EKS-EQC-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDKL	464.2	1.3E-139	13	297	285

Status

Unreviewed

Ensembl Protein

ENSECAP00000005338

UniProt Accession

F7BV09;

Protein Name

Protein Synonyms/Alias

Gene Name

CDKL5

Gene Synonyms/Alias

CDKL5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000007008	ENSECAP00000005338	ENSECAT00000007338

Organism

Equus caballus

Functional Description

Protein Length

905

Protein Sequence
(FASTA)

MKIPNIGNVM NKFEILGVVG EGAYGVVLKC RHKETHEIVA IKKFKDSEEN EEVKETTLRE 60

LKMLRTLKQE NIVELKEAFR RRGKLYLVFE YVEKNMLELL EEMPNGVPPE KVKSYIYQLI 120

KAIHWCHKND IVHRDIKPEN LLISHNDVLK LCDFGFARNL SEGNNANYTE YVATRWYRSP 180

ELLLGAPYGK SVDMWSVGCI LGELSDGQPL FPGESEIDQL FTIQKVLGPL PSEQMKLFYS 240

NPRFHGLRFP AVNHPQSLER RYLGILNSVL LDLMKNLLKL DPADRYLTEQ CLNHPTFQTQ 300

RLLDRSPSRS AKRKPYHVES STLSNRNQAS KSAALQSHHR SNSKDIQNLS VGLPRADEGL 360

PANESFLNGN LAGATLSPMH TKTYQASSQP GSTSKDLTNN NMPHLLSPKE AKSKTEFDFN 420

IDPKPSEGPG TKYLKSSSRS QQNRHSFMES SQSKAGTLQP SEKQSRHSYI DTIPQSSRSP 480

SYRTKAKSHG ALSDSKSVSN LSEARAQITE SNTSRYFPSS CLDLNSPTSP TPTRHSDTRT 540

LLSPSGRNNR SEGTLDSRRT TTRHSKTMEE LKLPEHMDSS HSHSLSAPHE SFSYGLGYTS 600

PFSSQQRPHR HSMYVTRDKV RAKGLDGSLS VGQGMAARAN SLQLLSPQPG EQLPPEMTVA 660

RSSVKESSRE GPSSFHTRQK SEGGSYHDPH SDDGTAPKEN RHLYNDPVPR RVGSFYRVPS 720

PRPDNSFHEN NVSTRVSSLP SESGSGTNHS KRQPAFDPWK SPENISHSEQ LKEKEKQGFF 780

RSMKKKKKKS QTVPNSDGPD LLTLQKAIHS ASTPSSRPKE WRPEKISDLQ TQSQPLKSLR 840

KLLHLSSASN HPASSDPRFQ PLAAQQTKNS FSEIRIHPLS QASGGSSNIR QEPTPKGRPA 900

LQLPG 905

Nucleotide Sequence
(FASTA)

