EKS-EQC-00474

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00474

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	415.6	6.5E-125	18	273	256

Status

Unreviewed

Ensembl Protein

ENSECAP00000005184

UniProt Accession

F7D9M8;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000006577	ENSECAP00000005184	ENSECAT00000007160

Organism

Equus caballus

Functional Description

Protein Length

805

Protein Sequence
(FASTA)

MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS 60

RGKHERLVVV AEHCERSLED LLRERKPVSY SKVLCIAFEV LQGLQYMNKH GIVHRALSPH 120

NILLDLKGHV KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGISKTT DHVPNGKPLP 180

SGPKSDVWSL GIILFELCMG RKLFQSLDIS ERLKFLLTLD CVDDTVIVLA EEHGCLDVVK 240

ELPENVMGLL KRCLTFHPSN RPTPSELMQD KVFSEVSPSY TPFTKPASLF SSSLRCADLT 300

LPEDISQLCQ DINSDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PVCTLPNFLF 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL 420

SAAATLPLII RERDTEYQLH RIVLFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL 480

GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLAVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPRPT 720

SDGSGARSST PYFSTECADP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF 780

KTPTKKTKPS KPKLLVVDIR NTEEY 805

Nucleotide Sequence
(FASTA)

ATGTTTCCCT TGAAGGATGC CGAAATGGGT GCCTTTACCT TTTTTGCCTC AGCTCTGCCA 60

CATGATGTTT GTGGAAGCAA CGGGCTTCCT CTTACGCCAA ATTCCATCAA AATTTTAGGG 120

CGCTTTCAAA TCCTTAAGAC CATCACACAT CCCAGACTGT GCCAGTACGT GGATATTTCT 180

AGGGGAAAGC ATGAGAGACT GGTGGTGGTG GCTGAGCACT GTGAACGGAG TCTAGAAGAC 240

TTGCTTCGAG AAAGGAAACC CGTGAGCTAT TCAAAGGTTT TGTGTATAGC GTTTGAGGTA 300

CTTCAGGGCT TGCAGTATAT GAACAAACAT GGTATAGTGC ACCGGGCACT GTCTCCTCAT 360

AATATCCTTT TGGACCTAAA GGGACATGTT AAATTGGCTA AATTTGGACT TTATCATATG 420

ACAGCTCATG GTGATGATGT TGATTTCCCA ATTGGGTATC CGTCGTACTT GGCGCCTGAG 480

GTAATTGCAC AAGGGATTTC CAAAACGACT GATCATGTGC CAAATGGAAA ACCGTTGCCT 540

TCTGGCCCCA AATCAGATGT ATGGTCTCTT GGAATCATTT TATTTGAGCT TTGCATGGGA 600

AGAAAGTTAT TTCAGAGCTT GGATATTTCT GAAAGACTAA AATTTTTGCT TACATTGGAC 660

TGCGTGGATG ACACTGTAAT AGTTCTGGCT GAAGAGCACG GTTGTCTGGA CGTTGTAAAG 720

GAGCTTCCTG AAAATGTGAT GGGTCTTTTG AAGAGGTGCC TCACCTTTCA CCCTTCCAAC 780

AGGCCAACCC CAAGTGAATT AATGCAGGAC AAGGTGTTCA GTGAAGTGTC ACCTTCATAC 840

ACCCCCTTTA CCAAACCTGC CAGTCTGTTT TCATCTTCTC TGAGATGTGC TGATTTAACT 900

CTGCCTGAGG ATATCAGTCA GCTGTGTCAA GACATAAACA GTGATTACCT GGCAGAAAGA 960

TCTATTGAAG AAGTGTATTA CCTTTGGTGT TTAGCTGGAG GTGACTTGGA GAAAGAGCTG 1020

GTCAACAAGG AGATCATTCG ATCCAAGCCG CCTGTCTGCA CACTCCCCAA TTTTCTCTTT 1080

GAAGATGGTG AAAGCTTTGG ACAAGGTCGA GATAGAAGCT CATTATTAGA TGACACCACT 1140

GTGACATTGT CATTATGCCA GCTGAGAAAT AGATTAAAAG ATGTTGGTGG AGAAGCATTT 1200

