EKS-EQC-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph492.42.3E-148614870257
StatusUnreviewed
Ensembl ProteinENSECAP00000006952
UniProt AccessionF6QAL5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA2
Gene Synonyms/Alias EPHA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000007650ENSECAP00000006952ENSECAT00000009174
OrganismEquus caballus
Functional Description
Protein Length975
Protein Sequence
(FASTA)
MERRAPRAGL ALLLGCLLAA AAAAQGKEVV LLDFAAAKGE LGWLTHPYGK GWDLMQNIMD 60
DMPIYMYSVC NVVAGDQDNW LRTNWVYRGE AERIFIELKF TVRDCNSFPG GASSCKETFN 120
LYYAESDVDY GTNFQKRQFT KIDTIAPDEI TVSSDFEARH VKLNVEERSV GPLSRKGFYL 180
AFQDIGACVA LLSVRVYYKK CPELLQGLAR FPETIAGSDA PSLATVPGTC VDHAVVPPGG 240
EEPRMHCAVD GEWLVPIGQC LCQAGYEKVE DACQACSPGF FKSEASESPC LECPAHTLPS 300
PEGATSCECE EGYFRAQQDP LSMPCTRPPS APHYLTAIGM GAKVELRWTP PQDNGGREDI 360
IYSVTCEQCW PESGECGPCE ASVHYSEPPH ALTRTSVTVS DLEPHMNYTF VVEARNGVSD 420
LVTSRSFRTA SVSINQTEPP KVKLEGRSTT SLSVSWSIPP PQQSRVWKYE VTYRKKGDSN 480
SYNVRRTEGF SVTLDDLAPD TTYLVQVQAL TQEGQGAGSK VHEFQTLSTE GSGNMAVIGG 540
VAVGVLLLLV LAGIGLFIHR RRRSLRTRQS SEDVYFSKSE QLKPLKTYVD PHTYEDPNQA 600
VLKFTTEIHP SCVTRQKVIG AGEFGEVYKG TLKVSGKKEV PVAIKTLKAG YTEKQRVDFL 660
SEASIMGQFS HHNIIRLEGV VSKYKPMMII TEYMENGALD KFLREKDGEF SVLQLVGMLR 720
GIAAGMKYLA NMNYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAT YTTSGGKIPI 780
RWTAPEAISY RKFTSASDVW SYGIVMWEVM TYGERPYWEL SNHEVMKAIN DGFRLPTPMD 840
CPSAIYQLMM QCWQQERARR PKFADIVSIL DKLIRAPDSL KTLADFDPRV SIRLPSTSGS 900
EGVPFHTVSE WLESIKMQQY TEHFLAAGYT AIEKVVQMTN DDIKRIGVRL PGHQKRIAYS 960
LLGLKDQVNT VGIPI 975
Nucleotide Sequence
(FASTA)
ATGGAGCGTC GGGCGCCCCG CGCCGGCCTC GCGCTGCTGT TGGGCTGCTT GCTGGCCGCG 60
GCCGCCGCCG CGCAGGGCAA GGAAGTTGTG CTGTTGGACT TTGCCGCAGC TAAAGGAGAG 120
CTCGGCTGGC TCACGCACCC GTACGGCAAA GGGTGGGACC TCATGCAGAA CATCATGGAC 180
GACATGCCCA TCTACATGTA CTCTGTGTGC AACGTGGTGG CCGGCGACCA GGACAACTGG 240
CTCCGCACCA ACTGGGTGTA CCGGGGTGAG GCCGAGCGCA TCTTCATCGA GCTCAAGTTC 300
ACCGTGCGCG ACTGCAACAG CTTCCCCGGG GGCGCCAGCT CCTGCAAGGA GACCTTCAAC 360
CTCTACTACG CTGAGTCGGA CGTGGACTAC GGCACCAACT TCCAGAAGCG CCAGTTCACC 420
AAGATCGACA CCATCGCGCC GGACGAGATC ACGGTCAGCA GCGACTTTGA GGCGCGCCAC 480
GTGAAGCTGA ACGTGGAGGA GCGCTCGGTG GGGCCGCTCA GCCGCAAGGG CTTCTACCTG 540
GCCTTCCAGG ACATCGGCGC CTGCGTGGCG CTGCTCTCCG TCCGCGTCTA CTACAAGAAG 600
TGCCCCGAGC TGCTGCAGGG CCTGGCCCGC TTCCCCGAGA CCATCGCGGG CTCCGACGCA 660
CCCTCCCTGG CCACCGTGCC TGGCACCTGT GTGGACCATG CTGTGGTGCC ACCCGGAGGC 720
GAAGAGCCCC GCATGCACTG CGCGGTGGAT GGCGAGTGGC TGGTGCCCAT CGGTCAGTGT 780
CTGTGCCAGG CGGGCTACGA GAAGGTGGAG GACGCCTGCC AGGCCTGCTC GCCTGGATTC 840
TTCAAGTCCG AGGCGTCCGA GAGCCCCTGT TTGGAGTGCC CTGCACACAC CCTGCCATCC 900
CCCGAGGGGG CCACCTCCTG TGAGTGTGAA GAAGGCTACT TCCGGGCACA GCAGGACCCG 960
CTGTCGATGC CCTGCACCCG CCCTCCCTCC GCTCCGCACT ACCTCACGGC CATAGGCATG 1020
GGCGCCAAAG TGGAGCTGCG CTGGACGCCC CCCCAGGACA ACGGGGGCCG CGAGGACATC 1080
