EPS-EQC-00019

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-EQC-00019

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	237.9	1.7E-70	95	344	250

Status

Unreviewed

Ensembl Protein

ENSECAP00000003796

UniProt Accession

F6Q474;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1K

Gene Synonyms/Alias

PPM1K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000005000	ENSECAP00000003796	ENSECAT00000005398

Organism

Equus caballus

Functional Description

Protein Length

372

Protein Sequence
(FASTA)

MSTAALITLV RSGGNQVRRR VLLGSRLLQD DRRLTLTCHG STSEPQCSRF DPDGSGCPAT 60

WDNFGIWDNR IDEPILLPPS IKYGKPIPQI SLANVGCASH IGKRKENEDR FGFARLTDEV 120

LYFAVYDGHG GPAAADFCHT HMEKCIKDLL PKEKNLETVL TLAFLEIDKA FARHARLSAD 180

ATLLTSGTTA TVALLRDGIE LVVASVGDSR AILCRKGKPM KLTTDHTPER KDEKERIKKC 240

GGFIAWNSVG QPHVNGRLAM TRSLGDLDLK TSGVIAEPET KRINLHHADD SFLVLTTDGI 300

NFMVNSQEIC DFVNQCHDPN EAAHAVTEQA IQYGTEDNST AVVVPFGAWG KYKNSEINFS 360

FSRSFASSGR WA 372

Nucleotide Sequence
(FASTA)

ATGTCAACAG CTGCCTTAAT TACTTTGGTT CGAAGTGGTG GGAACCAGGT GAGGAGGAGA 60

GTGCTGCTAG GCTCCCGCCT GCTGCAGGAC GACAGGCGGC TGACGCTCAC ATGCCACGGC 120

TCTACTTCAG AGCCCCAGTG TTCTCGGTTT GACCCAGATG GTAGCGGGTG TCCAGCCACC 180

TGGGATAATT TCGGGATCTG GGATAACCGC ATTGATGAAC CAATTCTGCT GCCACCCAGC 240

ATCAAGTATG GCAAACCAAT TCCCCAGATC AGCTTGGCGA ATGTGGGCTG TGCCTCACAT 300

ATTGGCAAAC GGAAAGAGAA TGAAGACCGC TTTGGCTTTG CCCGGCTAAC AGATGAGGTC 360

CTGTACTTCG CGGTGTACGA TGGACATGGG GGACCTGCAG CTGCTGATTT CTGTCACACA 420

CACATGGAGA AATGCATCAA GGATTTGCTT CCAAAGGAGA AGAACTTGGA AACTGTATTG 480

ACCTTGGCTT TTCTAGAAAT AGATAAAGCC TTTGCAAGGC ACGCCCGCCT GTCTGCTGAT 540

GCCACGCTAC TGACCTCTGG GACTACTGCC ACAGTAGCCC TATTGCGAGA TGGTATTGAA 600

CTGGTTGTAG CCAGTGTTGG GGATAGCCGG GCTATTTTGT GTAGAAAAGG AAAACCCATG 660

AAGCTGACCA CTGACCATAC TCCAGAAAGA AAAGACGAAA AAGAAAGGAT CAAGAAATGC 720

GGTGGTTTTA TAGCTTGGAA TAGCGTGGGA CAGCCTCATG TGAACGGCAG ACTTGCGATG 780

ACAAGGAGTC TTGGAGATTT GGATCTTAAA ACCAGTGGTG TGATAGCAGA ACCTGAAACA 840

AAGAGGATTA ATCTACATCA TGCTGATGAC AGCTTCCTGG TCCTCACTAC AGATGGAATT 900

AACTTCATGG TGAATAGTCA AGAGATTTGT GACTTTGTCA ATCAGTGCCA TGATCCCAAC 960

GAAGCAGCCC ATGCAGTGAC TGAACAGGCA ATACAGTATG GTACCGAAGA TAACAGTACT 1020

GCAGTGGTAG TGCCTTTTGG CGCTTGGGGA AAATACAAGA ACTCCGAAAT CAACTTCTCG 1080

TTCAGCAGAA GCTTTGCCTC CAGTGGACGC TGGGCCTGA 1119

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         vg++s  g+r+e ed++    +f++ +++   + +f+vyDGhgg  +a+fc+++++++++

Q: 95    VGCASHIGKRKENEDRF----GFARLTDE---VLYFAVYDGHGGPAAADFCHTHMEKCIK  147

         79999999999999999....67887665...78**************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidk....sGstavvalikds.kl  117

           l     +e++++++l+ aFl++d+++    +++l+ d+    sG+ta+val++d  +l

Q: 148   DLLP----KEKNLETVLTLAFLEIDKAF--ARHARLSADAtlltSGTTATVALLRDGiEL  201

         **87....********************..44444555555799*************9**

S: 118   yvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkd.ga.RvlGvLavs  175

         +va vGdSra+Lcr+gk+++l++dH+p+r+dE+eRi++ gg ++ ++ g+ +v+G La++

Q: 202   VVASVGDSRAILCRKGKPMKLTTDHTPERKDEKERIKKCGGFIAWNSvGQpHVNGRLAMT  261

         ****************************************99987779999*********

S: 176   RalGdlylk.pyvtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvlekke  233

         R+lGdl+lk + v++ePe+  ++l++ d+ fl+L +DG+  +v+++e++++v+++++

Q: 262   RSLGDLDLKtSGVIAEPETKRINLHHADDsFLVLTTDGINFMVNSQEICDFVNQCHD---  318

         *********566************999999***************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

          ++eaa+ ++++a+++g++dn +a+vv

Q: 319   -PNEAAHAVTEQAIQYGTEDNSTAVVV  344

         .***********************997

Domain Sequence
(FASTA)

VGCASHIGKR KENEDRFGFA RLTDEVLYFA VYDGHGGPAA ADFCHTHMEK CIKDLLPKEK 60

NLETVLTLAF LEIDKAFARH ARLSADATLL TSGTTATVAL LRDGIELVVA SVGDSRAILC 120

RKGKPMKLTT DHTPERKDEK ERIKKCGGFI AWNSVGQPHV NGRLAMTRSL GDLDLKTSGV 180

IAEPETKRIN LHHADDSFLV LTTDGINFMV NSQEICDFVN QCHDPNEAAH AVTEQAIQYG 240

TEDNSTAVVV 250

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

ecb:100063504

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013