EKS-EQC-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/Trio	369.2	1.3E-110	345	598	254

Status

Unreviewed

Ensembl Protein

ENSECAP00000000117

UniProt Accession

F7CZE9;

Protein Name

Protein Synonyms/Alias

Gene Name

SPEG

Gene Synonyms/Alias

SPEG;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000000174	ENSECAP00000000117	ENSECAT00000000161

Organism

Equus caballus

Functional Description

Protein Length

1447

Protein Sequence
(FASTA)

HAGVYKSVIA NKLGKAACYA HLYVTDVVPG PPDGAPQVVA VTGRMITLTW HPPRSLDMAI 60

DPDALTYTVQ HQVLGSDQWT ALATGLREPG WAATGLRKGV QHIFRVLSTT IKSSSKPSPP 120

SEPVQLLEHG PPLDEAPAVL DKPDIVYVVE GQPASVTVTF NHVEAQVVWR SCRGALLEAR 180

AGVYELSQPD DDQYCLRICR VSRRDVGPLT CTARNRHGTQ ACSVTLELAE APRFESIMED 240

VEVGAGETAR FAVVVEGKPL PDIMWFKRRA KVLSESSHAS FVYEDECSLV VLSTPRMEGV 300

YTCTARNLAG EVSCKAELAV PQAAMEVEGV GEDEDQRGRR LSDFYDIQQE IGRGAFSYLR 360

RVVERSSGLE FAAKFIPSQA KPKASAWREA RLLARLQHDC VLYFHEAFER RRGLVIVTEL 420

CTEELLERMA RKPTVCESEI RTYMRQVLEG ICYLHQNHVL HLDVKPENLL VWDGAEGEEQ 480

VRICDFGNAQ ELTLGEPQYC QYGTPEFVAP EIVNQTPVSG VTDIWPVGVV AFLCLTGISP 540

FVGENDRTTL MNIRNYNVAF EETTFLSLSR EARGFLIKVL VRDRLRPTAE ETLEHPWFKT 600

QAKGAEVSTD HLKLFLSRRR WQRSQISYKC HLVLRPIPEL LRAPPERVWV AVPRRPPPSG 660

GLSSSSDSEE EELEELPSVP RPLQPEFSGS RVSLTDIPTE EEALGAPEAG AATPMYCQEQ 720

GRAPSQDQEG RSLRLYLSQS RDPRLDSIPG GGELRGGSSA ESALPRAGPE RAGAFIRQHP 780

WSCRSAGAPA RGPTRLTRGG LGEGEYAQRL QALRQRLLRG GPEDGKVSGL RGPLLESLGG 840

RARDPRLARA ASKEQQLFPG GGGARGRHRR AGAPLEIPVA RLGARRLQES PSLTRPRLQA 900

CTTPRGSANP SAPTHTLCTD HAVTPAARPR AKPPADPWSP STGAQAPPGS NLESEAVFEA 960

KFKRSRDVEG SGRSRLRWGF SRLRKDKGSH PSLSASIQED LGSLKTRVFA LPPDFPPVFH 1020

IKLKDQVLLE GEAATLLCLP AACPTPHISW MKDKQSLQSE PSVIIVSCKD GRQLLSIPRV 1080

GKRHAGLYEC SATNVLGSIT SSCTVAVARI PGKLAPPEVP QTYQDTALVL WKPGDSRAPC 1140

TYTLERRVDG ESSWHPVSSG IPNCYYNVTH LPVGVTVRFR VACANRAGQG PFSNPSEKCP 1200

GHSKGRFGVV RACRENATGR TFVAKIVPYA AEGKRQVLQE YEVLRTLHHE RLMALHEAYI 1260

TPRYLVLIAE SCGNRELLCG LSDRFRYSED DVATYVVQLL QGLDYLHGRH VLHLDIKPDN 1320

LLLAPDNALK IVDFGSAQPY NPQALRPLGH RTGTLEFMAP EMVKGEPIGS ATDIWGVGVL 1380

TYIMSRPSLQ DCLAHPWLQD AYLMKLRRQT LTFTTNRLKE FLGEQRRRRA EAATRHKVLL 1440

RSYPGSP 1447

Nucleotide Sequence
(FASTA)

