EKS-EQC-00246

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00246

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	305.0	3.9E-91	1	226	226

Status

Unreviewed

Ensembl Protein

ENSECAP00000001806

UniProt Accession

F6U3N4;

Protein Name

Protein Synonyms/Alias

Gene Name

NUAK1

Gene Synonyms/Alias

NUAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000002145	ENSECAP00000001806	ENSECAT00000002536

Organism

Equus caballus

Functional Description

Protein Length

547

Protein Sequence
(FASTA)

VAIKSIRKDK IKDEQDMVHI RREIEIMSSL NHPHIISIYE VFENKDKIVI IMEYASKGEL 60

YDYISERRRL SERETRHFFR QIVSAVHYCH KNGVVHRDLK LENILLDDNC NIKIADFGLS 120

NLYQKDKFLQ TFCGSPLYAS PEIVNGRPYR GPEVDSWALG VLLYTLVYGT MPFDGFDHKN 180

LIRQISSGEY REPTQPSDAR GLIRWMLMVN PDRRATIEDI ANHWWVNWGY KSSVCDCDAL 240

HNSESPLLAR IIDWHHRSTG LQAEAEAKIK GLAKPGASEV MLERQRSLKK SKKENDFAQS 300

GQDSVPESPS KLNSKRPKGI LKKRSNSEHR SHSTGFIEGV PGKLSPKQSA TMPKKGILKK 360

TQQRESGYYS SPERSESSEL LDSNDGMGSS IPSPSPPDPA RVTSHSLSCR RKGILKHSSK 420

YSAGTMDPAL ASPEMPTLES LLEPGGLSRS YSRPSSVISE DSVLSSDSFD LLDLQENRPA 480

RQRIRSCVSA ENFLQIQDFE GLQNRPRPQY LKRYRNRLGD SSFSLLTDMD DVTQVYKKAL 540

EICNKLN 547

Nucleotide Sequence
(FASTA)

