EKS-EQC-00385

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00385

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	3.9E-97	1073	1337	265

Status

Unreviewed

Ensembl Protein

ENSECAP00000005141

UniProt Accession

F7DF72;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000006890	ENSECAP00000005141	ENSECAT00000007112

Organism

Equus caballus

Functional Description

Protein Length

1342

Protein Sequence
(FASTA)

REMENKETLK GLHKMEDRPE ERMIREKLKA TCMPAWKHEW LERRNRRGPV VVKPIPIKGD 60

GSEISNLATE SPGEGPASAA SPAPRGRRSP SPGSSPSGRT VKSESPGVRR KRVSPVPFQS 120

GRITPPRRAP SPDGFSPYSP EETSRRVNKV MRARLYLLQQ IGPNSFLIGG DSPDNKYRVF 180

IGPQVGLVTI YIFLFLINAF KSKSVNKILW YIPENFHEVE SLFQKYHSRR SSRIKAPSRN 240

TIQKFVSRMS NSHTLSSSST STSSSENSIK DEEEQMCPIC LLGMLDEESL TVCEDGCRNK 300

LHHHCMSIWA EECRRNREPL ICPLCRSKWR SHDFYSHELS SPVDSPSSLR AVQQQTIQQQ 360

PLAGSQRRNQ ESNFNLTHYG TQQIPPAYKD LAEPWIQVFG MELVGCLFSR NWNVREMALR 420

RLSHDVSGAL LLANGESTGN SGSNGGSSPN AGAASGSSQT SISGDVVEAC CNVLSMVCAD 480

PVYKVYVAAL KTLRAMLVYT PCHSLAERIK LQRLLRPVVD TILVKCADAN SRTSQLSIST 540

LLELCKGQAG ELAVGREILK AGSIGIGGVD YVLNCILGNQ TESSNWQELL GRLCLIDRLL 600

LEFPAEFYPH IVSTDVSQAE PVEVRYKKLL SLLTFALQSI DNSHSMVGKL SRRIYLSSAR 660

MVTAVPHVFS KLLEMLNVSS STHFTRMRRR LMAIADEVEI AEAIQLGIED TLDGRHDSFL 720

QASVPNSYPE TTANSSLERT DHLEKTGKGL CATKLSASSE DISDRLASIS VGLPSSTTME 780

QPKPMVQTKG RPHSQCLNSS PLSPHSQVMF PAFSTPSSSA PSVPAGTVTD VSKQRPQGFV 840

PCKIPSASPQ TQRKFSLQFQ RNCSENKDSE KLSPIFTQSR PLPSSNIHRP KPSRPTPGNT 900

SKQGDASKNS MTLDLNSTSK CGDSFGSSSN SSNAVIPSDE TVFTPVEEKC RLDVNTELNS 960

SIEDLLEASM PSSDTTVTFK SEVAVLSPEK DENDDTYKDD VNHNQKCKEK MEAEEEEALA 1020

IAMAMSASQD ALPIVPQLQV ENGEDIIIIQ QDTPETLPGH TKAKQPYRED TEWLKGQQIG 1080

LGAFSSCYQA QDVGTGTLMA VKQVTYVRNT SSEQEEVVEA LREEIRMMSH LNHPNIIRML 1140

GATCEKSNYN LFIEWMAGGS VAHLLSKYGA FKESVVINYT EQLLRGLSYL HENQIIHRDV 1200

KGANLLIDST GQRLRIADFG AAARLASKGT GAGEFQGQLL GTIAFMAPEV LRGQQYGRSC 1260

DVWSVGCAII EMACAKPPWN AEKHSNHLAL IFKIASATTA PSIPSHLSPG LRDVALRCLE 1320

LQPQDRPPSR ELLKHPVFRT TW 1342

Nucleotide Sequence
(FASTA)

