EPS-DAR-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-DAR-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	179.0	3.0E-52	596	823	228

Status

Unreviewed

Ensembl Protein

ENSDARP00000099194

UniProt Accession

F1RBX7;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000078694	ENSDARP00000099194	ENSDART00000111287

Organism

Danio rerio

Functional Description

Protein Length

1075

Protein Sequence
(FASTA)

KPHSIESSER IQLSGTYNVR KGKLQLPVNR WSRRQVILCG TCLMVSSVKA SHTGKMHILP 60

LIGGKVEEVK KHSHCLAFSS AGPQSQTYYI SFDSFTEHLR WHRHVAPDWS AVKSSSVDLS 120

CCSLEKLPPN LLFSQDLTHL NLKHNFLPAD QTLLQLQRFS RLRSLNLSNN QLCSFPQALC 180

SISSLSEVNL SCNRLRSISP DIARISRLQT LVLDGNLLCS LPLELGSLHR LVFLGLSFNE 240

FQQVPPVLER LPAVERLCMA GNKLTELNLQ SFRLLTVRHV DLRHHHHHMM CTCSMKEFLR 300

GVTQLDLRDN CLQELDASVF PRLEVLHCQR NRISQLRVCG GSSCCVLPSL ELQEILVSPA 360

ASNLTYIDIS RNCMKALPDW LSDSRKLEVL DISHNQMTEL PPRLLCSSSL RKILAGHNQL 420

KRLSERVERP LVEVLDLQHN QLEELPCNLF LKTDSLRCLN VSANKLESLP ASSLSEESSS 480

ILQELYLTNN LLTDKCVPQL TGHTHLRILH MAYNQLQTFP ARCLGVCGLH SPKLQELDLT 540

GNLRLNLDHK CVLAFSNIRC FRIDPPPSSF SANEASGGPA VWSHGYTEAS VAALSVNSFC 600

GSREALYGVF DGDRNVEVPY LLQCTMNDIL AEELHRTKSE EDYMTNTFLV MQIRKLGTAG 660

QKLGGSAVLC HIRHDPTDPG GCFTLTAANV GKCQAVLCRD GKALPLSLLH NISIPEEYSR 720

IRQHKAIIVK QDNKVNGVTD STRIMGYSFL YPAVLPRPYV TTLPLTPRDE FFILGSRGLF 780

EALEPSEAVE AVRKVPDALA AAKKLCTLAQ SYGCTDSLSA VVVQLSVAED TASASIHPQP 840

PPSPGPSLYP ATSSGAPPSS CSEISSEVSA SEMSSEVGST ASSDEPPLLL QDAHLHLHPH 900

PPRVQCCSLH LAPNTSGSFQ RQLSSATFSS ALSDNGLDSE DEEPIAGVFS NGSRVEVEAD 960

VHCLGLLPPP STPELPELDA DKSPDAWSKT LGKRRGNGSV APQERSHNLI EVAADAPSKK 1020

SGGYFTAPAQ PDPDDQFIIP PELEEEVKEI MKQHQQDQQR PTKSEQPADY YDTPL 1075

Nucleotide Sequence
(FASTA)

