EKS-DAR-00019
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00019
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR527.51.2E-1589891256268
StatusUnreviewed
Ensembl ProteinENSDARP00000096601
UniProt AccessionQ1LVG4;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene Nameinsrb
Gene Synonyms/Alias insrb; IRb; DKEY-6N3.1-001;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000071524ENSDARP00000096601ENSDART00000105823
OrganismDanio rerio
Functional Description
Protein Length1348
Protein Sequence
(FASTA)
MRLDTSVVVL VTFAYILCLC GSLHGEICPS TDIRNIATNL RVLENCTVIE GHLKILLMFK 60
TTQEDFRGLS FPKLVMVTDY LLIFRVYGLE SLGSLFPNLT VIRGSNLFFN YALVMFEMIQ 120
MKEIGLHSLT NITRGAVRIE KNPNLCYLST LDWSKILDSV EDNYIVANKD DLECGNICPG 180
TIAGTISCKQ TTINGNFGER CWNQNHCQRI CPSECVHGAC TSHKECCHEQ CLGGCSVPGN 240
STKCVACRNF LYGEACVDRC PPGYYTFKSW RCVSLQFCQD LHNQCKDKSG DCHAYVIHNG 300
ACIPECPSGY TTVNSTSLTC MPCTGRCPKV CTGVQTVDSV TAAQALRGCT VLNGSLIIKI 360
SGGNSIAAEL ESSLGQLEEI TGYLTIRRAY ALVSLSFLRK LHLIRGETLD GGNYSFHAMD 420
NQNLRQLWDW NKHNLTILKG RMKFIQNGKL CKSEILRMEQ ATGTKNRMND ISNEKDQSYC 480
ESHILKFTQI RTMSDKILIR WESFWPSDFR DLLGFMVLYK EAPHRNVTEY DGQDACGSNS 540
WAIADVEPPQ RPSEGKEVEP GYLIMPLKPW TQYAVMVKAQ LAASEDHQVR GAKTEIIYVR 600
TNATRPSVPL DPHSWSNSSS QIILKWKPPS DPNGNITHYI IYCQKQSEDI THYKFDYCQQ 660
GMKVPSHTPT HHDVEEDQKL NQTEVPDQKG HCCACPKTEM QLKKEAEETE FRKTFENYLH 720
NEVFEPRPHR RRRSVGVANA TLPNFGTTPT IIPNFPTTSI PEEEKSRKMV FKASSKEAMV 780
ISNLLHFTSY QIEIHACNDP TDPGRCSMPT YVKARTLPEL KADVIAEPVT HEFFPDEPDV 840
VYIRWKEPKT PNGMIILYEV KYLRMSDNYE DQICVSRISY EKNHGYRLRV GHPGNYSVRV 900
RATSLAGNGS WTDPAYFYVQ DREMSMKIVI ILAICIFLLV ILASVGYFVL KKKQTEGPTG 960
PLIASSNPEY ISANDVYIPD EWEVPREKIT VMRELGQGSF GMVYEGIAKD IIKGEPDTRV 1020
AVKTVNESAS LRERIEFLNE ASVMKAFSCH HVVRLLGVVS KGQPTLVVME LMTHGDLKSY 1080
LRSLRPDAEN NPGSPPPTLK EMIQMSAEIA DGMAYLNAKK FVHRDLAARN CMVAEDYTVK 1140
IGDFGMTRDI YETDYYRKGG KGLLPVRWMA PESLKDGVFT AHSDCWSFGV VLWEISTLAE 1200
QPYQGLSNEQ VLKFVMDGGY LDRPENCPER MHNLMQMCWQ YNPKMRPTFH EIIEMIKEDL 1260
HPTFQEVSFF YSEENKAPES EEFDMDFENM ESIPLDPSSY SQREESHSRD NGPSVGLRGN 1320
YEEHVPYTHM NGGKKNGRIL SLPRSSPS 1348
Nucleotide Sequence
