EKS-EQC-00237
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00237
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL347.54.4E-10427285259
StatusUnreviewed
Ensembl ProteinENSECAP00000004789
UniProt AccessionF7A7L9;
Protein Name
Protein Synonyms/Alias
Gene NameSIK1
Gene Synonyms/Alias SIK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000006288ENSECAP00000004789ENSECAT00000006703
OrganismEquus caballus
Functional Description
Protein Length783
Protein Sequence
(FASTA)
MVIMSEFSAA PAGSGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 60
TRLDSSNLEK IYREVQIMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 120
LSENEARKKF WQILSAVEYC HSHHIVHRDL KTENLLLDGN MDIKLAGKGP AREDFGFGNF 180
YKSGEPLSTW CGSPPYAAPE VFEGKEYEGP QLDVWSLGVV LYVLVCGSLP FDGPNLPALR 240
QRVLEGRFRI PFFMSQDCET LIRRMLVVDP AKRITVAQIR QHRWMQADPS LLRQACPAFS 300
ALSYNSNLGD YDEQVLGIMQ TLGVDRQRTV ESLQNSSYNH FAAIYYLLLE RLKEYRNAQP 360
SARPGPARQP RPRSSDLSGF EVPQEGLPGD AFRSALLCPQ PQSLGQSVLQ AEMDCDLHSS 420
LQPLFFPVDT NCNGVFRHRS ISPTSLLDTT ISEEVRQGQG LEEEQEAQMP LPSSSGRRHT 480
LAEVSTCFSP GAPPCKCIVI SSSVASPSEG TSSDSCLTSA GDGLVGLSGR LATQGLLGTC 540
SPLRLTSPLL GAQSATPVLQ AQEALGGAAP LPVSFQEGRR ASDTSLTQGL KAFRQQLRKN 600
ARTKGFLGLN KIKGLARQVC QPSSSSRATR GGLNAFQLPA PSPGLHGSGA SSREGRSLLE 660
EVLHQQRLLQ LQHHPAAPPT CQQAPLVLGP CDGALLKGLG LGPGPLLPPH LLQAGASPVA 720
SAAQLLDAHL RISRTSAPLP AATPPQPPFT MLPPRFDPTG LPQGDCEMED LTSGQLGTFV 780
LVQ 783
Nucleotide Sequence
(FASTA)
ATGGTGATCA TGTCCGAGTT CAGCGCGGCC CCCGCGGGCT CAGGCCAGGG CCAGCAGAAG 60
CCCCTCCGCG TGGGCTTCTA CGACATCGAG CGGACCCTGG GCAAGGGCAA TTTCGCGGTG 120
GTGAAGCTGG CCCGGCATCG AGTCACCAAA ACCCAGGTTG CGATAAAAAT AATCGATAAA 180
ACACGATTAG ATTCAAGCAA CTTGGAGAAA ATATATCGTG AGGTCCAGAT CATGAAGCTG 240
CTGAATCACC CTCATATCAT AAAGCTTTAT CAGGTTATGG AAACAAAGGA TATGCTTTAT 300
ATCGTCACTG AATTTGCAAA AAACGGAGAG ATGTTTGATT ATTTGACTTC CAACGGGCAC 360
CTAAGCGAGA ATGAAGCCCG GAAGAAGTTC TGGCAGATTC TGTCAGCCGT GGAGTACTGC 420
CACAGCCACC ACATTGTTCA CCGGGACCTC AAGACCGAGA ACCTGTTGCT GGATGGCAAC 480
ATGGACATCA AGCTGGCAGG CAAGGGGCCC GCCCGGGAGG ATTTCGGATT TGGGAATTTC 540
TACAAGTCAG GAGAGCCTCT GTCCACGTGG TGTGGGAGCC CCCCGTACGC AGCCCCGGAA 600
GTCTTCGAGG GGAAGGAATA TGAAGGCCCT CAGCTGGACG TCTGGAGCCT CGGCGTTGTG 660
CTGTACGTCC TCGTCTGTGG GTCTCTCCCC TTCGATGGGC CCAACCTTCC GGCTCTGCGG 720
CAGCGCGTGC TGGAGGGCCG CTTCCGCATC CCCTTCTTCA TGTCCCAGGA CTGTGAGACG 780
CTGATCCGCC GCATGCTGGT GGTGGACCCC GCCAAGCGCA TCACCGTGGC CCAGATCCGG 840