CATGCCGGCG TCTACAAGAG TGTCATCGCC AACAAGCTGG GCAAAGCTGC CTGCTATGCC 60

CACCTCTATG TCACAGATGT GGTTCCAGGC CCCCCGGATG GTGCCCCACA GGTGGTGGCT 120

GTGACTGGGA GGATGATCAC ACTCACATGG CACCCCCCCA GGAGTCTGGA CATGGCCATT 180

GACCCGGACG CCCTGACCTA CACTGTGCAG CACCAGGTGC TCGGCTCAGA CCAGTGGACA 240

GCGTTGGCCA CAGGCCTGCG GGAGCCTGGG TGGGCGGCCA CAGGGCTGCG TAAGGGGGTC 300

CAGCACATCT TCCGGGTCCT CAGCACCACC ATCAAGAGCA GCAGCAAGCC CTCGCCCCCC 360

TCCGAGCCGG TGCAGCTGCT GGAGCACGGC CCACCCCTGG ATGAGGCACC TGCTGTGCTG 420

GACAAGCCAG ACATCGTGTA TGTGGTGGAA GGCCAGCCTG CCAGTGTCAC CGTCACCTTC 480

AACCATGTGG AGGCCCAGGT CGTCTGGAGG AGCTGCCGAG GCGCCCTCCT GGAGGCACGG 540

GCAGGTGTGT ATGAGCTGAG CCAGCCCGAT GACGACCAGT ACTGCCTTCG GATCTGCCGG 600

GTGAGCCGCC GGGACGTGGG GCCCCTCACC TGCACTGCTC GCAACCGCCA CGGCACGCAG 660

GCCTGCTCGG TCACACTGGA GCTGGCAGAG GCCCCTCGGT TTGAGTCCAT CATGGAAGAC 720

GTGGAGGTGG GGGCTGGGGA GACTGCGCGC TTCGCAGTGG TGGTTGAGGG GAAACCGCTG 780

CCGGACATCA TGTGGTTCAA GAGAAGAGCA AAGGTATTGT CAGAGAGCAG CCACGCGAGC 840

TTTGTGTACG AGGACGAGTG CTCCCTGGTG GTGCTCAGCA CCCCCAGGAT GGAAGGCGTC 900

TACACCTGCA CCGCCCGGAA CTTGGCTGGT GAAGTCTCCT GCAAAGCAGA GTTGGCTGTG 960

CCTCAGGCAG CTATGGAGGT GGAAGGGGTC GGGGAAGATG AGGACCAGAG AGGAAGGAGA 1020

CTCAGCGACT TCTATGACAT CCAGCAGGAG ATCGGCAGGG GCGCCTTCTC CTACCTGCGC 1080

CGCGTGGTGG AGCGCAGCTC CGGCCTGGAG TTTGCGGCCA AGTTCATCCC CAGCCAGGCC 1140

AAGCCCAAGG CATCGGCGTG GCGGGAGGCC CGGCTGCTGG CCCGGCTCCA GCATGACTGC 1200

GTCCTCTACT TCCATGAGGC CTTCGAGAGG CGCCGGGGGC TGGTCATTGT CACTGAGCTA 1260

TGCACAGAGG AGCTGCTGGA GCGAATGGCC AGGAAACCCA CCGTGTGTGA GTCTGAGATC 1320

CGGACCTACA TGCGGCAGGT GCTGGAGGGA ATATGTTACC TGCACCAGAA CCACGTGCTG 1380

CACCTGGATG TCAAGCCCGA GAACCTGCTG GTATGGGATG GCGCAGAGGG AGAAGAGCAG 1440

GTGAGGATCT GTGACTTTGG GAACGCCCAG GAGCTGACTC TGGGGGAGCC CCAGTACTGC 1500

CAATACGGCA CACCCGAGTT CGTGGCGCCC GAGATTGTCA ACCAGACCCC TGTGTCCGGC 1560

GTCACTGACA TCTGGCCTGT GGGTGTCGTC GCCTTCCTCT GCCTGACAGG AATCTCCCCA 1620

TTCGTTGGGG AGAATGACCG GACAACGCTG ATGAACATCC GCAACTACAA TGTGGCGTTC 1680

GAGGAGACCA CGTTCCTGAG CCTCAGCCGC GAGGCCCGCG GCTTCCTCAT CAAAGTGCTG 1740

GTGCGGGACC GCCTGAGGCC TACCGCAGAG GAGACCCTGG AACATCCTTG GTTCAAAACA 1800

CAGGCAAAGG GCGCCGAGGT GAGCACGGAC CACCTGAAGC TGTTCCTCTC CCGGCGGAGG 1860

TGGCAGCGCT CACAGATCAG CTACAAGTGC CACCTGGTGC TGCGCCCCAT CCCCGAGCTG 1920

CTGCGGGCAC CCCCAGAGCG GGTGTGGGTG GCCGTGCCCA GAAGACCGCC CCCCAGTGGG 1980

