EKS-EQC-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	352.7	1.4E-105	36	286	251

Status

Unreviewed

Ensembl Protein

ENSECAP00000005691

UniProt Accession

F7E0W2;

Protein Name

Protein Synonyms/Alias

Gene Name

STK24

Gene Synonyms/Alias

STK24;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000007682	ENSECAP00000005691	ENSECAT00000007725

Organism

Equus caballus

Functional Description

Protein Length

445

Protein Sequence
(FASTA)

MDSKAQLLRL ALKPRRATIS LSLSLSNLKA DPEELFTKLE KIGKGSFGEV FKGIDNRTQK 60

VVAIKIIDLE EAEDEIEDIQ QEITVLSQCD SPYVTKYYGS YLKDTKLWII MEYLGGGSAL 120

DLLEPGPLDE TQIATILREI LKGLDYLHSE KKIHRDIKAA NVLLSEHGEV KLADFGVAGQ 180

LTDTQIKRNT FVGTPFWMAP EVIKQSAYDS KADIWSLGIT AIELAKGEPP HSELHPMKVL 240

FLIPKNNPPT LEGNYSRPLK EFVEACLNKE PSFRPTAKEL LKHKFIIRNA KKTSYLTELI 300

DRYKRWKAEQ SHEDSSSEDS DTDTDGQASG GSDSDSGDWN FTDSEKNSKS LENGTLRPSD 360

LERNKVSFLP QMPSSQCLST IISPLFAELK EKSQACGGNM GSIEELRRAI YLAEEACPGI 420

SDTMVAQLVQ RLQRYSLSGG GTLSH 445

Nucleotide Sequence
(FASTA)

ATGGACTCAA AAGCCCAGCT GTTACGATTG GCCTTGAAGC CAAGGAGGGC CACCATCTCT 60

CTCTCTCTCT CTCTCTCTAA CCTAAAAGCA GATCCAGAAG AGCTTTTTAC AAAACTGGAG 120

AAAATCGGAA AGGGCTCTTT TGGCGAGGTG TTCAAAGGCA TTGACAATCG GACTCAGAAA 180

GTGGTTGCCA TAAAAATCAT TGATCTGGAA GAAGCTGAAG ATGAGATAGA GGACATTCAA 240

CAGGAAATCA CAGTGCTGAG TCAGTGTGAC AGTCCATACG TAACCAAATA TTATGGATCC 300

TATCTGAAGG ATACTAAATT GTGGATAATC ATGGAATACC TTGGTGGAGG CTCCGCACTG 360

GATCTATTAG AACCTGGCCC TTTAGATGAA ACTCAGATTG CTACTATATT AAGAGAAATC 420

CTGAAAGGAC TTGATTATTT GCATTCGGAG AAGAAAATTC ATAGAGACAT TAAAGCTGCC 480

AACGTTCTGC TCTCGGAACA TGGAGAGGTG AAGCTGGCTG ACTTTGGAGT GGCGGGCCAG 540

TTGACGGATA CCCAGATAAA AAGAAATACC TTTGTGGGCA CCCCTTTCTG GATGGCCCCC 600

GAAGTCATTA AACAGTCTGC CTACGACTCA AAGGCAGACA TCTGGTCCCT GGGCATAACA 660

GCTATAGAAC TTGCGAAAGG GGAGCCCCCT CATTCCGAGC TGCATCCCAT GAAGGTTTTA 720

TTCCTCATTC CAAAGAACAA CCCCCCGACG CTGGAAGGAA ACTACAGCAG ACCCCTCAAG 780

GAGTTTGTGG AGGCCTGTCT GAATAAGGAG CCGAGCTTTA GACCCACTGC TAAGGAGTTA 840

CTGAAGCACA AGTTTATAAT ACGCAACGCA AAGAAGACGT CCTACTTGAC TGAGCTCATC 900

GACAGGTACA AGAGGTGGAA GGCCGAACAG AGCCACGAGG ACTCCAGCTC CGAGGACTCG 960

GACACAGACA CGGACGGCCA AGCGTCCGGA GGCAGCGACT CTGACTCCGG GGACTGGAAC 1020

TTCACGGACT CAGAGAAGAA TTCAAAGAGT CTCGAGAATG GAACTCTTCG GCCGTCTGAT 1080

TTGGAAAGAA ATAAGGTGTC TTTTCTTCCC CAGATGCCTT CCTCTCAGTG TTTATCTACA 1140

ATTATTTCTC CGCTCTTTGC AGAGTTGAAG GAGAAGAGCC AAGCGTGCGG CGGTAATATG 1200

GGGTCCATAG AAGAACTGCG AAGGGCCATC TACCTGGCAG AAGAGGCCTG CCCCGGCATC 1260

TCGGATACCA TGGTGGCCCA GCTCGTGCAG CGGCTCCAGA GATACTCTCT AAGTGGTGGA 1320

GGAACTTTAT CCCACTGA 1338

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.ekleelqkeisvlkklkhpniv  59

         ++ le+igkG++g+v+++ +++t+++vaik+i+le+  +++e++q+ei+vl+++++p+++

Q: 36    FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAeDEIEDIQQEITVLSQCDSPYVT  95

         7889*******************************99899********************

S: 60    eylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkv  119

         +y++s+lk+++lw++meyl gGs+ dl++     +l+E+qia+ilre+lk+L+ylHs+k+

Q: 96    KYYGSYLKDTKLWIIMEYLGGGSALDLLE---PGPLDETQIATILREILKGLDYLHSEKK  152

         *****************************...****************************

S: 120   iHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYde  179

         iHrdika+n+Ll+e+geVkL+dfgva ql++t+ kr+t+vgtp+wmAPEvi+  ++ Yd+

Q: 153   IHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIK--QSAYDS  210

         ****************************************************..9*****

S: 180   kaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclq  239

         kaDiwslGItaiela+gepP+++l+p+k+l++i+kn+pp+l+ +  +s+ +kefve+cl+

Q: 211   KADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGN--YSRPLKEFVEACLN  268

         *****************************************776..**************

S: 240   knpekRpsasellkhkFl  257

         k+p++Rp+a+ellkhkF+

Q: 269   KEPSFRPTAKELLKHKFI  286

         *****************7

Domain Sequence
(FASTA)

FTKLEKIGKG SFGEVFKGID NRTQKVVAIK IIDLEEAEDE IEDIQQEITV LSQCDSPYVT 60

KYYGSYLKDT KLWIIMEYLG GGSALDLLEP GPLDETQIAT ILREILKGLD YLHSEKKIHR 120

DIKAANVLLS EHGEVKLADF GVAGQLTDTQ IKRNTFVGTP FWMAPEVIKQ SAYDSKADIW 180

SLGITAIELA KGEPPHSELH PMKVLFLIPK NNPPTLEGNY SRPLKEFVEA CLNKEPSFRP 240

TAKELLKHKF I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006917	; P:induction of apoptosis
GO:0008631	; P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030336	; P:negative regulation of cell migration
GO:0046777	; P:protein autophosphorylation
GO:0048679	; P:regulation of axon regeneration

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013