ATCTACAGTG TCACCTGCGA ACAGTGCTGG CCCGAGTCAG GCGAGTGTGG GCCCTGTGAG 1140
GCCAGCGTGC ACTACTCTGA GCCACCGCAC GCGCTGACCC GCACCAGCGT GACGGTCAGT 1200
GACCTGGAGC CCCACATGAA CTACACCTTC GTCGTGGAGG CCCGCAACGG CGTCTCAGAC 1260
CTGGTGACCA GCCGCAGCTT CCGAACCGCC AGCGTCAGCA TCAACCAGAC AGAGCCCCCC 1320
AAGGTGAAGC TGGAGGGCCG CAGCACCACC TCACTGAGCG TCTCCTGGAG CATCCCCCCG 1380
CCACAGCAGA GCCGCGTGTG GAAGTACGAG GTCACCTACC GCAAGAAGGG GGACTCCAAC 1440
AGCTACAACG TGCGCCGCAC TGAGGGCTTC TCCGTGACCC TGGATGACCT GGCTCCGGAC 1500
ACCACCTACC TGGTCCAGGT GCAGGCGCTG ACGCAGGAGG GCCAGGGTGC CGGCAGCAAG 1560
GTGCACGAGT TCCAGACGCT GTCCACGGAA GGATCTGGCA ACATGGCGGT GATTGGCGGA 1620
GTGGCCGTCG GTGTGCTCTT GCTCCTGGTG CTGGCAGGAA TCGGCCTCTT CATCCACCGC 1680
AGGAGGAGGA GCCTGCGGAC CCGACAGTCC TCAGAGGACG TTTACTTCTC CAAGTCAGAA 1740
CAGCTGAAGC CCCTGAAGAC ATACGTGGAC CCCCACACAT ATGAGGACCC CAACCAGGCT 1800
GTGCTCAAAT TTACCACCGA GATCCATCCA TCTTGTGTCA CGCGGCAGAA GGTGATCGGA 1860
GCAGGTGAGT TTGGGGAGGT GTACAAAGGG ACCCTGAAGG TGTCAGGGAA GAAGGAGGTC 1920
CCTGTGGCCA TCAAGACGCT GAAAGCCGGC TACACAGAGA AGCAGCGGGT GGACTTCCTC 1980
AGCGAGGCCA GCATCATGGG CCAGTTCAGC CACCACAACA TCATCCGCCT GGAGGGCGTC 2040
GTCTCCAAAT ACAAGCCCAT GATGATCATC ACTGAGTACA TGGAGAACGG GGCCCTGGAC 2100
AAGTTCCTTC GGGAGAAGGA TGGTGAGTTC AGCGTGCTGC AGCTGGTGGG CATGCTGCGG 2160
GGCATCGCAG CCGGCATGAA GTACCTGGCC AACATGAACT ACGTCCACCG CGACCTGGCC 2220
GCCCGCAACA TCCTTGTCAA CAGCAACCTG GTCTGCAAGG TGTCTGACTT CGGCCTGTCC 2280
CGCGTGCTGG AGGATGACCC CGAGGCCACC TACACCACCA GTGGTGGCAA GATCCCCATC 2340
CGCTGGACGG CCCCGGAGGC CATCTCCTAC CGCAAGTTCA CCTCGGCCAG CGATGTGTGG 2400
AGCTATGGCA TTGTCATGTG GGAGGTGATG ACGTACGGCG AGCGGCCCTA CTGGGAGCTG 2460
TCGAACCACG AGGTGATGAA AGCCATCAAC GACGGCTTCC GGCTCCCCAC GCCCATGGAC 2520
TGCCCCTCCG CCATCTACCA GCTCATGATG CAGTGCTGGC AGCAGGAGCG CGCCCGCCGC 2580
CCCAAGTTCG CCGACATTGT CAGCATCCTC GACAAGCTCA TCCGGGCTCC CGACTCCCTC 2640
AAGACCCTGG CTGACTTTGA CCCCCGGGTG TCCATCCGGC TACCCAGCAC CAGCGGCTCG 2700
GAGGGAGTGC CCTTCCACAC AGTGTCCGAG TGGCTTGAGT CCATCAAGAT GCAGCAGTAC 2760
ACAGAGCACT TCCTGGCGGC TGGCTACACC GCCATCGAGA AGGTGGTGCA GATGACCAAC 2820
GACGACATCA AGAGGATTGG CGTGCGGCTG CCCGGCCACC AGAAACGCAT TGCCTACAGC 2880
CTGCTGGGGC TCAAGGACCA GGTGAACACA GTGGGGATCC CCATCTGA 2928
Domain Profile
S: 2     kiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpn  61
         + +kviGaGefGev++G+lk++gk+e++vaiktlkag+tekqr+dflseasi+Gqf+h+n
Q: 614   TRQKVIGAGEFGEVYKGTLKVSGKKEVPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHN  673
         6789********************************************************
S: 62    iirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmg  121
         iirleGvv+k kp+mi+teymengald+flr+kdg+f+v+qlvgmlrGia+gmkyl++m+
Q: 674   IIRLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMN  733
         ************************************************************
S: 122   yvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkf  181
