EKS-EQC-00137
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-EQC-00137
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt503.51.3E-151152409258
StatusUnreviewed
Ensembl ProteinENSECAP00000006890
UniProt AccessionF6RGP1;
Protein Name
Protein Synonyms/Alias
Gene NameAKT2
Gene Synonyms/Alias AKT2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSECAG00000008005ENSECAP00000006890ENSECAT00000009104
OrganismEquus caballus
Functional Description
Protein Length481
Protein Sequence
(FASTA)
MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC 60
QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDERREWM RAIQMVANSL KQRGPGEDPM 120
DYKCGSPSDS SAAEEMEVAV SKARAKVTMN DFDYLKLLGK GTFGKVILVR EKATGRYYAM 180
KILRKEVIIA KDEVAHTVTE SRVLQNTRHP FLTALKYAFQ THDRLCFVME YANGGELFFH 240
LSRERVFTEE RARFYGAEIV SALEYLHSRD VVYRDIKLEN LMLDKDGHIK ITDFGLCKEG 300
ISDGATMKTF CGTPEYLAPE VLEDNDYGRA VDWWGLGVVM YEMMCGRLPF YNQDHERLFE 360
LILMEEIRFP RTLSPEAKSL LAGLLKKDPK QRLGGGPSDA KEVMEHRFFL SINWQDVVQK 420
KLLPPFKPQV TSEVDTRYFD DEFTAQSITI TPPDRYDSLG SLDLDQRTHF PQFSYSASIR 480
E 481
Nucleotide Sequence
(FASTA)
ATGAACGAGG TGTCTGTCAT CAAAGAAGGC TGGCTCCACA AGCGCGGTGA ATACATCAAG 60
ACCTGGAGGC CCCGGTACTT CCTGCTGAAG AGTGACGGCT CCTTCATTGG CTACAAGGAG 120
CGGCCCGAGG CGCCCGACCA GACCCTGCCC CCCCTAAACA ACTTCTCTGT CGCAGAGTGC 180
CAGCTGATGA AGACCGAGAG ACCACGGCCC AACACCTTTG TCATACGCTG CCTGCAGTGG 240
ACCACGGTCA TCGAGAGGAC CTTCCACGTA GACTCTCCGG ACGAGAGGCG AGAATGGATG 300
CGGGCCATCC AGATGGTCGC CAACAGCCTG AAGCAGCGGG GCCCCGGGGA GGACCCCATG 360
GACTACAAGT GTGGCTCCCC CAGCGACTCT TCGGCGGCCG AGGAGATGGA GGTGGCGGTT 420
AGCAAGGCGC GGGCCAAGGT GACCATGAAC GACTTCGACT ATCTCAAACT CCTGGGCAAG 480
GGCACCTTTG GCAAAGTCAT CCTGGTGCGG GAGAAGGCCA CTGGCCGCTA CTACGCCATG 540
AAGATTCTGC GGAAGGAGGT GATCATCGCC AAGGATGAAG TCGCCCACAC GGTCACCGAG 600
AGCCGAGTCC TCCAGAACAC CAGGCACCCG TTCCTCACCG CCCTGAAGTA TGCCTTCCAG 660
ACCCACGACC GCCTGTGCTT CGTGATGGAG TACGCCAACG GTGGTGAGCT GTTCTTCCAC 720
TTGTCCCGGG AGCGCGTCTT CACGGAGGAG CGGGCCCGCT TCTATGGCGC AGAGATCGTC 780
TCGGCCCTGG AGTACCTGCA CTCTCGGGAC GTGGTGTACC GCGACATCAA GCTGGAAAAC 840
CTCATGCTGG ACAAAGATGG CCACATCAAG ATCACTGACT TCGGCCTGTG CAAGGAGGGC 900
ATCAGTGATG GGGCCACCAT GAAGACCTTC TGTGGGACCC CTGAATACCT GGCTCCCGAG 960
GTGCTGGAGG ACAATGACTA CGGCCGGGCT GTGGACTGGT GGGGGCTGGG CGTGGTGATG 1020
TACGAGATGA TGTGCGGCCG CCTGCCCTTC TACAACCAGG ACCACGAGCG CCTCTTCGAG 1080
CTCATCCTCA TGGAGGAGAT CCGCTTCCCG CGCACGCTCA GCCCCGAGGC CAAGTCCCTG 1140
CTTGCTGGGC TGCTTAAGAA GGACCCCAAG CAGAGGCTCG GCGGGGGGCC CAGCGATGCC 1200
AAGGAGGTCA TGGAGCACAG GTTCTTCCTC AGCATCAACT GGCAGGACGT GGTACAGAAG 1260
