EKS-EQC-00397
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00397
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR569.04.7E-171579908330
StatusUnreviewed
Ensembl ProteinENSECAP00000002580
UniProt AccessionF6YXS1;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000000860ENSECAP00000002580ENSECAT00000003682
OrganismEquus caballus
Functional Description
Protein Length969
Protein Sequence
(FASTA)
MGLGALLVLL VATAWHGQGV PVIQPSGPEL IVEPGTRVTL RCVGNGSVEW DGPISPSWTL 60
DPDAPGSILT TNNATFQNTG TYRCTEPGDP LGGSATIHLF VKDPVRPWKV LAEEVTVLEG 120
QDALLPCLLT DPALEAGVSL MRVRGRPVLR QTSYSFSLWH GFTIHKAKFI ESQDYQCSAR 180
VDGRTATSIS IRLKVQKVVP GPPTLTLEPA ELVRIQGETA QIVCSASDVD VNFDVFLQHE 240
DTKLTISQQS DFRDNRYHKV LTLSLGHVGF QDAGSYSCVA TNAQGVRSSS MVFRVVESAY 300
LNLTSEQNLL QEVTVGEKLN LKVKVEAYPG LQGFNWTYWG PFSDHPPKLT FTTVEDTYRY 360
SSTLSLPRLK SSEAGRYSFL ARNAKGEETL TFELTLRYPP EVTVSRALIN GSEALLCVAS 420
GYPQPNVTWL QCGGRTERCD DAQVLVLEDS HPEVLSQEPF HKVTVQSQLA VGTLEYNRTY 480
QCRAHNSMGN SSQAFWSISV GASMQPPDEP LFTPVLVTCM SIMALLLLLL LLLLYKYKQK 540
PKYQVRWKII ESYEGNSYTF IDPTQLPYNE KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG 600
LGKEDAVLKV AVKMLKSTAH ADEKEALMSE LKIMSHLGQH ENIVNLLGAC THGGPVLVIT 660
EYCCYGDLLN FLRRKAEAML GPSLSQGQDL EAGTGYKNIH LEKKYVRRDS GFSSQGVDTY 720
VEMRPVSTSS SNDSFSEQDL DKEDGWPLEL RDLLHFSSQV AQGMAFLASK NCIHRDVAAR 780
NVLLTSGRVA KIGDFGLARD IMNDSNYIVK GNARLPVKWM APESIFDCIY TVQSDVWSYG 840
ILLWEIFSLG LNPYPGILVN SKFYKLVKDG YQMAQPAFAP KNIYSIMQAC WALEPTHRPT 900
FQQICCFLQE QTQVDRREQD YTNLPSSSSS GSSGSSSEPE EESSSEHLAC CEQGDIAQPL 960
LQPNNYQFC 969
Nucleotide Sequence
(FASTA)
ATGGGCCTGG GGGCTCTGCT GGTCCTGCTG GTGGCCACCG CTTGGCATGG TCAGGGGGTC 60
CCAGTGATAC AGCCCAGTGG CCCTGAGCTG ATTGTGGAGC CAGGAACAAG GGTGACCCTG 120
CGATGTGTGG GCAACGGCAG CGTGGAATGG GATGGCCCCA TCTCCCCATC TTGGACCCTG 180
GACCCAGATG CCCCCGGCAG CATCCTGACC ACGAATAATG CCACCTTCCA AAACACGGGG 240
ACCTATCGCT GCACGGAGCC TGGAGACCCC CTGGGGGGCA GCGCCACCAT CCACCTCTTT 300
GTCAAAGACC CTGTTCGGCC CTGGAAGGTT CTGGCCGAGG AAGTGACAGT GCTGGAGGGT 360
CAGGATGCAC TACTGCCTTG CCTGCTCACC GACCCGGCGC TGGAGGCTGG CGTCTCGCTG 420
ATGCGGGTGC GCGGCCGGCC TGTCTTGCGC CAAACCAGCT ACTCCTTCTC ACTATGGCAC 480
GGCTTCACCA TCCACAAGGC CAAGTTCATT GAGAGCCAGG ACTACCAATG CAGTGCTCGG 540
GTAGACGGCA GGACGGCGAC GTCGATCAGC ATCCGGCTTA AAGTGCAGAA AGTTGTCCCA 600
GGGCCCCCAA CCTTGACACT GGAGCCTGCA GAGCTGGTGC GGATTCAAGG GGAAACTGCC 660
CAGATCGTGT GCTCAGCCAG TGACGTTGAT GTCAACTTTG ACGTCTTCCT CCAACATGAA 720
GACACCAAGC TCACAATCTC TCAACAATCC GACTTCCGTG ATAACCGTTA CCACAAAGTC 780
CTGACCCTCA GCCTCGGTCA CGTGGGCTTC CAAGATGCCG GCAGCTACTC CTGCGTGGCC 840
ACCAATGCCC AGGGCGTCCG CTCCTCCTCC ATGGTCTTCC GGGTGGTAGA GAGTGCCTAC 900
TTGAACCTGA CCTCTGAGCA GAACCTCCTC CAGGAGGTGA CCGTGGGTGA GAAGCTCAAC 960
CTCAAAGTCA AGGTGGAGGC CTACCCAGGC CTACAAGGTT TCAACTGGAC CTACTGGGGA 1020
CCCTTCTCTG ACCACCCACC CAAGCTCACT TTTACGACTG TCGAGGACAC ATACAGGTAC 1080
AGCTCCACCC TCTCCCTGCC TCGCCTGAAG TCCTCTGAGG CCGGCCGCTA CTCATTCCTG 1140
GCCAGAAACG CCAAAGGCGA GGAAACCCTG ACCTTTGAAC TTACCCTGCG ATACCCCCCA 1200
GAGGTAACGG TGTCGAGAGC CCTTATCAAT GGCTCCGAGG CCCTGCTCTG TGTGGCCTCT 1260
GGGTACCCCC AACCTAATGT GACATGGCTG CAGTGCGGAG GCCGCACTGA AAGATGTGAT 1320
GATGCCCAAG TGTTGGTCTT GGAGGACTCA CACCCTGAGG TCCTGAGCCA GGAGCCCTTC 1380
