EKS-DAR-00600

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DAR-00600

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	470.4	6.0E-141	209	522	314

Status

Unreviewed

Ensembl Protein

ENSDARP00000122944

UniProt Accession

Q5RHV3;

Protein Name

Protein Synonyms/Alias

Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2;

Gene Name

dyrk2

Gene Synonyms/Alias

dyrk2; CH211-266A5.8-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSDARG00000094646	ENSDARP00000122944	ENSDART00000145069

Organism

Danio rerio

Functional Description

Protein Length

587

Protein Sequence
(FASTA)

MLTKKPCAAA AAYPTGKGGD ICQQSSPGLG IGGPRAGAGT ETTSPVTLPP LRNSNSLTAG 60

GNKYTMNDHL HVGNHQQIHV QQLFEENSNK RTVLTSQPNG LTPVGRAGLA MPEKQQEISQ 120

CRQGSSTSIK STESKPKPAP LTPEQAMKQY MSKLSVFEHQ EILSYTEIYF IGPNAKKRQG 180

VVGGSNNGGY DDDQGSYIHV PHDHIAYRYE VLKVIGKGSF GQVVKAYDHK NHQHVALKMV 240

RNEKRFHRQA AEEIRILEHL RKQDKDSTMN VIHMLENFTF RNHICMTFEL LSMNLYELIK 300

KNKFQGFSLP LVRKFAHSIL QCLESLHKNR IIHCDLKPEN ILLKQQGRSG IKVIDFGSSC 360

YEHQRVYTYI QSRFYRAPEV ILGARYGMPI DMWSLGCILA ELLTGYPLLP GEDEGDQLAC 420

VIEMLGMPSE KLLESSKRAK NFISSKGHPR YCTVTTLPDA SVVLNGGRSR RGKLRGPPGS 480

RDWVTALKGC DDPLFLDFLK QCLEWDPSQR MTPSQALRHP WLRRRLPKPP TEKTTVKRIT 540

EGTGAITSIS KLPPPSGSAT KLRTNLAQMT DANGNIQQRT VLPKLVS 587

Nucleotide Sequence
(FASTA)

