAACATGTCG TACACCACCT CAGCCCTCGC CATCCCAACA CAAGGTACAG 2160
CTGCACATTG ATGGAGTAAT ATTTGAAGCG CCTGTCAGCT ACACCTACAA CAAGAACCCA 2220
CACATCTCCA GCGTCCAGCC CAAACATTCT TTCATCAGTG GAGGAAGCAC GGTGACAGTG 2280
AATGGCTTCT ACCTGCACTC AGCTCTTCAG CCTCAGATGG TTCTCACTGC TGCCACTGAG 2340
GGCAAACTCT TCCAAGTGAC CTGCAGTCAT GATGAGGATA AGAGAAATAT CCTTTGCATC 2400
ACGCCCTCCC TGAAAGGCCT CAGCGTTCAG CCTCCGGTCG CCACTAAAAT GACCTTCGTC 2460
CTGGATGGTT TTTCCACTGA TCAGTACGAC CTGCTGTACG TGGAAGATCC CAAATTTGAG 2520
GAGTTTCAGA AGCCCACTGT CACACCAAGG GGCAAAAAGA ACATTCTGGA GATTAAGGTC 2580
CCCCCTGTGA ATCAAGAGGC GGTGAAAAAC GGTGAGGTGC TGAGAGTTTC AAATCGGACC 2640
TGCGAGAGTG TCACTTTGGT GGGCAACACG CTCGAATGCA CCGTACCCAT GGAGCTCCAG 2700
ACCGCCGCCA AAGAGCTGGA GGTGGAGTGG AAGCAGGCCA CATCATCTGT GATCTTGGGC 2760
CGTGTGATTT TGGCTCAAGA CCAGGATTAC AGGATACTGA TCACTGGAGG AGTGTGTGTG 2820
TCCATCCTCC TCCTGCTCCT GATCGCTGTG TTTGTTTGGA TCAAGAGAAA GAAGCACATT 2880
AATGATTTAG CTAAGACTAT GGTTTGGTAT GACGGCCGGG CTCACATTCC GCACTTGGAC 2940
ATGTTGGCAA ACGCGAGGAG TGTCAGTCCC ACTAATGAAA TGGTCTCTCA CGAGTCGGTG 3000
GACTATAGAA CCACTTTGCT TGAGGACCAA AACTTGCCTC TGTCTCAGAC AGAGTCCTGC 3060
CGGCCTCATC TCTACGCTCA TTCCCATGTG GATCTGTCCC CAATGCTCGG GCCAATGGAA 3120
GGGGACCTGG CGTCTCCGCT GCTGCCCTCT ACAGCGCCTA TAGATCTAGG CAGCCTCCAT 3180
CCTGAGCTGC TGAAGGAGGT CCAGCATGTG GTCATCGCAA GAGAAGATCT GCTCTTACAT 3240
GTCAATGAGA TCATCGGGAG AGGGCACTTC GGCTGCGTGT TTCATGGAAC CCTCCTCGAG 3300
CCAGATGGCC AGAAGCAGCA CTGCGCCATC AAGTCCTTAA ACCGAATCAC AGATATCGAG 3360
GAGGTGTCTC AGTTTCTGAA GGAGGGCATC ATCATGAAGG ATTTCAGCCA TCCCAATGTG 3420
CTTTCTCTGC TGGGAATCTG CCTGCCCAGC GAGGGTTCGC CTCTCGTCGT GTTGCCTTAC 3480
ATGAAGCACG GAGATCTGCG CAACTTTATC AGAGATGAAA GTCATAACCC CACAGTGAAG 3540
GACCTGATGG GTTTCGGGCT GCAGGTGGCT AAAGGAATGG AGTATCTCGC CAGCAAGAAA 3600
TTTGTTCACC GAGACCTCGC GGCCAGAAAC TGCATGCTGG ATGAGAGCTA CACAGTGAAG 3660
GTGGCAGATT TTGGCCTGGC CAGAGACGTG TATGATAAAG AATACTACAG CGTACACAAC 3720
AAGCACGGAG TGAAGCTGCC TGTCAAATGG ATGGCGTTAG AAAGCCTGCA GACACACAAG 3780
TTCACAACCA AATCGGATGT GTGGTCGTTT GGTGTTTTGC TGTGGGAACT GATGACCCGA 3840
GGTGCTCCGC CATACTCTGA TGTGAACTCC TTCGACATTA CAGTGTTTCT TCTGCAAGGC 3900
CGGAGACTGT TACAACCAGA GTTCTGCCCG GATGCACTCT ATAATGTCAT GATTGAGTGC 3960
TGGCACCCCA AACCCGAGCG TCGACCAACT TTCTCAGAAC TAGTGTCTCG CATCTCCGCC 4020
ATCTTCTCAA GCTTCAGCGG AGAGCACTAC ATCCTCCTGA ACACCACCTA CGTCAACATC 4080
GACAAAATGA CACCCTACCC CTCTCTCATA TCATCTCAGA GCAACCTCGA CCGCGACTGC 4140
TGCACCTGA 4149
Domain Profile
S: 2     dkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhpn  61
         +++e+iG+GhfG+v++g+l++++++k+++a+ksl+ritdie+v++fl+eg++mk+++hpn
Q: 1080  HVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIMKDFSHPN  1139
         789*********************************************************