(FASTA)
ATGCGGCTGG ACACATCTGT GGTTGTTTTG GTCACTTTCG CCTACATCTT GTGCCTCTGC 60
GGATCACTAC ATGGAGAAAT TTGCCCCAGC ACAGACATCC GCAACATCGC CACCAACCTG 120
CGGGTTTTGG AGAACTGCAC TGTAATCGAA GGCCACCTGA AGATCCTGCT CATGTTCAAG 180
ACCACGCAGG AGGATTTCAG GGGCTTGAGC TTTCCGAAAC TGGTCATGGT CACCGACTAT 240
CTGCTCATCT TCCGCGTCTA TGGCCTGGAG AGCCTTGGCA GCCTCTTTCC AAACCTCACT 300
GTCATCCGCG GCAGCAACCT GTTTTTCAAC TACGCCCTAG TCATGTTCGA GATGATCCAG 360
ATGAAGGAAA TCGGCCTCCA CAGTTTGACC AACATCACGC GGGGAGCGGT GCGCATCGAG 420
AAGAACCCAA ACCTGTGCTA TTTGTCCACT CTGGACTGGT CCAAGATCTT GGATTCGGTG 480
GAGGACAATT ATATCGTAGC AAACAAGGAC GATTTGGAGT GTGGAAACAT CTGTCCAGGC 540
ACCATCGCGG GGACGATATC CTGCAAACAG ACCACCATAA ACGGAAATTT TGGAGAGCGA 600
TGCTGGAACC AGAATCATTG CCAGAGAATT TGTCCTTCTG AATGTGTCCA CGGAGCCTGT 660
ACGTCCCATA AGGAGTGCTG TCACGAGCAG TGTCTGGGTG GCTGCTCTGT GCCGGGGAAC 720
TCCACCAAAT GCGTGGCCTG CCGCAACTTC CTGTACGGCG AGGCGTGCGT GGACCGCTGT 780
CCGCCAGGAT ACTACACCTT TAAGAGCTGG CGCTGCGTGT CCCTTCAGTT CTGCCAGGAC 840
CTGCACAACC AGTGTAAGGA CAAGAGCGGA GACTGTCACG CATACGTCAT CCACAACGGG 900
GCCTGCATCC CAGAATGCCC GTCCGGATAC ACCACCGTCA ACTCCACCTC GTTGACCTGC 960
ATGCCCTGCA CCGGTCGGTG TCCTAAAGTG TGTACAGGAG TGCAGACGGT GGACTCGGTC 1020
ACGGCCGCTC AGGCGCTGCG GGGATGCACA GTGCTCAACG GCAGCCTCAT CATTAAGATC 1080
AGCGGAGGAA ACAGCATCGC CGCGGAGCTG GAGTCCAGTC TGGGTCAGCT GGAGGAGATC 1140
ACAGGATATC TGACCATCCG AAGGGCCTAT GCTCTCGTCT CACTCTCCTT CCTCCGCAAG 1200
CTGCATCTCA TTCGTGGAGA AACGCTGGAC GGCGGAAACT ATTCGTTCCA CGCGATGGAC 1260
AACCAGAACC TGCGCCAGCT GTGGGACTGG AACAAACACA ACCTCACCAT CCTCAAAGGC 1320
CGAATGAAGT TCATCCAAAA CGGCAAACTC TGCAAGTCTG AGATCCTGCG CATGGAACAA 1380
GCCACCGGCA CCAAGAACAG GATGAACGAC ATCAGCAATG AGAAAGACCA GTCCTACTGT 1440
GAAAGTCACA TACTCAAATT TACACAAATC CGCACCATGA GCGACAAGAT CCTCATCCGA 1500
TGGGAGTCCT TCTGGCCCTC GGACTTCAGA GACCTGCTGG GATTCATGGT GCTCTACAAG 1560
GAAGCTCCTC ACAGGAACGT GACTGAATAC GACGGGCAGG ACGCGTGTGG CTCTAACAGC 1620
TGGGCCATTG CAGACGTAGA GCCGCCGCAG AGACCTAGTG AAGGTAAAGA GGTGGAGCCG 1680
GGGTACCTGA TCATGCCTCT CAAGCCCTGG ACTCAATACG CCGTCATGGT GAAAGCCCAG 1740
CTCGCAGCCT CAGAAGACCA TCAGGTCAGA GGAGCCAAGA CCGAGATCAT CTACGTCAGG 1800