ATGAAGATTC CTAACATTGG TAATGTGATG AATAAATTTG AGATCCTTGG GGTTGTAGGT 60

GAAGGAGCCT ATGGAGTTGT ACTTAAATGC AGACACAAGG AAACACATGA AATTGTGGCA 120

ATCAAGAAAT TCAAGGACAG TGAAGAAAAT GAAGAAGTCA AGGAAACGAC TTTACGAGAG 180

CTTAAAATGC TTCGTACTCT CAAACAGGAA AACATTGTGG AGCTAAAGGA AGCCTTTCGT 240

CGGCGGGGGA AATTGTACTT GGTGTTTGAG TATGTTGAAA AAAATATGCT TGAATTGCTG 300

GAAGAAATGC CAAATGGAGT TCCACCTGAA AAAGTAAAAA GTTATATCTA TCAGCTAATC 360

AAAGCTATTC ACTGGTGCCA TAAGAATGAT ATTGTCCATC GGGATATAAA GCCAGAGAAT 420

CTCTTAATCA GCCACAATGA TGTTTTGAAA CTGTGTGACT TTGGTTTTGC TCGGAATCTA 480

TCAGAAGGCA ATAATGCTAA TTATACAGAA TATGTGGCCA CCAGATGGTA TCGGTCCCCA 540

GAACTCTTGC TTGGGGCTCC CTATGGAAAG TCTGTGGATA TGTGGTCGGT GGGCTGTATT 600

CTTGGGGAGC TTAGTGATGG ACAGCCTTTG TTTCCTGGAG AAAGCGAAAT TGACCAACTT 660

TTTACTATTC AGAAGGTGCT AGGACCACTT CCATCTGAGC AGATGAAACT CTTCTACAGT 720

AATCCTCGCT TCCACGGGCT CCGGTTTCCA GCTGTTAACC ATCCTCAGTC ATTGGAGAGA 780

AGATACCTTG GAATTTTAAA TAGCGTTTTA CTTGACTTAA TGAAGAATTT ACTGAAGTTG 840

GACCCAGCTG ACAGATACTT GACAGAACAG TGTTTGAATC ACCCTACATT TCAAACCCAG 900

AGACTTTTGG ATCGTTCCCC TTCAAGGTCA GCGAAAAGAA AACCTTACCA CGTGGAAAGC 960

AGCACTTTGT CTAATAGAAA CCAAGCCAGC AAAAGTGCTG CTTTGCAGTC TCACCACAGA 1020

TCAAACAGCA AGGACATCCA GAACCTAAGT GTGGGTCTGC CCCGGGCTGA TGAAGGTCTT 1080

CCTGCCAATG AAAGCTTCCT AAATGGAAAC CTTGCTGGAG CTACTCTTAG TCCCATGCAC 1140

ACCAAAACCT ACCAAGCAAG CAGCCAGCCT GGGTCTACCA GCAAAGATCT TACCAACAAC 1200

AACATGCCAC ACCTTCTCAG CCCAAAAGAA GCCAAGTCAA AGACAGAGTT TGATTTTAAT 1260

ATTGACCCAA AGCCTTCGGA AGGCCCAGGC ACAAAGTACC TCAAGTCAAG CAGCAGATCT 1320

CAGCAGAACC GGCACTCATT CATGGAAAGC TCTCAGAGCA AAGCGGGAAC ACTGCAGCCC 1380

AGTGAAAAAC AGAGTCGACA TAGCTACATT GACACTATTC CCCAGTCCTC TAGGAGTCCC 1440

TCCTACAGGA CCAAGGCCAA AAGCCATGGG GCCTTGAGTG ACTCCAAGTC AGTGAGCAAC 1500

CTTTCTGAAG CCAGGGCCCA AATTACAGAG TCTAATACCA GTAGGTACTT TCCATCCAGC 1560

TGCTTGGACT TGAACTCTCC CACCAGCCCA ACCCCCACCA GGCACAGTGA CACCAGAACT 1620

TTGCTCAGCC CCTCTGGGAG AAATAACCGA AGTGAGGGCA CTCTCGACTC ACGCCGAACC 1680

ACAACCAGGC ATTCTAAAAC GATGGAGGAG TTGAAGCTGC CTGAGCACAT GGACAGCAGC 1740

CATTCTCATT CACTGTCTGC ACCTCATGAG TCGTTTTCAT ATGGGCTGGG CTACACCAGC 1800

CCTTTCTCTT CCCAGCAACG CCCACACCGG CATTCCATGT ACGTGACCCG GGACAAAGTG 1860

AGAGCCAAAG GCTTGGACGG AAGCTTGAGC GTAGGGCAAG GGATGGCGGC CAGAGCCAAC 1920

AGCCTGCAGC TCTTATCGCC TCAGCCTGGA GAACAGCTCC CTCCGGAGAT GACTGTGGCG 1980

CGATCTTCCG TTAAAGAGTC CTCCAGAGAA GGGCCCTCTT CATTCCATAC ACGGCAGAAG 2040

TCTGAGGGTG GATCGTATCA TGACCCTCAC TCTGATGATG GCACTGCCCC TAAAGAAAAT 2100

AGACACCTAT ACAATGATCC TGTTCCAAGG AGAGTTGGCA GCTTCTACAG AGTGCCGTCT 2160