AAACCTCACA GTATCGAGAG CTCGGAGCGA ATCCAGCTAT CTGGGACGTA TAACGTGCGG 60

AAGGGAAAGC TGCAGCTCCC GGTGAACCGC TGGAGCCGCC GGCAGGTCAT TTTATGCGGC 120

ACGTGTCTGA TGGTGTCCTC GGTGAAGGCC AGCCATACGG GGAAGATGCA CATCCTGCCC 180

CTGATTGGAG GAAAGGTGGA GGAGGTGAAG AAACACAGCC ACTGTCTGGC CTTCAGCTCG 240

GCGGGTCCTC AGAGTCAGAC CTACTATATC AGCTTCGACA GCTTCACTGA ACACCTGCGC 300

TGGCACCGGC ATGTGGCTCC TGATTGGTCG GCTGTGAAAA GCAGCTCAGT GGATCTGTCC 360

TGCTGTAGTC TGGAGAAGCT TCCTCCAAAC CTGCTGTTCA GTCAGGATCT GACGCACCTC 420

AACCTCAAAC ACAACTTCCT TCCTGCCGAC CAGACGCTGC TGCAGCTCCA GAGGTTCAGT 480

CGTCTGCGCA GTCTGAATCT CTCCAATAAT CAGCTGTGCA GTTTCCCGCA GGCGCTCTGC 540

TCCATCAGCA GCCTGAGCGA AGTCAACCTG AGCTGCAACC GCCTGCGCTC CATCAGCCCC 600

GATATCGCCC GCATCAGCAG GTTGCAGACG CTGGTGCTGG ACGGTAATCT GCTGTGTTCG 660

CTGCCGCTGG AGCTGGGCTC TCTGCACCGG CTGGTGTTTC TGGGTCTGTC CTTTAATGAG 720

TTCCAGCAGG TTCCGCCGGT GCTGGAGCGG CTGCCCGCGG TCGAGAGGCT CTGCATGGCG 780

GGAAACAAAC TGACAGAGCT CAACCTGCAG AGCTTCAGAC TGCTCACCGT CAGACACGTG 840

GACCTACGGC ATCATCATCA TCACATGATG TGTACATGTT CAATGAAGGA GTTCTTGCGC 900

GGGGTCACTC AGCTGGACCT GCGGGATAAC TGTCTGCAGG AGCTGGACGC CTCCGTGTTC 960

CCCCGGCTGG AGGTGCTGCA CTGCCAGAGG AACCGCATCT CTCAGCTGCG CGTGTGCGGC 1020

GGATCCTCAT GCTGTGTGTT GCCCTCCTTA GAGTTGCAGG AGATTCTGGT CAGTCCTGCT 1080

GCCTCAAACC TGACGTACAT CGACATCTCC AGGAACTGTA TGAAGGCTCT TCCAGACTGG 1140

TTGAGTGACA GCAGGAAGCT GGAGGTTCTG GACATCAGTC ACAATCAGAT GACGGAACTT 1200

CCTCCCAGGT TATTGTGCAG CTCGAGTTTG AGGAAGATTC TGGCGGGTCA CAATCAGCTG 1260

AAGCGTCTGT CGGAGCGGGT GGAGCGCCCC CTGGTGGAGG TGCTGGATCT ACAACACAAC 1320

CAGCTGGAGG AGCTGCCCTG CAACCTGTTC CTCAAGACTG ATAGTCTGCG TTGTCTGAAC 1380

GTGTCGGCCA ATAAGCTCGA GAGTCTGCCA GCCTCCAGCC TATCAGAGGA GAGCAGCAGC 1440

ATCTTACAGG AGCTCTACCT GACCAACAAC CTGCTGACGG ACAAGTGTGT GCCGCAGCTG 1500

ACCGGACACA CACACCTGCG CATCCTGCAC ATGGCCTACA ACCAGCTGCA GACCTTCCCC 1560

GCCAGGTGCT TAGGTGTGTG TGGTTTACAT TCTCCTAAAC TACAAGAGCT GGACCTGACA 1620

GGGAACCTGC GCTTAAACCT GGACCACAAG TGTGTTTTGG CTTTCAGTAA CATCCGCTGT 1680

TTCCGGATAG ACCCGCCCCC ATCGTCGTTT TCAGCCAATG AGGCGTCAGG AGGGCCGGCG 1740

GTCTGGAGTC ATGGTTACAC TGAAGCATCC GTAGCAGCGC TCTCCGTCAA CAGTTTCTGC 1800

GGCAGTAGGG AAGCTCTATA CGGAGTGTTC GACGGCGACA GGAACGTGGA GGTGCCGTAT 1860

CTGCTGCAGT GCACCATGAA CGACATCCTG GCGGAGGAGC TGCACAGGAC CAAGAGTGAG 1920

GAAGACTACA TGACCAACAC CTTCCTCGTC ATGCAGATCA GGAAGCTGGG CACAGCGGGG 1980

CAAAAGCTGG GCGGTTCGGC GGTGCTCTGC CATATCCGGC ATGACCCCAC TGACCCCGGT 2040

GGCTGCTTCA CCCTAACTGC CGCCAACGTG GGCAAGTGCC AGGCGGTGCT GTGCCGCGAC 2100

GGTAAAGCCC TGCCACTGTC TCTGCTGCAC AACATCAGCA TCCCGGAGGA GTACAGCCGC 2160

ATACGCCAGC ATAAAGCCAT CATTGTCAAA CAGGACAACA AAGTGAACGG CGTCACGGAC 2220

TCCACACGCA TCATGGGCTA CTCGTTCCTG TACCCGGCGG TGCTGCCGCG GCCGTACGTC 2280

ACCACGCTCC CGCTGACCCC CAGAGACGAG TTCTTCATTC TGGGCAGCAG GGGGCTGTTC 2340

