EKS-DAR-00756
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DAR-00756
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK349.22.7E-104127384258
StatusUnreviewed
Ensembl ProteinENSDARP00000097982
UniProt AccessionF1Q527;
Protein Name
Protein Synonyms/Alias
Gene Namesi:ch211-120p12.3
Gene Synonyms/Alias si:ch211-120p12.3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSDARG00000079473ENSDARP00000121127ENSDART00000144282
ENSDARG00000079473ENSDARP00000097982ENSDART00000110070
OrganismDanio rerio
Functional Description
Protein Length1017
Protein Sequence
(FASTA)
MDVPQAVFPN GEGRLSLQDH VCTESSNSRA WAHSAPVCPR SLWTAVFDYE ASGEDELSLR 60
RGDVVEVLSK DAAISGDEGW WTGKINHRVG IFPSNYVTFQ PVIYRAVGAR ESDPSAPVRI 120
PFSELVLQEI IGVGGFGKVY RGTWKVQEVA VKAARQDPDE DIKATADSVK QEAKLFSMLQ 180
HPNIIKLEGV CLEEPNLCLV MEYARGGTLN RALTGRRIPP HILVNWAVQI ARGMQYLHEE 240
AVVPIIHRDL KSSNILLLEK IENDDIGRKT LKITDFGLAR EWHKTTKMSA AGTYSWMAPE 300
VIKSSLFSKG SDVWSYGVLL WELLTGEIPY RGIDGLAVAY GVAVNKLTLP IPSTCPEPFA 360
KLMEECWEQD PHIRPSFAAI LEQLTAIEEA VMATMPQDSF HSMQEDWRVE IQEMFDELRT 420
KEKELRSREE ELTRAALQQK SHEELLKRRE QQLAEREINV LERELNILIF QQNKDKPNVK 480
KRKGKFKRSR LKLKDGNRIS LPSDFQHKIT VQASPTMDKR RSLNSTNSSP PSSPTLIPRL 540
RAIQLSHRGD TSRKGSMFVY HQDVDVTSEC KPPSVFSKKV TLDESNRTWG RSTNYKPEEF 600
EDVKKGFKKK GRTWGPSSVQ TKERGNGAER IRPLSDGSSP WSTSLLKSQK SVPLAALFAD 660
QGTNKDEAGS ADSSDNKPKQ LKFPNQVYID LPLWKDEPGE NQSSTGGGAE SQEDPTTSTS 720
STSTTPQHTP TNSLKRSTTR RRTDSVLYGC ASILASVAFG FDLQEICKNP ANEEPEPREE 780
KKKKEGLFQR ATRFRRSTSP PGGRSRKDEI STAPVNLLAM SSISECNSTK CLLQSDFEGP 840
GFNLVNETGI SPQSNGTGEG LHLTPVQELS SGANSRLRRK KSSPAVCQNV NGSSNSPVSP 900
ADSSTTSTKK KADKEPPQDK QTSGESVSRP RPLSLRGKSH SWSLLKSRNK SYSLGHYSGE 960
KSVQNLDMLL PAEVKTGCSL LDMDTEGQKR DCTVPLCRIQ STPSRGSVFE LEKQFLS 1017
Nucleotide Sequence
(FASTA)
ATGGATGTTC CCCAGGCCGT TTTCCCAAAC GGTGAGGGGC GCCTGAGCCT TCAAGACCAT 60
GTCTGTACGG AGTCCTCCAA CTCCAGGGCT TGGGCTCACT CTGCCCCCGT GTGTCCCCGC 120
TCGCTCTGGA CCGCGGTGTT TGACTACGAG GCCAGCGGGG AGGACGAGCT CAGTCTGCGG 180
CGAGGAGACG TGGTGGAGGT CCTGTCGAAG GACGCTGCCA TCTCAGGAGA CGAAGGCTGG 240
TGGACTGGTA AAATTAACCA CCGCGTGGGC ATCTTCCCAT CTAATTATGT TACGTTCCAA 300
CCAGTCATTT ACAGAGCGGT TGGGGCTCGA GAAAGCGACC CTTCCGCGCC TGTTCGGATA 360
CCTTTTTCTG AACTGGTTCT ACAGGAAATT ATCGGCGTCG GTGGGTTTGG CAAAGTCTAC 420
CGGGGAACCT GGAAGGTGCA GGAGGTCGCA GTGAAGGCAG CTCGACAGGA CCCCGATGAG 480
GACATTAAAG CGACTGCGGA CAGTGTTAAG CAAGAAGCCA AACTTTTCTC AATGCTTCAA 540
CATCCTAACA TTATCAAACT GGAGGGGGTG TGTTTGGAGG AGCCCAACCT GTGTCTGGTC 600
ATGGAATATG CCCGTGGAGG GACTCTGAAC CGTGCTTTGA CCGGCAGGAG GATCCCCCCT 660
CACATCCTCG TGAACTGGGC CGTCCAGATC GCCAGAGGCA TGCAGTATCT CCACGAGGAA 720
GCGGTGGTTC CCATTATTCA CCGGGACCTG AAGTCCAGCA ACATTTTATT ACTTGAAAAA 780