CCACGTCCAG ACAATTCATT CCATGAAAAT AATGTGTCAA CCAGAGTTTC TTCCCTACCA 2220

TCAGAAAGCG GCTCTGGAAC TAACCACTCA AAAAGACAAC CAGCGTTTGA TCCATGGAAA 2280

AGTCCTGAAA ACATTAGTCA TTCTGAACAA CTCAAGGAAA AGGAAAAACA AGGTTTTTTC 2340

AGGTCAATGA AAAAGAAAAA GAAGAAATCA CAAACAGTGC CCAATTCTGA TGGCCCCGAT 2400

CTTCTGACAT TACAGAAAGC CATTCACTCT GCTAGCACTC CGAGCAGCAG ACCAAAGGAG 2460

TGGCGTCCTG AGAAGATCTC TGATCTACAG ACCCAAAGCC AGCCATTAAA ATCACTGCGC 2520

AAGCTGTTAC ATCTCTCTTC AGCCTCAAAT CACCCAGCTT CCTCAGACCC CCGCTTCCAG 2580

CCCTTAGCAG CTCAACAAAC CAAAAATTCC TTCTCAGAAA TTCGGATTCA CCCCTTGAGC 2640

CAAGCCTCTG GCGGGAGCAG TAACATCCGG CAGGAGCCCA CACCAAAGGG CAGGCCAGCC 2700

CTCCAGCTGC CAGGT 2715

Domain Profile

S: 1     yeklgkvGeGsyGvvlkcrnkdtgqivaikkfleseddkevkkialreikllkqlkhenl  60

         +e lg+vGeG+yGvvlkcr+k+t++ivaikkf++se+++evk+++lre+k+l++lk+en+

Q: 13    FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENI  72

         799*********************************************************

S: 61    vnllevfrrkkklylvfeyvdktvldelerypnGveeelvkkilyqilkaiefchknnii  120

         v+l+e+frr+ klylvfeyv+k++l+ le++pnGv+ e+vk+++yq++kai++chkn+i+

Q: 73    VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIV  132

         ************************************************************

S: 121   hrdikpenilisksgvvklcdfGfarlla.apgdvytdyvatrwyrapellvgdtkyGks  179

         hrdikpen+lis+++v+klcdfGfar+l+ +++++yt+yvatrwyr+pell+g + yGks

Q: 133   HRDIKPENLLISHNDVLKLCDFGFARNLSeGNNANYTEYVATRWYRSPELLLG-APYGKS  191

         ****************************98999********************.9*****

S: 180   vdvwaiGcllaelltGeplfpgksdvdqlykirktlGeliprhqkifsknevfaGvklpe  239

         vd+w++Gc+l el++G+plfpg+s++dql++i+k+lG+l ++++k+f++n++f+G+++p+

Q: 192   VDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPA  251

         ************************************************************

S: 240   vedleslekkyp.klnevlldllkkclkldpaerlsceellkheyf  284

         v++++sle++y   ln+vlldl+k++lkldpa+r+++e++l+h++f

Q: 252   VNHPQSLERRYLgILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTF  297

         ***********9899****************************998

Domain Sequence
(FASTA)

FEILGVVGEG AYGVVLKCRH KETHEIVAIK KFKDSEENEE VKETTLRELK MLRTLKQENI 60

VELKEAFRRR GKLYLVFEYV EKNMLELLEE MPNGVPPEKV KSYIYQLIKA IHWCHKNDIV 120

HRDIKPENLL ISHNDVLKLC DFGFARNLSE GNNANYTEYV ATRWYRSPEL LLGAPYGKSV 180

DMWSVGCILG ELSDGQPLFP GESEIDQLFT IQKVLGPLPS EQMKLFYSNP RFHGLRFPAV 240

NHPQSLERRY LGILNSVLLD LMKNLLKLDP ADRYLTEQCL NHPTF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013