EPS-EQC-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	153.7	3.3E-45	96	241	146

Status

Unreviewed

Ensembl Protein

ENSECAP00000000617

UniProt Accession

F7D7N9;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP27

Gene Synonyms/Alias

DUSP27;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000000783	ENSECAP00000000617	ENSECAT00000000771

Organism

Equus caballus

Functional Description

Protein Length

1117

Protein Sequence
(FASTA)

YSLVSDAETE SIFMEPIHLS SAVAAKQIIN EELKPPGLRA EAECPVMLES AEQLLVEDLY 60

NRVREKMDDT SLYNTPCVLD LQRALVQDRQ ETPWNEVDEV WPNVFIAEKS VAVNKGRLKR 120

LGITHILNAA HGTGVYTGPE FYTGMEIQYL GVEVDDFPEV DISQHFRRAA EFLDEALLTY 180

RGKVLVSSEM GISRSAALVV AYLMVFHHMA ILEALMTVRK KRAICPNDGF LKQLRELNEK 240

LMEEREEEEG ADEAEEGEDV GSTVGARVHA LTVEEEDDTT SHLSGSSLGK ASQVSKPLTL 300

IDEDEEEKLY EEWKKRQGLP TGKVPQGGEG RRSASSGQGG EEPEDEDVER IIREWQSRNE 360

RYQAEGHRSW SREEEVEEDS NAGSFVGRRR RHTLSESSTS ESVTSHDIRI LKQQLEMSSQ 420

NQGGRRRSDS VSTDSTWDMW NQRLLEIEKE ASRRYHSRSK REEVDTSSEV GSRVREDDED 480

SVSSEASSFY NFCHRNKDKL TALERWKIKR IQFGFHKKDS EAGDSSTEQG AEEAEGEKNL 540

SDASLTAYQT WKLKHQKKVG SENKEEVVEL SKGEDTASAK KRQRRLELLE RSRQTLEESQ 600

SMASWEADSS AASRSIPLSA FWSAAPSVSA DGDTASVLSA QSHSSHPSQA VSNERGCLAS 660

NPTTPLPNLP VGPGDTISIA SIQNWIANVV SETLAQKQNE LLLLSRSPSV ASIKVAPAVG 720

CLGDDQVSML SGQSSSSLGS CLLPQSQPRA SSDTHSVLSS HTALSSRTEG TGSKVKGTSK 780

PIYSLFADDI DLKELGRKER EMQMELREKM SEYKMEKLAS DNKRSSLFKK KKVREEEDDD 840

VGDRDEDTDS AIGSFQHSSG SNSQKPETDT SSSLAVSDGY ASGSRAGKEM DSSINRWLSG 900

LRTEDKSPPQ SDWSGSSRGR YTRSSLLRET ESKSCSYKFS KSRSEEQDTS SYHEANGGSA 960

RSTSRFSSSS TREGREMHKF SRSKFSETSS SREESPEPYF FRRSPEPSEG EESPEPRRPN 1020

WARPRDWEDV EESSKSDFSE FGAKRKFTQS FMRSEEEGEK ERTENREEGR FASGRRSQYR 1080

RSTDREEEEE MDDEAIIAAW RRRQEETRTK LQRRRED 1117

Nucleotide Sequence
(FASTA)

