EKS-DAR-00595

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00595

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	417.8	3.5E-125	61	313	253

Status

Unreviewed

Ensembl Protein

ENSDARP00000109716

UniProt Accession

E7EXD4;

Protein Name

Protein Synonyms/Alias

Gene Name

plk2a

Gene Synonyms/Alias

plk2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000090752	ENSDARP00000109716	ENSDART00000125299

Organism

Danio rerio

Functional Description

Protein Length

678

Protein Sequence
(FASTA)

MDILRTIAHH HHHHQPVNSG KMCEHTHSRA SESRRRKLED TSYATQEMSR IVTDSATGKC 60

YCRGKVLGKG GFAKCYEFTD LSTGKMYAAK IIPHTRVSKP HQREKIDREI ELHRALHHKH 120

IVQFYHHFED KDNIYILLEY CSRRSLAHIL KARKVLTEPE VRYYLKQIVS GLKYLHEQEI 180

LHRDLKLGNF FINEFMELKV GDFGLAAKLE PLENRRRTIC GTPNYLSPEV LNKQGHGCES 240

DVWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSTPS SLSPQAKHLI SSMLAKNPVD 300

RPQLCDILRH DFFCQGFTPD RLSANCCHAA PDIHHTSPAK SFFKKAAATL FGGKKDKAKY 360

LETRNKPAKE EEEININRLC IDLRKTSVSP QPCRQTLENN KPSIPSAGKP AVLTKDASSK 420

QHIRDSIRMI VRGTLRSCSS SSSECLENCT VGSVADTVAR VLQGCLENMS EANNISKESM 480

NSSFQWVTKW VDYSNKYGFG YQLSDHTVGV LFNNGTHMSL LSDKKTVHYY AELGQCSVFL 540

TSEAPEQFVG QATILKYFAH YMEENLMDGG DLPNITDANK PRLYLLQWLK SDQALMMLFN 600

DGTFQVNFYH DHTKIILCNH REEYLLTYIN EERVSTTLRL STLLASGCSA DLQSRMDYAL 660

NMLLQRCGDV TDGKSRML 678

Nucleotide Sequence
(FASTA)