CAGCACAGGT GGATGCAGGC CGACCCCTCC CTGCTTCGGC AGGCCTGCCC CGCCTTCTCC 900
GCGCTCAGCT ACAACTCCAA CCTGGGCGAT TACGACGAGC AGGTGCTGGG CATCATGCAG 960
ACCCTCGGGG TCGACCGGCA GAGGACGGTG GAGTCGCTGC AGAACAGCAG CTATAACCAC 1020
TTTGCTGCCA TTTATTACCT CCTCCTCGAG CGCCTGAAGG AGTATCGGAA CGCCCAGCCG 1080
TCGGCCCGCC CCGGCCCAGC CAGGCAGCCG AGGCCTAGAA GCTCGGACCT CAGCGGCTTT 1140
GAGGTGCCTC AGGAAGGGCT CCCCGGCGAT GCTTTCCGGT CCGCCCTGCT GTGCCCGCAG 1200
CCCCAGAGCC TGGGGCAGTC CGTCCTGCAG GCTGAAATGG ACTGTGACCT CCACAGCTCG 1260
CTCCAGCCCC TATTCTTCCC TGTGGACACC AACTGCAACG GAGTGTTCCG GCATCGCTCC 1320
ATCTCCCCCA CCAGCCTGCT GGACACGACC ATCAGCGAGG AGGTCAGGCA GGGCCAGGGC 1380
CTCGAGGAGG AGCAGGAGGC ACAGATGCCC CTGCCCAGCA GCTCAGGCCG GAGGCACACG 1440
CTGGCCGAGG TCTCCACCTG CTTCTCCCCG GGCGCCCCTC CCTGTAAGTG TATAGTCATC 1500
TCCTCCTCTG TGGCGAGTCC TTCCGAAGGC ACCAGCTCCG ACAGCTGTCT GACCTCAGCG 1560
GGTGATGGCC TGGTGGGGCT CAGCGGACGC CTGGCCACTC AGGGTCTGCT GGGCACCTGC 1620
TCCCCACTCC GACTGACCTC ACCACTCCTG GGGGCCCAGT CGGCCACACC AGTGCTCCAG 1680
GCGCAGGAGG CCCTGGGGGG AGCCGCCCCG CTCCCCGTCA GCTTCCAGGA AGGCCGGAGG 1740
GCGTCGGACA CCTCACTCAC TCAAGGGCTG AAAGCCTTTC GGCAGCAGCT GAGGAAGAAT 1800
GCGCGGACCA AAGGGTTTCT GGGGCTGAAC AAGATCAAGG GGCTGGCTCG CCAGGTGTGC 1860
CAGCCCTCCT CCTCCAGCCG GGCCACCAGG GGTGGCCTGA ACGCCTTCCA GCTGCCCGCG 1920
CCGAGCCCAG GCCTGCATGG CAGCGGGGCC AGCAGCCGGG AGGGCAGGAG TCTGCTGGAG 1980
GAGGTGCTGC ACCAGCAGAG GTTGCTCCAG TTGCAGCATC ACCCGGCAGC CCCACCCACC 2040
TGCCAGCAGG CCCCGCTGGT CCTCGGCCCC TGTGACGGCG CCCTCCTGAA GGGGCTGGGG 2100
CTGGGGCCCG GCCCACTGCT GCCACCCCAC CTCCTGCAGG CTGGGGCCTC CCCCGTGGCA 2160
TCGGCAGCCC AGCTCCTGGA CGCCCACCTG CGCATCAGCC GCACCTCAGC CCCCCTCCCG 2220
GCTGCCACTC CCCCACAGCC GCCCTTCACC ATGTTGCCCC CGAGGTTCGA CCCCACGGGG 2280
CTGCCTCAGG GGGACTGTGA GATGGAGGAC CTGACCTCTG GCCAGCTGGG CACGTTTGTC 2340
CTGGTGCAGT GA 2352
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60
         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++++leki+rE++i+k l+hp+i
Q: 27    YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQIMKLLNHPHI  86
         899*********************************************************
S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120
         ikl++v+etk++ly+v+e+a++ge+fdy++++g+l+e+eark f q++sav+Y+hs++iv
Q: 87    IKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHSHHIV  146
         ************************************************************
S: 121   HrDlKpeNllldkkenikia.......DFGlanlfkegklletfcGsppYaaPellkgkk  173