AAGCTCCTGC CACCCTTCAA ACCTCAGGTC ACATCCGAGG TTGACACGAG GTACTTCGAC 1320
GACGAGTTCA CTGCCCAGTC CATCACCATC ACCCCCCCGG ACCGCTATGA CAGCCTGGGC 1380
TCGCTCGACC TGGACCAGCG GACCCACTTC CCCCAGTTCT CCTACTCGGC CAGCATCCGC 1440
GAGTGA 1446
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         fd+lkllGkGtfGkvilvrekat+++ya+kil+kevi+akdevaht+te+rvl++t+hpf
Q: 152   FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPF  211
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         l+alky+fqt+++lc+v+ey+nGGelffhls+ervf+e+rarfygaeivsal+ylhs+dv
Q: 212   LTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDV  271
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         vyrd+klenl+ldkdGhikitdfGlcke+i+dg+++ktfcGtpeylapevled+dyg+av
Q: 272   VYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAV  331
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dwwglGvv+yem+cGrlpfyn+dhe+lfelil+ee++fpr+ls+eaksll+Gllkkdpk+
Q: 332   DWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQ  391
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlGgg++dake++eh+ff
Q: 392   RLGGGPSDAKEVMEHRFF  409
         *****************9
Domain Sequence
(FASTA)
FDYLKLLGKG TFGKVILVRE KATGRYYAMK ILRKEVIIAK DEVAHTVTES RVLQNTRHPF 60
LTALKYAFQT HDRLCFVMEY ANGGELFFHL SRERVFTEER ARFYGAEIVS ALEYLHSRDV 120
VYRDIKLENL MLDKDGHIKI TDFGLCKEGI SDGATMKTFC GTPEYLAPEV LEDNDYGRAV 180
DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR TLSPEAKSLL AGLLKKDPKQ 240
RLGGGPSDAK EVMEHRFF 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00132
EKS-ANC-00134
EKS-BOT-00140
EKS-CAE-00113
EKS-CAJ-00144
EKS-CAF-00146
EKS-CAP-00139
EKS-DAR-00423
EKS-DAN-00010
EKS-ECT-00022
EKS-FEC-00131
EKS-GAM-00069
EKS-GAA-00163
EKS-GOG-00141
EKS-HOS-00145
EKS-ICT-00133
EKS-LOA-00138
EKS-MAM-00139
EKS-MUM-00144
EKS-MUP-00143
EKS-MYL-00150
EKS-ORN-00172
EKS-ORL-00161
EKS-OTG-00145
EKS-POA-00135
EKS-PTV-00130
EKS-RAN-00137
EKS-SUS-00123
EKS-TAR-00182
EKS-TEN-00173
EKS-XET-00128
EKS-XIM-00167
Gene Ontology
GO:0030027; C:lamellipodium
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008286; P:insulin receptor signaling pathway
GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport
GO:0032287; P:peripheral nervous system myelin maintenance
GO:2000147; P:positive regulation of cell motility
GO:0032000; P:positive regulation of fatty acid beta-oxidation
GO:2001275; P:positive regulation of glucose import in response to insulin stimulus
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0072659; P:protein localization to plasma membrane
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013