EKS-EQC-00396
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00396
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR584.87.1E-176595928334
StatusUnreviewed
Ensembl ProteinENSECAP00000002875
UniProt AccessionF6WN82;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameFLT3
Gene Synonyms/Alias FLT3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000002171ENSECAP00000002875ENSECAT00000004167
OrganismEquus caballus
Functional Description
Protein Length978
Protein Sequence
(FASTA)
VVFSTMIFET ITNQDLPVIK CVLINHKNND SSVGISSSYP TVSESPEDLG CALRPESTEA 60
VYKAATVEVA TSASITLQVL VNTPGNISCL WVFKHSSLNC QPHFDLQNRG VVSMVILKMT 120
ETQAGEYLLF IQSEAANYTI LFTVSIRNTL LYTLRRPYFR KMENQDALVC VSESIPEPIV 180
EWVFCDSQSD SCKGESPAVV RKEESVLHEL FGTDIRCCAR NELGRECTKL FTIDLNQTPQ 240
TTLPQLFLKV GEPLWIRCKA VHVNHGFGLT WELEHRALEE GSYFEMSTYS TNRTMIRILF 300
AFVSSVGRND TGYYTCSSSK HPSKSALVTI LEKGFINASK SSENYEIDQY EEFCFSVRFK 360
AYPQIRCTWT FSQKSFPCEQ TGLDDGYSIS KFCNHKHQPG EYVFHAENDD AQFTKMFTLN 420
IRRKPQVLAE ASASQASCSS DGYPLPSWTW KKCSDKSLNC TEEITEGIWN KKANRKVFGK 480
WVSSSTLNMS EAIKGFLVKC CAYNSLGTSC ETILLNSPGT FPFIQDNIFY ATIGICLPFI 540
AILTMLICHK YKKQFRYESQ LQMVQVTGSL DNEYFYIDFR EYEYDLKWEF PRENLEFGKV 600
LGSGAFGKVM NATAYGISKT GVSIQVAVKM LKEKADSSER EALMSELKMM THLGNHENIV 660
NLLGACTLSG PIYLIFEYCC YGDLLNYLRS KREKFHRTWT EIFKEHNFSF YPTFQSHPNS 720
SMPGSREVQI HQDLDHISGF NGNSFQSEDE IEYENQKRLE EEEDLNVLTF EDLLCFAYQV 780
AKGMEFLEFK SCVHRDLAAR NVLVTHGKVV KICDFGLARD IMSDSNYVIR GNARLPVKWM 840
APESLFEGIY TIKSDVWSYG ILLWEIFSLG VNPYPGIPVD ANFYKLIQSG FKMDQPFYAT 900
EEIYFIMQSC WAFDSRKRPS FPNLTSFLGC QLADAEEAMY QNMDGHVSGR PSVYQNRRPY 960
SREVDSGLPS PQAHVEDS 978
Nucleotide Sequence
(FASTA)
GTTGTTTTTT CAACAATGAT ATTTGAGACT ATTACAAATC AAGATCTGCC TGTGATCAAG 60
TGTGTTTTAA TCAATCACAA GAACAATGAC TCCTCAGTGG GGATATCATC ATCATATCCC 120
ACGGTGTCAG AATCCCCGGA AGACCTGGGA TGTGCCTTGC GGCCTGAGAG CACAGAGGCA 180
GTCTACAAAG CAGCCACCGT GGAAGTGGCC ACATCTGCCT CCATCACACT GCAAGTGCTG 240
GTCAACACCC CTGGGAACAT TTCCTGTCTC TGGGTCTTTA AACACAGCTC CCTGAACTGC 300
CAGCCACACT TTGATTTACA AAACAGAGGA GTTGTTTCCA TGGTCATTTT GAAAATGACA 360
GAAACCCAAG CTGGAGAATA CCTACTTTTT ATTCAGAGTG AAGCTGCCAA TTACACAATA 420
TTGTTTACAG TGAGTATAAG AAATACACTG CTTTACACAT TAAGGAGACC TTACTTTAGA 480
AAAATGGAGA ATCAGGACGC CCTGGTCTGC GTATCTGAGA GCATTCCAGA ACCAATCGTG 540
GAATGGGTGT TTTGCGATTC ACAGAGTGAC AGCTGTAAAG GAGAGAGTCC AGCTGTTGTT 600
AGAAAGGAGG AAAGCGTACT TCATGAATTA TTTGGAACAG ACATAAGGTG CTGTGCAAGA 660
AATGAGCTGG GCAGGGAATG CACCAAGCTC TTCACAATAG ATCTAAATCA AACTCCTCAG 720
ACCACACTGC CACAATTATT TCTTAAAGTA GGGGAACCCC TCTGGATAAG ATGCAAAGCT 780