ACCAACGCCA CACGGCCTTC AGTGCCGCTG GATCCTCACT CCTGGTCAAA CTCGTCCTCT 1860
CAGATCATCC TCAAGTGGAA ACCGCCGTCA GACCCCAATG GAAACATCAC ACACTACATC 1920
ATCTACTGCC AGAAGCAGAG CGAGGACATC ACACACTACA AGTTTGACTA CTGCCAGCAA 1980
GGTATGAAAG TGCCGTCCCA CACGCCGACG CACCACGACG TCGAGGAGGA CCAGAAGCTT 2040
AACCAGACGG AGGTTCCAGA CCAGAAGGGG CACTGCTGCG CCTGTCCCAA AACCGAAATG 2100
CAGCTCAAGA AAGAGGCAGA GGAAACTGAG TTTCGCAAGA CCTTCGAGAA CTACCTGCAC 2160
AATGAAGTGT TCGAGCCCAG GCCCCACCGT CGGCGTCGCT CAGTTGGCGT AGCCAATGCA 2220
ACGTTGCCAA ATTTTGGAAC CACACCAACT ATAATACCCA ACTTTCCAAC CACTTCAATC 2280
CCAGAGGAAG AAAAGAGCCG GAAGATGGTG TTCAAAGCCA GCTCCAAAGA GGCCATGGTC 2340
ATCTCCAACC TGCTCCACTT CACCAGCTAC CAGATTGAGA TCCACGCTTG CAACGACCCC 2400
ACAGACCCGG GCCGCTGCAG CATGCCAACA TACGTCAAAG CCCGCACACT CCCTGAACTG 2460
AAAGCTGATG TCATTGCCGA GCCAGTGACT CACGAATTTT TTCCTGACGA GCCGGATGTT 2520
GTTTACATCA GATGGAAAGA GCCCAAAACT CCTAACGGCA TGATCATACT GTATGAAGTC 2580
AAGTATCTAC GGATGTCTGA TAACTACGAG GATCAAATCT GCGTGTCCAG AATTTCCTAT 2640
GAGAAAAACC ATGGCTATCG ATTAAGAGTA GGGCATCCTG GGAATTACAG TGTGCGAGTT 2700
CGTGCCACCT CGCTGGCTGG CAATGGTTCT TGGACTGATC CTGCATACTT TTATGTTCAA 2760
GACAGGGAAA TGAGCATGAA AATCGTTATC ATCCTAGCCA TCTGCATTTT CTTACTGGTG 2820
ATTCTGGCCA GCGTAGGCTA CTTTGTCTTG AAGAAGAAAC AAACTGAAGG ACCAACTGGC 2880
CCACTGATTG CTTCCTCCAA CCCAGAATAT ATAAGTGCAA ATGATGTGTA CATCCCTGAC 2940
GAATGGGAAG TTCCTCGTGA GAAGATCACT GTCATGAGAG AGCTTGGGCA GGGATCATTT 3000
GGGATGGTGT ATGAAGGCAT TGCTAAAGAC ATCATAAAGG GTGAACCGGA CACTCGAGTT 3060
GCTGTGAAAA CTGTAAATGA GTCGGCGAGT CTGCGCGAGA GGATTGAGTT CCTTAATGAG 3120
GCTTCAGTCA TGAAAGCCTT TAGCTGCCAC CATGTGGTGC GTTTGCTTGG TGTGGTATCC 3180
AAGGGACAGC CGACATTGGT TGTCATGGAA CTAATGACGC ACGGAGATCT GAAAAGCTAC 3240
CTGCGTAGCC TGAGGCCTGA TGCGGAAAAT AACCCAGGCA GTCCACCGCC AACCCTAAAG 3300
GAGATGATCC AAATGTCAGC TGAGATAGCA GATGGGATGG CATATCTCAA TGCTAAGAAG 3360
TTTGTCCACA GAGATCTCGC TGCAAGAAAC TGCATGGTGG CTGAAGATTA CACCGTCAAA 3420
ATTGGAGATT TTGGCATGAC GCGAGACATT TACGAGACTG ATTACTATCG CAAGGGCGGG 3480
AAAGGCCTTC TGCCTGTCAG ATGGATGGCA CCAGAGTCGT TGAAAGATGG TGTATTCACT 3540
GCTCACTCAG ACTGCTGGTC TTTCGGAGTG GTGTTATGGG AGATCAGCAC ACTTGCTGAG 3600