S: 62    vlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylask  121
         vlsllGi+l++eg+plvvlpymk+Gdl++fir+e++n+tvkdl++f+lqvakgmeylask
Q: 1140  VLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVAKGMEYLASK  1199
         ************************************************************
S: 122   kfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqtf  181
         kfvhrdlaarnc+lde++tvkvadfGlardv+dke+y+v+++++ +lpvkw+aleslqt+
Q: 1200  KFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKHGVKLPVKWMALESLQTH  1259
         ************************************************************
S: 182   kqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvml  241
         k fttksdvwsfGvllwel+trga+pys+v+sfd+t++l +grrl +pe+cpd+ly+vm+
Q: 1260  K-FTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMI  1318
         *.**********************************************************
S: 242   kcwkakpaerpqfsdlvsiis  262
         +cw++kp++rp+fs+lvs+is
Q: 1319  ECWHPKPERRPTFSELVSRIS  1339
         *******************98
Domain Sequence
(FASTA)
HVNEIIGRGH FGCVFHGTLL EPDGQKQHCA IKSLNRITDI EEVSQFLKEG IIMKDFSHPN 60
VLSLLGICLP SEGSPLVVLP YMKHGDLRNF IRDESHNPTV KDLMGFGLQV AKGMEYLASK 120
KFVHRDLAAR NCMLDESYTV KVADFGLARD VYDKEYYSVH NKHGVKLPVK WMALESLQTH 180
KFTTKSDVWS FGVLLWELMT RGAPPYSDVN SFDITVFLLQ GRRLLQPEFC PDALYNVMIE 240
CWHPKPERRP TFSELVSRIS 260
KeywordATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00115
EKS-ANC-00111
EKS-BOT-00123
EKS-CAE-00100
EKS-CAF-00126
EKS-CAP-00120
EKS-CIS-00142
EKS-EQC-00119
EKS-FEC-00114
EKS-GAG-00103
EKS-GAA-00142
EKS-GOG-00122
EKS-HOS-00125
EKS-LAC-00128
EKS-LOA-00118
EKS-MAM-00119
EKS-MEG-00093
EKS-MOD-00120
EKS-MUM-00124
EKS-MUP-00126
EKS-MYL-00133
EKS-NOL-00115
EKS-OCP-00079
EKS-ORN-00150
EKS-ORA-00101
EKS-ORC-00115
EKS-ORL-00139
EKS-OTG-00126
EKS-PAT-00111
EKS-PES-00105
EKS-PEM-00067
EKS-POA-00116
EKS-RAN-00120
EKS-SAH-00115
EKS-SUS-00109
EKS-TAG-00152
EKS-TAR-00154
EKS-TEN-00142
EKS-VIP-00058
EKS-XET-00102
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007275; P:multicellular organismal development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR013783; Ig-like_fold.
IPR014756; Ig_E-set.
IPR002909; IPT_TIG_rcpt.
IPR011009; Kinase-like_dom.
IPR003659; Plexin-like.
IPR016201; Plexin-like_fold.
IPR002165; Plexin_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001627; Semaphorin/CD100_Ag.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016244; Tyr_kinase_HGF/MSP_rcpt.
IPR015943; WD40/YVTN_repeat-like_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF01437; PSI; 1.
PF01403; Sema; 1.
PF01833; TIG; 2.
SMARTs
SM00429; IPT; 4.
SM00423; PSI; 1.
SM00630; Sema; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS51004; SEMA; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013