EKS-EQC-00332
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00332
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK365.52.1E-109171584414
StatusUnreviewed
Ensembl ProteinENSECAP00000005706
UniProt AccessionF7DLX9;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK1
Gene Synonyms/Alias EIF2AK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000007200ENSECAP00000005706ENSECAT00000007741
OrganismEquus caballus
Functional Description
Protein Length633
Protein Sequence
(FASTA)
RRAMLGGSSG AREGDEAEGD GAGAVPAPPA IDFPAEGSDP KYDESDVPAE LRVFRGPLQQ 60
PAFPFAVANQ LLLVSLLEHL SHVHEPNPLR SRQVFKLLCQ TFIKMGLLSS FTCSDEFSSL 120
RLHHNRAITH LMRSAKERVR QDPCEDNSHI QKIRSREIAF EAQTSRYLNE FEELAVLGKG 180
GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI VGYHTAWIEH 240
VHVAQTQDRI SLQLPSLEVI SDREDERDQY DVKNDESNGS SIIFAEFTPE KEKSFGESGV 300
ENQNNRLVNY TSNLITRDSE FESSSELQGN GLADLSSRSI LEHQLPPRHN SDLEENFTST 360
EESSEGKLNL LGQTEVQYHL MLHIQMQLCE LSLWDWIAER NRRGRECVDE SACPYVMASV 420
ATKIFQQLVE GVFYIHNMGI VHRDLKPRNI FLHGPDQQVK IGDFGLACTD IIQNTDWTNR 480
NGKRTPTHTS RVGTCLYASP EQLEGSEYDA KSDMYSLGVI LLELFQPFGT EMERAEVLTG 540
LRTGQIPESL GKRCPVQAKY IQHLTRKNSS QRPSARQLLQ SELFQNSGNV NLNLQMKILE 600
QEKEIEELRK QISLLSRDKG VKGDTQPGDV SGL 633
Nucleotide Sequence
(FASTA)
CGGCGGGCGA TGCTCGGGGG CAGCTCTGGA GCCCGGGAGG GCGACGAGGC GGAGGGCGAC 60
GGGGCGGGGG CTGTGCCTGC GCCACCTGCC ATCGACTTCC CGGCCGAGGG CTCGGACCCC 120
AAGTATGATG AGTCCGATGT CCCAGCGGAG CTCCGGGTGT TCCGAGGACC CCTGCAACAG 180
CCGGCTTTCC CCTTTGCTGT TGCAAACCAA CTGCTGCTTG TTTCTTTGCT GGAACACCTT 240
AGCCATGTGC ATGAACCAAA CCCACTTCGT TCAAGACAGG TGTTTAAATT ACTTTGTCAG 300
ACCTTCATCA AGATGGGCCT GCTGTCTTCC TTCACTTGCA GCGACGAGTT CAGCTCCCTG 360
AGGCTACATC ACAACAGGGC CATCACCCAT TTGATGAGGT CGGCTAAGGA GAGAGTTCGT 420
CAGGATCCTT GTGAGGATAA TTCTCACATC CAGAAGATCA GGTCAAGGGA AATAGCCTTT 480
GAAGCGCAAA CGTCACGTTA CTTAAATGAA TTTGAAGAGC TTGCGGTCTT AGGAAAAGGT 540
GGCTACGGAA GAGTGTACAA GGTCAGGAAT AAATTAGATG GTCAGTATTA TGCAATTAAA 600
AAAATCCTGA TTAAAGGTGC AACTAAAACA GATTGCATGA AGGTACTCCG GGAAGTGAAG 660
GTGCTGGCGG GGCTCCAGCA TCCTAATATC GTCGGCTATC ACACCGCTTG GATAGAACAC 720
GTGCACGTGG CCCAAACGCA AGATAGGATT TCTCTTCAGT TGCCATCCCT GGAAGTGATC 780
TCTGACCGTG AGGACGAGAG AGATCAGTAT GATGTTAAAA ATGATGAAAG TAACGGCTCA 840
TCCATTATCT TCGCCGAGTT CACCCCAGAA AAAGAAAAAT CCTTTGGAGA ATCTGGCGTG 900
GAAAATCAGA ATAACAGATT GGTGAACTAC ACCAGCAATT TAATCACAAG AGACAGTGAA 960
TTTGAATCAT CCAGTGAGCT CCAAGGAAAT GGCTTGGCTG ATTTGTCTTC AAGATCCATT 1020
CTTGAGCATC AGCTGCCCCC TAGGCATAAT TCAGACTTAG AAGAGAATTT CACGTCCACT 1080
GAGGAATCTT CTGAAGGAAA GTTAAACTTG TTGGGGCAGA CAGAGGTGCA GTACCATCTC 1140
ATGCTGCACA TCCAGATGCA GCTGTGTGAG CTTTCGCTGT GGGACTGGAT CGCCGAGAGG 1200
AACAGGCGCG GCCGAGAGTG TGTGGACGAA TCTGCTTGTC CTTATGTTAT GGCCAGTGTT 1260
GCAACGAAAA TTTTTCAACA ATTGGTGGAA GGTGTATTTT ACATACATAA CATGGGAATT 1320
GTACACAGAG ACCTGAAGCC CAGAAATATT TTCCTTCACG GCCCTGATCA GCAAGTGAAA 1380
ATTGGAGACT TCGGTTTGGC CTGTACCGAC ATCATACAGA ACACAGACTG GACCAACAGA 1440
AACGGGAAGA GAACACCCAC ACATACTTCC AGAGTGGGCA CTTGTCTGTA CGCTTCACCC 1500
GAACAGTTGG AAGGATCCGA GTACGACGCC AAGTCAGATA TGTATAGCTT GGGTGTCATC 1560
CTGCTAGAGC TCTTCCAGCC ATTTGGAACC GAAATGGAGC GAGCAGAAGT TTTAACAGGT 1620
TTAAGAACTG GTCAGATACC TGAATCCCTC GGTAAAAGGT GTCCCGTACA AGCCAAGTAC 1680
ATCCAACACT TAACGAGAAA GAACTCGTCC CAGAGACCGT CTGCTCGTCA GCTGCTGCAG 1740
AGTGAACTTT TCCAAAATTC CGGAAACGTT AATCTCAACC TGCAGATGAA GATACTAGAG 1800
CAAGAAAAAG AAATCGAAGA ACTGAGGAAG CAGATCAGCC TCCTTTCTCG GGACAAAGGG 1860
GTTAAGGGTG ACACGCAGCC TGGGGACGTA AGTGGACTTT AA 1902
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59
         fee++vlGkGg+g+V+k++nkld+++yaik+i ++ a+k+ ++kv+revk+La l+hpni