CAGCCGTACC AGGGACTGTC CAATGAGCAG GTGCTCAAGT TCGTCATGGA CGGAGGATAC 3660
CTGGATAGAC CGGAGAACTG TCCGGAGAGA ATGCACAACC TCATGCAGAT GTGTTGGCAG 3720
TACAACCCGA AGATGCGGCC AACCTTCCAC GAGATCATCG AGATGATCAA GGAGGACCTG 3780
CATCCTACTT TTCAAGAGGT CTCGTTCTTC TACAGCGAGG AGAACAAAGC GCCTGAGAGC 3840
GAGGAGTTTG ACATGGACTT CGAGAACATG GAGAGCATAC CACTGGACCC CTCATCCTAT 3900
TCCCAACGCG AGGAGAGCCA CAGTAGAGAC AACGGCCCCT CAGTGGGCCT ACGGGGCAAT 3960
TACGAGGAGC ATGTGCCCTA CACACATATG AACGGTGGAA AGAAAAATGG CCGAATTCTG 4020
TCTTTACCCA GATCTAGTCC GTCCTAA 4047
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+++relGqGsfGmvyeG+akd++kge +trva+ktvne+as reriefl+easvmk+f+
Q: 989   ITVMRELGQGSFGMVYEGIAKDIIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFS  1048
         7899********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrp++en+++ +pp+l+++iqm+ae
Q: 1049  CHHVVRLLGVVSKGQPTLVVMELMTHGDLKSYLRSLRPDAENNPGSPPPTLKEMIQMSAE  1108
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 1109  IADGMAYLNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1168
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdGvft++sd wsfGvvlwei tlaeqpyqGlsneqvlkfv+dgg+l++pencp
Q: 1169  MAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPENCP  1228
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e++++lm++cwqynpk+rp+f ei+e++
Q: 1229  ERMHNLMQMCWQYNPKMRPTFHEIIEMI  1256
         *************************976
Domain Sequence
(FASTA)
ITVMRELGQG SFGMVYEGIA KDIIKGEPDT RVAVKTVNES ASLRERIEFL NEASVMKAFS 60
CHHVVRLLGV VSKGQPTLVV MELMTHGDLK SYLRSLRPDA ENNPGSPPPT LKEMIQMSAE 120
IADGMAYLNA KKFVHRDLAA RNCMVAEDYT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MAPESLKDGV FTAHSDCWSF GVVLWEISTL AEQPYQGLSN EQVLKFVMDG GYLDRPENCP 240
ERMHNLMQMC WQYNPKMRPT FHEIIEMI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Gorilla gorilla"; ?>Petromyzon marinus"; ?>
EKS-CAE-00002
EKS-GOG-00019
EKS-PEM-00008
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0048589; P:developmental growth
GO:0009790; P:embryo development
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
dre:245700;
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013