GTTCACGTAA ATCATGGATT CGGGCTCACC TGGGAGCTGG AGCATAGAGC ACTGGAGGAG 840
GGCAGCTACT TTGAGATGAG CACCTATTCC ACAAACAGGA CTATGATACG GATTCTGTTT 900
GCTTTTGTGT CATCAGTGGG AAGAAACGAC ACTGGATATT ACACTTGTTC CTCCTCGAAG 960
CATCCCAGTA AATCAGCTTT GGTCACCATC CTAGAAAAAG GATTTATAAA TGCTTCCAAA 1020
TCAAGTGAAA ATTATGAAAT TGACCAGTAT GAAGAGTTTT GCTTTTCTGT CAGGTTTAAA 1080
GCATACCCAC AAATCAGATG TACGTGGACC TTCTCTCAAA AATCATTTCC TTGTGAGCAA 1140
ACTGGCCTCG ACGACGGGTA CAGCATATCT AAGTTTTGCA ACCACAAACA CCAGCCAGGA 1200
GAATATGTAT TCCATGCAGA AAATGATGAC GCCCAGTTCA CAAAAATGTT CACACTGAAT 1260
ATAAGAAGGA AACCTCAAGT GCTAGCCGAG GCGTCAGCAA GTCAGGCTTC TTGCTCCTCC 1320
GATGGATACC CATTACCATC GTGGACCTGG AAGAAGTGCT CAGACAAGTC TCTGAACTGC 1380
ACAGAAGAAA TCACAGAAGG AATTTGGAAT AAAAAGGCTA ACAGAAAAGT GTTTGGAAAG 1440
TGGGTCTCGA GCAGTACTCT CAACATGAGT GAGGCCATAA AAGGGTTCCT GGTGAAGTGC 1500
TGTGCATACA ATTCCCTTGG CACATCTTGT GAAACAATCC TTTTAAACTC ACCAGGCACC 1560
TTCCCTTTCA TCCAGGACAA CATCTTCTAT GCAACAATTG GGATTTGTCT TCCCTTCATT 1620
GCCATTTTAA CCATGCTGAT TTGTCACAAG TACAAAAAGC AATTTAGGTA TGAAAGCCAG 1680
CTGCAAATGG TACAGGTGAC TGGTTCTTTG GATAATGAGT ACTTCTACAT TGATTTCAGA 1740
GAATATGAAT ATGATCTCAA ATGGGAGTTT CCAAGAGAAA ATTTAGAATT TGGGAAGGTG 1800
CTAGGATCGG GTGCTTTTGG AAAAGTGATG AATGCAACAG CTTATGGAAT TAGTAAAACA 1860
GGGGTGTCAA TCCAGGTTGC AGTCAAAATG CTGAAAGAAA AAGCAGACAG TTCTGAAAGA 1920
GAGGCTCTCA TGTCTGAACT CAAAATGATG ACTCACCTGG GAAACCATGA GAATATTGTG 1980
AATCTGCTGG GGGCATGCAC GCTGTCAGGA CCAATTTACT TGATTTTTGA GTATTGTTGC 2040
TATGGTGATC TTCTCAACTA TCTAAGAAGT AAAAGAGAAA AATTTCACAG GACGTGGACG 2100
GAAATTTTCA AGGAACACAA TTTCAGTTTT TACCCCACAT TCCAATCACA TCCAAATTCC 2160
AGTATGCCTG GTTCAAGAGA AGTTCAGATA CACCAGGACT TGGATCATAT CTCAGGGTTC 2220
AATGGGAATT CATTTCAATC CGAAGATGAA ATTGAATATG AAAACCAAAA AAGGCTGGAG 2280
GAAGAAGAGG ACTTGAACGT GCTTACGTTT GAAGACCTTC TTTGCTTTGC ATACCAAGTT 2340
GCCAAAGGAA TGGAATTTCT GGAATTTAAG TCGTGTGTTC ACAGAGACCT GGCAGCCAGG 2400
AATGTGCTCG TGACCCACGG GAAGGTGGTG AAGATATGTG ATTTTGGACT GGCTCGAGAT 2460
ATTATGAGTG ATTCCAACTA CGTTATCAGG GGCAATGCCC GTTTGCCTGT GAAGTGGATG 2520
GCTCCTGAAA GCTTATTTGA AGGGATCTAC ACAATTAAGA GTGATGTCTG GTCATACGGA 2580
ATATTACTCT GGGAAATATT CTCGCTTGGT GTCAATCCTT ACCCTGGTAT TCCTGTTGAC 2640
GCTAACTTCT ATAAACTCAT TCAGAGTGGA TTTAAAATGG ATCAGCCATT TTATGCTACA 2700
GAAGAAATAT ACTTTATAAT GCAATCCTGC TGGGCTTTTG ACTCAAGGAA ACGACCATCC 2760
TTCCCTAATC TGACTTCGTT TTTAGGCTGT CAGCTGGCAG ATGCAGAAGA AGCGATGTAT 2820
CAGAACATGG ATGGTCACGT TTCGGGACGT CCTTCTGTCT ATCAAAACAG GCGACCTTAC 2880
AGCAGAGAGG TGGATTCAGG GCTACCCTCT CCACAGGCTC ACGTTGAAGA TTCGTAG 2937
