EKS-DAR-00739

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00739

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Lmr	488.3	1.1E-146	134	407	274

Status

Unreviewed

Ensembl Protein

ENSDARP00000125077

UniProt Accession

F8W5J1;

Protein Name

Protein Synonyms/Alias

Gene Name

aatkb

Gene Synonyms/Alias

aatkb;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000077477	ENSDARP00000125077	ENSDART00000148387
ENSDARG00000077477	ENSDARP00000102054	ENSDART00000111560

Organism

Danio rerio

Functional Description

Protein Length

1658

Protein Sequence
(FASTA)

SMSGTVTLLV MSASFFNPSF ALSSHFDSDG APLSDLSWSS SLAVVAVSFS GLFTFIFLML 60

ACLCCKRGNI GFKEFENAEG EEYPADMSTP ASPASHSGPD VYILPLTEVS LPVAKQPGRS 120

VQLLRSTDLG RQSLLYIKEI GNGWFGKVLL GEVHSGLSST QVVVKELKAS ASVQDQMHFL 180

EEARPYRSLQ HPALVQCLAQ CTEVTPYLVV MEFCPLGDVK GYLCSCRTAD SLIPDPLLLQ 240

RMACEITSGL LHLHKNNFTH RDLALRNCLL TSDIKVKIGD YGLSHNKYKD DYFVTSDQTW 300

VPLRWIAPEL VDEVHGNLLV VDQTKESNIW SLGVTIWELF ELGNQPYRHY SDRQVLSYAV 360

KDQQLKLSKP ILKYPLADRW YEVMQFCWLQ PDQRPNAEEV HLLLSYLCAK GASEAEEDFE 420

RRWNSMRPNT SQANIHGAGA LAIDMPMSST TSSFPLLEQF PSGDGYHSES GDDILTVTET 480

SHGLNFEYKW EQARAEQHYH SSSTTGTLGQ GNPHCQEVYY PPGGIVGGCA VDGLALGVSP 540

SYYEPKQLHT PGVVPVLSAH SPSVSNEYYI RIEEPVQSNI DMNFTMCAYS PEFGGSNGSF 600

LTGSGDSGEC MNCPPEAKPD IYWSAEVHKS GAYDSDSSPA MSLTMEPLLG HGSPLRAWES 660

GHYVSYKDRD GGYYFEPSPP KVMGRYMIRD STETLQESWG SRSLRQALGE LEDPLGISPS 720

LGSPPQGYAD PYLESIQGSI IGKNVTGGYY DMMGSLRKTM PGGHSVCTDI ASGGAVFVGR 780

DDSESDEEED IFVERRGRSW SASNPPNTNP RTLRQRQGSC IQDSYADFHY TMPMTDIEDT 840

WPEQQTLSYH MTKPVDYLEA PIKSNTCLVH GRHVPSNPSP ECNSYIHMCH EPREAEVYPV 900

PCCQALSSSH FVDPLTGTLV RNCFMIDCIP GKTMTLPNRD QHLPLSAGHI ISKIEASREG 960

AKQFDISEQF VDTAVGETNL KQEKTLHQDI STADPKTEII AIYPQLEKSP AELSKPEPES 1020

ELSKTADSGM DRGHSSISLV EIDDCSDDDI TDVTSGIFGD FAIEVETVDY PSPAFKSLQK 1080

QVGTPDSMDS IDIPSTACSS ETLSPASIHP SSSPKTVDSG YDTENNESPE FVLKEPHEVQ 1140

DSKTFIQPLG KVTSGTSFVS EDQEITTTEC EKLEGDFYTA VALTASESSD GELKALSDKT 1200

PYRDSAYFSD YDAGKDKESE EDINELEDQK DRPGEIIYKE EQLPPQKETD VDEYLMPSTK 1260

KSEKIPELSD HSISNLPSMT DESLSVCGTI CSVSLSPLKD VSTIKSSFED NENIGVVSDL 1320

SAELLASEEL GTDGKQEESF KQVESEDSLS HDQVTFEGDL VNKPNPEVLT DENEEDIVKD 1380

VSCAILSEEE LQSQKEKAEK NDSPTHEELK SKSKDCEGEG RKRISARSGS PPPPLEGRVS 1440

PTDGEEADEE DGDSEDSDES DEELRTYSIQ EQSEESEDEV LTVPIIISDC SDAHKLRSLL 1500

KMPTSLLSEE TEGKKKVVSF FDDVTVYLFD QESPTRELAD HSFPLGGESS KPSAKGKAQH 1560

QQDKVNASDD SSDGNISEES AGFEWEDDFP LLPLPTSSKG SPPDHTEKPN LASISPKPVA 1620

QVSRFTVSPS SVSRFSITHV SDSDMDSAGG SSEDGEKE 1658

Nucleotide Sequence
(FASTA)

