EPS-DAR-00106

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00106

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	253.2	3.6E-75	138	309	172

Status

Unreviewed

Ensembl Protein

ENSDARP00000100006

UniProt Accession

E7FH66;

Protein Name

Protein Synonyms/Alias

Gene Name

tenc1a

Gene Synonyms/Alias

tenc1a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000076292	ENSDARP00000100006	ENSDART00000112445
ENSDARG00000076292	ENSDARP00000123088	ENSDART00000140557

Organism

Danio rerio

Functional Description

Protein Length

1606

Protein Sequence
(FASTA)

MGCALSGDSC GDEPDPVPLR GSLRRERAKS RGNMRLTKAG KGEPHVFKEK AFKKKRQCGV 60

CRQSVENLGS FCRVCKTATH KKCEAKINTA CIPAQPSELR RGTSSSRHIQ HLGSTKSLTY 120

TKQRNTLPRS FSVDRVMDRV MERHYDFDLT YITERIISVF FPPLLEEQRY RLNLREVAAM 180

LKSKHQDKFL LLNLSERRHD ITRLNPKVHD FGWPDMHSPP LDKICAMCKA MENWLNSDPQ 240

HVVVLHCKGN KGKTGVIIAA YMHYSKISAG ADQALSTLAM RKFCEDKVAS SLQPSQNRYI 300

QYFGGLLSGS IKMNSSPLFL HQVLIPTIPN FQEDDGFFPF LKIYQSMQLV YTSGIYDLQG 360

SASRRLIITI EPALLLKGDI MVKCYHRRVE SAERDSVFRL QFHTCTVHAA QLWFGKGELD 420

EACSDDKFPP DAIVEFVFSS GPEKIKGRVS QRNDPAVSVD YNTNDPVVRW DSYENFNQRH 480

QDSLEDIAHT RGPVDGSLYA QVKKRRAAAG CSSLPSTNGS PARSSEERPS QLLSVSTDSG 540

HSSVPPDRLD EPTRPAPPTQ QEREELERLL GGIEGDGLRD RDRETAILDD GDSLPPERTG 600

SLRLGRSCSC RVGYRSQGCA EPGCNGFHHL PNGHCLDRPT TTNGHTGALS PGMSSVIGLC 660

QHHSTHPHQS LPPPDLLWDR QQGPQHYLHR TCSEGPSRHL YPYPSQEINS HPHSLSPRLL 720

CRPDEYISYP HHHHNHSHHP KPSGPYHDVM MIDGLVTPGC PCRDCALRRE EFHTLRLDRE 780

DGIHWEREAE LHRDNGLRRT READMQRGAE IWEREPGLRR GREMSLHWDR DRDAELQWER 840

EREAEYWHRR ATVSPYGPHG HELPAFNFDP LPAGHPAYPE PSRSHSHAHL DLKYSSSSSG 900

YQTPHQTCPC SPYQPSPSES RGYASGYQSE STSPLPPPSA SCPGPVHHAS GPTENQTDPH 960

SQHFTSDSNT DCPGADSIGW RNHITHGSLR RMHPHAPYST PSDISGPPTP VHTSSPLRTQ 1020

ESPSLSVRDY DSREGNSESS SAHSLNRPHP ATIQPNMTNA GSRQTLLSSS PETPEINPLP 1080

TTPTTAQHLA AHSLPTTPPT PQIATEHSPP LTPESESTQP QANCSPTAAT VLPTVEMVPQ 1140

STETIKPAHS PHPSSPVLAE SIPAHMQSNG VPPSPESDAP KPASSAPASP QPPAGDHESS 1200

SSPEPSVPGF ATLGRKLMLG SETSLSAGHS MDASSNSTPT FPVSPACCTP SPPPGSYPGC 1260

PSSSVPQPPL PEKRRPSGLP GSPNGRSGTL RASMSHQPSG QHHVTFSPSV GELAVPIGQV 1320

EVGVEGEIGN RVSVKFVQDS SRFWYKPGIS REQAIAALKE REPGAFLIRD SNSFQGAYGL 1380

ALKVASPPPN VNNHSSKGDP LEQLVRHFLI ETGPRGVKIK GCQNEPYFGS LSALVYQHSI 1440

TPISLPCALR IPEKDPIGDV VEVQPVSNMS TAADLLKQGA ACNVLYLNSV ETESLTGPQA 1500

IAKATGATLS RSPRPSATVV HFKVSAQGIT LTDSQRRVFF RRHYPINSVT YSSIDPQDRR 1560

VFGFVAKKPG SVAENVCHLF AELDPEQPAT AIVNFINKVM LAPQRR 1606

Nucleotide Sequence
(FASTA)