GAGGCTCTGG AGCCCAGCGA GGCAGTGGAG GCTGTGAGGA AGGTGCCTGA CGCCCTAGCG 2400

GCCGCTAAGA AGCTATGCAC GCTAGCTCAG TCATACGGCT GCACGGATAG CCTGAGCGCG 2460

GTGGTGGTGC AGCTGAGCGT AGCTGAAGAC ACCGCCTCCG CCAGCATCCA CCCGCAGCCT 2520

CCGCCAAGCC CCGGCCCCAG CCTATATCCG GCAACATCCT CCGGCGCGCC TCCGTCCTCC 2580

TGCAGCGAGA TCAGCTCTGA GGTCAGCGCA TCTGAGATGA GTTCTGAAGT GGGATCTACA 2640

GCATCTTCAG ACGAGCCGCC GCTTCTCCTG CAGGACGCAC ACCTCCACCT GCACCCCCAC 2700

CCGCCACGGG TACAGTGCTG CTCATTACAC CTAGCGCCTA ACACCAGCGG CTCATTCCAG 2760

AGGCAGCTCT CCAGCGCCAC GTTTTCCAGC GCACTGTCTG ATAATGGGTT GGACAGCGAG 2820

GATGAGGAGC CGATCGCTGG TGTGTTCTCC AATGGGAGTA GGGTGGAGGT GGAGGCAGAT 2880

GTCCACTGCC TAGGGCTCCT GCCTCCACCT TCCACCCCTG AGTTGCCGGA GCTGGACGCA 2940

GATAAGAGTC CGGACGCATG GAGCAAGACT TTAGGCAAGC GTCGGGGGAA CGGCTCAGTG 3000

GCGCCGCAAG AGCGCAGCCA TAATCTGATC GAGGTGGCGG CGGACGCTCC GTCCAAGAAA 3060

AGCGGGGGTT ATTTTACAGC TCCAGCGCAG CCGGACCCTG ACGACCAGTT CATCATCCCT 3120

CCAGAGCTAG AGGAGGAGGT GAAGGAGATC ATGAAGCAGC ACCAGCAGGA CCAGCAGCGG 3180

CCCACCAAGA GCGAGCAGCC CGCAGACTAC TACGACACGC CGCTCTGA 3228

Domain Profile

S: 22    spnflkspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalak  81

         +++f+ s+e     a++gv+DG+++ ev + +++++ +ilaeel     +++  ++++++

Q: 596   VNSFCGSRE-----ALYGVFDGDRNVEVPYLLQCTMNDILAEELH----RTKSEEDYMTN  646

         444444433.....79***************************99....999999*****

S: 82    aFlstdeelkvleeksldidksGstavvalikds........klyvanvGdSravLcrng  133

         +Fl ++ +        ++ +k G +av+++i+++        +l+ anvG+++avLcr+g

Q: 647   TFLVMQIRK-----LGTAGQKLGGSAVLCHIRHDptdpggcfTLTAANVGKCQAVLCRDG  701

         *****9766.....6889******************************************

S: 134   kavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGdlylkpyvtpePev  193

         ka++ls  H++s ++E++Ri+++++ ++++d ++v+Gv+  +R +G  +l+p v p+P v

Q: 702   KALPLSLLHNISIPEEYSRIRQHKAIIVKQD-NKVNGVTDSTRIMGYSFLYPAVLPRPYV  760

         ***********************98877776.8***************************

S: 194   tshrltsedefliLasDGlwdvvsneeavslvrdvlekkeaeqeaakkLvklalargskd  253

         t  +lt++def+iL+s Gl++ +++ eav++vr+v +    + +aakkL++la+++g++d

Q: 761   TTLPLTPRDEFFILGSRGLFEALEPSEAVEAVRKVPD----ALAAAKKLCTLAQSYGCTD  816

         *************************************....*******************

S: 254   nvsaivv  260

         ++sa+vv

Q: 817   SLSAVVV  823

         *****97

Domain Sequence
(FASTA)

VNSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDILAEELH RTKSEEDYMT NTFLVMQIRK 60

LGTAGQKLGG SAVLCHIRHD PTDPGGCFTL TAANVGKCQA VLCRDGKALP LSLLHNISIP 120

EEYSRIRQHK AIIVKQDNKV NGVTDSTRIM GYSFLYPAVL PRPYVTTLPL TPRDEFFILG 180

SRGLFEALEP SEAVEAVRKV PDALAAAKKL CTLAQSYGCT DSLSAVVV 228

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>