EKS-EQC-00362
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00362
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src433.82.1E-130262510249
StatusUnreviewed
Ensembl ProteinENSECAP00000005837
UniProt AccessionF7CK20;
Protein Name
Protein Synonyms/Alias
Gene NameFGR
Gene Synonyms/Alias FGR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000007837ENSECAP00000005837ENSECAT00000007886
OrganismEquus caballus
Functional Description
Protein Length527
Protein Sequence
(FASTA)
MGCVFCKKLE PGPKEDAGLE GDLRGYGAAD HYGPDPTQGR PSSSFAHIPN YNNFSPQPAS 60
SAFLDAGTIR GISGTGVTLF IALYDYEART EDDLTFTKGE KFHILNNTEG DWWEARSLSS 120
GQTGYIPSNY VAPVDSIQAE EWYFGKIGRK DAERQLLSPG NPRGAFLIRE SETTKGAYSL 180
SIRDWDEARG DHVKHYKIRK LDTGGYYITT RTQFDSVQEL VQHYTEVNDG LCHLLTAACT 240
TMRPQTLGLA KDAWEISRSS IALERRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA 300
FLAEAQVMKL LRHDKLVQLY AVVSEEPIYI VTEFMCHGSL LEFLKDRKGQ DLKLPQLVDM 360
AAQVAAGMAY MERMNYIHRD LRAANILVGE RLVCKIADFG LARLIKDDEY NPRQGAKFPI 420
KWTAPEAALF GRFTIKSDVW SFGILLTELI SKGRVPYPGM NNREVLEQVE HGYHMPCPPG 480
CPASLYEAME QTWRLDPEER PTFEYLQSFL EDYFTSTEPQ YQPGDQT 527
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTTCTGCAA GAAGTTGGAG CCAGGGCCCA AGGAGGATGC TGGCCTGGAA 60
GGGGACTTGA GGGGCTACGG GGCTGCGGAT CACTATGGCC CTGACCCTAC TCAGGGCCGG 120
CCTTCGTCCT CCTTTGCCCA TATCCCCAAC TACAACAACT TCTCCCCTCA GCCCGCCAGC 180
TCTGCCTTCC TTGATGCGGG CACCATCAGG GGCATCTCAG GCACTGGGGT GACCCTGTTC 240
ATCGCCCTGT ATGACTATGA GGCCCGGACA GAGGATGACC TTACCTTCAC CAAGGGCGAG 300
AAGTTCCACA TCCTGAATAA CACTGAGGGT GACTGGTGGG AGGCTCGGTC CCTCAGCTCT 360
GGACAAACTG GCTACATTCC CAGCAACTAT GTGGCCCCTG TGGACTCCAT CCAGGCTGAA 420
GAGTGGTACT TTGGAAAGAT CGGGAGGAAG GATGCGGAGA GGCAGCTGCT CTCCCCCGGC 480
AATCCTCGGG GTGCCTTTCT CATTCGAGAG AGCGAGACCA CCAAAGGTGC CTACTCCCTG 540
TCCATCCGAG ATTGGGATGA GGCCAGAGGT GATCACGTGA AGCATTACAA GATCCGAAAG 600
CTGGACACAG GTGGCTACTA CATCACCACT CGGACCCAGT TCGACTCGGT GCAGGAGCTG 660
GTACAGCACT ACACTGAGGT AAACGATGGA CTGTGCCACC TGCTGACGGC GGCCTGCACC 720
ACCATGAGGC CGCAGACCCT GGGCCTGGCC AAGGACGCCT GGGAGATCAG CCGTAGCTCC 780
ATCGCGCTCG AGCGCCGGCT GGGCACTGGC TGCTTCGGCG ACGTGTGGCT GGGCACGTGG 840
AATGGCAGCA CGAAGGTGGC AGTGAAGACG CTGAAGCCAG GTACCATGTC CCCAAAGGCC 900
TTCCTGGCGG AGGCGCAGGT CATGAAGCTG CTGCGGCATG ACAAGCTGGT GCAGCTGTAC 960
GCGGTGGTGT CGGAGGAGCC CATCTACATC GTGACGGAGT TCATGTGCCA CGGTAGCTTG 1020
CTGGAATTCC TTAAGGACCG GAAGGGTCAG GATTTGAAGC TGCCCCAGCT GGTGGACATG 1080
GCAGCCCAGG TAGCTGCGGG CATGGCCTAC ATGGAGCGCA TGAACTATAT CCATCGTGAC 1140