ATGGGTTGCG CCTTGAGTGG GGATAGCTGT GGGGACGAAC CAGATCCAGT ACCCTTGAGA 60

GGGTCTTTAA GGAGGGAGAG AGCAAAATCC AGGGGAAACA TGAGGCTGAC CAAGGCGGGG 120

AAGGGCGAGC CACACGTCTT CAAAGAAAAG GCCTTCAAAA AGAAGCGCCA ATGTGGAGTG 180

TGCAGGCAGA GCGTGGAGAA CCTGGGCTCT TTTTGTCGAG TCTGCAAAAC AGCCACCCAT 240

AAGAAATGCG AAGCCAAGAT CAACACGGCC TGCATCCCAG CGCAGCCCTC AGAGCTGCGA 300

AGGGGAACAT CCTCCTCTAG ACACATTCAG CATCTGGGCT CAACCAAGTC TCTGACCTAC 360

ACCAAACAGA GGAACACTCT CCCGAGGAGC TTCAGTGTGG ATCGGGTGAT GGACAGAGTG 420

ATGGAGAGAC ACTATGATTT CGACCTCACA TACATCACAG AGAGGATCAT CTCAGTCTTC 480

TTTCCTCCTC TGCTGGAGGA ACAGCGCTAC CGCCTCAACC TCAGAGAGGT GGCAGCCATG 540

CTCAAGTCCA AACACCAAGA CAAGTTTCTG TTATTAAATC TGTCTGAGCG AAGGCATGAC 600

ATCACCCGCT TAAACCCAAA GGTTCATGAC TTCGGCTGGC CAGATATGCA CTCTCCTCCG 660

CTGGATAAGA TCTGTGCCAT GTGCAAAGCC ATGGAGAACT GGCTGAACTC TGACCCCCAG 720

CATGTGGTCG TTCTGCACTG TAAGGGCAAC AAAGGAAAGA CCGGTGTAAT CATTGCTGCC 780

TATATGCATT ACAGCAAGAT ATCAGCGGGG GCAGATCAGG CGCTCAGCAC GTTGGCCATG 840

AGGAAGTTTT GTGAAGATAA AGTAGCGTCC TCTCTCCAGC CCTCTCAGAA CAGGTATATC 900

CAGTACTTTG GAGGGCTTCT CTCAGGGTCT ATCAAAATGA ACAGCAGTCC TCTCTTCCTC 960

CACCAGGTCC TCATTCCTAC CATCCCCAAC TTCCAGGAAG ATGATGGTTT CTTCCCTTTC 1020

CTGAAGATCT ATCAGTCCAT GCAGCTTGTC TATACTTCTG GCATATATGA TCTGCAGGGC 1080

TCTGCGAGCA GGCGGCTGAT CATTACTATT GAGCCTGCAT TGCTCCTGAA AGGAGACATC 1140

ATGGTGAAGT GTTATCACAG GCGAGTGGAG TCTGCTGAGA GAGACTCAGT GTTTCGACTG 1200

CAGTTTCATA CATGCACCGT TCATGCAGCT CAGCTCTGGT TCGGCAAAGG GGAACTGGAT 1260

GAAGCTTGTT CAGATGACAA ATTTCCCCCT GATGCCATAG TGGAGTTTGT GTTTTCATCT 1320

GGGCCTGAGA AAATTAAAGG GAGAGTGAGC CAAAGGAATG ATCCAGCTGT CAGTGTGGAC 1380

TATAACACAA ATGATCCAGT GGTGCGCTGG GACTCATATG AGAACTTCAA TCAGAGGCAT 1440

CAGGACAGCC TAGAGGATAT TGCTCATACA CGTGGCCCTG TAGATGGCAG CTTGTATGCA 1500

CAGGTTAAAA AGCGCCGCGC TGCTGCTGGC TGCTCCTCTC TGCCATCGAC CAATGGAAGC 1560

CCTGCAAGAA GCTCTGAGGA AAGACCAAGT CAGCTTTTGT CTGTTAGCAC TGATTCCGGA 1620

CACTCATCTG TTCCTCCTGA TCGACTCGAT GAACCGACTC GACCGGCCCC GCCTACTCAG 1680

CAAGAGAGGG AGGAGCTTGA GCGGCTATTG GGTGGGATTG AAGGCGATGG ACTGAGAGAC 1740

CGTGACCGAG AGACGGCTAT TTTGGATGAT GGTGATTCCT TGCCTCCTGA AAGAACTGGG 1800

TCTCTGAGGT TAGGCCGTTC ATGTTCTTGT CGTGTGGGTT ACCGATCTCA GGGTTGTGCT 1860

GAGCCTGGAT GTAATGGATT TCATCATTTA CCCAATGGCC ATTGCCTTGA TCGGCCCACC 1920

ACCACTAATG GACACACAGG GGCTCTGTCT CCAGGTATGT CATCTGTCAT AGGACTTTGC 1980

CAACATCACA GCACCCATCC TCACCAATCC CTTCCTCCTC CAGACCTGCT CTGGGACCGC 2040

CAGCAAGGTC CACAGCACTA CCTGCATCGC ACTTGTTCAG AGGGACCATC TCGCCACCTG 2100