ATTGAAAATG ATGACATTGG TCGAAAAACC CTGAAGATTA CTGACTTTGG CCTTGCTCGT 840
GAGTGGCACA AAACGACCAA AATGAGTGCA GCTGGCACTT ACTCCTGGAT GGCTCCTGAA 900
GTCATCAAGT CTTCTCTGTT TTCCAAAGGG AGTGATGTCT GGAGTTATGG AGTCCTCCTT 960
TGGGAATTAC TGACTGGAGA GATTCCTTAC CGTGGCATCG ACGGTTTGGC AGTTGCTTAT 1020
GGCGTGGCCG TCAACAAATT AACCCTTCCA ATTCCATCTA CATGCCCAGA GCCTTTTGCC 1080
AAGCTCATGG AAGAATGTTG GGAGCAGGAT CCACATATCC GTCCATCCTT TGCAGCCATC 1140
TTGGAGCAGC TGACTGCCAT AGAGGAGGCT GTGATGGCCA CCATGCCTCA GGATTCCTTC 1200
CATTCAATGC AGGAGGACTG GAGAGTAGAG ATCCAGGAAA TGTTTGATGA GCTGCGCACT 1260
AAAGAAAAGG AGCTTCGTTC TCGTGAGGAG GAGCTGACGC GAGCAGCGCT TCAGCAGAAG 1320
TCTCATGAAG AGCTGTTGAA GAGGAGGGAG CAGCAGCTGG CGGAGCGGGA GATTAACGTG 1380
TTGGAGCGTG AGCTCAACAT CCTCATCTTC CAACAAAACA AGGACAAGCC CAATGTTAAG 1440
AAACGGAAGG GCAAATTCAA ACGCAGCCGC CTCAAGCTCA AAGATGGAAA CCGCATCAGC 1500
TTACCCTCAG ATTTTCAGCA CAAAATCACA GTTCAGGCCT CTCCTACGAT GGACAAGAGA 1560
CGAAGTCTCA ATAGCACAAA CTCAAGCCCT CCCAGCAGCC CGACTCTGAT CCCTCGCCTC 1620
CGTGCTATTC AATTGAGCCA CAGAGGTGAC ACTAGCCGAA AGGGCAGTAT GTTTGTCTAT 1680
CACCAGGATG TGGATGTCAC AAGCGAGTGT AAACCTCCTA GCGTGTTTAG CAAGAAAGTG 1740
ACTCTGGATG AGAGCAACAG GACATGGGGA CGAAGCACCA ATTACAAACC GGAGGAGTTT 1800
GAAGATGTCA AGAAAGGGTT TAAGAAGAAG GGTCGCACAT GGGGACCAAG CTCTGTGCAA 1860
ACGAAGGAAA GAGGAAATGG TGCTGAAAGA ATTCGTCCTC TTTCAGATGG AAGCAGTCCT 1920
TGGTCCACCA GTCTATTGAA GTCTCAGAAA TCTGTTCCAT TAGCTGCATT GTTTGCAGAC 1980
CAGGGGACCA ATAAAGATGA AGCAGGCTCT GCTGATTCAT CCGACAACAA ACCAAAGCAA 2040
CTCAAGTTCC CCAACCAGGT GTATATCGAT CTACCTCTGT GGAAAGATGA ACCAGGCGAG 2100
AACCAGAGTT CAACAGGAGG AGGAGCTGAG AGCCAGGAGG ACCCAACCAC CTCCACCAGC 2160
TCCACCAGCA CCACCCCACA GCACACACCC ACCAACAGCC TGAAGCGCAG CACCACCCGC 2220
CGCCGCACTG ACTCTGTTCT CTACGGCTGT GCCTCAATCC TGGCATCTGT CGCATTCGGC 2280
TTTGACCTGC AAGAGATCTG TAAGAACCCT GCCAATGAAG AACCTGAGCC TCGTGAGGAG 2340
AAGAAGAAAA AAGAAGGCCT GTTTCAGCGC GCCACTCGCT TCCGCCGCAG CACCAGCCCT 2400
CCAGGCGGAC GTTCGCGAAA AGATGAGATT TCCACAGCAC CCGTAAACCT GCTCGCCATG 2460
TCATCCATTT CTGAGTGCAA CTCCACCAAG TGCCTCCTGC AGTCAGATTT TGAGGGTCCT 2520
GGGTTTAACC TGGTTAACGA GACTGGCATT TCGCCTCAGA GTAATGGTAC TGGTGAAGGA 2580
CTGCACTTAA CACCTGTACA AGAGCTCTCT TCTGGAGCCA ACTCTCGACT GAGGAGGAAA 2640
AAGTCCAGTC CGGCTGTGTG CCAGAACGTC AATGGAAGCA GCAACTCTCC AGTCAGTCCA 2700
GCTGATTCTT CTACCACTTC TACAAAGAAG AAGGCTGACA AAGAGCCTCC TCAAGACAAG 2760
CAGACCTCTG GGGAATCAGT ATCTCGACCC AGACCGCTTT CCCTCAGAGG CAAATCTCAT 2820
TCCTGGAGTC TTCTGAAGAG TCGCAATAAG AGCTATTCTC TGGGACACTA CTCTGGGGAG 2880
AAGAGTGTCC AAAACCTGGA CATGCTGCTC CCTGCTGAGG TCAAAACCGG CTGCTCATTA 2940
CTGGACATGG ACACAGAGGG TCAAAAACGA GACTGCACCG TTCCCCTCTG CCGGATACAG 3000