GTCGCTATAA AATCCATTCG TAAGGACAAA ATTAAGGATG AACAAGACAT GGTTCACATC 60

AGACGAGAGA TTGAGATCAT GTCATCCCTC AACCATCCTC ATATCATCAG TATTTATGAA 120

GTGTTTGAGA ACAAAGATAA GATTGTGATC ATCATGGAGT ACGCAAGCAA AGGGGAGCTG 180

TACGATTACA TCAGCGAGCG GCGACGCCTC AGTGAGCGGG AGACCAGACA CTTCTTCCGG 240

CAGATTGTGT CCGCCGTGCA CTACTGTCAC AAGAACGGCG TGGTCCACCG GGACTTGAAG 300

CTGGAAAATA TACTGCTCGA TGACAACTGC AATATTAAGA TTGCTGACTT TGGGCTTTCC 360

AACCTGTACC AGAAGGACAA GTTCTTGCAA ACTTTCTGTG GGAGCCCACT CTACGCATCT 420

CCTGAAATTG TCAATGGGAG GCCTTACCGA GGGCCAGAGG TGGACAGCTG GGCCCTGGGC 480

GTGTTGCTTT ACACTCTCGT TTATGGTACC ATGCCCTTCG ATGGTTTCGA TCACAAAAAC 540

CTCATTCGGC AGATCAGCAG TGGAGAGTAC CGGGAGCCCA CGCAGCCCTC AGATGCTCGA 600

GGACTCATTC GGTGGATGCT GATGGTGAAC CCTGATCGCC GGGCCACCAT CGAGGACATA 660

GCCAACCACT GGTGGGTGAA CTGGGGCTAC AAGAGCAGCG TCTGCGACTG TGATGCCCTT 720

CACAACTCCG AGTCCCCGCT CTTGGCGCGC ATTATCGATT GGCATCACCG TTCCACGGGG 780

CTGCAGGCTG AGGCCGAAGC CAAAATTAAG GGCCTGGCCA AACCCGGGGC CTCTGAGGTC 840

ATGCTGGAGC GGCAGCGGTC GCTGAAGAAG TCCAAGAAGG AGAATGACTT TGCCCAGTCC 900

GGCCAGGACT CGGTGCCCGA AAGCCCATCC AAGTTGAATT CCAAGAGGCC CAAAGGGATC 960

CTGAAGAAGC GAAGCAACAG CGAGCATCGC TCTCACAGCA CCGGCTTCAT CGAAGGCGTG 1020

CCTGGTAAAC TCAGCCCCAA ACAGTCAGCC ACGATGCCCA AGAAAGGCAT CTTGAAGAAG 1080

ACCCAGCAGA GAGAATCGGG TTACTACTCC TCCCCAGAGC GCAGCGAGTC TTCAGAGCTG 1140

TTGGACAGTA ATGACGGGAT GGGCAGCAGC ATCCCCTCCC CCAGCCCCCC GGACCCAGCC 1200

AGAGTGACGT CCCACAGCCT CTCCTGCCGC AGGAAGGGCA TCTTGAAACA CAGCAGCAAG 1260

TACTCAGCAG GCACCATGGA CCCGGCCCTC GCGAGCCCCG AAATGCCCAC ACTGGAATCC 1320

TTGCTGGAGC CTGGCGGCCT CTCCCGGAGC TACAGCCGGC CTTCCAGCGT CATCAGCGAA 1380

GACAGCGTCC TGTCCAGCGA CTCCTTCGAC TTGCTGGATT TGCAGGAGAA TCGCCCTGCC 1440

CGCCAGCGCA TCCGCAGCTG CGTCTCCGCC GAAAACTTCC TCCAGATCCA GGACTTTGAG 1500

GGGCTCCAGA ACCGGCCCCG GCCCCAGTAC CTAAAGCGGT ACCGGAACCG GCTGGGAGAC 1560

AGCAGCTTCT CGCTCCTCAC GGACATGGAT GACGTGACTC AGGTCTACAA GAAAGCGCTG 1620

GAGATCTGCA ACAAGCTCAA CTAG 1644

Domain Profile

S: 27    vavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvleyasggeL  85

         va+K i+k+k+ +e+ + +i+rEiei+++l+hp+ii+++ev+e+k+k+++++eyas+geL

Q: 1     VAIKSIRKDKIkDEQDMVHIRREIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGEL  60

         8********995667788******************************************

S: 86    fdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGla  145

         +dyi+e++rl+e+e+r++f+q+vsav+Y+h++g+vHrDlK+eN+lld++ nikiaDFGl+

Q: 61    YDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLS  120

         ************************************************************

S: 146   nlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlke  205

         nl++++k l+tfcGsp Ya+Pe+++g++Y+gp+vD W+lGv+Ly+lv+g++Pfd+ + k+

Q: 121   NLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKN  180

         ************************************************************

S: 206   llekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         l ++i++g+++ p++  ++++ L+r +L+v+p++Ratie+i +h w+

Q: 181   LIRQISSGEYREPTQ-PSDARGLIRWMLMVNPDRRATIEDIANHWWV  226

         *************99.7789**************************6

Domain Sequence
(FASTA)

VAIKSIRKDK IKDEQDMVHI RREIEIMSSL NHPHIISIYE VFENKDKIVI IMEYASKGEL 60

YDYISERRRL SERETRHFFR QIVSAVHYCH KNGVVHRDLK LENILLDDNC NIKIADFGLS 120

NLYQKDKFLQ TFCGSPLYAS PEIVNGRPYR GPEVDSWALG VLLYTLVYGT MPFDGFDHKN 180

LIRQISSGEY REPTQPSDAR GLIRWMLMVN PDRRATIEDI ANHWWV 226

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030155	; P:regulation of cell adhesion
GO:2000772	; P:regulation of cellular senescence
GO:0035507	; P:regulation of myosin-light-chain-phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013