TACCCGTTAC TTGAAGATGA CCAGTCTAAC TTGCCTCATT CAAACAGCAA TAATGAGTTG 1260

TCTGCAGCTG CCACTCTCCC TTTAATCATC CGAGAGAGGG ACACAGAGTA CCAACTTCAC 1320

AGAATTGTTC TCTTTGACAG GCTGCTAAAG GCGTATCCAT ATAAAAAAAA TCAGATCTGG 1380

AAAGAAGCAA GAGTTGACAT TCCTCCTCTA ATGAGGGGTT TAACCTGGGC TGCTCTTCTG 1440

GGAGTTGAGG GGGCTATTCA TGCGAAGTAT GATGCAATTG ATAAAGATAC TCCAATTCCT 1500

ACAGATAGAC AAATTGAAGT GGATATTCCT CGTTGTCATC AGTATGATGA ACTCTTATCA 1560

TCACCAGAAG GTCATGCAAA GTTTAGACGT GTACTGAAAG CCTGGGTGGT GTCCCATCCT 1620

GATCTTGTGT ATTGGCAAGG TCTTGACTCA CTTTGTGCTC CATTCCTATA TTTAAATTTC 1680

AATAATGAAG CCTTGGCTTA TGCGTGTATG TCTGCCTTTA TCCCCAAATA CCTGTATAAC 1740

TTCTTCTTGA AAGACAACTC ACATGTAATA CAAGAGTATC TGGCTGTGTT CTCTCAGATG 1800

ATTGCGTTCC ATGATCCAGA GCTGAGCAAT CATCTCAATG AGATTGGGTT TATTCCGGAT 1860

CTGTATGCCA TCCCTTGGTT TCTCACCATG TTTACTCATG TATTTCCACT GCACAAAATT 1920

TTCCACCTCT GGGATACCTT ACTACTGGGG AATTCCTCTT TCCCCTTCTG TATTGGAGTA 1980

GCAATTCTTC AGCAGCTACG GGACCGGCTT TTGGCTAATG GCTTTAATGA GTGCATTCTT 2040

CTCTTCTCTG ATTTACCAGA AATTGACATT GAACGCTGTG TACGAGAATC AATCAATCTA 2100

TTTTGTTGGA CTCCTAAAAG TGCTACTTAC AGACAGCATG CTCAGCCTCC AAGGCCGACT 2160

TCTGATGGCA GTGGAGCCAG AAGTTCGACT CCTTATTTCT CCACTGAGTG TGCAGACCCT 2220

CCAAAAACAG ATCTGTCAAG AGAGTCCATC CCATTAAATG ACCTGAAGTC TGAAGTATCC 2280

CCACGGATTT CAGCGGAGGA CCTGATTGAC TTGTGCGAGC TCACAGTGAC AGGTCACTTC 2340

AAAACACCCA CCAAGAAGAC AAAGCCCAGT AAACCGAAGC TCCTGGTCGT GGACATCCGG 2400

AATACTGAAG AGTAT 2415

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher++vvaeh+e+s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDISRGKHERLVVVAEHCERS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+erkpvs s+vl+ia+evl+gl+y+nkh+ivhral+p++illd kg+ vkLak+G

Q: 78    LEDLLRERKPVSYSKVLCIAFEVLQGLQYMNKHGIVHRALSPHNILLDLKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G+dvdfpigy+sylaPe+i+q+         + k+l++++ksDvWsLg+il+e

Q: 137   LYHMTAHGDDVDFPIGYPSYLAPEVIAQGiskttdhvpNGKPLPSGPKSDVWSLGIILFE  196

         *************************************99*********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+serlk+ll+l++vd+t+i+laee++cld++k+l+e++  llk+CLt+

Q: 197   LCMGRKLFQSLDISERLKFLLTLDCVDDTVIVLAEEHGCLDVVKELPENVMGLLKRCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +ps Rp+p+el+++kvf

Q: 257   HPSNRPTPSELMQDKVF  273

         ***************98

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DISRGKHERL VVVAEHCERS 60

LEDLLRERKP VSYSKVLCIA FEVLQGLQYM NKHGIVHRAL SPHNILLDLK GHVKLAKFGL 120

YHMTAHGDDV DFPIGYPSYL APEVIAQGIS KTTDHVPNGK PLPSGPKSDV WSLGIILFEL 180

CMGRKLFQSL DISERLKFLL TLDCVDDTVI VLAEEHGCLD VVKELPENVM GLLKRCLTFH 240

PSNRPTPSEL MQDKVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013