EKS-EQC-00252
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00252
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK428.31.1E-12822274253
StatusUnreviewed
Ensembl ProteinENSECAP00000000786
UniProt AccessionF6TSY5;
Protein Name
Protein Synonyms/Alias
Gene NamePLK2
Gene Synonyms/Alias PLK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000000354ENSECAP00000000786ENSECAT00000000973
ENSECAG00000000354ENSECAP00000001395ENSECAT00000001929
OrganismEquus caballus
Functional Description
Protein Length619
Protein Sequence
(FASTA)
HHSHSGAEVS RIIVDPTTGK RYCRGKVLGK GGFAKCYEMT DLTNNKVYAA KIIPHSRVAK 60
PHQREKIDKE IELHRILHHK HVVQFYHYFE DKENIYILLE YCSRRSMAHI LKARKVLTEP 120
EVRYYLRQIV SGLKYLHEQE ILHRDLKLGN FFINEAMELK VGDFGLAARL EPLEHRRRTI 180
CGTPNYLSPE VLNKQGHGCE SDIWALGCVM YTMLLGRPPF ETTNLKETYR CIREARYTMP 240
SSLLAPAKHL IASMLSKNPE DRPSLDDIIR HEFFLQGFTP DRLSSSCCHT VPDFHLSSPA 300
KNFFKKAAAA LFGGKKDKAR YIDTQNRASK EDEEIYKLRH DLKKTSITQQ PSKHRTDEEK 360
LLSFSLMMLE NKQQIGDAIR MIVRGTLGSC SSSSECLEDS TMGSVADTVA RVLRGCLENM 420
PEADCIPKEQ LSTSFQWVTK WVDYSNKYGF GYQLSDHTVG VLFNNGAHMS LLPDKKTVHY 480
YAELGQCSVF PATDAPEQFI SQVTVLKYFS HYMEENLMDG GDLPSVTDIR RPRLYLLQWL 540
KSDKALMMLF NDGTFQVNFY HDHTKIIICS QNEEYLLTYI NEDRISTTFR LTTLLMSGCS 600
SELKNRMEYA LNMLLQRCN 619
Nucleotide Sequence
(FASTA)
CACCACTCGC ACTCGGGGGC CGAGGTGTCG CGGATTATCG TCGACCCCAC GACGGGGAAG 60
CGCTACTGCC GGGGCAAAGT GCTGGGAAAG GGTGGCTTCG CGAAATGTTA CGAGATGACA 120
GATTTGACCA ACAACAAAGT CTATGCTGCA AAAATTATTC CTCACAGCAG AGTAGCTAAA 180
CCTCATCAAA GGGAAAAGAT TGACAAAGAA ATAGAACTTC ACAGGATTCT TCATCATAAG 240
CATGTAGTGC AGTTTTACCA CTACTTTGAG GACAAAGAAA ACATTTACAT TCTCTTGGAA 300
TACTGCAGTA GAAGGTCCAT GGCTCATATC TTGAAAGCAA GGAAGGTGTT GACAGAGCCA 360
GAAGTCCGAT ACTACCTCAG GCAGATTGTG TCTGGACTAA AGTACCTTCA TGAACAAGAA 420
ATCTTGCACA GAGATCTCAA ACTAGGGAAC TTTTTTATTA ATGAAGCCAT GGAACTGAAA 480
GTCGGGGACT TTGGTTTGGC AGCCAGGTTG GAACCCTTAG AACACAGAAG GAGAACAATA 540
TGTGGTACCC CAAATTATCT TTCTCCTGAA GTCCTCAACA AACAAGGACA TGGCTGTGAA 600
TCAGACATTT GGGCCTTAGG CTGTGTCATG TATACAATGT TACTAGGAAG ACCCCCATTT 660
GAAACTACAA ATCTGAAAGA AACTTACAGG TGCATAAGAG AAGCAAGGTA TACAATGCCA 720
TCGTCATTGC TGGCTCCTGC TAAGCACCTA ATAGCCAGCA TGTTGTCTAA AAATCCAGAG 780
GATCGTCCTA GTTTGGATGA CATCATTAGA CATGAATTTT TTTTGCAGGG CTTCACTCCA 840
GACAGACTTT CTTCTAGCTG TTGTCATACA GTTCCAGATT TCCACTTGTC AAGCCCAGCT 900
AAGAATTTCT TTAAGAAAGC AGCTGCTGCT CTTTTTGGTG GCAAAAAAGA CAAAGCAAGA 960
TACATTGACA CACAAAACAG AGCATCTAAA GAAGATGAAG AAATTTACAA GCTTAGGCAT 1020
GATTTGAAAA AGACTTCAAT AACTCAGCAG CCTAGCAAAC ACAGGACAGA TGAGGAGAAA 1080
CTTTTGTCTT TTAGTTTAAT GATGCTGGAA AACAAGCAGC AGATTGGAGA TGCTATTCGG 1140
ATGATAGTCA GAGGGACTCT GGGCAGCTGC AGCAGTAGCA GTGAATGCCT CGAAGACAGT 1200
ACCATGGGGA GTGTGGCAGA CACAGTGGCA CGAGTCCTTC GAGGATGTCT AGAAAACATG 1260
CCAGAAGCCG ACTGCATCCC CAAAGAGCAG CTGAGCACTT CCTTTCAGTG GGTCACTAAG 1320
TGGGTCGACT ACTCTAACAA GTATGGCTTT GGATACCAGC TCTCAGACCA CACTGTAGGT 1380
GTCCTTTTCA ACAACGGTGC TCACATGAGC CTCCTTCCAG ACAAAAAAAC AGTTCACTAT 1440