Q: 171   FEELAVLGKGGYGRVYKVRNKLDGQYYAIKKILIKGATKTdCMKVLREVKVLAGLQHPNI  230
         899*********************************************************
S: 60    vrYfaawleekeesl...............................td.sseveaeaele  87
         v Y++aw+e+ +  +                               ++ ss ++ae+++e
Q: 231   VGYHTAWIEHVHVAQtqdrislqlpslevisdrederdqydvkndeSNgSSIIFAEFTPE  290
         ************99999**************************99867799999999999
S: 88    esesseesdtk.................................................  98
         +++s+ es ++                                                 
Q: 291   KEKSFGESGVEnqnnrlvnytsnlitrdsefessselqgngladlssrsilehqlpprhn  350
         9999999999999***********************************************
S: 99    ..............................llyiqmelceketLkdwiderk......ll  122
                                       +l+iqm+lce  +L+dwi er+      ++
Q: 351   sdleenftsteessegklnllgqtevqyhlMLHIQMQLCE-LSLWDWIAERNrrgrecVD  409
         ****************************************.*********9999999899
S: 123   esrselvm.....rlfkqllegleylHskgliHrdLkpsniFld.sddqvKigDFgLata  176
         es++ +vm     ++f+ql+eg+ y+H++g++HrdLkp+niFl+  d+qvKigDFgLa++
Q: 410   ESACPYVMasvatKIFQQLVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQVKIGDFGLACT  469
         99999999************************************99**************
S: 177   laealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGlilfeLlypf  236
         ++ + ++d+++++ +++++ht++vgt+ly+sPeqle+s+Y++k+D++sLG+il+eL++pf
Q: 470   DIIQ-NTDWTNRNGKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVILLELFQPF  528
         6655.779****************************************************
S: 237   stemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasellksell  292
          temer+e+lt lr+g+ipe++ +++p+++k++q+l+++++++Rpsa++ll+sel+
Q: 529   GTEMERAEVLTGLRTGQIPESLGKRCPVQAKYIQHLTRKNSSQRPSARQLLQSELF  584
         *****************************************************986
Domain Sequence
(FASTA)
FEELAVLGKG GYGRVYKVRN KLDGQYYAIK KILIKGATKT DCMKVLREVK VLAGLQHPNI 60
VGYHTAWIEH VHVAQTQDRI SLQLPSLEVI SDREDERDQY DVKNDESNGS SIIFAEFTPE 120
KEKSFGESGV ENQNNRLVNY TSNLITRDSE FESSSELQGN GLADLSSRSI LEHQLPPRHN 180
SDLEENFTST EESSEGKLNL LGQTEVQYHL MLHIQMQLCE LSLWDWIAER NRRGRECVDE 240
SACPYVMASV ATKIFQQLVE GVFYIHNMGI VHRDLKPRNI FLHGPDQQVK IGDFGLACTD 300
IIQNTDWTNR NGKRTPTHTS RVGTCLYASP EQLEGSEYDA KSDMYSLGVI LLELFQPFGT 360
EMERAEVLTG LRTGQIPESL GKRCPVQAKY IQHLTRKNSS QRPSARQLLQ SELF 414
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00318
EKS-ANC-00332
EKS-BOT-00340
EKS-CAJ-00349
EKS-CAF-00348
EKS-CAP-00374
EKS-CII-00191
EKS-DAR-00704
EKS-FEC-00331
EKS-GAG-00286
EKS-GAA-00423
EKS-GOG-00338
EKS-HOS-00347
EKS-ICT-00324
EKS-LAC-00356
EKS-LOA-00351
EKS-MAM-00345
EKS-MEG-00281
EKS-MOD-00336
EKS-MUM-00375
EKS-MUP-00334
EKS-MYL-00339
EKS-ORN-00444
EKS-ORA-00299
EKS-ORC-00319
EKS-ORL-00411
EKS-OTG-00345
EKS-PES-00300
EKS-PEM-00181
EKS-POA-00332
EKS-PTV-00080
EKS-RAN-00355
EKS-SAH-00319
EKS-SUS-00303
EKS-TAG-00416
EKS-TAR-00447
EKS-TEN-00443
EKS-XIM-00431
EKS-SCP-00085
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004694; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0020037; F:heme binding
GO:0008285; P:negative regulation of cell proliferation
GO:0046986; P:negative regulation of hemoglobin biosynthetic process
GO:0046777; P:protein autophosphorylation
GO:0046501; P:protoporphyrinogen IX metabolic process
GO:0010999; P:regulation of eIF2 alpha phosphorylation by heme
GO:0009605; P:response to external stimulus
GO:0006950; P:response to stress
KEGG
InterPros
IPR015516; Haem-reg_EIF2A_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013