EKS-EQC-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	6.8E-126	192	478	287

Status

Unreviewed

Ensembl Protein

ENSECAP00000000141

UniProt Accession

F7CD19;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000000138	ENSECAP00000000141	ENSECAT00000000199

Organism

Equus caballus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 120

EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTGCAAAGTT GGCGTTCGCC GTCTTTCTTA TCTCCTGTTC TTCAGGTGCT 60

ATACTTGGTA GATCAGAAAC TCAGGAGTGT ATTTTCTATA ATGCTAATTG GGAAAGAGAC 120

AGAACCAATC GAACTGGTGT CGAACCCTGT TATGGTGACA AAGATAAACG GCGACATTGT 180

TTTGCTACCT GGAAGAATAT TTCTGGCTCC ATTGAAATAG TGAAGCAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG CCCTGAAGTA 300

TATTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAGGT TTTCCTATTT TCCGGAGATG 360

GAAGTCACAC AGCCTACTTC GAATCCAGTT ACACCTAAGC CACCCTATTA CAACATCTTG 420

CTCTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATTTGTGC ATTTTGGGTG 480

TACAGGCATC ATAAGATGGC CTACCCTCCC GTACTTGTTC CAACTCAAGA CCCAGGACCA 540

CCCCCACCTT CTCCATTACT AGGTTTGAAG CCGCTGCAGT TATTAGAAGT GAAAGCAAGA 600

GGAAGATTTG GTTGTGTCTG GAAAGCCCAG TTGCTTAATG AATACGTGGC TGTGAAAATA 660

TTTCCAATAC AGGACAAACA GTCATGGCAA AATGAATATG AAGTCTATAG TTTGCCTGGA 720

ATGAAGCATG AGAACATATT ACAGTTCATT GGTGCAGAAA AACGAGGCAC CAGCGTTGAT 780

GTGGATCTCT GGCTAATCAC AGCGTTTCAT GAAAAGGGTT CACTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAATTGTGT CATATTGCAG AAACCATGGC TAGAGGATTG 900

GCATATTTAC ATGAGGATAT ACCTGGCCTA AAAGATGGCC ACAAACCCGC CATATCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACAGCTTG CATTGCTGAC 1020

TTTGGGTTGG CGTTAAAGTT TGAGGCTGGC AAGTCTGCAG GTGATACCCA TGGACAGGTT 1080

GGTACCCGGA GGTATATGGC TCCAGAGGTA TTAGAGGGTG CTATAAACTT CCAAAGGGAT 1140

GCATTTTTGA GGATAGATAT GTACGCCATG GGATTAGTCC TGTGGGAACT GGCTTCTCGC 1200

TGTACTGCCG CAGATGGACC TGTAGATGAG TACATGTTGC CATTTGAGGA GGAAATTGGC 1260

CAGCATCCAT CTCTTGAAGA CATGCAGGAA GTTGTTGTGC ATAAAAAAAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACACGCTGGA ATGGCAATGC TTTGTGAAAC AATAGAAGAA 1380

TGTTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCTGGCT GTGTAGGTGA AAGAATTACT 1440

CAGATGCAAA GACTAACAAA TATCATTACC ACAGAGGACA TTGTAACAGT GGTCACGATG 1500

GTGACAAACG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0009952	; P:anterior/posterior pattern specification
GO:0030509	; P:BMP signaling pathway
GO:0007368	; P:determination of left/right symmetry
GO:0048706	; P:embryonic skeletal system development
GO:0001702	; P:gastrulation with mouth forming second
GO:0007498	; P:mesoderm development
GO:0043084	; P:penile erection
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0060011	; P:Sertoli cell proliferation
GO:0023014	; P:signal transduction by phosphorylation
GO:0042713	; P:sperm ejaculation
GO:0007283	; P:spermatogenesis

KEGG

ecb:100049823

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013