EKS-EQC-00061

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00061

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	381.4	2.7E-114	142	423	282

Status

Unreviewed

Ensembl Protein

ENSECAP00000002303

UniProt Accession

F6YSP2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK18

Gene Synonyms/Alias

CDK18;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000000622	ENSECAP00000002303	ENSECAT00000003231

Organism

Equus caballus

Functional Description

Protein Length

472

Protein Sequence
(FASTA)

IMNKMKNFRR RFSLSVPRTE TIEESLAEFT EQLNQLHNRR NEDLQLSPLG RDPQPEPSTF 60

SPPDGGEDPR QPSPGTRYRR QNQRRFSMED ISKRLSLPTD IRLPQEFLQK LQLESPDLPK 120

PLSRVSRRAS LSDIGFGKLE TYVKLDKLGE GTYATVFKGR SKLTENLVAL KEIRLEHEEG 180

APCTAIREVS LLKNLKHANI VTLHDLIHTE RSLTLVFEYL DSDLKQYLDH CGNLMSMHNV 240

KIFMFQLLRG LAYCHRRKIL HRDLKPQNLL INERGELKLA DFGLARAKSV PTKTYSNEVV 300

TLWYRPPDVL LGSTEYSTPI DMWGVGCIHY EMATGRPLFP GSAVKEELHL IFRLLGTPTE 360

ETWPGVTALS EFRAYNFPRY LPQPLISHAP RLDPEGINLL TSLLLYESKS RMSAEAALSH 420

PYFRSLGERV HQLEDTASIF SLKEIQLQKD PGYRGLAFQQ PGRGKNRRQS IF 472

Nucleotide Sequence
(FASTA)

ATCATGAACA AGATGAAGAA CTTTAGGCGC CGCTTTTCCC TGTCAGTGCC CCGCACTGAG 60

ACCATCGAGG AGTCCTTGGC GGAGTTCACA GAGCAGCTGA ACCAGCTCCA CAACCGGCGC 120

AATGAGGACC TGCAGCTCAG TCCTCTTGGC AGAGACCCCC AGCCAGAGCC CAGCACCTTC 180

TCCCCCCCAG ATGGTGGAGA GGACCCCAGG CAGCCGTCCC CTGGCACGCG GTACCGGCGC 240

CAGAACCAGC GCCGCTTCTC CATGGAGGAC ATCAGTAAGA GGCTCTCCCT GCCCACGGAC 300

ATCCGTCTGC CCCAGGAATT CCTGCAGAAG CTACAGCTGG AAAGCCCAGA CCTGCCCAAA 360

CCGCTAAGCC GCGTGTCCCG CCGTGCCTCC CTGTCAGACA TCGGCTTTGG GAAATTGGAA 420

ACGTATGTGA AACTGGACAA ACTGGGGGAG GGTACCTATG CCACCGTCTT CAAAGGGCGC 480

AGCAAACTGA CAGAGAACCT CGTGGCCCTG AAGGAGATCC GGCTGGAGCA TGAGGAGGGG 540

GCGCCCTGCA CTGCCATCCG AGAGGTGTCT CTCCTGAAGA ACCTGAAGCA TGCCAATATT 600

GTGACCCTGC ACGACCTCAT CCATACGGAG CGGTCTCTCA CCCTGGTGTT TGAGTACCTG 660

GACAGTGACC TGAAGCAGTA TCTGGACCAC TGTGGAAACC TCATGAGCAT GCACAACGTC 720

AAGATTTTCA TGTTCCAACT GCTCAGGGGC CTTGCCTACT GCCACCGCCG CAAGATCCTG 780

CACCGGGACC TGAAACCCCA GAACCTGCTC ATCAACGAGA GGGGGGAGCT GAAGCTGGCT 840

GACTTTGGAC TGGCCCGGGC CAAGTCCGTG CCCACAAAGA CCTACTCCAA TGAGGTGGTG 900

ACCCTGTGGT ACAGGCCCCC GGATGTGCTG CTGGGGTCCA CAGAGTACTC TACCCCCATC 960

GATATGTGGG GCGTGGGCTG CATCCACTAC GAGATGGCCA CCGGGAGGCC CCTCTTCCCC 1020

GGCTCCGCCG TCAAGGAGGA GCTGCACCTC ATCTTCCGGC TCCTCGGGAC CCCTACAGAA 1080

GAGACGTGGC CTGGCGTGAC GGCCCTGTCG GAGTTCCGAG CCTACAACTT CCCCCGGTAC 1140

CTCCCGCAGC CGCTCATCAG CCACGCCCCC AGGTTGGACC CTGAAGGCAT CAACCTCCTG 1200

ACCAGCCTCC TCCTGTATGA ATCCAAGAGC CGCATGTCCG CAGAGGCTGC CCTGAGCCAC 1260

CCCTACTTCC GGTCTCTGGG CGAGCGTGTG CACCAGCTGG AAGACACTGC CTCCATCTTC 1320

TCCCTGAAGG AGATCCAACT TCAGAAGGAC CCAGGCTACC GGGGCCTGGC CTTTCAGCAG 1380

CCAGGACGAG GGAAGAACCG GCGACAGAGC ATCTTCTGA 1419

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y kl+k+geGty++v+k+++k t+++vAlK+irle+e eg p+ta+rE+sllk+lkh+ni

Q: 142   YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANI  200

         7899********************************9.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v+L+++++ ++++l+Lvfe+l++dLk++l+++ +  +s+++vk +++qll+glay+H++k

Q: 201   VTLHDLIH-TERSLTLVFEYLDSDLKQYLDHCGN-LMSMHNVKIFMFQLLRGLAYCHRRK  258

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLi+++g+lklaDfGlara s+p+kty++evvTlwYr+P++Llg++eYst

Q: 259   ILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYST  318

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfp  239

          +D+W+vgci  e++t +plf+g+  +++l+ if+llgtp+e++wp+v+ l+e++ ++fp

Q: 319   PIDMWGVGCIHYEMATGRPLFPGSAVKEELHLIFRLLGTPTEETWPGVTALSEFRaYNFP  378

         *******************************************************99***

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         ++ ++ l ++ ++l+ ++++ll++ll ++ k+R+sa++al+h+yf

Q: 379   RYLPQPLISHAPRLDPEGINLLTSLLLYESKSRMSAEAALSHPYF  423

         ********************************************9

Domain Sequence
(FASTA)

YVKLDKLGEG TYATVFKGRS KLTENLVALK EIRLEHEEGA PCTAIREVSL LKNLKHANIV 60

TLHDLIHTER SLTLVFEYLD SDLKQYLDHC GNLMSMHNVK IFMFQLLRGL AYCHRRKILH 120

RDLKPQNLLI NERGELKLAD FGLARAKSVP TKTYSNEVVT LWYRPPDVLL GSTEYSTPID 180

MWGVGCIHYE MATGRPLFPG SAVKEELHLI FRLLGTPTEE TWPGVTALSE FRAYNFPRYL 240

PQPLISHAPR LDPEGINLLT SLLLYESKSR MSAEAALSHP YF 282

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013