CGAGAGATGG AGAATAAAGA AACTCTCAAG GGACTGCACA AGATGGAAGA CCGCCCAGAA 60

GAACGAATGA TCAGGGAGAA ACTGAAGGCA ACCTGTATGC CAGCTTGGAA GCACGAATGG 120

CTGGAAAGGA GAAATAGGAG AGGCCCTGTG GTGGTAAAAC CAATCCCTAT TAAAGGAGAT 180

GGATCTGAAA TTAGTAACTT GGCAACTGAG TCTCCAGGAG AGGGCCCGGC AAGCGCCGCT 240

TCACCAGCTC CCAGAGGCCG ACGCAGTCCT TCCCCTGGCA GCTCCCCATC AGGTCGCACA 300

GTGAAATCAG AATCTCCCGG AGTAAGAAGA AAAAGGGTTT CCCCCGTGCC TTTTCAGAGT 360

GGTAGAATCA CACCACCTCG AAGAGCCCCT TCACCAGATG GCTTCTCACC ATACAGCCCC 420

GAGGAAACAA GCCGCCGTGT CAACAAGGTG ATGCGGGCCA GGCTGTACTT ACTGCAGCAG 480

ATAGGACCCA ACTCTTTCCT CATTGGAGGA GACAGCCCAG ATAATAAATA CCGGGTGTTC 540

ATCGGGCCTC AGGTAGGACT TGTTACCATT TATATTTTCT TATTTTTAAT AAATGCCTTT 600

AAGAGTAAAT CTGTCAACAA AATTTTATGG TATATTCCTG AAAATTTCCA TGAGGTTGAG 660

AGTTTGTTCC AGAAATATCA CAGTAGGCGT AGCTCAAGAA TCAAAGCTCC ATCTCGTAAC 720

ACCATCCAGA AGTTTGTTTC ACGCATGTCA AATTCTCATA CATTGTCATC ATCTAGTACC 780

TCTACATCTA GTTCAGAAAA CAGTATAAAA GATGAAGAGG AACAGATGTG TCCTATTTGC 840

CTGTTGGGCA TGCTTGATGA AGAAAGTCTC ACAGTGTGTG AAGATGGCTG CAGGAACAAG 900

CTGCACCACC ACTGCATGTC AATTTGGGCA GAAGAATGTA GAAGAAATAG AGAACCTTTA 960

ATATGTCCCC TTTGTAGGTC TAAGTGGAGA TCCCATGATT TCTACAGCCA CGAGTTGTCA 1020

AGCCCTGTGG ATTCCCCTTC TTCCCTGCGA GCTGTGCAGC AGCAAACCAT ACAGCAGCAG 1080

CCTTTGGCTG GATCACAGCG AAGGAATCAG GAGAGCAATT TTAACCTTAC TCATTACGGA 1140

ACTCAGCAGA TCCCTCCTGC TTATAAAGAT TTAGCTGAGC CATGGATTCA GGTATTTGGA 1200

ATGGAACTCG TTGGCTGCTT ATTTTCTAGA AACTGGAATG TAAGAGAGAT GGCTCTCAGG 1260

CGTCTTTCCC ATGATGTTAG TGGAGCCCTG CTACTGGCAA ATGGAGAGAG CACTGGAAAT 1320

TCTGGGAGCA ATGGTGGAAG CAGCCCAAAT GCTGGAGCCG CCAGTGGGTC TTCCCAGACC 1380

AGTATCTCAG GAGACGTGGT GGAGGCGTGC TGCAACGTTC TGTCAATGGT CTGTGCCGAC 1440

CCTGTCTACA AAGTGTACGT TGCTGCTTTA AAAACGCTGA GAGCCATGCT AGTGTATACT 1500

CCTTGCCATA GTTTGGCAGA AAGAATCAAA CTGCAGAGAC TGCTTCGGCC AGTCGTAGAC 1560

ACCATTCTCG TCAAGTGTGC AGATGCCAAC AGTCGCACCA GCCAGCTGTC TATATCAACA 1620

CTGTTGGAGT TGTGCAAAGG CCAAGCAGGA GAATTGGCAG TTGGCAGAGA AATACTTAAA 1680

GCTGGATCCA TTGGTATTGG TGGTGTTGAT TATGTCTTAA ATTGTATTCT TGGAAACCAA 1740

ACTGAATCAA GCAACTGGCA AGAACTCCTG GGCCGCCTTT GTCTTATAGA TAGACTGCTG 1800

TTGGAATTTC CTGCTGAATT TTACCCTCAT ATTGTCAGTA CTGATGTTTC CCAAGCTGAG 1860

CCTGTTGAAG TCAGGTATAA GAAGCTGCTG TCCCTCTTAA CCTTTGCTTT GCAGTCCATT 1920

GATAATTCCC ACTCAATGGT TGGTAAACTC TCCAGAAGGA TATATTTGAG TTCTGCGAGA 1980

ATGGTTACTG CAGTACCCCA TGTATTTTCA AAACTGTTAG AAATGCTGAA TGTTTCCAGT 2040

TCCACTCATT TTACCAGGAT GCGTCGTCGT TTGATGGCTA TTGCAGATGA GGTAGAAATT 2100

GCTGAGGCCA TCCAGCTGGG CATAGAAGAC ACTTTGGATG GTCGACATGA CAGCTTTTTG 2160

CAGGCATCTG TCCCTAACAG CTATCCAGAA ACCACAGCGA ACAGTTCCCT TGAGCGCACA 2220

GACCATTTAG AGAAAACTGG AAAAGGATTG TGTGCTACAA AACTAAGTGC CAGTTCAGAG 2280

GACATTTCTG ACAGACTGGC CAGCATTTCA GTAGGACTTC CTAGTTCAAC AACAATGGAG 2340

