EKS-EQC-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	467.7	1.5E-140	177	464	288

Status

Unreviewed

Ensembl Protein

ENSECAP00000003921

UniProt Accession

F7DAS1;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR1

Gene Synonyms/Alias

TGFBR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000004757	ENSECAP00000003921	ENSECAT00000005562

Organism

Equus caballus

Functional Description

Protein Length

475

Protein Sequence
(FASTA)

ALQCFCHLCT KDNFTCVTDG LCFVSVTETT DKVIHNSMCI AEIDLIPRDR PFVCAPSSKT 60

GSVTTTYCCN QDHCNKIELP TVGPFSGKPS SGLGPVELAA VIAGPVCFVC ISLMLMVYIC 120

HNRTVIHHRV PNEEDPSLDR PFISEGTTLK DLIYDMTTSG SGSGLPLLVQ RTIARTIVLQ 180

ESIGKGRFGE VWRGKWRGEE VAVKIFSSRE ERSWFREAEI YQTVMLRHEN ILGFIAADNK 240

DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT VEGMIKLALS TASGLAHLHM EIVGTQGKPA 300

IAHRDLKSKN ILVKKNGTCC IADLGLAVRH DSATDTIDIA PNHRVGTKRY MAPEVLDDSI 360

NMKHFESFKR ADIYAMGLVF WEIARRCSVG GIHEDYQLPY YDLVPSDPSV EEMRKVVCEQ 420

KLRPNIPNRW QSCEALRVMA KIMRECWYAN GAARLTALRI KKTLSQLSQQ EGIKM 475

Nucleotide Sequence
(FASTA)

GCATTACAGT GTTTCTGCCA CCTTTGTACA AAAGACAATT TTACTTGTGT CACAGATGGG 60

CTCTGCTTTG TCTCTGTCAC AGAGACCACA GATAAAGTTA TACACAATAG CATGTGTATA 120

GCTGAAATCG ACCTAATTCC TCGAGACAGG CCGTTTGTAT GTGCACCGTC CTCAAAAACT 180

GGGTCTGTTA CTACAACGTA TTGCTGCAAT CAGGACCATT GCAATAAAAT AGAACTCCCA 240

ACTGTTGGCC CTTTTTCAGG AAAGCCATCA TCTGGCCTTG GTCCTGTCGA ACTGGCAGCT 300

GTCATTGCTG GACCAGTCTG CTTCGTCTGC ATCTCACTCA TGTTGATGGT CTATATCTGC 360

CATAACCGCA CTGTCATTCA CCATCGAGTG CCAAATGAAG AGGATCCTTC ATTAGATCGC 420

CCTTTTATTT CAGAGGGCAC TACGTTAAAA GACTTAATTT ATGATATGAC AACATCAGGT 480

TCTGGATCAG GTTTACCATT GCTTGTTCAG AGAACAATCG CGAGAACTAT CGTGTTACAA 540

GAAAGTATCG GCAAAGGTCG ATTTGGAGAA GTTTGGCGAG GGAAGTGGAG AGGAGAAGAA 600

GTCGCTGTTA AAATATTCTC CTCTAGAGAA GAACGTTCAT GGTTCCGTGA GGCCGAGATT 660

TATCAAACTG TAATGTTACG TCATGAAAAC ATCTTGGGAT TTATAGCAGC GGACAATAAA 720

GACAACGGTA CATGGACTCA GCTCTGGTTG GTGTCAGATT ATCATGAGCA TGGCTCCCTT 780

TTTGATTATT TGAACAGATA CACAGTGACT GTGGAAGGGA TGATAAAACT CGCTCTGTCC 840

ACGGCAAGTG GACTCGCCCA TCTTCACATG GAGATTGTTG GTACCCAAGG AAAACCAGCC 900

ATTGCTCATA GAGATTTGAA ATCCAAGAAT ATCTTGGTAA AGAAGAATGG AACTTGCTGC 960

ATTGCAGACT TGGGACTGGC AGTAAGGCAT GATTCGGCCA CAGATACAAT TGATATTGCT 1020

CCAAACCACA GAGTGGGAAC AAAAAGGTAC ATGGCCCCTG AAGTTCTAGA TGATTCCATA 1080

AATATGAAAC ACTTTGAATC CTTCAAACGT GCCGACATCT ATGCAATGGG CTTAGTGTTC 1140

TGGGAAATAG CTCGACGATG CTCCGTTGGT GGAATTCATG AAGATTACCA GCTGCCTTAT 1200

TATGATCTTG TACCTTCTGA TCCATCAGTT GAAGAAATGA GAAAGGTTGT TTGTGAACAG 1260

AAGTTAAGGC CAAATATTCC AAACAGATGG CAGAGCTGTG AAGCTCTGAG AGTAATGGCT 1320

AAAATCATGA GAGAATGCTG GTATGCCAAT GGAGCGGCAA GGCTTACAGC TCTGCGGATT 1380

AAGAAAACAT TGTCACAGCT CAGTCAACAA GAAGGCATCA AAATGTAA 1428

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 177   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  236

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +++lals+asGlahLH+eivgt+

Q: 237   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQ  296

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 297   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  354

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+  ++++e+y+lp+++ v+sdPs+eem

Q: 355   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSV-GGIHEDYQLPYYDLVPSDPSVEEM  413

         **********************************9.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 414   RKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  464

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK LALSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSVGGIHEDY QLPYYDLVPS DPSVEEMRKV 240

VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0044459	; C:plasma membrane part
GO:0043235	; C:receptor complex
GO:0005923	; C:tight junction
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000186	; P:activation of MAPKK activity
GO:0001525	; P:angiogenesis
GO:0009952	; P:anterior/posterior pattern specification
GO:0048844	; P:artery morphogenesis
GO:0001824	; P:blastocyst development
GO:0071560	; P:cellular response to transforming growth factor beta stimulus
GO:0030199	; P:collagen fibril organization
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0043542	; P:endothelial cell migration
GO:0001837	; P:epithelial to mesenchymal transition
GO:0008354	; P:germ cell migration
GO:0007507	; P:heart development
GO:0006917	; P:induction of apoptosis
GO:0001822	; P:kidney development
GO:0002088	; P:lens development in camera-type eye
GO:0043066	; P:negative regulation of apoptotic process
GO:0032331	; P:negative regulation of chondrocyte differentiation
GO:0048663	; P:neuron fate commitment
GO:0060021	; P:palate development
GO:0060017	; P:parathyroid gland development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0060037	; P:pharyngeal system development
GO:0030307	; P:positive regulation of cell growth
GO:0008284	; P:positive regulation of cell proliferation
GO:0051272	; P:positive regulation of cellular component movement
GO:0051491	; P:positive regulation of filopodium assembly
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0051897	; P:positive regulation of protein kinase B signaling cascade
GO:0060391	; P:positive regulation of SMAD protein import into nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0009791	; P:post-embryonic development
GO:0043393	; P:regulation of protein binding
GO:0031396	; P:regulation of protein ubiquitination
GO:0048538	; P:thymus development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013