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         le+GkvlGsGafGkv++atayG+sk++++++vavkmlk++a+sse+ealmselk+++hlG
Q: 595   LEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTHLG  654
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact +Gpiy+i+eyccyGdllnylr+kre+f+++++e++ke++++++ + 
Q: 655   NHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPT-  713
         *********************************************************99.
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
               ++s+ ++s+++s+e v++++d++++s ++ ++++se++ +++++++   +eeed
Q: 714   ------FQSHPNSSMPGSRE-VQIHQDLDHISGFNGNSFQSEDEIEYENQKRL--EEEED  764
         ......9*************.**************************999877..78999
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
          +vl++edll+f+yqvakGmefl++k+cvhrdlaarnvl+t+GkvvkicdfGlardim+d
Q: 765   LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD  824
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyv++Gnarlpvkwmapes+f+++yt+ksdvwsyGillweifslG++pypg++vd++fy
Q: 825   SNYVIRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY  884
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         kli++G++m+qp+yateeiy imq+cw+++++krpsf +l+++l
Q: 885   KLIQSGFKMDQPFYATEEIYFIMQSCWAFDSRKRPSFPNLTSFL  928
         ****************************************9986
Domain Sequence
(FASTA)
LEFGKVLGSG AFGKVMNATA YGISKTGVSI QVAVKMLKEK ADSSEREALM SELKMMTHLG 60
NHENIVNLLG ACTLSGPIYL IFEYCCYGDL LNYLRSKREK FHRTWTEIFK EHNFSFYPTF 120
QSHPNSSMPG SREVQIHQDL DHISGFNGNS FQSEDEIEYE NQKRLEEEED LNVLTFEDLL 180
CFAYQVAKGM EFLEFKSCVH RDLAARNVLV THGKVVKICD FGLARDIMSD SNYVIRGNAR 240
LPVKWMAPES LFEGIYTIKS DVWSYGILLW EIFSLGVNPY PGIPVDANFY KLIQSGFKMD 300
QPFYATEEIY FIMQSCWAFD SRKRPSFPNL TSFL 334
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00375
EKS-ANC-00393
EKS-BOT-00404
EKS-CAJ-00408
EKS-CAF-00404
EKS-CAP-00433
EKS-DAR-00790
EKS-FEC-00388
EKS-GAG-00343
EKS-GOG-00396
EKS-HOS-00410
EKS-ICT-00383
EKS-LOA-00413
EKS-MAM-00403
EKS-MEG-00337
EKS-MOD-00392
EKS-MUM-00436
EKS-MUP-00397
EKS-MYL-00399
EKS-NOL-00369
EKS-OCP-00084
EKS-ORA-00348
EKS-ORC-00379
EKS-OTG-00406
EKS-PES-00360
EKS-POA-00395
EKS-SAH-00374
EKS-SUS-00354
EKS-TAG-00475
EKS-TUT-00119
EKS-XET-00516
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0002318; P:myeloid progenitor cell differentiation
GO:0045578; P:negative regulation of B cell differentiation
GO:0008285; P:negative regulation of cell proliferation
GO:0002328; P:pro-B cell differentiation
GO:0002572; P:pro-T cell differentiation
GO:0046777; P:protein autophosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013