TATCCATATC CATCCCAAGA GATCAATTCT CATCCACACA GTCTGTCCCC CCGACTGCTT 2160

TGTAGACCAG ATGAGTACAT TTCATATCCT CACCATCATC ACAATCATTC ACACCATCCC 2220

AAACCCAGCG GACCCTACCA TGATGTCATG ATGATAGATG GCCTAGTGAC ACCCGGCTGC 2280

CCCTGTCGAG ACTGTGCTCT ACGACGAGAA GAGTTCCACA CTTTACGTTT GGACAGAGAG 2340

GATGGAATAC ACTGGGAGAG AGAGGCAGAG CTTCACCGGG ATAATGGGTT AAGACGGACA 2400

AGAGAGGCTG ACATGCAGAG AGGGGCAGAG ATATGGGAGC GGGAGCCAGG ACTAAGGAGA 2460

GGAAGAGAGA TGTCTCTTCA CTGGGACAGA GACAGAGATG CAGAACTACA GTGGGAGAGA 2520

GAACGTGAGG CTGAATACTG GCACAGAAGG GCTACTGTAT CCCCATACGG GCCCCACGGT 2580

CATGAATTAC CTGCGTTTAA TTTTGATCCA CTCCCAGCAG GCCATCCTGC ATACCCAGAA 2640

CCCTCCCGCT CTCACTCTCA TGCCCATCTG GATCTTAAAT ACAGCAGCAG CTCCAGTGGC 2700

TACCAGACAC CACACCAGAC GTGCCCTTGC TCCCCCTACC AGCCTTCACC CTCAGAGAGT 2760

CGAGGATATG CCTCGGGTTA CCAGTCTGAG TCTACGTCTC CTCTTCCGCC TCCATCTGCC 2820

TCCTGCCCCG GCCCGGTGCA CCATGCCAGT GGACCTACAG AAAACCAAAC TGACCCCCAT 2880

TCTCAGCATT TCACCTCTGA CTCAAATACA GATTGCCCTG GTGCAGATAG CATAGGATGG 2940

CGTAATCATA TTACCCATGG ATCCCTCCGG CGGATGCATC CACATGCTCC ATATTCAACA 3000

CCCTCTGATA TTTCAGGACC TCCAACACCA GTCCACACAA GCAGCCCTTT ACGAACCCAG 3060

GAAAGTCCAA GCCTGAGTGT CCGTGACTAT GACTCAAGAG AGGGGAACAG TGAAAGCAGT 3120

TCTGCTCACT CCCTCAACAG GCCGCATCCA GCTACCATAC AGCCCAACAT GACCAATGCA 3180

GGATCACGGC AAACTCTACT CTCTTCCAGT CCAGAGACTC CTGAGATTAA CCCGCTTCCT 3240

ACCACACCCA CCACTGCCCA ACATCTTGCA GCTCATTCCC TTCCTACAAC ACCTCCAACC 3300

CCACAAATTG CAACAGAACA CTCACCCCCC TTAACGCCCG AGTCAGAATC CACCCAACCA 3360

CAGGCAAATT GCTCGCCTAC TGCTGCTACA GTGCTGCCCA CAGTGGAAAT GGTGCCACAA 3420

TCAACTGAGA CTATAAAACC AGCACATTCC CCACATCCCT CCTCTCCAGT CCTGGCTGAG 3480

TCCATTCCAG CTCACATGCA AAGCAATGGA GTACCACCAT CTCCTGAATC AGATGCCCCT 3540

AAACCTGCTT CTTCAGCACC TGCATCCCCT CAGCCACCTG CTGGTGACCA CGAGAGCTCT 3600

TCTTCCCCTG AACCTTCAGT GCCTGGATTT GCCACACTGG GCAGGAAGTT GATGTTGGGC 3660

TCTGAAACCT CACTTTCTGC AGGACACAGT ATGGATGCCA GTTCTAATTC TACTCCCACT 3720

TTCCCAGTCT CTCCTGCCTG CTGTACTCCA TCTCCTCCAC CAGGCTCCTA CCCAGGGTGC 3780

CCATCATCCT CCGTCCCACA GCCTCCTCTC CCAGAGAAAC GCCGCCCATC CGGCCTCCCA 3840

GGCTCACCCA ATGGGAGGTC TGGAACACTG AGGGCATCCA TGAGTCACCA GCCCTCTGGG 3900

CAGCACCATG TTACATTCTC GCCCTCAGTA GGGGAGCTGG CCGTACCCAT TGGTCAGGTT 3960

GAAGTTGGTG TGGAGGGTGA GATTGGCAAC CGTGTCAGTG TGAAATTTGT GCAGGACAGC 4020

TCACGATTTT GGTATAAACC TGGCATCTCC AGAGAGCAAG CTATAGCAGC ACTGAAGGAA 4080

AGAGAGCCAG GGGCCTTCCT CATCCGAGAC AGTAACTCCT TCCAGGGGGC CTACGGTCTG 4140