TACTCACTGG TCTCAGACGC AGAAACAGAA AGCATCTTCA TGGAGCCCAT TCACCTCTCC 60

TCAGCTGTGG CAGCTAAACA GATCATCAAT GAAGAACTCA AGCCTCCGGG GCTCAGAGCC 120

GAGGCAGAGT GTCCAGTCAT GCTGGAGTCT GCTGAGCAGT TGCTGGTGGA GGACCTGTAC 180

AACCGCGTCA GGGAGAAGAT GGACGACACC AGCCTGTACA ATACACCCTG CGTCCTGGAC 240

CTACAGCGGG CCTTGGTCCA AGACCGCCAA GAGACACCCT GGAATGAAGT GGATGAGGTC 300

TGGCCCAACG TCTTCATAGC AGAGAAGAGT GTGGCTGTGA ACAAGGGGAG GCTGAAGAGG 360

CTGGGAATCA CCCACATCCT GAATGCTGCC CATGGCACTG GCGTCTACAC TGGGCCTGAA 420

TTCTACACTG GCATGGAGAT CCAGTACCTG GGTGTGGAGG TGGATGACTT CCCCGAGGTG 480

GACATCTCCC AGCATTTCCG GAGGGCTGCC GAGTTCCTCG ATGAGGCCCT GCTGACCTAT 540

AGAGGGAAAG TCCTGGTCAG TAGTGAAATG GGCATCAGCC GTTCAGCAGC GCTGGTGGTG 600

GCCTACCTGA TGGTCTTCCA CCACATGGCC ATCCTGGAGG CCTTGATGAC TGTGCGTAAG 660

AAACGGGCCA TCTGCCCCAA CGATGGCTTC CTGAAGCAGC TCCGGGAGCT CAACGAGAAG 720

TTGATGGAGG AGAGAGAAGA GGAGGAGGGT GCAGATGAGG CTGAGGAGGG TGAGGATGTG 780

GGGAGCACTG TCGGGGCCAG AGTACATGCT CTCACAGTGG AGGAGGAGGA TGACACCACC 840

AGCCACCTGA GTGGCTCCTC CTTGGGGAAG GCCAGCCAGG TCTCTAAGCC CCTCACCCTC 900

ATTGATGAAG ACGAGGAGGA GAAACTATAT GAGGAGTGGA AGAAGAGGCA GGGCCTCCCT 960

ACAGGCAAGG TCCCCCAGGG TGGAGAGGGC AGGCGCTCAG CCTCCTCTGG CCAGGGTGGG 1020

GAGGAGCCCG AGGATGAGGA TGTGGAGAGG ATCATCCGGG AGTGGCAGAG CCGAAATGAG 1080

AGGTACCAGG CAGAAGGGCA CCGGAGTTGG AGTAGGGAGG AGGAAGTGGA GGAGGATAGC 1140

AATGCTGGCT CCTTTGTGGG AAGAAGACGG AGGCACACCC TGAGCGAGAG CAGCACCTCA 1200

GAGAGTGTAA CCAGCCATGA CATACGCATC CTGAAGCAGC AGCTGGAGAT GAGCAGCCAG 1260

AACCAAGGTG GGAGACGCCG CTCTGACTCT GTGTCCACAG ACAGCACCTG GGACATGTGG 1320

AACCAGAGGC TGCTGGAGAT TGAGAAGGAA GCTTCCCGGA GGTACCACTC CAGGAGCAAG 1380

AGAGAGGAGG TGGACACAAG CTCAGAGGTG GGGAGCAGGG TGCGAGAGGA TGATGAGGAC 1440

AGTGTGTCCT CTGAGGCCAG CTCCTTCTAT AACTTCTGCC ACAGGAACAA GGACAAACTC 1500

ACTGCCCTAG AAAGGTGGAA GATCAAGAGA ATCCAATTTG GATTTCACAA GAAAGACTCA 1560

GAGGCAGGAG ACAGCAGCAC TGAGCAAGGT GCAGAGGAGG CAGAAGGGGA GAAGAACCTC 1620

TCTGACGCCA GCCTGACGGC CTACCAGACC TGGAAGCTGA AACACCAGAA GAAGGTGGGC 1680

AGTGAGAACA AGGAGGAGGT GGTGGAGCTC AGCAAGGGAG AGGACACGGC CTCAGCCAAG 1740

AAGAGGCAAC GACGGCTGGA GCTGCTGGAG AGAAGCAGGC AGACGCTGGA GGAGAGCCAG 1800

TCCATGGCAA GCTGGGAGGC GGACAGCTCG GCTGCCAGCA GGAGCATCCC CCTGTCTGCA 1860

TTCTGGTCTG CAGCCCCCTC GGTCAGTGCT GATGGGGACA CAGCATCAGT ACTCAGCGCC 1920

CAGAGCCACA GCTCCCACCC ATCTCAGGCC GTAAGCAACG AGAGGGGATG CTTGGCCTCC 1980

AACCCCACCA CACCACTGCC TAACCTGCCA GTGGGGCCTG GAGACACAAT TTCCATTGCC 2040

AGTATCCAGA ACTGGATTGC CAATGTAGTC AGCGAAACTC TTGCCCAGAA GCAAAATGAA 2100

TTGCTGTTGT TGTCCCGCTC GCCATCCGTT GCAAGCATAA AGGTGGCACC AGCAGTGGGC 2160

TGCCTGGGGG ATGACCAAGT CTCCATGCTC AGTGGACAGA GCAGCTCCTC CCTGGGCAGC 2220

