EKS-DAR-00071

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00071

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	419.2	1.5E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSDARP00000109027

UniProt Accession

Q7T3L7;

Protein Name

Protein Synonyms/Alias

Cell division control protein 2; Cell division cycle 2;

Gene Name

cdk1

Gene Synonyms/Alias

cdk1; cdc2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000087554	ENSDARP00000109027	ENSDART00000122407

Organism

Danio rerio

Functional Description

Protein Length

302

Protein Sequence
(FASTA)

MDDYLKIEKI GEGTYGVVYK GRNKTTGQVV AMKKIRLESE EEGVPSTAVR EISLLKELQH 60

PNVVRLLDVL MQESKLYLVF EFLSMDLKKY LDSIPSGEFM DPMLVKSYLY QILEGILFCH 120

CRRVLHRDLK PQNLLIDNKG VIKLADFGLA RAFGVPVRVY THEVVTLWYR APEVLLGASR 180

YSTPVDLWSI GTIFAELATK KPLFHGDSEI DQLFRIFRTL GTPNNEVWPD VESLPDYKNT 240

FPKWKSGNLA NTVKNLDKNG IDLLMKMLIY DPPKRISARQ AMTHPYFDDL DKSSLPASNL 300

KI 302

Nucleotide Sequence
(FASTA)

ATGGATGACT ATCTGAAGAT AGAGAAAATT GGTGAAGGTA CGTATGGTGT AGTATATAAG 60

GGCAGGAATA AAACCACAGG ACAGGTGGTG GCGATGAAGA AGATCCGTCT GGAGAGTGAG 120

GAGGAAGGCG TTCCCAGCAC TGCTGTCAGA GAAATCTCCC TCCTCAAGGA GCTCCAGCAC 180

CCAAACGTTG TACGCCTGCT AGATGTGCTG ATGCAGGAAT CCAAATTATA TCTAGTTTTT 240

GAGTTTCTGT CCATGGATCT GAAGAAATAT TTGGACTCCA TCCCATCAGG CGAATTCATG 300

GATCCTATGT TGGTCAAGAG TTACCTTTAT CAGATCCTGG AGGGGATTCT GTTCTGCCAC 360

TGTCGCAGGG TTCTGCATCG AGACCTGAAG CCCCAGAACC TGCTTATCGA CAATAAAGGT 420

GTAATTAAAC TGGCAGATTT CGGCTTAGCC CGTGCCTTTG GGGTCCCAGT AAGAGTCTAT 480

ACTCATGAGG TGGTCACTCT GTGGTACAGA GCTCCAGAAG TGCTGCTGGG GGCTTCACGC 540

TATTCCACAC CTGTAGATCT CTGGAGTATT GGCACCATCT TTGCTGAACT CGCCACCAAG 600

AAACCTCTCT TCCATGGAGA CTCCGAAATA GACCAACTCT TTAGGATCTT CAGGACTCTG 660

GGGACCCCTA ACAATGAGGT CTGGCCAGAT GTTGAGTCTC TGCCAGACTA TAAGAATACC 720

TTCCCAAAGT GGAAATCTGG GAATCTGGCC AACACTGTGA AAAACCTGGA CAAGAACGGC 780

ATCGACCTTC TCATGAAAAT GCTGATTTAT GACCCCCCTA AGAGGATTTC GGCACGACAA 840

GCAATGACAC ATCCGTATTT TGACGATTTG GATAAGAGCA GTCTTCCAGC CAGCAACCTC 900

AAGATATAA 909

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+n+

Q: 4     YLKIEKIGEGTYGVVYKGRNKTTGQVVAMKKIRLESEEEGVPSTAVREISLLKELQHPNV  63

         779*********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v+Ll+v++ +++klyLvfefl++dLkk+l++ ++   +++  vks+l+q+leg+ ++H +

Q: 64    VRLLDVLM-QESKLYLVFEFLSMDLKKYLDSIPSGeFMDPMLVKSYLYQILEGILFCHCR  122

         ********.99********************99874789999******************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf++p++ yt+evvTlwYraPe+Llga++Ys

Q: 123   RVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGASRYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vD+Ws+g i+ael+t+kplf+g+seidql+rif++lgtp+++vwp+v++lp+yk++fp

Q: 183   TPVDLWSIGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNEVWPDVESLPDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l+++vk+l+++++dll k+l +dp kRisa++a++h+yf

Q: 243   KWKSGNLANTVKNLDKNGIDLLMKMLIYDPPKRISARQAMTHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YLKIEKIGEG TYGVVYKGRN KTTGQVVAMK KIRLESEEEG VPSTAVREIS LLKELQHPNV 60

VRLLDVLMQE SKLYLVFEFL SMDLKKYLDS IPSGEFMDPM LVKSYLYQIL EGILFCHCRR 120

VLHRDLKPQN LLIDNKGVIK LADFGLARAF GVPVRVYTHE VVTLWYRAPE VLLGASRYST 180

PVDLWSIGTI FAELATKKPL FHGDSEIDQL FRIFRTLGTP NNEVWPDVES LPDYKNTFPK 240

WKSGNLANTV KNLDKNGIDL LMKMLIYDPP KRISARQAMT HPYF 284

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division
GO:0009794	; P:regulation of mitotic cell cycle, embryonic

KEGG

dre:80973

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013