EKS-EQC-00113

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00113

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	394.9	1.9E-118	46	309	264

Status

Unreviewed

Ensembl Protein

ENSECAP00000004678

UniProt Accession

F7B0G7;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000006233	ENSECAP00000004678	ENSECAT00000006573

Organism

Equus caballus

Functional Description

Protein Length

837

Protein Sequence
(FASTA)

MKKFFDSRRE QGCSGLGSGS SGGGGSTSGL GSGYIGRVFG IGRQQVTVDE VLAEGGFAIV 60

FLVRTSNGMK CALKRMFVNN EHDLQVCKRE IQIMRDLSGH KNIVGYIDSS INNVSSGDVW 120

EVLILMDFCR GGQVVNLMNQ RLQTGFTENE VLQIFCDTCE AVARLHQCKT PIIHRDLKVE 180

NILLHDRGHY VLCDFGSATN KFQNPQTEGV NAVEDEIKKY TTLSYRAPEM VNLYSGKIIT 240

TKADIWALGC LLYKLCYFTL PFGESQVAIC DGNFTIPDNS RYSQDMHCLI RYMLEPDPDK 300

RPDIYQVSYF SFKLLKKECP IPNVQNSPIP AKLPEPVKAS EAAAKKTQPK ARLTDPIPTT 360

ETSIAPRQRP KAGQTQPNPG ILPIQPALTP RKRATVQPPP QAAGSSNQPG LLASVPQPKT 420

QPPPSQPLPQ SQPKQPQAPP APQQPPSTPA QGLPTQAQAT PQHQQQLFLK QQQQQQQQQQ 480

QPPPPSQQPA GTFYQQQQQA QAQQFQAVHP ATQQPAIAQF PVVSQGSSQQ QLMQNFYQQQ 540

QQQQQQQQQQ LATTLHQQQL LTQQAALQQK TAVAAVQQPQ AQQTTAPQPP PAQEPAIQAP 600

VRQQPKVQTT PPPAIQGQKL GSLTPPSSPK TQRAGHRRIL SDVTHSAVFG VPASKSTQLL 660

QAAAAEASLN KSKSATTTPS GSPRTSQQNV YNPSESSTWN PFDDDNFSKL TAEELLNKDF 720

AKLGEGKHPE KLGGSAESLI PGFQPTQGDA FATASFPAGA AEKRKGGQTV DPSLPLLSVS 780

DPFIPLQVPD APEKLIEGLK SPDTSLLLPD LLPMTDPFGS TSDAVIGKVI ISFFSHA 837

Nucleotide Sequence
(FASTA)

ATGAAGAAGT TTTTCGACTC TCGGCGAGAG CAGGGCTGCT CTGGCCTGGG CTCTGGCTCC 60

AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG GGTCTTTGGC 120

ATTGGGCGGC AGCAGGTCAC TGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATCGTG 180

TTTCTGGTGA GGACAAGCAA TGGAATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 240

GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGACCT GTCAGGACAC 300

AAGAACATTG TGGGTTACAT TGACTCCAGT ATCAACAATG TGAGTAGCGG TGATGTATGG 360

GAAGTTCTCA TTCTGATGGA CTTCTGCAGG GGAGGCCAGG TGGTCAACCT GATGAACCAA 420

CGCCTACAAA CAGGTTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA CACCTGTGAA 480

GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGTGACCT GAAGGTTGAA 540

AATATCCTTT TGCATGACCG AGGCCACTAC GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 600

AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 660

ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 720

ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA TTTCACTTTA 780

CCATTTGGGG AGAGTCAAGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAACTCT 840

CGATATTCCC AAGATATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 900

AGGCCGGATA TTTACCAGGT CTCCTACTTC TCATTTAAAC TACTCAAGAA GGAATGCCCA 960

ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 1020

GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 1080

GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAGGCTGGGC AGACTCAGCC GAACCCAGGA 1140

ATCCTTCCCA TCCAGCCAGC CCTGACACCT CGAAAGAGGG CCACAGTTCA GCCCCCACCT 1200

CAGGCTGCAG GATCCAGCAA TCAACCTGGC CTTTTAGCCA GTGTTCCCCA ACCGAAAACC 1260

CAGCCCCCAC CCAGCCAACC TCTACCACAG TCTCAACCCA AGCAGCCACA GGCTCCACCT 1320

GCCCCACAGC AGCCGCCTTC CACTCCGGCC CAGGGTCTGC CTACTCAGGC CCAGGCGACA 1380

CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAGCAGC AGCAGCAGCA GCAACAACAA 1440

CAGCCACCGC CACCATCACA GCAGCCAGCC GGCACGTTCT ACCAGCAGCA GCAGCAGGCC 1500

CAGGCTCAGC AGTTTCAGGC AGTACACCCA GCAACCCAGC AACCAGCGAT TGCCCAGTTC 1560

CCTGTGGTAT CCCAAGGAAG CTCTCAACAG CAGCTGATGC AGAACTTCTA CCAGCAGCAG 1620

CAGCAGCAGC AGCAGCAGCA ACAGCAGCAA CTGGCCACAA CCCTACATCA ACAACAGCTG 1680

CTGACTCAGC AGGCTGCCTT GCAGCAGAAA ACTGCTGTGG CGGCAGTACA GCAGCCCCAG 1740

GCACAGCAGA CCACAGCCCC GCAGCCACCC CCGGCCCAGG AGCCAGCAAT TCAGGCCCCA 1800

GTAAGACAAC AGCCAAAGGT TCAGACAACC CCACCTCCTG CCATCCAGGG GCAGAAACTC 1860

GGATCTCTCA CTCCTCCATC ATCCCCCAAG ACCCAGCGTG CTGGGCACAG GCGGATTCTC 1920

AGTGATGTAA CCCACAGTGC AGTCTTTGGA GTCCCTGCCA GCAAATCAAC CCAGCTGCTC 1980

CAGGCAGCTG CAGCTGAGGC CAGTCTCAAT AAGTCCAAGT CTGCAACCAC CACTCCATCA 2040

GGCTCTCCTC GAACCTCCCA GCAAAATGTT TATAATCCTT CAGAAAGTTC TACATGGAAT 2100

CCTTTCGATG ATGACAATTT TTCCAAACTG ACAGCTGAAG AACTGCTAAA CAAGGACTTT 2160

GCCAAGCTGG GGGAAGGCAA ACATCCTGAG AAGCTTGGAG GCTCAGCTGA GAGTTTGATC 2220

CCAGGCTTTC AGCCCACCCA AGGTGATGCT TTTGCCACTG CCTCGTTTCC TGCTGGAGCC 2280

GCTGAAAAAA GGAAGGGTGG GCAGACTGTG GATCCTAGCC TCCCACTTCT AAGTGTATCT 2340

GATCCTTTCA TTCCTCTTCA AGTACCTGAT GCACCAGAAA AACTAATTGA GGGACTCAAA 2400

TCTCCTGACA CTTCTCTTCT GCTCCCTGAC CTCTTGCCTA TGACAGATCC TTTTGGTAGT 2460

ACTTCCGATG CTGTGATTGG TAAAGTCATC ATCTCATTCT TTAGTCATGC ATGA 2514

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 46    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  104

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 105   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  163

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 164   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  222

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 223   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  281

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 282   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  309

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013