AGCACACCAA GTCGGGGGTC TGTATTCGAA CTGGAGAAAC AGTTTTTATC CTGA 3054
Domain Profile
S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60
         l+e+ig g fgkvy+++w+ +evavK++r++  e  k++++++++eakl+s+l+hpnii+
Q: 127   LQEIIGVGGFGKVYRGTWKVQEVAVKAARQDPDEdiKATADSVKQEAKLFSMLQHPNIIK  186
         589****************************99989999*********************
S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120
         l Gvcleepnl+lvmey++gg L+++l +   r+i+++ lv+wa+qiArGm+YLh+ea++
Q: 187   LEGVCLEEPNLCLVMEYARGGTLNRALTG---RRIPPHILVNWAVQIARGMQYLHEEAVV  243
         *****************************...9***************************
S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173
         +iihrdLks+n+Ll       +   ktlki+dFG are++k+tkmsaagt+ wmaPEv+k
Q: 244   PIIHRDLKSSNILLlekiendDIGRKTLKITDFGLAREWHKTTKMSAAGTYSWMAPEVIK  303
         **************9**99988889***********************************
S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233
         ++ +s+ sDvwSygv+LWellt+e+Py++++ la+ay+va+++l+lpips+cpe+++kLm
Q: 304   SSLFSKGSDVWSYGVLLWELLTGEIPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLM  363
         ************************************************************
S: 234   kecwnedpekRpsfseivksl  254
         +ecw++dp+ Rpsf+ i+++l
Q: 364   EECWEQDPHIRPSFAAILEQL  384
         *****************9986
Domain Sequence
(FASTA)
LQEIIGVGGF GKVYRGTWKV QEVAVKAARQ DPDEDIKATA DSVKQEAKLF SMLQHPNIIK 60
LEGVCLEEPN LCLVMEYARG GTLNRALTGR RIPPHILVNW AVQIARGMQY LHEEAVVPII 120
HRDLKSSNIL LLEKIENDDI GRKTLKITDF GLAREWHKTT KMSAAGTYSW MAPEVIKSSL 180
FSKGSDVWSY GVLLWELLTG EIPYRGIDGL AVAYGVAVNK LTLPIPSTCP EPFAKLMEEC 240
WEQDPHIRPS FAAILEQL 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00353
EKS-ANC-00364
EKS-BOT-00378
EKS-CAE-00302
EKS-CAJ-00380
EKS-CAF-00378
EKS-CHH-00044
EKS-CII-00213
EKS-CIS-00134
EKS-DIO-00059
EKS-EQC-00376
EKS-GAM-00227
EKS-GAG-00324
EKS-GAA-00459
EKS-GOG-00368
EKS-LOA-00384
EKS-MAM-00377
EKS-MAE-00045
EKS-MEG-00310
EKS-MIM-00054
EKS-MOD-00367
EKS-MUM-00410
EKS-MUP-00377
EKS-ORN-00484
EKS-ORC-00354
EKS-OTG-00381
EKS-PAT-00358
EKS-PES-00340
EKS-PEM-00200
EKS-PTV-00099
EKS-RAN-00392
EKS-SAH-00346
EKS-SOA-00062
EKS-SUS-00330
EKS-TAG-00454
EKS-TAR-00481
EKS-TEN-00489
EKS-XIM-00475
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0000186; P:activation of MAPKK activity
GO:0000165; P:MAPK cascade
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR015785; MAPKKK9/10/11-like.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR001452; SH3_domain.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00018; SH3_1; 1.
SMARTs
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50002; SH3; 1.
Prints
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013