ATGTTAACTA AGAAACCCTG CGCTGCGGCT GCTGCCTACC CGACTGGCAA AGGGGGTGAT 60

ATTTGCCAGC AGTCTTCCCC CGGACTGGGC ATCGGGGGTC CCCGTGCTGG AGCAGGCACT 120

GAAACCACAT CACCCGTCAC ATTACCACCA CTCAGGAACA GCAACTCTCT CACGGCTGGA 180

GGCAATAAGT ACACAATGAA TGACCATCTG CATGTTGGGA ATCACCAGCA GATCCACGTT 240

CAACAACTGT TTGAGGAGAA CAGCAACAAA CGAACAGTGT TAACTTCGCA GCCCAATGGC 300

TTGACACCTG TAGGTAGAGC AGGTCTAGCC ATGCCGGAGA AGCAGCAAGA AATCAGCCAG 360

TGTCGACAAG GCAGCTCAAC TTCTATCAAA TCAACTGAAA GCAAACCTAA GCCAGCACCT 420

TTGACTCCTG AGCAGGCCAT GAAACAGTAC ATGTCTAAGC TTTCAGTATT TGAACACCAA 480

GAGATCCTCA GCTACACTGA GATCTATTTT ATAGGTCCAA ATGCAAAGAA AAGACAAGGT 540

GTAGTTGGGG GGTCAAACAA CGGAGGTTAT GATGATGATC AGGGCTCCTA CATTCATGTG 600

CCTCATGACC ATATAGCATA TAGGTATGAG GTACTAAAAG TTATTGGTAA AGGCAGTTTT 660

GGCCAAGTGG TAAAAGCCTA TGACCACAAG AACCATCAGC ATGTGGCTCT GAAAATGGTG 720

CGTAACGAAA AGCGTTTCCA TCGCCAAGCA GCTGAGGAAA TTCGGATTCT GGAACACTTA 780

CGCAAGCAGG ATAAGGACTC CACCATGAAT GTCATTCACA TGCTGGAGAA CTTTACATTC 840

CGCAACCATA TTTGCATGAC GTTTGAGTTG CTCAGCATGA ACCTCTATGA GCTCATCAAG 900

AAAAACAAGT TTCAGGGGTT TAGTTTGCCA CTAGTGCGCA AGTTTGCACA CTCTATATTG 960

CAGTGTTTGG AATCCTTGCA CAAGAACAGA ATCATTCACT GCGATCTCAA GCCTGAGAAT 1020

ATCCTTCTGA AGCAGCAGGG TCGAAGTGGG ATAAAAGTGA TTGACTTTGG CTCCAGCTGC 1080

TATGAGCATC AACGGGTCTA CACTTACATC CAATCACGCT TTTACAGGGC CCCAGAGGTC 1140

ATTCTGGGTG CTAGATATGG GATGCCAATT GATATGTGGA GCTTAGGTTG TATCTTAGCG 1200

GAATTACTTA CAGGGTACCC TCTGTTGCCT GGAGAAGATG AAGGGGACCA ACTAGCATGT 1260

GTCATAGAGA TGCTAGGTAT GCCCTCTGAG AAGTTACTGG AATCATCCAA GAGAGCCAAA 1320

AATTTCATCA GTTCAAAGGG ACATCCCCGT TACTGCACAG TCACAACCTT ACCTGATGCC 1380

TCTGTGGTCC TGAATGGGGG AAGGTCACGT AGGGGCAAAC TCAGAGGTCC ACCAGGCAGC 1440

AGGGACTGGG TGACAGCACT AAAGGGCTGT GATGACCCTC TCTTCTTGGA CTTCCTCAAA 1500

CAGTGTCTAG AGTGGGACCC GTCCCAGCGT ATGACCCCTA GTCAGGCCCT TCGCCACCCG 1560

TGGCTCAGAA GACGCTTGCC AAAACCTCCC ACGGAGAAAA CAACTGTAAA GCGGATCACT 1620

GAGGGTACTG GTGCTATAAC TTCAATCTCC AAATTACCTC CCCCTTCTGG CTCAGCCACA 1680

AAATTAAGGA CTAACCTGGC ACAAATGACT GATGCCAATG GGAATATACA ACAAAGGACA 1740

GTGTTGCCAA AATTAGTCAG CTGA 1764

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqVvka+d+k++++va+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 209   YEVLKVIGKGSFGQVVKAYDHKNHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDST  268

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le f+frnh+c++fells+nLyel+kknkf+g+sl lvrk+a++il++L+ L++

Q: 269   MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLESLHK  328

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         ++iiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg++y

Q: 329   NRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-VYTYIQSRFYRAPEVILGARYG  387

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWSlGc+laEl+tG+pL+pGe+e dqla+++e+lg+p+eklle++k+ak+f+++k+

Q: 388   MPIDMWSLGCILAELLTGYPLLPGEDEGDQLACVIEMLGMPSEKLLESSKRAKNFISSKG  447

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  d +++l+ ++++++k r +p+s+++++alk ++d lf d+lk++le+dp

Q: 448   HPRYCTVTTLPDASVVLNGGRSRRGKLRGPPGSRDWVTALKGCDDPLFLDFLKQCLEWDP  507

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+tp++al+hp++

Q: 508   SQRMTPSQALRHPWL  522

         **************6

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVVKAYD HKNHQHVALK MVRNEKRFHR QAAEEIRILE HLRKQDKDST 60

MNVIHMLENF TFRNHICMTF ELLSMNLYEL IKKNKFQGFS LPLVRKFAHS ILQCLESLHK 120

NRIIHCDLKP ENILLKQQGR SGIKVIDFGS SCYEHQRVYT YIQSRFYRAP EVILGARYGM 180

PIDMWSLGCI LAELLTGYPL LPGEDEGDQL ACVIEMLGMP SEKLLESSKR AKNFISSKGH 240

PRYCTVTTLP DASVVLNGGR SRRGKLRGPP GSRDWVTALK GCDDPLFLDF LKQCLEWDPS 300

QRMTPSQALR HPWL 314

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

dre:557602

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013