EKS-EQC-00034
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00034
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RAD53434.12.0E-130221487267
StatusUnreviewed
Ensembl ProteinENSECAP00000004610
UniProt AccessionF7B9A4;
Protein Name
Protein Synonyms/Alias
Gene NameCHEK2
Gene Synonyms/Alias CHEK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000004845ENSECAP00000004610ENSECAT00000006491
OrganismEquus caballus
Functional Description
Protein Length544
Protein Sequence
(FASTA)
MSQEKDVECQ QSHGSASSQA QSGSSQSHGL SSQTQGASSQ SQGTSSSSTS TAPTSSQSSH 60
SSSGTLSSLD TVSTQELYSI PEDQEPEEPV PVPWARLWAL QDGFSNLDCV NDNYWFGRDK 120
SCEYCFDEPL LKKTDKYRTY SKKHFRIFRE MGPKNSYIAY IEDHSGNGTF VNRELVGKGR 180
RLPLNNNSEI ALSVWNNKVF VFFDLTVDDQ SVYPKELRDQ YIMSKTLGSG ACGEVKLAFE 240
RKTCKKVAIK IISKRKFAIG SGREADPALN VETEIEILKK LNHPCIIKIK DFFDAEDYYI 300
VLELMEGGEL FDRVVGNKRL KEATCKLYFY QMLLAVQYLH ENGIIHRDLK PENVLLSSQK 360
EDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLNSF GTAGYNRAVD CWSLGVILFI 420
CLSGYPPFSE HKTQVSLKDQ ITSGKYNFIP EVWAEVSEKA LDLVKKLLIV DPKARFTTEE 480
ALRHPWLQDE DMKRKFQNLL SEENKSTALP EAPAQPSTSR KRPLEGEAED SDTTKRPTVC 540
TAVS 544
Nucleotide Sequence
(FASTA)
ATGTCTCAGG AGAAGGATGT GGAGTGTCAG CAGTCCCACG GCAGTGCCTC CTCGCAGGCC 60
CAGAGTGGCT CCTCGCAGTC CCATGGGCTT TCCTCACAGA CACAGGGCGC CTCCTCGCAG 120
TCCCAGGGCA CGTCCAGCTC CTCCACCAGC ACAGCGCCCA CGTCCAGCCA GTCCTCTCAC 180
TCCAGCTCGG GGACGCTGAG CTCCTTGGAC ACAGTGTCCA CTCAGGAACT CTATTCTATT 240
CCTGAGGACC AAGAACCTGA GGAGCCTGTC CCTGTCCCTT GGGCTCGATT ATGGGCCCTT 300
CAGGATGGAT TCTCCAATCT TGACTGTGTT AATGACAACT ACTGGTTTGG GAGGGATAAA 360
AGCTGTGAAT ACTGCTTTGA TGAGCCACTG CTGAAAAAAA CGGATAAATA CCGGACTTAC 420
AGCAAGAAGC ACTTTCGGAT TTTCAGAGAA ATGGGTCCTA AAAACTCTTA CATCGCATAC 480
ATCGAAGATC ACAGTGGGAA TGGAACCTTT GTAAATAGAG AGCTTGTAGG GAAAGGAAGA 540
CGCCTTCCTT TGAATAACAA TTCTGAAATC GCACTTTCAG TATGGAATAA TAAAGTTTTT 600
GTATTTTTTG ATCTGACTGT AGATGACCAG TCAGTTTATC CTAAGGAATT AAGAGATCAA 660
TACATCATGT CAAAAACTCT TGGAAGTGGT GCTTGTGGTG AGGTGAAGCT AGCTTTTGAG 720
AGGAAAACAT GTAAGAAAGT AGCCATAAAA ATCATCAGCA AAAGGAAGTT TGCTATTGGC 780
TCTGGGAGAG AGGCTGATCC AGCTCTCAAT GTGGAAACAG AAATAGAAAT CTTGAAAAAA 840
CTAAATCATC CTTGTATCAT CAAGATTAAA GACTTTTTTG ATGCTGAAGA TTATTATATT 900
GTTTTGGAAT TGATGGAAGG AGGAGAGCTC TTTGACAGGG TGGTGGGGAA TAAACGCCTG 960
AAAGAAGCTA CATGCAAACT CTATTTTTAC CAGATGCTCC TGGCTGTACA GTACCTTCAT 1020
GAAAATGGCA TTATCCATCG GGACTTAAAG CCAGAGAATG TTCTCCTCTC ATCTCAAAAA 1080
GAGGACTGTC TTATAAAGAT TACAGATTTT GGGCAGTCCA AGATTCTGGG GGAGACCTCT 1140
CTCATGAGAA CCTTATGTGG TACCCCCACC TACTTGGCTC CTGAAGTTCT TAATTCCTTT 1200
GGAACTGCCG GATATAACCG TGCTGTGGAC TGCTGGAGTT TAGGAGTTAT TCTTTTTATT 1260
TGCCTTAGTG GGTATCCACC TTTCTCTGAG CATAAGACTC AAGTGTCACT GAAGGATCAG 1320
ATCACCAGTG GAAAATACAA CTTCATTCCT GAAGTCTGGG CAGAGGTCTC AGAGAAGGCT 1380
CTGGACCTTG TCAAGAAGTT GTTGATAGTG GATCCAAAGG CACGTTTTAC AACAGAAGAA 1440
GCTTTAAGAC ACCCGTGGCT TCAGGATGAG GACATGAAGA GAAAATTTCA GAATTTGCTT 1500
TCTGAAGAAA ATAAATCAAC GGCTCTACCT GAGGCCCCAG CCCAGCCTTC CACAAGTCGA 1560
AAGCGGCCTC TTGAAGGGGA AGCAGAGGAT TCTGACACCA CAAAGCGCCC GACTGTGTGC 1620