TGCCTGCTGC CTCAAAGCCA GCCAAGAGCC AGCTCTGACA CACACTCCGT GCTGTCCTCC 2280

CACACTGCGC TGAGCTCGAG GACCGAAGGT ACTGGGAGCA AAGTGAAGGG GACCAGCAAG 2340

CCTATCTATA GCCTCTTTGC TGACGATATT GACCTAAAGG AACTTGGCAG GAAGGAGCGG 2400

GAGATGCAGA TGGAGCTGAG GGAGAAGATG TCTGAGTACA AAATGGAGAA GCTGGCCTCT 2460

GACAACAAAC GCAGCTCCCT TTTCAAGAAG AAGAAGGTCA GGGAAGAAGA GGATGATGAC 2520

GTGGGTGATA GGGACGAGGA CACTGACAGC GCCATAGGGA GCTTCCAACA TTCTTCCGGC 2580

AGTAATTCCC AAAAGCCTGA AACAGACACC TCCTCCTCCC TGGCTGTCTC TGACGGCTAT 2640

GCAAGTGGCA GCAGAGCTGG CAAAGAGATG GATAGCAGTA TTAACAGGTG GCTCAGTGGC 2700

CTCAGGACAG AGGACAAATC TCCTCCCCAA AGTGATTGGT CTGGAAGCTC CCGGGGGAGG 2760

TACACCAGAT CTTCCCTGCT CCGGGAGACG GAGTCTAAAT CTTGCAGTTA CAAGTTCTCC 2820

AAATCCCGGT CAGAGGAACA GGACACCTCC TCCTACCACG AGGCCAATGG CGGCTCTGCA 2880

AGAAGCACCT CCCGGTTCTC TTCTTCCTCC ACCAGAGAGG GGAGAGAGAT GCACAAGTTC 2940

TCCAGGTCGA AGTTCAGTGA GACCTCAAGC TCCCGAGAGG AAAGCCCGGA GCCCTACTTC 3000

TTCCGCCGGA GCCCTGAGCC CTCGGAAGGG GAAGAGTCCC CGGAACCACG GCGTCCGAAT 3060

TGGGCCAGGC CCAGGGATTG GGAAGATGTG GAAGAGTCGT CCAAGTCAGA CTTTTCCGAA 3120

TTTGGAGCCA AGAGGAAATT CACCCAGAGC TTCATGAGGT CTGAAGAGGA GGGAGAGAAA 3180

GAGAGGACGG AAAACAGAGA AGAAGGGAGG TTTGCTTCAG GGCGGCGGTC CCAGTATCGG 3240

AGAAGCACTG ACAGGGAGGA AGAGGAAGAA ATGGACGATG AAGCCATCAT TGCTGCCTGG 3300

AGACGCCGGC AGGAAGAAAC CAGGACTAAG CTGCAGAGAA GGAGGGAGGA TTAA 3354

Domain Profile

S: 1     evteilpglylgdqataldrreLsklgitvvinaslsvikvqviPeylikkgityknipv  60

         ev+e++p+++++++ +a+++  L++lgit+++na++++    ++Pe+++ ++i+y++++v

Q: 96    EVDEVWPNVFIAEKSVAVNKGRLKRLGITHILNAAHGTGV-YTGPEFYTGMEIQYLGVEV  154

         69**********************************8765.79*****************

S: 61    dDsdvtdllqyfdeaaefidea.kekggkvlvHCaaGvsRSatlvlaYLmkveglslsdA  119

         dD ++ d++q+f++aaef+dea  + +gkvlv +++G+sRSa+lv+aYLm ++++++ +A

Q: 155   DDFPEVDISQHFRRAAEFLDEAlLTYRGKVLVSSEMGISRSAALVVAYLMVFHHMAILEA  214

         **********************8999**********************************

S: 120   ieavkrkrpsiepnegfleQLlelekkl  147

         +++v++kr +i+pn+gfl+QL+el++kl

Q: 215   LMTVRKKR-AICPNDGFLKQLRELNEKL  241

         ********.***************9987

Domain Sequence
(FASTA)

EVDEVWPNVF IAEKSVAVNK GRLKRLGITH ILNAAHGTGV YTGPEFYTGM EIQYLGVEVD 60

DFPEVDISQH FRRAAEFLDE ALLTYRGKVL VSSEMGISRS AALVVAYLMV FHHMAILEAL 120

MTVRKKRAIC PNDGFLKQLR ELNEKL 146

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR020417	; Atypical_DUSP.
IPR020405	; Atypical_DUSP_famA.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR000387	; Tyr/Dual-specificity_Pase.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

PR01908	; ADSPHPHTASE.
PR01909	; ADSPHPHTASEA.

Created Date

20-Feb-2013