GGGCTCTCAT CGTCCTCCGA CTCTGAAGAG GAGGAGCTGG AGGAGCTGCC CTCCGTGCCC 2040

CGGCCACTGC AGCCCGAGTT CTCGGGCTCC CGGGTGTCCC TCACTGACAT TCCCACTGAG 2100

GAGGAGGCCC TGGGGGCCCC AGAGGCTGGG GCTGCCACCC CCATGTACTG TCAGGAGCAG 2160

GGAAGAGCCC CCTCTCAGGA CCAGGAGGGG CGCAGCCTAC GGCTTTATCT TTCCCAGTCC 2220

AGGGATCCCC GGCTGGACTC AATCCCCGGC GGGGGGGAGC TCCGAGGGGG CAGCTCAGCT 2280

GAGAGCGCCC TGCCCCGGGC CGGGCCCGAG CGGGCCGGAG CCTTCATAAG GCAGCATCCG 2340

TGGAGCTGCC GCAGCGCCGG AGCCCCAGCC CGGGGGCCCA CCCGCCTGAC CCGGGGAGGC 2400

CTGGGCGAGG GCGAGTATGC CCAGAGGCTG CAGGCCCTGC GCCAGCGGCT GCTGCGGGGG 2460

GGCCCTGAGG ATGGCAAGGT TAGCGGCCTC AGGGGCCCCC TGCTAGAGAG CCTAGGGGGC 2520

CGTGCCCGGG ACCCCCGGCT GGCGCGGGCC GCCTCCAAAG AGCAGCAGCT TTTCCCAGGG 2580

GGAGGCGGAG CCCGGGGCCG GCACCGCCGG GCTGGGGCAC CCCTCGAGAT CCCGGTGGCC 2640

CGGCTTGGGG CCCGCAGGCT ACAGGAGTCT CCTTCCTTAA CCCGTCCCAG GCTCCAAGCC 2700

TGCACAACCC CCCGTGGCTC TGCAAACCCC AGCGCCCCCA CTCACACCCT ATGCACAGAT 2760

CATGCAGTCA CTCCAGCTGC CAGGCCACGT GCCAAGCCCC CCGCAGACCC TTGGAGCCCC 2820

TCCACTGGAG CCCAAGCCCC ACCCGGCAGT AACCTGGAGT CGGAGGCCGT GTTCGAGGCC 2880

AAGTTCAAGC GCAGCCGTGA TGTGGAGGGG TCGGGCCGAA GCCGGCTGCG CTGGGGCTTC 2940

TCTCGGCTGC GGAAGGACAA GGGGTCGCAT CCAAGCCTCT CTGCCAGCAT CCAGGAGGAC 3000

CTGGGGTCCC TGAAGACCCG TGTCTTTGCT CTCCCTCCAG ACTTCCCCCC AGTTTTCCAC 3060

ATCAAACTCA AGGACCAGGT GCTGCTGGAG GGAGAGGCAG CCACCCTGCT CTGCCTGCCG 3120

GCGGCCTGCC CTACACCCCA CATCTCCTGG ATGAAAGACA AGCAGTCCTT GCAGTCAGAG 3180

CCCTCGGTGA TCATCGTGTC CTGCAAAGAC GGACGGCAGC TGCTGAGCAT CCCCCGGGTG 3240

GGCAAGCGGC ATGCTGGGCT CTATGAGTGC TCTGCCACCA ATGTCCTAGG CAGCATCACC 3300

AGCTCCTGTA CCGTGGCTGT GGCTCGCATC CCAGGAAAGC TAGCTCCTCC CGAGGTGCCC 3360

CAGACCTACC AGGACACAGC GCTGGTGCTC TGGAAACCAG GAGACAGCCG GGCACCTTGC 3420

ACGTACACAC TGGAGCGACG GGTAGATGGG GAGTCCTCCT GGCACCCAGT AAGCTCAGGC 3480

ATCCCCAACT GTTACTACAA CGTGACCCAC CTACCAGTCG GTGTGACCGT GAGGTTCCGT 3540

GTGGCCTGTG CCAACCGTGC TGGGCAAGGG CCCTTCAGCA ATCCTTCTGA GAAGTGCCCA 3600

GGTCACTCCA AGGGCCGCTT CGGCGTAGTG CGGGCCTGCC GGGAGAACGC CACGGGGCGG 3660

ACCTTCGTGG CCAAGATCGT GCCCTATGCA GCTGAGGGCA AGCGTCAGGT CCTGCAGGAG 3720

TACGAAGTGC TGCGCACGCT GCACCACGAG CGGCTCATGG CCCTGCATGA GGCCTACATC 3780

ACCCCACGTT ACCTCGTGCT CATTGCTGAA AGCTGCGGCA ACCGGGAACT CCTCTGTGGG 3840

CTCAGTGACA GGTTCCGGTA TTCGGAGGAC GACGTGGCCA CGTACGTGGT ACAGCTGCTG 3900

CAAGGCCTGG ACTACCTCCA TGGTCGCCAC GTCCTGCACC TGGACATCAA GCCCGACAAC 3960

CTGCTGCTGG CCCCGGACAA CGCCCTCAAG ATCGTGGACT TCGGCAGTGC CCAGCCGTAC 4020