         HrDlK+eNllld +++ik+a       DFG++n++k+g+ l+t+cGsppYaaPe+++gk+
Q: 147   HRDLKTENLLLDGNMDIKLAgkgpareDFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKE  206
         *******************88888888*********************************
S: 174   YegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklL  233
         Yegp++DvWslGvvLy+lv+g+lPfd++nl +l++++l+g+++ip+ +s+++e+L+r++L
Q: 207   YEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPALRQRVLEGRFRIPFFMSQDCETLIRRML  266
         ************************************************************
S: 234   vvdpekRatieeilkhewl  252
         vvdp+kR+t+ +i++h+w+
Q: 267   VVDPAKRITVAQIRQHRWM  285
         ******************8
Domain Sequence
(FASTA)
YDIERTLGKG NFAVVKLARH RVTKTQVAIK IIDKTRLDSS NLEKIYREVQ IMKLLNHPHI 60
IKLYQVMETK DMLYIVTEFA KNGEMFDYLT SNGHLSENEA RKKFWQILSA VEYCHSHHIV 120
HRDLKTENLL LDGNMDIKLA GKGPAREDFG FGNFYKSGEP LSTWCGSPPY AAPEVFEGKE 180
YEGPQLDVWS LGVVLYVLVC GSLPFDGPNL PALRQRVLEG RFRIPFFMSQ DCETLIRRML 240
VVDPAKRITV AQIRQHRWM 259
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00224
EKS-ANC-00233
EKS-BOT-00240
EKS-CAJ-00248
EKS-CAF-00251
EKS-CAP-00267
EKS-DAR-00558
EKS-DIO-00009
EKS-FEC-00227
EKS-GAM-00143
EKS-GAG-00202
EKS-GAA-00297
EKS-GOG-00241
EKS-HOS-00253
EKS-ICT-00229
EKS-LAC-00268
EKS-LOA-00237
EKS-MAM-00254
EKS-MEG-00189
EKS-MIM-00009
EKS-MOD-00243
EKS-MUM-00249
EKS-MYL-00243
EKS-NOL-00225
EKS-OCP-00018
EKS-ORN-00311
EKS-ORA-00212
EKS-ORL-00296
EKS-OTG-00249
EKS-PAT-00232
EKS-PES-00216
EKS-POA-00238
EKS-PTV-00026
EKS-RAN-00240
EKS-SAH-00227
EKS-SUS-00211
EKS-TAG-00259
EKS-TAR-00306
EKS-TEN-00305
EKS-XIM-00305
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0008140; F:cAMP response element binding protein binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0072333; P:anoikis by p53 class mediator
GO:0055007; P:cardiac muscle cell differentiation
GO:0007243; P:intracellular protein kinase cascade
GO:0032792; P:negative regulation of CREB transcription factor activity
GO:0045721; P:negative regulation of gluconeogenesis
GO:0010868; P:negative regulation of triglyceride biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0007346; P:regulation of mitotic cell cycle
GO:0010830; P:regulation of myotube differentiation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR015940; UBA/transl_elong_EF1B_N_euk.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS50030; UBA; 1.
Prints
Created Date20-Feb-2013