AGTATGTCAG GGACTGTAAC ACTGTTGGTC ATGTCTGCGT CGTTTTTCAA CCCCAGTTTT 60

GCGCTGAGCT CTCATTTTGA CTCAGATGGC GCTCCTCTGA GTGATCTGTC CTGGTCGTCC 120

TCTCTTGCTG TGGTGGCTGT GTCTTTCTCT GGACTCTTTA CCTTCATCTT CCTCATGCTG 180

GCTTGTCTGT GCTGTAAAAG AGGCAACATT GGCTTTAAGG AGTTTGAGAA TGCAGAGGGA 240

GAGGAATATC CAGCGGACAT GTCCACCCCG GCATCTCCTG CATCTCACAG CGGTCCTGAC 300

GTCTACATCC TGCCTCTCAC CGAGGTCTCG CTGCCTGTCG CAAAGCAACC TGGCCGATCA 360

GTCCAGCTCC TGAGATCCAC CGATCTTGGC CGCCAGAGTT TGCTCTACAT TAAGGAGATT 420

GGAAATGGCT GGTTTGGCAA GGTGTTGTTG GGGGAGGTTC ACTCTGGTCT TAGCAGTACC 480

CAGGTGGTGG TGAAGGAACT GAAGGCCAGT GCCAGTGTGC AGGACCAGAT GCATTTCCTG 540

GAGGAGGCAC GGCCTTATCG ATCTCTCCAG CATCCAGCTC TAGTGCAATG CCTCGCTCAG 600

TGCACAGAGG TCACACCCTA CTTGGTGGTC ATGGAGTTCT GCCCACTGGG TGATGTTAAA 660

GGTTACCTGT GCAGCTGCCG GACTGCCGAT TCCTTGATCC CTGACCCTTT ACTGCTTCAG 720

AGGATGGCAT GCGAAATCAC TTCAGGCCTG CTGCACCTTC ACAAAAACAA CTTCACCCAT 780

AGGGATCTGG CTTTAAGAAA CTGCCTGCTA ACATCAGACA TAAAAGTTAA GATCGGAGAC 840

TATGGACTAT CACACAACAA GTACAAGGAT GACTACTTTG TGACATCAGA CCAGACCTGG 900

GTACCTTTAC GCTGGATTGC CCCTGAACTG GTGGATGAGG TTCATGGCAA TTTGCTGGTA 960

GTGGACCAAA CCAAGGAAAG CAACATCTGG TCACTTGGTG TAACCATCTG GGAGCTGTTT 1020

GAGTTAGGGA ATCAGCCGTA CCGCCATTAT TCAGACCGAC AGGTTCTCAG TTATGCTGTG 1080

AAGGATCAGC AATTGAAGCT GTCCAAGCCT ATTCTTAAGT ACCCACTTGC TGACCGCTGG 1140

TATGAAGTAA TGCAGTTTTG TTGGCTTCAG CCTGACCAAA GGCCCAATGC AGAAGAAGTT 1200

CATCTTTTGC TTAGTTACTT ATGTGCCAAA GGAGCCAGTG AGGCAGAGGA AGACTTTGAG 1260

AGACGCTGGA ACTCCATGAG ACCAAACACA AGCCAAGCTA ATATTCATGG AGCCGGAGCA 1320

CTCGCAATTG ATATGCCAAT GTCATCCACC ACTTCGTCGT TCCCCCTGCT GGAGCAGTTT 1380

CCCAGTGGAG ATGGCTACCA TTCAGAGTCT GGAGATGACA TCTTAACGGT TACTGAAACT 1440

AGTCATGGCC TCAACTTTGA GTACAAATGG GAGCAGGCAC GTGCTGAGCA GCACTATCAT 1500

TCCTCATCCA CAACAGGCAC TTTGGGTCAA GGCAATCCTC ATTGTCAGGA GGTCTACTAT 1560

CCTCCAGGAG GAATAGTGGG GGGATGTGCT GTTGATGGAC TTGCCCTAGG GGTTTCTCCT 1620