CAACCAAAGC CAATGGTTCA AACAAAAGGC AGACCCCACA GTCAGTGTTT GAACTCCTCT 2400

CCTTTATCTC CTCATTCCCA AGTAATGTTC CCAGCCTTCT CAACTCCTTC TTCATCCGCC 2460

CCGTCTGTCC CAGCTGGCAC TGTAACAGAT GTCTCTAAGC AGAGACCTCA GGGATTCGTT 2520

CCCTGCAAAA TACCTTCTGC ATCTCCTCAG ACACAGCGCA AGTTTTCTCT ACAGTTCCAG 2580

AGAAACTGTT CCGAAAACAA AGACTCAGAA AAACTTTCCC CAATCTTTAC TCAGTCAAGA 2640

CCCCTGCCCT CCAGTAATAT ACACAGGCCA AAGCCATCTC GACCTACCCC GGGTAATACA 2700

AGTAAACAGG GAGATGCCTC AAAAAATAGC ATGACGCTTG ATCTGAACAG TACTTCTAAA 2760

TGTGGTGACA GCTTTGGCAG TAGCAGCAAT AGCAGTAATG CTGTTATACC CAGTGATGAG 2820

ACAGTGTTCA CCCCAGTAGA GGAGAAATGC AGATTAGATG TCAATACAGA GCTCAACTCC 2880

AGTATTGAGG ACCTTCTTGA AGCATCTATG CCTTCAAGTG ACACAACAGT AACTTTTAAG 2940

TCAGAAGTTG CTGTTCTCTC ACCTGAGAAG GATGAAAATG ATGATACCTA CAAAGATGAT 3000

GTGAATCATA ATCAGAAGTG CAAAGAAAAG ATGGAAGCTG AAGAAGAAGA AGCTTTAGCA 3060

ATTGCCATGG CAATGTCAGC GTCTCAGGAT GCCCTCCCCA TCGTTCCTCA GTTACAGGTT 3120

GAAAATGGAG AAGATATCAT CATCATTCAA CAGGATACAC CAGAGACTCT ACCAGGACAT 3180

ACCAAAGCAA AGCAACCTTA TAGAGAAGAC ACTGAGTGGC TGAAAGGTCA GCAGATAGGC 3240

CTTGGAGCAT TTTCTTCTTG TTATCAGGCT CAAGATGTGG GAACTGGAAC TTTAATGGCT 3300

GTTAAACAGG TGACATATGT CAGAAATACA TCTTCTGAGC AAGAAGAAGT AGTGGAAGCA 3360

TTAAGAGAAG AAATAAGAAT GATGAGCCAT CTGAATCATC CAAATATCAT TAGGATGTTG 3420

GGAGCCACGT GTGAGAAGAG CAATTATAAT CTCTTCATCG AATGGATGGC AGGGGGATCT 3480

GTGGCTCATT TGCTCAGTAA ATATGGAGCC TTCAAGGAAT CAGTAGTTAT TAACTATACT 3540

GAACAATTAC TTCGTGGCCT TTCATATCTC CATGAAAACC AGATCATTCA CAGAGATGTC 3600

AAAGGTGCCA ATTTGCTAAT TGACAGCACA GGTCAGAGAC TGAGAATTGC AGATTTCGGA 3660

GCTGCAGCCA GGTTGGCATC AAAAGGAACT GGTGCAGGAG AGTTTCAGGG ACAGTTATTG 3720

GGGACAATTG CATTTATGGC ACCTGAGGTA CTAAGAGGTC AGCAGTATGG TAGGAGCTGT 3780

GATGTGTGGA GTGTTGGCTG TGCTATTATA GAAATGGCTT GTGCTAAACC ACCTTGGAAT 3840

GCAGAAAAAC ACTCCAATCA TCTTGCTTTG ATATTTAAGA TTGCTAGTGC AACTACTGCT 3900

CCATCAATCC CTTCACATTT ATCTCCTGGT TTACGAGATG TGGCTCTTCG TTGTTTAGAA 3960

CTTCAACCTC AGGACAGACC TCCATCAAGA GAGCTACTGA AGCATCCAGT CTTCCGTACT 4020

ACATGGTAG 4029

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1073  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1132

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1133  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1192

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1193  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1252

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1253  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1310

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1311  LRDVALRCLELQPQDRPPSRELLKHPV  1337

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011989	; ARM-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.

Prints

Created Date

20-Feb-2013