CTGAGGGCAG CCAACATCCT CGTAGGGGAG CGGCTGGTGT GCAAGATTGC TGACTTTGGG 1200
CTGGCCCGCC TCATCAAGGA TGATGAGTAC AACCCCCGGC AAGGGGCCAA GTTCCCCATC 1260
AAGTGGACAG CCCCGGAGGC TGCCCTCTTT GGCAGATTCA CCATCAAGTC AGATGTGTGG 1320
TCCTTTGGGA TCCTGCTCAC TGAACTCATC AGCAAGGGCC GGGTCCCCTA CCCAGGCATG 1380
AATAACCGAG AAGTGTTGGA ACAGGTGGAG CACGGATACC ACATGCCGTG CCCCCCCGGT 1440
TGCCCAGCGT CCCTATACGA GGCCATGGAG CAAACCTGGC GTCTGGACCC GGAAGAGAGG 1500
CCTACGTTCG AGTACCTGCA GTCCTTCCTG GAGGACTACT TCACCTCCAC AGAACCCCAG 1560
TACCAGCCTG GGGATCAGAC ATAG 1584
Domain Profile
S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61
          l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afl+eaq++k lrh+klv+lya
Q: 262   ALERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLAEAQVMKLLRHDKLVQLYA  321
         789*********************************************************
S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121
         vvse ePiyivte+m +Gsll+flk+++g+ lklp+lvd+aaqva+Gmay+e++n+ihrd
Q: 322   VVSE-EPIYIVTEFMCHGSLLEFLKDRKGQDLKLPQLVDMAAQVAAGMAYMERMNYIHRD  380
         ***9.*******************************************************
S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181
         l+a+n+lvge+lv+k+adfGlarli+ddey++++gak+PikWtaPea+ +g+ftiksdvW
Q: 381   LRAANILVGERLVCKIADFGLARLIKDDEYNPRQGAKFPIKWTAPEAALFGRFTIKSDVW  440
         ************************************************************
S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241
         sfGillte+++kG+vPypGm+n+evleqve+gy++p+p  cp++lye+++++w+ dpeer
Q: 441   SFGILLTELISKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPASLYEAMEQTWRLDPEER  500
         ************************************************************
S: 242   Ptfetlqevl  251
         Ptfe+lq++l
Q: 501   PTFEYLQSFL  510
         *******986
Domain Sequence
(FASTA)
ALERRLGTGC FGDVWLGTWN GSTKVAVKTL KPGTMSPKAF LAEAQVMKLL RHDKLVQLYA 60
VVSEEPIYIV TEFMCHGSLL EFLKDRKGQD LKLPQLVDMA AQVAAGMAYM ERMNYIHRDL 120
RAANILVGER LVCKIADFGL ARLIKDDEYN PRQGAKFPIK WTAPEAALFG RFTIKSDVWS 180
FGILLTELIS KGRVPYPGMN NREVLEQVEH GYHMPCPPGC PASLYEAMEQ TWRLDPEERP 240
TFEYLQSFL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>
EKS-AIM-00344
EKS-ANC-00357
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-DRM-00174
EKS-FEC-00357
EKS-GAA-00446
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MAM-00370
EKS-MUM-00402
EKS-MUP-00364
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
EKS-TUT-00101
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
ecb:100056804;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013