TCATATTATG AGCCCAAACA ATTACACACC CCTGGTGTGG TGCCTGTGCT GAGTGCTCAT 1680

AGTCCATCAG TGAGTAACGA GTACTATATT CGCATTGAGG AGCCAGTACA AAGCAATATT 1740

GATATGAACT TTACCATGTG TGCTTACAGC CCAGAGTTTG GTGGCAGTAA TGGAAGCTTT 1800

TTAACCGGTA GTGGAGACTC TGGTGAGTGT ATGAACTGTC CCCCTGAGGC TAAACCAGAC 1860

ATTTACTGGT CAGCTGAAGT TCACAAAAGT GGTGCTTATG ATTCTGACTC CAGCCCTGCT 1920

ATGTCTTTAA CTATGGAGCC TCTTTTGGGC CACGGTAGCC CCCTTAGAGC ATGGGAATCA 1980

GGCCACTATG TCTCATACAA AGACAGGGAT GGAGGTTATT ACTTTGAACC ATCACCTCCT 2040

AAGGTTATGG GCCGCTATAT GATACGAGAC TCAACAGAAA CTCTACAAGA AAGCTGGGGC 2100

TCTCGAAGTC TGAGACAAGC ACTTGGGGAA CTGGAGGACC CTTTAGGCAT CTCACCATCA 2160

CTTGGAAGTC CTCCACAAGG CTATGCTGAT CCTTATTTGG AGAGCATTCA AGGCTCCATT 2220

ATAGGAAAGA ATGTAACGGG TGGATACTAT GATATGATGG GCTCTTTGAG AAAGACTATG 2280

CCAGGTGGCC ACTCTGTTTG TACTGACATA GCATCAGGTG GTGCTGTATT TGTAGGTCGA 2340

GATGACAGCG AGTCTGATGA AGAGGAAGAC ATCTTTGTGG AGAGGCGAGG AAGAAGCTGG 2400

TCTGCCAGCA ATCCACCAAA TACAAACCCA AGGACCTTGC GTCAGAGGCA GGGGTCTTGT 2460

ATCCAGGATT CCTATGCAGA CTTCCACTAC ACTATGCCAA TGACTGATAT TGAGGATACA 2520

TGGCCAGAGC AGCAGACCCT GTCATACCAT ATGACCAAAC CTGTTGACTA CTTGGAGGCA 2580

CCGATTAAAA GCAATACTTG CTTGGTACAT GGAAGACATG TACCTTCAAA CCCTTCACCT 2640

GAGTGCAACT CATACATCCA TATGTGCCAC GAACCTAGAG AGGCTGAAGT ATACCCTGTG 2700

CCATGTTGTC AAGCTTTGAG CAGTTCACAT TTTGTAGACC CTTTAACAGG AACACTTGTG 2760

AGGAACTGCT TCATGATTGA CTGTATTCCA GGGAAAACCA TGACCTTGCC CAACAGAGAC 2820

CAACATCTAC CTTTATCTGC TGGACATATA ATCTCCAAAA TAGAAGCATC AAGGGAAGGA 2880

GCCAAACAGT TTGACATCTC GGAGCAATTT GTGGATACTG CAGTAGGAGA AACAAACTTA 2940

AAACAAGAAA AAACGTTGCA TCAAGATATA TCTACAGCAG ATCCAAAAAC TGAAATTATC 3000

GCCATATACC CACAGTTGGA AAAATCCCCA GCAGAATTAT CCAAACCAGA ACCAGAGTCT 3060

GAGCTGAGTA AGACTGCAGA CAGTGGTATG GACCGTGGAC ACTCTAGTAT CAGCCTGGTT 3120

GAGATAGATG ACTGCAGTGA TGATGACATC ACTGACGTAA CCTCAGGCAT TTTTGGTGAT 3180

TTTGCAATTG AAGTGGAAAC TGTTGACTAC CCCAGTCCAG CATTCAAGTC ATTACAAAAA 3240

