EPS-DAR-00033

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00033

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	104.5	8.8E-30	4	141	138

Status

Unreviewed

Ensembl Protein

ENSDARP00000117482

UniProt Accession

F1QYI8;

Protein Name

Protein Synonyms/Alias

Gene Name

dusp12

Gene Synonyms/Alias

dusp12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000076330	ENSDARP00000120307	ENSDART00000143437
ENSDARG00000076330	ENSDARP00000102008	ENSDART00000114546
ENSDARG00000076330	ENSDARP00000117482	ENSDART00000136113

Organism

Danio rerio

Functional Description

Protein Length

291

Protein Sequence
(FASTA)

MIPVASGLYI GSVSDLKDAE SLSAAGITHI LTVDSEEASV TGFNTKFIRA LDDESTDLLS 60

RLDDCTSFIS EALSTQADSK SAAVLVHCHV GQSRSAAVVT AYLMKTQHLT LQEAYSKLQN 120

IKPDVKMNEE FLDQLALYEL MDCKVDTTSP VYKQFRLKKI TEKYPELQNV PKDVFAVDPA 180

QTQNAEAVYR CRKCRRTLFR HSSILSHCVG SGASAFSHKK TRIVSSSAED ETQCTSYFIE 240

PVQWMEQALL GVMDGQLLCP KCSSKLGSFN WYGEQCSCGR WVTPAFQMHK N 291

Nucleotide Sequence
(FASTA)

ATGATACCCG TGGCGTCTGG ACTCTACATC GGGTCAGTGT CTGATCTGAA GGATGCTGAG 60

AGTCTGTCAG CTGCAGGTAT AACACACATT CTGACTGTAG ACTCAGAGGA AGCTTCTGTC 120

ACTGGATTCA ACACCAAATT CATCCGAGCT CTGGATGATG AGTCCACAGA CCTGCTGAGC 180

AGACTAGATG ACTGTACCAG CTTTATTTCT GAAGCCCTTA GCACACAAGC TGACTCCAAA 240

TCAGCAGCAG TTCTTGTGCA TTGCCATGTG GGGCAAAGCA GAAGTGCTGC AGTGGTGACT 300

GCTTACCTGA TGAAAACACA GCACCTGACC TTACAGGAAG CATATTCTAA ACTGCAAAAC 360

ATAAAACCAG ATGTCAAAAT GAATGAAGAG TTTCTGGATC AGCTGGCACT TTATGAATTG 420

ATGGACTGTA AAGTGGACAC CACAAGTCCT GTTTACAAAC AGTTTAGGCT GAAAAAGATT 480

ACAGAGAAAT ATCCAGAGCT CCAGAATGTG CCAAAAGATG TATTTGCTGT TGACCCTGCA 540

CAAACCCAGA ATGCAGAAGC TGTATACAGA TGTAGAAAGT GCAGACGCAC ACTTTTCCGA 600

CACTCCAGCA TTCTCAGTCA CTGTGTGGGA AGTGGAGCGT CTGCCTTCTC TCATAAGAAG 660

ACACGGATTG TGAGCTCTTC AGCTGAAGAT GAGACACAGT GCACTTCCTA TTTTATAGAG 720

CCGGTGCAGT GGATGGAGCA GGCTTTACTA GGGGTCATGG ATGGACAGCT TCTGTGTCCC 780

AAGTGCAGCT CAAAGCTGGG CTCCTTTAAC TGGTATGGTG AACAGTGTTC GTGTGGCCGC 840

TGGGTCACAC CGGCCTTCCA GATGCACAAG AAC 873

Domain Profile

S: 5     ilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipvdDsd  64

         + +gly+g+  +  d  +Ls++git+++++  +             +g + k i + D++

Q: 4     VASGLYIGSVSDLKDAESLSAAGITHILTVDSEEAS---------VTGFNTKFIRALDDE  54

         6789*************************9988887.........468888999******

S: 65    vtdllqyfdeaaefidea.....kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         +tdll+ +d ++ fi ea      +k  +vlvHC++G sRSa++v+aYLmk+++l+l++A

Q: 55    STDLLSRLDDCTSFISEAlstqaDSKSAAVLVHCHVGQSRSAAVVTAYLMKTQHLTLQEA  114

         ********************9999999*********************************

S: 120   ieavkrkrpsiepnegfleQLlelekk  146

         ++++++ +p +++ne+fl QL ++e +

Q: 115   YSKLQNIKPDVKMNEEFLDQLALYELM  141

         ************************976

Domain Sequence
(FASTA)

VASGLYIGSV SDLKDAESLS AAGITHILTV DSEEASVTGF NTKFIRALDD ESTDLLSRLD 60

DCTSFISEAL STQADSKSAA VLVHCHVGQS RSAAVVTAYL MKTQHLTLQE AYSKLQNIKP 120

DVKMNEEFLD QLALYELM 138

Keyword

Complete proteome; Hydrolase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0035335	; P:peptidyl-tyrosine dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013