CACAAAGTGA CTGTCCAGAG CCAGCTGGCT GTTGGGACCT TGGAATACAA CAGGACGTAT 1440
CAGTGCAGGG CCCACAACAG CATGGGGAAC AGCTCCCAGG CCTTCTGGTC CATCTCTGTG 1500
GGAGCCAGCA TGCAGCCCCC GGACGAGCCC CTGTTCACAC CGGTGCTGGT CACCTGCATG 1560
TCCATCATGG CCTTGCTGCT GCTGCTGCTG TTGTTGCTTT TGTACAAGTA CAAGCAGAAG 1620
CCCAAGTACC AGGTGCGCTG GAAAATCATC GAGAGCTACG AGGGCAACAG CTACACCTTC 1680
ATCGACCCCA CCCAGCTGCC CTACAACGAG AAGTGGGAGT TCCCCCGCAA CAACCTGCAG 1740
TTTGGTAAGA CCCTCGGAGC TGGCGCCTTT GGGAAGGTGG TAGAGGCCAC GGCCTTTGGT 1800
CTGGGAAAGG AAGATGCTGT CCTGAAGGTG GCTGTGAAGA TGCTGAAGTC CACGGCTCAC 1860
GCTGACGAGA AGGAGGCCCT CATGTCAGAA CTGAAGATCA TGAGTCACCT GGGCCAGCAT 1920
GAGAACATAG TCAACCTGCT GGGAGCCTGC ACCCACGGAG GTCCTGTCCT GGTCATCACC 1980
GAGTACTGTT GCTATGGCGA CCTGCTCAAC TTTCTTCGAA GGAAAGCTGA GGCCATGCTG 2040
GGACCCAGCC TGAGTCAGGG CCAGGACCTT GAGGCGGGAA CTGGCTACAA GAACATCCAC 2100
CTGGAAAAGA AATACGTCCG CAGGGACAGT GGCTTCTCCA GCCAGGGTGT GGACACCTAT 2160
GTGGAGATGA GACCCGTGTC CACTTCCTCT TCAAATGACT CGTTCTCTGA GCAAGACCTG 2220
GACAAAGAAG ACGGGTGGCC GCTGGAGCTG AGGGACCTGC TCCACTTCTC GAGCCAGGTG 2280
GCCCAGGGCA TGGCTTTCCT TGCTTCTAAG AATTGCATCC ACCGGGACGT GGCGGCCCGA 2340
AATGTGCTGC TGACCAGTGG GCGTGTGGCC AAGATTGGGG ACTTTGGGTT GGCCAGGGAC 2400
ATCATGAATG ACTCCAACTA CATCGTCAAG GGCAACGCCC GCCTGCCTGT GAAGTGGATG 2460
GCTCCTGAGA GCATCTTCGA CTGCATCTAC ACAGTGCAGA GTGACGTCTG GTCCTACGGC 2520
ATCCTGCTCT GGGAGATCTT CTCACTCGGG CTGAACCCCT ACCCTGGCAT CCTGGTGAAC 2580
AGCAAGTTCT ATAAACTGGT CAAGGACGGA TACCAAATGG CCCAGCCTGC GTTTGCCCCA 2640
AAGAACATAT ACAGCATCAT GCAGGCCTGC TGGGCCCTGG AGCCCACCCA CAGACCCACC 2700
TTCCAGCAGA TCTGCTGCTT CCTTCAGGAG CAGACCCAAG TGGACAGGAG AGAGCAGGAC 2760
TACACCAACC TGCCAAGCAG CAGCAGCAGT GGCAGCAGCG GCAGCAGCAG CGAGCCAGAG 2820
GAGGAGAGCT CCAGCGAGCA CCTGGCCTGC TGTGAGCAGG GAGATATTGC CCAACCCCTG 2880
CTGCAGCCCA ACAACTACCA GTTCTGCTGA 2910
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 579   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  638
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl++ ++ e+ + +k+
Q: 639   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSQGQDLEAGTGYKN  698
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s+++   se+            l++e
Q: 699   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSSNDSFSEQ-----------DLDKE  743
         *999***********************....6666555544444...........37899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d  +lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 744   DGWPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGRVAKIGDFGLARDIMN  803
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 804   DSNYIVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  863
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q++ +l
Q: 864   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICCFL  908
         *****************************************9876
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSQGQ DLEAGTGYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSSNDSFSEQ DLDKEDGWPL ELRDLLHFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTSGR VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC IYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APKNIYSIMQ ACWALEPTHR PTFQQICCFL 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013