CAAGTTGGTA CTCCAGACTC CATGGACTCT ATTGACATAC CGTCTACTGC ATGTTCCAGT 3300

GAGACTCTCA GTCCGGCTTC CATCCATCCA TCAAGCTCTC CTAAGACTGT GGATAGTGGC 3360

TATGACACAG AAAACAATGA ATCTCCAGAG TTTGTCTTAA AGGAACCTCA TGAGGTACAA 3420

GATTCCAAGA CTTTCATTCA ACCTTTGGGA AAGGTAACAT CTGGGACAAG TTTTGTCAGT 3480

GAAGACCAAG AGATTACAAC AACAGAATGT GAGAAGCTTG AGGGTGATTT TTATACTGCA 3540

GTGGCCTTGA CAGCATCTGA GAGCAGTGAT GGAGAGCTGA AAGCACTGAG TGATAAAACA 3600

CCATACAGAG ATTCTGCCTA CTTTTCTGAT TATGATGCTG GCAAAGATAA AGAAAGCGAA 3660

GAGGACATCA ATGAACTTGA AGATCAGAAA GACAGACCAG GGGAAATTAT ATATAAAGAG 3720

GAACAACTTC CTCCACAAAA GGAGACAGAT GTAGATGAAT ATCTTATGCC ATCTACAAAG 3780

AAGAGTGAAA AAATCCCTGA ACTGTCTGAT CATTCAATCT CAAACCTTCC ATCAATGACA 3840

GATGAAAGTT TGTCTGTGTG TGGCACAATC TGTAGCGTGT CTCTCTCACC TCTTAAAGAC 3900

GTTTCTACCA TAAAAAGTAG TTTTGAAGAT AATGAAAATA TTGGTGTTGT TTCAGATCTC 3960

TCTGCAGAAC TTTTAGCATC TGAAGAACTT GGTACTGATG GAAAGCAAGA GGAATCTTTC 4020

AAACAAGTAG AAAGTGAAGA TAGTCTGTCT CATGACCAAG TTACTTTTGA AGGCGATCTT 4080

GTAAACAAGC CCAATCCAGA GGTACTTACT GATGAGAACG AAGAGGACAT AGTCAAAGAT 4140

GTCAGCTGTG CCATTTTGTC CGAAGAGGAA CTACAGTCTC AAAAGGAAAA AGCAGAAAAG 4200

AATGACTCTC CTACACATGA GGAGCTAAAA TCCAAGAGTA AGGACTGTGA AGGAGAAGGA 4260

CGGAAAAGAA TCTCCGCACG ATCTGGCTCT CCTCCCCCTC CTCTAGAAGG GCGGGTTTCT 4320

CCCACAGATG GTGAGGAGGC AGATGAGGAA GATGGCGACT CTGAGGACAG CGATGAGTCT 4380

GATGAGGAGC TGCGCACATA CAGCATCCAA GAGCAGAGTG AAGAAAGCGA GGACGAGGTC 4440

TTGACAGTGC CCATCATTAT AAGTGACTGC AGTGATGCGC ACAAGCTCAG AAGCCTTCTT 4500

AAGATGCCAA CATCTTTGCT TTCTGAGGAA ACGGAGGGCA AAAAGAAGGT TGTGTCCTTC 4560

TTCGATGATG TCACAGTATA TTTGTTTGAC CAGGAAAGTC CAACCAGAGA GTTGGCAGAT 4620

CACAGTTTTC CCTTGGGTGG AGAATCAAGC AAACCTAGTG CAAAGGGTAA AGCGCAGCAC 4680

CAACAGGATA AGGTCAATGC CTCCGATGAC TCGTCGGATG GAAACATCTC AGAAGAGAGT 4740

GCAGGATTTG AATGGGAAGA TGATTTCCCA TTGTTGCCCC TTCCCACATC TTCCAAGGGG 4800

TCCCCTCCTG ACCACACTGA AAAGCCAAAC CTAGCGTCCA TTAGCCCTAA ACCTGTGGCA 4860