TACGCAGAGC TTGGCCAGTG CTCTGTTTTC CCAGCAACAG ATGCTCCTGA ACAATTCATT 1500
AGTCAAGTGA CGGTGCTGAA ATACTTCTCT CACTACATGG AGGAGAACCT CATGGATGGT 1560
GGAGACCTGC CTAGTGTTAC TGATATTCGC AGACCTCGGC TCTACCTCCT TCAGTGGCTA 1620
AAATCTGATA AGGCCTTAAT GATGCTCTTC AATGATGGCA CCTTTCAGGT GAATTTCTAC 1680
CATGACCATA CAAAAATAAT CATCTGTAGC CAAAATGAAG AATACCTTCT CACGTACATC 1740
AATGAGGACA GGATATCTAC AACGTTCAGA CTGACAACTC TGCTCATGTC TGGCTGTTCA 1800
TCAGAATTAA AAAATCGAAT GGAATATGCT CTGAACATGC TCTTACAGAG ATGTAACTAA 1860
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+rgk+lGkGgfakcye++dl++++v+a+k++p+s++ak++qrek++keie+hr l+hk+
Q: 22    YCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKH  81
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         +v++y++fedken+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i
Q: 82    VVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  141
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+
Q: 142   LHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  201
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diW+lGc++yt+l+G+PPfet++lkety++i++a+y++Pssl ++ak+lia++l+k+Pe+
Q: 202   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPED  261
         ************************************************************
S: 241   rpsleevlkdefl  253
         rpsl++++++ef+
Q: 262   RPSLDDIIRHEFF  274
         ************8
Domain Sequence
(FASTA)
YCRGKVLGKG GFAKCYEMTD LTNNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRILHHKH 60
VVQFYHYFED KENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120
LHRDLKLGNF FINEAMELKV GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180
DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYTMPS SLLAPAKHLI ASMLSKNPED 240
RPSLDDIIRH EFF 253
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00243
EKS-ANC-00250
EKS-BOT-00260
EKS-CAJ-00266
EKS-CAF-00267
EKS-CAP-00295
EKS-CHH-00011
EKS-CII-00157
EKS-DAR-00595
EKS-DAN-00009
EKS-ECT-00011
EKS-FEC-00246
EKS-GAM-00160
EKS-GAG-00218
EKS-GAA-00323
EKS-GOG-00258
EKS-HOS-00267
EKS-ICT-00245
EKS-LAC-00272
EKS-LOA-00270
EKS-MAM-00262
EKS-MEG-00208
EKS-MIM-00016
EKS-MOD-00259
EKS-MUM-00292
EKS-MYL-00263
EKS-NOL-00241
EKS-ORN-00338
EKS-ORC-00246
EKS-OTG-00266
EKS-PES-00232
EKS-PEM-00136
EKS-POA-00253
EKS-PRC-00018
EKS-RAN-00275
EKS-SUS-00226
EKS-TAG-00276
EKS-TAR-00334
EKS-TEN-00329
EKS-VIP-00009
EKS-XET-00335
EKS-XIM-00330
EKS-SAC-00030
Gene Ontology
GO:0005814; C:centriole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0004871; F:signal transducer activity
GO:0000082; P:G1/S transition of mitotic cell cycle
GO:0007613; P:memory
GO:0007093; P:mitotic cell cycle checkpoint
GO:0007052; P:mitotic spindle organization
GO:0043066; P:negative regulation of apoptotic process
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599; P:regulation of centriole replication
GO:0048167; P:regulation of synaptic plasticity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013