         yvhrdlaarnilvnsnlvckvsdfGlsrvledd+ea+yttsggkipirwtapeai+yrkf
Q: 734   YVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKF  793
         ************************************************************
S: 182   tsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcw  241
         tsasdvwsyGiv+wev++yGerpyw++sn++v+kai++g+rlp+pmdcp+a+yqlm++cw
Q: 794   TSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCW  853
         ************************************************************
S: 242   qkdraerpkfeqivsil  258
         q++ra+rpkf++ivsil
Q: 854   QQERARRPKFADIVSIL  870
         **************985
Domain Sequence
(FASTA)
TRQKVIGAGE FGEVYKGTLK VSGKKEVPVA IKTLKAGYTE KQRVDFLSEA SIMGQFSHHN 60
IIRLEGVVSK YKPMMIITEY MENGALDKFL REKDGEFSVL QLVGMLRGIA AGMKYLANMN 120
YVHRDLAARN ILVNSNLVCK VSDFGLSRVL EDDPEATYTT SGGKIPIRWT APEAISYRKF 180
TSASDVWSYG IVMWEVMTYG ERPYWELSNH EVMKAINDGF RLPTPMDCPS AIYQLMMQCW 240
QQERARRPKF ADIVSIL 257
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00009
EKS-ANC-00009
EKS-BOT-00008
EKS-CAJ-00009
EKS-CAF-00010
EKS-CAP-00007
EKS-DAR-00015
EKS-FEC-00007
EKS-GAM-00004
EKS-GAA-00015
EKS-GOG-00009
EKS-HOS-00011
EKS-ICT-00009
EKS-LAC-00010
EKS-LOA-00010
EKS-MAM-00009
EKS-MAE-00001
EKS-MEG-00012
EKS-MUM-00010
EKS-MUP-00010
EKS-MYL-00011
EKS-NOL-00009
EKS-OCP-00002
EKS-ORN-00018
EKS-ORA-00008
EKS-ORC-00009
EKS-ORL-00015
EKS-OTG-00010
EKS-PAT-00012
EKS-PES-00008
EKS-POA-00010
EKS-RAN-00009
EKS-SAH-00008
EKS-SUS-00007
EKS-TAR-00014
EKS-TEN-00014
EKS-XIM-00015
Gene Ontology
GO:0005925; C:focal adhesion
GO:0005887; C:integral to plasma membrane
GO:0031256; C:leading edge membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
GO:0032863; P:activation of Rac GTPase activity
GO:0006915; P:apoptotic process
GO:0048320; P:axial mesoderm formation
GO:0046849; P:bone remodeling
GO:0060444; P:branching involved in mammary gland duct morphogenesis
GO:0060326; P:cell chemotaxis
GO:0030216; P:keratinocyte differentiation
GO:0070309; P:lens fiber cell morphogenesis
GO:0033598; P:mammary gland epithelial cell proliferation
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0021915; P:neural tube development
GO:0030182; P:neuron differentiation
GO:0060035; P:notochord cell development
GO:0014028; P:notochord formation
GO:0001649; P:osteoblast differentiation
GO:0030316; P:osteoclast differentiation
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0043491; P:protein kinase B signaling cascade
GO:0045765; P:regulation of angiogenesis
GO:0043535; P:regulation of blood vessel endothelial cell migration
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0010591; P:regulation of lamellipodium assembly
GO:0070848; P:response to growth factor stimulus
GO:0001501; P:skeletal system development
GO:0001570; P:vasculogenesis
KEGG
ecb:100053644;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013