CAGGTCTCCC GTTTTACCGT TTCTCCATCC AGCGTATCCC GTTTCTCTAT CACTCATGTC 4920

TCAGATTCAG ATATGGATTC TGCAGGAGGG AGCAGTGAAG ATGGGGAAAA GGAGTGA 4977

Domain Profile

S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60

         l y+keig+gwfgkvllgev+s++ss+qvvvkelkasas+++q++fleea+pyr+lqhp

Q: 134   LLYIKEIGNGWFGKVLLGEVHSGLSSTQVVVKELKASASVQDQMHFLEEARPYRSLQHPA  193

         78**********************************************************

S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslspdlrtlqrmalevaaglahl  120

         ++qcl+qc+e++pyl+v+efc+lgd+k+yl ++r+a sl pd+++lqrma+e+++gl+hl

Q: 194   LVQCLAQCTEVTPYLVVMEFCPLGDVKGYLCSCRTADSLIPDPLLLQRMACEITSGLLHL  253

         ************************************************************

S: 121   hklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaapelvde  180

         hk+n+ h dlalrnclltsd++vk+gdygl+h kyk+dy++t+d+ +vplrw+apelvde

Q: 254   HKNNFTHRDLALRNCLLTSDIKVKIGDYGLSHNKYKDDYFVTSDQTWVPLRWIAPELVDE  313

         ************************************************************

S: 181   lhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvklakprlk  240

         +h++llvvdqtkesn+wslgvt+welfelg qpyr++sd++vl+++v++q++kl+kp lk

Q: 314   VHGNLLVVDQTKESNIWSLGVTIWELFELGNQPYRHYSDRQVLSYAVKDQQLKLSKPILK  373

         ************************************************************

S: 241   lpysdrwyevlqfcwlppekrpaaedvhllltyl  274

          p++drwyev+qfcwl+p++rp ae+vhlll+yl

Q: 374   YPLADRWYEVMQFCWLQPDQRPNAEEVHLLLSYL  407

         *********************************8

Domain Sequence
(FASTA)

LLYIKEIGNG WFGKVLLGEV HSGLSSTQVV VKELKASASV QDQMHFLEEA RPYRSLQHPA 60

LVQCLAQCTE VTPYLVVMEF CPLGDVKGYL CSCRTADSLI PDPLLLQRMA CEITSGLLHL 120

HKNNFTHRDL ALRNCLLTSD IKVKIGDYGL SHNKYKDDYF VTSDQTWVPL RWIAPELVDE 180

VHGNLLVVDQ TKESNIWSLG VTIWELFELG NQPYRHYSDR QVLSYAVKDQ QLKLSKPILK 240

YPLADRWYEV MQFCWLQPDQ RPNAEEVHLL LSYL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013