ACTGCTGTCT CATGA 1635
Domain Profile
S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59
         yi+sk+lG+Ga+g+vkla+e+kt+kkva+ki+skrk +i+s re++ a +ve+e+eilkk
Q: 221   YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKfAIGSGREADPALNVETEIEILKK  280
         89*********************************999**********************
S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119
         l+hP+i+k+kd+f++e++ y+vlel+egGel+d+vv +k+lke+++kl+f+q+l av+yl
Q: 281   LNHPCIIKIKDFFDAEDY-YIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYL  339
         *****************9.*****************************************
S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179
         he+giihrDlkPen+Lls+++ed+l+kitDfG++k+lge+slm+tlCGtp+y+aPevl +
Q: 340   HENGIIHRDLKPENVLLSSQKEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLNS  399
         ************************************************************
S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239
          g+a+y+++vD+WslGv+lf++lsGypPfse++tqvslk+qi++gky+fi+e+w+++se+
Q: 400   FGTAGYNRAVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWAEVSEK  459
         ************************************************************
S: 240   akdlikklLvvdPeerlsieealnhpWl  267
         a+dl+kklL+vdP++r+++eeal+hpWl
Q: 460   ALDLVKKLLIVDPKARFTTEEALRHPWL  487
         ***************************8
Domain Sequence
(FASTA)
YIMSKTLGSG ACGEVKLAFE RKTCKKVAIK IISKRKFAIG SGREADPALN VETEIEILKK 60
LNHPCIIKIK DFFDAEDYYI VLELMEGGEL FDRVVGNKRL KEATCKLYFY QMLLAVQYLH 120
ENGIIHRDLK PENVLLSSQK EDCLIKITDF GQSKILGETS LMRTLCGTPT YLAPEVLNSF 180
GTAGYNRAVD CWSLGVILFI CLSGYPPFSE HKTQVSLKDQ ITSGKYNFIP EVWAEVSEKA 240
LDLVKKLLIV DPKARFTTEE ALRHPWL 267
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00032
EKS-BOT-00037
EKS-CAE-00032
EKS-CAJ-00036
EKS-CAF-00037
EKS-CAP-00037
EKS-CII-00014
EKS-CIS-00038
EKS-DAR-00048
EKS-DRM-00013
EKS-FEC-00034
EKS-GAG-00030
EKS-GOG-00035
EKS-HOS-00037
EKS-ICT-00032
EKS-LAC-00038
EKS-LOA-00036
EKS-MAM-00036
EKS-MEG-00032
EKS-MOD-00036
EKS-MUM-00038
EKS-MUP-00038
EKS-MYL-00038
EKS-NOL-00035
EKS-ORN-00053
EKS-ORA-00032
EKS-ORC-00035
EKS-ORL-00049
EKS-OTG-00038
EKS-PAT-00034
EKS-PES-00033
EKS-POA-00034
EKS-RAN-00038
EKS-SAH-00035
EKS-TAG-00034
EKS-TAR-00053
EKS-TEN-00057
EKS-XET-00037
EKS-XIM-00051
EKS-SCP-00036
Gene Ontology
GO:0000781; C:chromosome, telomeric region
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0044257; P:cellular protein catabolic process
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0006302; P:double-strand break repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010332; P:response to gamma radiation
GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307; P:spindle assembly involved in mitosis
KEGG
ecb:100059288;
InterPros
IPR000253; FHA_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008984; SMAD_FHA_domain.
Pfam
PF00498; FHA; 1.
PF00069; Pkinase; 1.
SMARTs
SM00240; FHA; 1.
SM00220; S_TKc; 1.
Prosites
PS50006; FHA_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013