EKS-EQC-00068

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-EQC-00068

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	348.2	3.5E-104	1	284	284

Status

Unreviewed

Ensembl Protein

ENSECAP00000006101

UniProt Accession

F6V4K1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK9

Gene Synonyms/Alias

CDK9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSECAG00000007965	ENSECAP00000006101	ENSECAT00000008182

Organism

Equus caballus

Functional Description

Protein Length

341

Protein Sequence
(FASTA)

EVFKAKDRKT GQKVALKKVL MENEKEGFPI TALREIKILQ LLKHENVVNL IEICRTKASP 60

YNRCKGSIYL VFDFCEHDLA GLLSNVLVKF TLSEIKRVMQ MLLNGLYYIH RNKILHRDMK 120

AANVLITRDG VLKLADFGLA RAFSLAKNSQ PNRYTNRVVT LWYRPPELLL GERDYGPPID 180

LWGAGCIMAE MWTRSPIMQG NTEQHQLALI SQLCGSITPE VWPNVDKYEL FEKLDLVKGQ 240

KRKVKDRLKA YVRDPYALDL IDKLLVLDPA QRIDSDDALN HDFFWSDPMP SDLKGMLSTH 300

LTSMFEYLAP PRRKGSQITQ QSTNQSRNPA TTNQTEFERV F 341

Nucleotide Sequence
(FASTA)

GAGGTGTTTA AGGCAAAGGA CCGCAAGACC GGCCAAAAGG TGGCTCTAAA GAAGGTGCTG 60

ATGGAGAACG AGAAGGAGGG GTTCCCCATT ACAGCCTTGC GGGAAATCAA GATCCTCCAG 120

CTTCTAAAAC ATGAGAACGT GGTCAACTTG ATTGAGATCT GTCGAACCAA AGCGTCCCCC 180

TATAACCGCT GCAAAGGCAG TATATACTTG GTGTTTGACT TCTGTGAGCA TGACCTTGCT 240

GGGCTTCTGA GCAACGTCTT AGTGAAGTTC ACGCTGTCTG AGATCAAGAG GGTCATGCAG 300

ATGTTGCTCA ACGGCCTCTA CTACATCCAC AGGAACAAGA TCCTGCACAG GGACATGAAG 360

GCGGCTAACG TGCTCATCAC CCGCGATGGG GTTCTGAAGC TGGCTGACTT TGGGCTGGCC 420

CGGGCCTTCA GCCTGGCCAA GAACAGCCAG CCCAACCGCT ATACCAACCG TGTGGTGACG 480

CTCTGGTACC GGCCCCCGGA GCTGTTGCTC GGAGAGCGGG ACTACGGCCC CCCCATTGAC 540

CTGTGGGGTG CTGGGTGCAT CATGGCGGAG ATGTGGACCC GCAGCCCTAT CATGCAGGGC 600

AACACGGAAC AGCACCAGCT CGCCCTCATC AGCCAGCTCT GTGGCTCCAT CACCCCTGAG 660

GTGTGGCCAA ATGTGGACAA GTATGAGCTG TTTGAGAAAC TGGACCTGGT CAAGGGCCAG 720

AAGCGGAAGG TGAAGGACAG GCTGAAGGCC TACGTGCGTG ACCCCTACGC GCTGGACCTC 780

ATCGACAAGT TGCTGGTGCT GGATCCCGCA CAGCGCATTG ACAGTGACGA CGCCCTCAAC 840

CACGACTTCT TCTGGTCTGA CCCCATGCCC TCGGACCTCA AGGGCATGCT GTCCACCCAC 900

CTGACGTCCA TGTTCGAGTA CCTGGCGCCA CCACGCCGGA AGGGCAGCCA GATCACCCAG 960

CAGTCCACCA ACCAGAGCCG CAATCCCGCC ACCACCAACC AGACAGAGTT TGAGCGCGTC 1020

TTCTGA 1026

Domain Profile

S: 14    kvykakdketgevvAlKkirlekekegvpitalrEisllkelkhknivkLlevva.....  68

         +v+kakd++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+v+L+e++

Q: 1     EVFKAKDRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRtkasp  60

         59*****************************************************99999

S: 69    ..kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnkilHRDl  126

           + k ++yLvf+f+e+dL+ ll++    k++l+e+k+++++ll+gl y+H+nkilHRD+

Q: 61    ynRCKGSIYLVFDFCEHDLAGLLSNVLV-KFTLSEIKRVMQMLLNGLYYIHRNKILHRDM  119

         988889*********************9.*******************************

S: 127   KpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraPelLlgakeYstav  182

         K++N+Li+++g+lklaDfGlaraf    +s+ ++yt++vvTlwYr+PelLlg+++Y+  +

Q: 120   KAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPPELLLGERDYGPPI  179

         ************************7776555557**************************

S: 183   DiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksfpkk  241

         D+W++gci+ae++tr+p++qg++e++ql  i++l+g+++ +vwp+v k++ ++  ++ k

Q: 180   DLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDKYELFEkLDLVKG  239

         *****************************************************7799999

S: 242   kkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf  284

         +k+k+k+++k++ ++  aldl++kll ldp++Ri++++al+h++f

Q: 240   QKRKVKDRLKAYVRDpyALDLIDKLLVLDPAQRIDSDDALNHDFF  284

         999999999887755469*************************98

Domain Sequence
(FASTA)

EVFKAKDRKT GQKVALKKVL MENEKEGFPI TALREIKILQ LLKHENVVNL IEICRTKASP 60

YNRCKGSIYL VFDFCEHDLA GLLSNVLVKF TLSEIKRVMQ MLLNGLYYIH RNKILHRDMK 120

AANVLITRDG VLKLADFGLA RAFSLAKNSQ PNRYTNRVVT LWYRPPELLL GERDYGPPID 180

LWGAGCIMAE MWTRSPIMQG NTEQHQLALI SQLCGSITPE VWPNVDKYEL FEKLDLVKGQ 240

KRKVKDRLKA YVRDPYALDL IDKLLVLDPA QRIDSDDALN HDFF 284

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016605	; C:PML body
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0017069	; F:snRNA binding
GO:0044212	; F:transcription regulatory region DNA binding
GO:0071345	; P:cellular response to cytokine stimulus
GO:0071157	; P:negative regulation of cell cycle arrest
GO:0006282	; P:regulation of DNA repair
GO:0031056	; P:regulation of histone modification
GO:0043111	; P:replication fork arrest

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013