GCCCTGAAAG TTGCCAGCCC ACCCCCCAAC GTCAATAATC ATAGCAGCAA AGGAGACCCT 4200

CTGGAACAGC TGGTTCGTCA CTTTCTGATT GAGACGGGGC CGCGAGGGGT GAAGATCAAG 4260

GGCTGTCAGA ACGAGCCCTA CTTTGGGAGT CTTTCAGCAC TGGTGTATCA GCATTCCATT 4320

ACACCCATCT CTCTGCCCTG TGCCCTCCGT ATCCCAGAGA AAGACCCAAT AGGTGATGTA 4380

GTGGAGGTTC AGCCGGTGAG TAACATGAGC ACAGCCGCAG ACCTCCTGAA ACAGGGAGCA 4440

GCCTGTAATG TGCTGTACCT GAATTCAGTG GAGACCGAGT CCCTGACGGG GCCACAGGCT 4500

ATCGCTAAAG CTACAGGGGC CACATTGTCT CGCAGTCCTC GCCCCTCTGC CACAGTGGTC 4560

CACTTTAAGG TGTCTGCGCA AGGCATCACA CTGACAGACA GCCAGCGCAG GGTGTTCTTC 4620

AGGAGACACT ATCCCATCAA CAGTGTGACT TACAGCAGCA TCGACCCACA AGACAGGAGA 4680

GTTTTCGGGT TTGTGGCCAA GAAGCCGGGC AGTGTGGCAG AGAATGTGTG CCATCTTTTC 4740

GCAGAGCTGG ACCCTGAACA GCCCGCGACC GCCATCGTCA ACTTCATCAA CAAAGTGATG 4800

CTGGCACCGC AGAGGCGCTA G 4821

Domain Profile

S: 1     rrltedgfdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcse  60

         +r++e+ +d+dlty+terii+v fP   +e++yr nlrev+ +l+skh++k++l nl se

Q: 138   DRVMERHYDFDLTYITERIISVFFPPLLEEQRYRLNLREVAAMLKSKHQDKFLLLNL-SE  196

         699******************************************************.**

S: 61    rrydltklnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGv  120

         rr+d+t+ln+kv++fg++d+++P+l+k++++ck++++Wl+ d+++vvvlhckg+kg++Gv

Q: 197   RRHDITRLNPKVHDFGWPDMHSPPLDKICAMCKAMENWLNSDPQHVVVLHCKGNKGKTGV  256

         ************************************************************

S: 121   ivcayllaseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqllkg  173

         i++ay+++s+isa+ad+al t+++r+++edkva+  qPsq+ry++yf +ll+g

Q: 257   IIAAYMHYSKISAGADQALSTLAMRKFCEDKVASSLQPSQNRYIQYFGGLLSG  309

         **************************************************987

Domain Sequence
(FASTA)

DRVMERHYDF DLTYITERII SVFFPPLLEE QRYRLNLREV AAMLKSKHQD KFLLLNLSER 60

RHDITRLNPK VHDFGWPDMH SPPLDKICAM CKAMENWLNS DPQHVVVLHC KGNKGKTGVI 120

IAAYMHYSKI SAGADQALST LAMRKFCEDK VASSLQPSQN RYIQYFGGLL SG 172

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0046872	; F:metal ion binding
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011993	; PH_like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR013625	; PTB.
IPR006020	; PTyr_interaction_dom.
IPR000980	; SH2.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF08416	; PTB; 1.
PF10409	; PTEN_C2; 1.
PF00017	; SH2; 1.

SMARTs

SM00109	; C1; 1.
SM00462	; PTB; 1.
SM00252	; SH2; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50001	; SH2; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013