AACCCCCAGG CCCTGCGGCC CCTTGGCCAT CGCACGGGCA CACTGGAGTT CATGGCTCCT 4080

GAGATGGTGA AGGGAGAACC CATCGGCTCT GCCACGGACA TCTGGGGAGT GGGTGTCCTC 4140

ACTTACATCA TGAGCCGGCC CTCCCTGCAG GACTGCCTGG CCCACCCGTG GCTGCAGGAC 4200

GCCTACCTGA TGAAGCTGCG CCGCCAGACG CTCACCTTTA CCACCAACCG GCTCAAGGAG 4260

TTCCTGGGCG AGCAGCGGCG CCGCCGGGCC GAGGCCGCCA CGCGTCACAA GGTGCTGCTC 4320

CGATCCTACC CCGGCAGCCC CTAG 4344

Domain Profile

S: 1     yevleeigRGrFsvvkkvrekatkravaakfvpkkakkkaqvlrEaeiLkrLqHpllvsl  60

         y++++eigRG+Fs++++v+e++++ ++aakf+p++ak ka++ rEa++L+rLqH++++++

Q: 345   YDIQQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASAWREARLLARLQHDCVLYF  404

         99**********************************************************

S: 61    hdayetprslvlilElcsdeeLLdrlaekeslsEsevkaylrqllealqYLHnsrvlHLD  120

         h+a+e++r lv+++Elc+ eeLL+r+a+k +++Ese+++y+rq+le+++YLH+++vlHLD

Q: 405   HEAFERRRGLVIVTELCT-EELLERMARKPTVCESEIRTYMRQVLEGICYLHQNHVLHLD  463

         ******************.9****************************************

S: 121   ikpenllv..laaaeeavkivDlgnAqeltpeepqekllgtpEfvaPEiiegepvseatD  178

         +kpenllv   a  ee+v+i+D+gnAqelt  epq++++gtpEfvaPEi++++pvs +tD

Q: 464   VKPENLLVwdGAEGEEQVRICDFGNAQELTLGEPQYCQYGTPEFVAPEIVNQTPVSGVTD  523

         ********9888999*********************************************

S: 179   iWavGvlayvlLsgvsPfldeskretllnilkgrvsfseelfaglseeAkeFlkkvLqed  238

         iW+vGv+a+++L+g+sPf++e++r+tl+ni++++v+f+e++f +ls+eA+ Fl+kvL++d

Q: 524   IWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLVRD  583

         ************************************************************

S: 239   prkRPsaaecLqhpWl  254

          r RP+a+e+L+hpW+

Q: 584   -RLRPTAEETLEHPWF  598

         .**************8

Domain Sequence
(FASTA)

YDIQQEIGRG AFSYLRRVVE RSSGLEFAAK FIPSQAKPKA SAWREARLLA RLQHDCVLYF 60

HEAFERRRGL VIVTELCTEE LLERMARKPT VCESEIRTYM RQVLEGICYL HQNHVLHLDV 120

KPENLLVWDG AEGEEQVRIC DFGNAQELTL GEPQYCQYGT PEFVAPEIVN QTPVSGVTDI 180

WPVGVVAFLC LTGISPFVGE NDRTTLMNIR NYNVAFEETT FLSLSREARG FLIKVLVRDR 240

LRPTAEETLE HPWF 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR015726	; Ser/Thr_kin_striated_muscle-sp.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07679	; I-set; 3.
PF00069	; Pkinase; 2.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00220	; S_TKc; 2.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013