ATGGACATAC TCAGGACTAT AGCACACCAC CACCATCACC ACCAGCCTGT AAATAGCGGG 60

AAGATGTGTG AACACACACA CAGCAGAGCC AGTGAAAGCA GACGAAGGAA ATTAGAGGAT 120

ACTTCATATG CCACTCAAGA AATGTCACGC ATTGTCACGG ATTCAGCCAC TGGGAAATGT 180

TACTGTAGAG GGAAAGTTTT AGGCAAGGGC GGTTTTGCCA AGTGCTATGA ATTTACAGAT 240

CTAAGCACAG GCAAAATGTA TGCAGCCAAA ATCATTCCAC ACACACGCGT TTCCAAACCT 300

CACCAAAGGG AAAAGATTGA TAGAGAAATC GAATTGCACA GAGCCCTGCA TCACAAACAC 360

ATTGTTCAGT TCTACCATCA CTTCGAGGAC AAAGACAACA TTTACATCCT ACTTGAATAC 420

TGCAGCAGAC GGTCACTAGC ACACATTCTC AAGGCCCGAA AAGTGCTTAC AGAACCAGAG 480

GTTCGGTACT ACTTAAAACA GATTGTCTCG GGACTGAAGT ATCTACATGA GCAAGAGATT 540

CTGCACAGAG ACCTTAAACT AGGTAACTTC TTCATCAATG AATTTATGGA ACTGAAGGTT 600

GGAGACTTTG GTCTGGCTGC AAAACTGGAG CCGCTTGAGA ACCGTCGAAG AACAATATGT 660

GGGACACCAA ACTACTTGTC ACCTGAAGTC CTCAACAAGC AAGGGCACGG TTGTGAATCT 720

GATGTCTGGG CCCTCGGCTG TGTGATGTAT ACCATGCTGT TGGGAAGACC CCCATTTGAA 780

ACCACAAACC TTAAAGAAAC GTATCGATGT ATACGAGAAG CACGATACTC AACGCCATCA 840

TCTTTGTCGC CTCAAGCCAA GCATCTCATT AGCAGTATGT TGGCCAAGAA TCCTGTGGAT 900

AGGCCACAAT TGTGTGATAT TCTTCGCCAT GACTTTTTCT GCCAGGGTTT CACACCAGAC 960

AGACTGTCTG CTAACTGTTG TCATGCAGCC CCAGACATCC ACCACACAAG TCCTGCTAAG 1020

AGTTTCTTCA AGAAAGCTGC AGCTACCCTG TTTGGTGGGA AGAAGGACAA AGCAAAGTAT 1080

TTGGAGACTC GAAATAAGCC TGCCAAGGAA GAGGAAGAAA TAAACATAAA CAGACTTTGC 1140

ATAGACCTTC GGAAAACATC AGTTAGTCCT CAACCCTGCA GACAAACCCT TGAGAACAAT 1200

AAACCCTCCA TTCCGTCTGC TGGAAAACCA GCTGTCTTGA CAAAGGACGC CAGCAGCAAA 1260

CAGCACATTA GAGACAGCAT TCGAATGATA GTGCGAGGGA CTCTTAGGAG CTGCAGTAGC 1320

AGCAGCAGCG AATGTCTTGA GAACTGCACG GTGGGAAGCG TTGCAGACAC CGTGGCCAGA 1380

GTACTACAAG GCTGTCTCGA GAACATGTCG GAAGCTAATA ACATATCAAA AGAAAGCATG 1440

AACAGCAGCT TCCAGTGGGT GACAAAGTGG GTGGACTATT CCAACAAGTA CGGTTTTGGC 1500

TATCAGTTGT CAGATCACAC AGTCGGCGTT CTCTTCAACA ATGGCACTCA CATGAGCCTG 1560

CTGTCGGACA AAAAGACTGT GCATTACTAT GCAGAGCTGG GACAATGTTC AGTCTTCTTA 1620

ACAAGTGAAG CTCCAGAGCA GTTTGTTGGC CAGGCCACCA TCCTAAAATA CTTTGCCCAC 1680

TACATGGAGG AGAATCTGAT GGATGGAGGA GATTTACCCA ATATTACGGA TGCAAACAAA 1740

CCAAGATTGT ACCTTCTTCA GTGGCTCAAA TCTGATCAAG CATTGATGAT GCTCTTCAAT 1800

GACGGCACTT TCCAGGTGAA CTTTTACCAC GATCACACCA AGATAATCCT GTGCAATCAC 1860

CGAGAGGAAT ACTTACTGAC ATACATCAAC GAGGAACGCG TGTCCACCAC GCTGCGACTC 1920

AGCACTCTGC TTGCGTCTGG ATGCTCAGCG GATCTGCAAA GTCGCATGGA CTATGCACTT 1980

AACATGCTGT TGCAGAGATG TGGAGACGTA ACTGATGGGA AATCGAGGAT GCTTTGA 2037

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++++a+k++p++++ k++qrek+++eie+hr l+hk+

Q: 61    YCRGKVLGKGGFAKCYEFTDLSTGKMYAAKIIPHTRVSKPHQREKIDREIELHRALHHKH  120

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv++y++fedk+n+y++le+csrrsla++lk+rk+ltepevryyl+qivsglkylhe++i

Q: 121   IVQFYHHFEDKDNIYILLEYCSRRSLAHILKARKVLTEPEVRYYLKQIVSGLKYLHEQEI  180

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne +e+k+gdfGla++le+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 181   LHRDLKLGNFFINEFMELKVGDFGLAAKLEPLENRRRTICGTPNYLSPEVLNKQGHGCES  240

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+W+lGc++yt+l+G+PPfet++lkety++i++a+ys Pssls++ak+li+++l+k+P +

Q: 241   DVWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSTPSSLSPQAKHLISSMLAKNPVD  300

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp l ++l+++f+

Q: 301   RPQLCDILRHDFF  313

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEFTD LSTGKMYAAK IIPHTRVSKP HQREKIDREI ELHRALHHKH 60

IVQFYHHFED KDNIYILLEY CSRRSLAHIL KARKVLTEPE VRYYLKQIVS GLKYLHEQEI 120

LHRDLKLGNF FINEFMELKV GDFGLAAKLE PLENRRRTIC GTPNYLSPEV LNKQGHGCES 180

DVWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSTPS SLSPQAKHLI SSMLAKNPVD 240

RPQLCDILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:100148413

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013